Ligand Tetrahydropteroylpentaglutamate

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Basic Ligand Information

Molecular Structure
Picture of Tetrahydropteroylpentaglutamate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C39H51N11O18
Tetrahydropteroylpentaglutamate
MEFNETHLDFHDHW-BTNSXGMBSA-N
Synonyms:
(6S)-5,6,7,8-tetrahydropteroylpentaglutamate, 5,6,7,8-tetrahydropteroyl-Glu5, tetrahydropteroyl-Glu5

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor = sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
10-formyltetrahydropteroylpentaglutamate + NADP+ + H2O = tetrahydropteroylpentaglutamate + CO2 + NADPH
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
tetrahydropteroylpentaglutamate + NADP+ = ?
show the reaction diagram
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N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor = sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor
show the reaction diagram
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tetrahydropteroylpentaglutamate + 2-dehydropantoate = 5,10-methylenetetrahydropteroylpentaglutamate + 3-methyl-2-oxobutanoate + H2O
show the reaction diagram
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tetrahydropteroylpentaglutamate + N-formimino-L-glutamate = 5-formiminotetrahydropteroylpentaglutamate + L-glutamate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
10-formyltetrahydropteroylpentaglutamate + NADP+ + H2O = tetrahydropteroylpentaglutamate + CO2 + NADPH
show the reaction diagram
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N5-methyltetrahydropteroylpentaglutamate + L-homocysteine = tetrahydropteroylpentaglutamate + L-methionine
show the reaction diagram
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ATP + 5,6,7,8-tetrahydropteroyl-Glu4 + L-glutamate = ADP + phosphate + 5,6,7,8-tetrahydropteroyl-Glu5
show the reaction diagram
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Enzyme Cofactor/Cosubstrate (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
strong product inhibition
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Enzyme Kinetic Parameters

KM Value (4 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.025
-
-
0.1
-
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Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for Tetrahydropteroylpentaglutamate

ChEBI
PubChem
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PubChem