Ligand Insulin

insulin stimulates 11beta-HSD1 activity and expression in a time- and concentration-dependent manner, the p38 MAPK inhibitor SB-220025, but not the ERK inhibitor U-0126 or the phosphatidylinositol 3-kinase inhibitor LY294002, prevent insulin stimulation of 11beta-HSD1 activity

697625

1.1.1.49

stimulates, in pregnant women with types 1 diabetes insulin effect on the enzyme activity is lower than in the control. In the group of pregnant women with type 2 diabetes and gestational diabetes the effect of insulin is decreased as compared to control

696152

1.14.19.1

causes 5fold increace of activity

437657

1.3.1.24

increases BVR tyrosine autophosphorylation

666747

2.1.1.5

is effective in counteracting the stimulation of BHMT activity and mRNA levels produced by triamcinolone in rat hepatoma H4IIE cells

673003

2.3.1.15

Gpat1 is upregulated by insulin

686601

2.3.1.20

treatment of adipocytes with insulin increases DGAT2 mRNA

486513

2.4.1.1

Insulin promotes conversion of GPa to GPb via protein kinase B activation

tyrosine phosphorylation of OGT increases significantly after a 10 min insulin treatment

693100

2.5.1.60

promotes the phosphorylation of the alpha subunit of enzyme without an effect on beta subunit, and activation of enzyme, insulin increases the amount of geranylgeranylated Rab3 and Rab4 proteins

638598

2.7.1.1

stimulating effect is abolished when lactate is added

stimulates PI3K activity

stimulation

high glucose or high insulin rapidly increase inactivating Ser366 phosphorylation of eEF2 kinase

684318

2.7.11.24

causes weak activation

insulin-induced hypoglycaemia in rats increases AMPK phosphorylation and alpha2AMPK activity in the arcuate nucleus/dorso-mediobasal hypothalamus and paraventricular nucleus

705267

3.1.1.34

combination of 100 nM dexmethasone with 100 nM insulin appreciably enhances lipoprotein lipase activity

690344

3.1.3.106

insulin therapy increases both PAP1 activity and lipin mRNA expression in diabetic patients

707381

3.1.3.17

induces the enzyme in diabetic rats

649721

3.1.3.4

increases the phosphorylation of multiple sites, markedly increases the amounts of lipin and PAP activity in the soluble fraction, effects of insulin are attenuated by rapamycin or by inhibiting PI 3 kinase

stimulates

in part, may activate GPI-PLC, via phosphatidylinositol-specific phospholipase C/intracellular Ca2+, which may consequently stimulate the release of GPI-renal dipeptidase

677866

3.1.6.2

human recombinant insulin, 30% activation at 10 ng/ml

stimulates indirectly the release of RDPase in association with Ca2+ in a concentration-dependent manner (half maximal release at 0.58 nM)

677866

3.4.19.3

alters the hypothalamic activity of soluble PAP-I

682252

3.4.24.81

0.001 mM, stimulates the cleavage of the extracellular domain of Klotho

the stimulatory effect of insulin on adenylyl cyclase is decreased to 28% in the presence of 0.1 mM Ca2+

714665

5.4.2.8

incubation with insulin for 45min led to a more than twofold activation of the enzyme

treatment of hepatocytes induces the expression of only the heavy enzyme subunit

650330

6.4.1.2

ACC specific activity is increased in response to insulin

671950

7.1.1.9

insulin treatment at early stage of diabetes (1-week diabetic animals) results in hyper-stimulation, but it is ineffective in restoring the activity in 1-month diabetic animals

694360

7.2.2.13

control of Na,K-ATPase activity and expression

677134

7.2.2.8

insulin reverses the effect of copper and stimulates retrograde trafficking of ATP7B from the canalicular membranes, consistent with the enhanced ability of ATP7B to sequester copper away from the cytosol. Physiological concentrations of insulin increase endogenous ATP7B activity in cultured hepatic cells and in tissues by 40%, whereas glucagon inhibits this activity by 70%. The opposite effects of the hormones on ATP7B activity involve receptor-mediated signaling pathways and membrane-bound kinases PKA and PKB/Akt

749966

7.2.2.9

increase of mRNA and protein levels of ATP7A

684963

Inhibitor in Enzyme-catalyzed Reactions (19 results)

acute and selective

inhibits enzyme expression in glial cell culture

639403

1.6.5.4

inhibition of the enzyme in plasma membrane

392736

2.4.1.11

pre-treatment of cells inhibits, 0.001 mM isoproterenol reverses inhibition

488441

2.7.1.1

decreases glucokinase activity at 5.5 mM glucose and at 10 mM glucose. No effect at 2.8 mM glucose or at 20 mM glucose

insulin induces phosphorylation of the Ser9 residue, thereby inactivating GSK-3beta

significantly reduces endothelial lipase mRNA and protein expression in a dose dependent manner

690674

3.1.1.5

insulin reduces NRE mRNA levels in a dose-dependent manner in 3T3-L1 adipocytes

693213

3.1.1.7

AChE activity in detergent soluble fraction of scopolamine amnesic mice is inhibited by donepezil, insulin and melatonin with varying extent in different brain regions, whereas AChE activity in salt soluble fraction is not much affected, overview

690686