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Ligand Thionicotinamide adenine dinucleotide

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Substrate (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.22

UDP-glucose + thionicotinamide adenine dinucleotide + H2O = UDP-glucuronate + ?

286293, 286297

-

1.1.1.37

thionicotinamide adenine dinucleotide + L-malate = ?

286671

-

1.1.1.51

testosterone + thionicotinamide adenine dinucleotide = ?

287074

-

3.6.1.9

thionicotinamide adenine dinucleotide + H2O = thionicotinamide mononucleotide + 5'-AMP

246809

-

Activator in Enzyme-catalyzed Reactions (3 results)

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Show Activating Compound (3 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.141

5-33% of the activity with NAD+, depending on substrate

285915, 285923

-

1.1.1.141

can replace NAD+

285915

-

1.1.1.141

2 entries

1.1.1.22

can replace NAD+

286293, 286297

-

Inhibitor in Enzyme-catalyzed Reactions (5 results)

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Show Inhibitors (5 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.27

competitive versus NAD+ and noncompetitive versus L-lactate

286471

-

1.1.1.416

noncompetitive

745254

-

1.2.1.102

noncompetitive

745254

-

2.4.2.12

-

489739

-

3.13.2.1

0.02 mM, 74% residual activity in presence of 0.05 mM NAD, pH 7.4

710157

-

3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (2 entries)

EC NUMBER

ENZYME 3D STRUCTURE

1.2.1.12

1ihx, 3D-view

1.6.1.2

1ptj, 3D-view

Enzyme Kinetic Parameters

K_M Value (2 results)

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Show KM Value (2 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.1.1.37

0.132

-

-

286671

1.1.1.51

0.083

-

testosterone as substrate

287074

K_i Value (2 results)

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Show KI Value (2 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.1.1.416

0.13

-

pH 8.0, 25°C

745254

1.2.1.102

0.13

-

pH 8.0, 25°C

745254

References & Links

Literature References (11)

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Show Reference (11 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

246809

9453136

Characterization of H. parasuis periplasmic nucleotide pyrophosphatase as a potential target enzyme for inhibition of growth

1997

Wise, D.J.; Anderson, C.D.; Anderson, B.M.

Vet. Microbiol.

58

261-276

285915

1117007

Studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta. Purification and partial characterization

1975

Braithwaite, S.S.; Jabarak, J.

J. Biol. Chem.

250

2315-2318

285923

7132749

Isolation and properties of an NAD+-dependent 15-hydroxyprostaglandin dehydrogenase from human placenta

1982

Jabarak, J.

Methods Enzymol.

86

126-130

286293

4568129

Partial purification and properties of UDPG dehydrogenase from Escherichia coli

1973

Schiller, J.G.; Bowser, A.M.; Feingold, D.S.

Biochim. Biophys. Acta

293

1-10

286297

4290043

Biosynthesis of uridine diphosphate D-xylose. 3. Uridine diphosphate D-glucose dehydrogenase of Cryptococcus laurentii

1966

Ankel, H.; Ankel, E.; Feingold, D.S.

Biochemistry

5

1864-1869

286471

1989512

Kinetic mechanism of the endogenous lactate dehydrogenase activity of duck epsilon-crystallin

1991

Chang, G.G.; Huang, S.M.; Chiou, S.H.

Arch. Biochem. Biophys.

284

285-291

286671

9244395

Purification and kinetic characterization of Haemophilus parasuis malate dehydrogenase

1997

Wise, D.J.; Anderson, C.D.; Anderson, B.M.

Arch. Biochem. Biophys.

344

176-183

287074

193846

3(17)beta-Hydroxysteroid dehydrogenase of Pseudomonas testosteroni. Ligand binding properties

1977

Schultz, R.M.; Groman, E.V.; Engel, L.L.

J. Biol. Chem.

252

3784-3790

489739

4402158

Inhibition of nicotinamide phosphoribosyltransferase by pyridine nucleotides

1972

Dietrich, L.S.; Muniz, O.

Biochemistry

11

1691-1695

710157

20183597

Evaluation of NAD(H) analogues as selective inhibitors for Trypanosoma cruzi S-adenosylhomocysteine hydrolase

2009

Li, Q.; Cai, S.; Fang, J.; Borchardt, R.; Kuczera, K.; Middaugh, C.; Schowen, R.

Nucleosides Nucleotides Nucleic Acids

28

473-484

745254

3533936

Enzymes of vitamin B6 degradation. Purification and properties of isopyridoxal dehydrogenase and 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylic-acid dehydrogenase

1986

Lee, Y.; Nelson, M.; Snell, E.

J. Biol. Chem.

261

15106-15111

Links to other databases for Thionicotinamide adenine dinucleotide

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Show Links (1 entry)

ChEBI

PubChem

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