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Ligand D-glycerate

Basic Ligand Information

Molecular Structure

Pathway Source

Pathways

BRENDA

degradation of sugar acids, Entner Doudoroff pathway, glycolate and glyoxylate degradation, serine metabolism

KEGG

Biosynthesis of secondary metabolites, Carbon metabolism, Glycerolipid metabolism, Glycine, serine and threonine metabolism, Glyoxylate and dicarboxylate metabolism, Methane metabolism, Microbial metabolism in diverse environments, Pentose phosphate pathway more

MetaCyc

2-deoxy-D-ribose degradation II, 2-O-alpha-mannosyl-D-glycerate degradation, D-galactarate degradation I, D-glucarate degradation I, Entner-Doudoroff pathway II (non-phosphorylative), formaldehyde assimilation I (serine pathway), glucosylglycerate biosynthesis II, glycolate and glyoxylate degradation I, L-serine biosynthesis II, mannosylglucosylglycerate biosynthesis II, mannosylglycerate biosynthesis II, photorespiration I, photorespiration II, photorespiration III more

Show all BRENDA pathways known for D-glycerate

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (12 results)

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Show Natural Substrate (12 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.79

D-glycerate + NAD+ = hydroxypyruvate + NADH + H+

739242

2gcg, 3D-view

1.1.1.81

D-glycerate + NAD+ = hydroxypyruvate + NADH + H+

737745, 739242

-

1.1.1.81

D-glycerate + NADP+ = hydroxypyruvate + NADPH + H+

737745

-

1.1.1.81

2 entries

2.4.1.268

ADP-glucose + D-glycerate = 2-O-(alpha-D-glucopyranosyl)-D-glycerate + ADP

708933

-

2.4.1.269

GDP-alpha-D-glucose + D-glycerate = 2-O-(alpha-D-glucopyranosyl)-D-glycerate + GDP

710045

-

2.4.1.269

GDP-mannose + D-glycerate = 2-O-(alpha-D-mannopyranosyl)-D-glycerate + GDP

393091

-

2.4.1.269

2 entries

2.4.1.352

alpha-D-glucopyranose 1-phosphate + D-glycerate = 2-O-(alpha-D-glucopyranosyl)-D-glycerate + phosphate

744114

-

2.7.1.165

ATP + (R)-glycerate = ADP + 2-phospho-(R)-glycerate

685823, 5083, 696906

-

2.7.1.165

ATP + D-glycerate = ADP + 2-phospho-(R)-glycerate

759053, 759581

-

2.7.1.165

ATP + D-glycerate = ADP + 2-phospho-D-glycerate

739413, 739276, 722247

-

2.7.1.31

ATP + D-glycerate = ADP + 3-phospho-D-glycerate

739413, 660135

-

2.7.1.31

ATP + D-glycerate = ADP + phospho-D-glycerate

759778

-

2.7.1.165

3 entries

2.7.1.31

2 entries

In Vivo Product in Enzyme-catalyzed Reactions (20 results)

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Show Natural Product (20 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.26

hydroxypyruvate + NADH = D-glycerate + NAD+

0

-

1.1.1.29

hydroxypyruvate + NADH + H+ = D-glycerate + NAD+

0

-

1.1.1.29

hydroxypyruvate + NADH = D-glycerate + NAD+

0

-

1.1.1.60

tartronate semialdehyde + NAD(P)H = (R)-glycerate + NAD(P)+

287164, 287165, 287166, 287162, 4589

-

1.1.1.60

tartronate semialdehyde + NADH = (R)-glycerate + NAD+

0

-

1.1.1.79

hydroxypyruvate + NAD(P)H = D-glycerate + NAD(P)+ + H+

0

2gcg, 3D-view

1.1.1.79

hydroxypyruvate + NADH + H+ = D-glycerate + NAD+

0

2gcg, 3D-view

1.1.1.79

hydroxypyruvate + NADPH + H+ = D-glycerate + NADP+

0

2gcg, 3D-view

1.1.1.81

hydroxypyruvate + NAD(P)H + H+ = D-glycerate + NAD(P)+

0

-

1.1.1.81

hydroxypyruvate + NAD(P)H = D-glycerate + NAD(P)+ + H+

287375, 0, 287380, 287376, 287377, 287378, 287379, 287383, 287368, 287371, 286505, 286510, 287372, 287373, 287374, 287370, 287381, 287382, 287364, 287369, 287365, 286508

-

1.1.1.81

hydroxypyruvate + NADH + H+ = D-glycerate + NAD+

0

-

1.1.1.81

hydroxypyruvate + NADPH + H+ = D-glycerate + NADP+

0

-

1.1.1.81

hydroxypyruvate + NADPH = D-glycerate + NADP+

0

-

1.1.1.29

2 entries

1.1.1.60

2 entries

1.1.1.79

3 entries

1.1.1.81

5 entries

1.1.1.92

2-hydroxy-3-oxosuccinate + NAD(P)H = D-glycerate + NAD(P)+ + CO2

287509, 287510

-

1.2.1.89

D-glyceraldehyde + NADP+ + H2O = D-glycerate + NADPH + H+

0

-

1.2.99.8

D-glyceraldehyde + H2O + acceptor = D-glycerate + reduced acceptor

0

-

2.4.1.352

2-O-(alpha-D-glucopyranosyl)-D-glycerate + phosphate = alpha-D-glucopyranose 1-phosphate + D-glycerate

0

-

3.2.1.208

2-O-(alpha-D-glucopyranosyl)-D-glycerate + H2O = D-glucopyranose + D-glycerate

0

-

3.2.1.208

2-O-(alpha-D-mannopyranosyl)-D-glycerate + H2O = D-mannopyranose + D-glycerate

0

-

3.2.1.208

2 entries

4.1.1.73

L-tartrate = D-glycerate + CO2

0

-

Substrate in Enzyme-catalyzed Reactions (52 results)

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Show Substrate (52 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.276

D-glycerate + NADP+ = ?

639084, 639082

-

1.1.1.29

D-glycerate + NAD+ = hydroxypyruvate + NADH + H+

286508

-

1.1.1.381

D-glycerate + NADP+ = ?

639084

-

1.1.1.387

D-glycerate + NAD+ = ?

725474

-

1.1.1.60

(R)-glycerate + NAD(P)+ = tartronate semialdehyde + NAD(P)H

287168, 287167, 287162

-

1.1.1.60

D-glycerate + NADP+ = 2-hydroxy-3-oxopropanoate + NADPH + H+

726270

-

1.1.1.60

2 entries

1.1.1.79

D-glycerate + NAD+ = hydroxypyruvate + NADH + H+

739242

2gcg, 3D-view

1.1.1.81

D-glycerate + NAD+ = 3-hydroxypyruvate + NADH + H+

287383, 286508

-

1.1.1.81

D-glycerate + NAD+ = hydroxypyruvate + NADH + H+

737745, 739242

-

1.1.1.81

D-glycerate + NADP+ = hydroxypyruvate + NADPH + H+

737745

-

1.1.1.81

3 entries

1.1.2.4

D-glycerate + ferricytochrome c = ?

698932

-

1.1.5.10

D-glycerate + ubiquinone-10 = ? + ubiquinol-10

763205

-

1.1.5.12

D-glycerate + 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide = ?

763205

-

1.1.5.12

D-glycerate + 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide = ? + reduced 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide

763205

-

1.1.5.12

D-glycerate + 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide = D-glyceraldehyde + reduced 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide

761384

-

1.1.5.12

D-glycerate + ubiquinone-10 = ? + ubiquinol-10

763205

-

1.1.5.12

4 entries

1.1.99.6

D-glycerate + acceptor = hydroxypyruvate + reduced acceptor

287840

-

2.4.1.268

ADP-glucose + D-glycerate = 2-O-(alpha-D-glucopyranosyl)-D-glycerate + ADP

708933, 680490

-

2.4.1.268

GDP-alpha-D-glucose + D-glycerate = 2-O-(alpha-D-glucopyranosyl)-D-glycerate + GDP

680490

-

2.4.1.268

UDP-glucose + D-glycerate = 2-O-(alpha-D-glucopyranosyl)-D-glycerate + UDP

680490

-

2.4.1.269

GDP-alpha-D-glucose + D-glycerate = 2-O-(alpha-D-glucopyranosyl)-D-glycerate + GDP

723506, 710045

-

2.4.1.269

GDP-mannose + D-glycerate = 2-O-(alpha-D-mannopyranosyl)-D-glycerate + GDP

723506, 722705, 393091, 710045

-

2.4.1.268

3 entries

2.4.1.269

2 entries

2.4.1.352

alpha-D-glucopyranose 1-phosphate + D-glycerate = 2-O-(alpha-D-glucopyranosyl)-D-glycerate + phosphate

744114, 758811

-

2.7.1.165

ADP + (R)-glycerate = AMP + 2-phospho-(R)-glycerate

673501, 696906

-

2.7.1.165

ADP + (R)-glycerate = AMP + 3-phospho-(R)-glycerate

673501

-

2.7.1.165

AMP + (R)-glycerate = adenosine + 2-phospho-(R)-glycerate

696906

-

2.7.1.165

ATP + (R)-glycerate = ADP + 2-phospho-(R)-glycerate

5083, 685823, 673501, 686769, 696906, 699594

-

2.7.1.165

ATP + (R)-glycerate = ADP + 3-phospho-(R)-glycerate

672720, 673501, 672800, 673730, 641336, 641338

-

2.7.1.165

CTP + (R)-glycerate = CDP + 2-phospho-(R)-glycerate

685823, 673501, 696906

-

2.7.1.165

CTP + (R)-glycerate = CDP + 3-phospho-(R)-glycerate

641338, 673501

-

2.7.1.165

diphosphate + (R)-glycerate = phosphate + 2-phospho-(R)-glycerate

673501, 696906

-

2.7.1.165

diphosphate + (R)-glycerate = phosphate + 3-phospho-(R)-glycerate

673501

-

2.7.1.165

GTP + (R)-glycerate = GDP + 2-phospho-(R)-glycerate

696906, 685823, 673501

-

2.7.1.165

GTP + (R)-glycerate = GDP + 3-phospho-(R)-glycerate

641338, 673501

-

2.7.1.165

TTP + (R)-glycerate = TDP + 2-phospho-(R)-glycerate

685823

-

2.7.1.165

UTP + (R)-glycerate = UDP + 2-phospho-(R)-glycerate

685823, 673501, 696906

-

2.7.1.165

UTP + (R)-glycerate = UDP + 3-phospho-(R)-glycerate

641338, 673501

-

2.7.1.165

ADP + D-glycerate = AMP + 2-phospho-D-glycerate

696906

-

2.7.1.165

AMP + D-glycerate = adenosine + 2-phospho-D-glycerate

696906

-

2.7.1.165

ATP + D-glycerate = ADP + 2-phospho-(R)-glycerate

759053, 759581

-

2.7.1.165

ATP + D-glycerate = ADP + 2-phospho-D-glycerate

739413, 722379, 739276, 672720, 673501, 722247, 696906

-

2.7.1.165

CTP + D-glycerate = CDP + 2-phospho-D-glycerate

696906

-

2.7.1.165

diphosphate + D-glycerate = phosphate + 2-phospho-D-glycerate

696906

-

2.7.1.165

GTP + D-glycerate = GDP + 2-phospho-D-glycerate

696906

-

2.7.1.165

UTP + D-glycerate = UDP + 2-phospho-D-glycerate

696906

-

2.7.1.31

ATP + (R)-glycerate = ADP + 3-phospho-(R)-glycerate

641287, 641330, 641331, 641329, 641340, 641343, 641332, 641337, 641341, 641333, 641342

-

2.7.1.31

GTP + (R)-glycerate = GDP + 3-phospho-(R)-glycerate

641340, 641341

-

2.7.1.31

UTP + (R)-glycerate = UDP + 3-phospho-(R)-glycerate

641340, 641341

-

2.7.1.31

ATP + D-glycerate = ADP + 3-phospho-D-glycerate

660135, 723461, 739413

-

2.7.1.31

ATP + D-glycerate = ADP + 3-phosphoglycerate

686769

-

2.7.1.31

ATP + D-glycerate = ADP + phospho-D-glycerate

759778

-

2.7.1.165

22 entries

2.7.1.31

6 entries

4.2.1.9

D-glycerate = pyruvate + H2O

732214

-

Product in Enzyme-catalyzed Reactions (50 results)

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Show Product (50 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.237

hydroxypyruvate + NADH + H+ = D-glycerate + NAD+

0

-

1.1.1.237

hydroxypyruvate + NADPH + H+ = D-glycerate + NADP+

0

-

1.1.1.26

hydroxypyruvate + NADH + H+ = D-glycerate + NAD+

0

-

1.1.1.26

hydroxypyruvate + NADH = D-glycerate + NAD+

0

-

1.1.1.26

hydroxypyruvate + NADPH + H+ = D-glycerate + NADP+

0

-

1.1.1.29

hydroxypyruvate + NADH + H+ = D-glycerate + NAD+

0

-

1.1.1.29

hydroxypyruvate + NADH = D-glycerate + NAD+

0

-

1.1.1.29

hydroxypyruvate + NADPH + H+ = D-glycerate + NADP+

0

-

1.1.1.60

tartronate semialdehyde + NAD(P)H = (R)-glycerate + NAD(P)+

287168, 287167, 287164, 287165, 287166, 287162, 4589

-

1.1.1.60

tartronate semialdehyde + NADH + H+ = (R)-glycerate + NAD+

0

-

1.1.1.60

tartronate semialdehyde + NADH = (R)-glycerate + NAD+

0

-

1.1.1.60

2-hydroxy-3-oxopropanoate + NADH + H+ = D-glycerate + NAD+

0

-

1.1.1.79

hydroxypyruvate + NAD(P)H = D-glycerate + NAD(P)+ + H+

0

2gcg, 3D-view

1.1.1.79

hydroxypyruvate + NADH + H+ = D-glycerate + NAD+

0

2gcg, 3D-view

1.1.1.79

hydroxypyruvate + NADH = D-glycerate + NAD+

0

2gcg, 3D-view

1.1.1.79

hydroxypyruvate + NADPH + H+ = D-glycerate + NADP+

0

2gcg, 3D-view

1.1.1.79

hydroxypyruvate + NADPH = D-glycerate + NADP+

0

2gcg, 3D-view

1.1.1.81

3-hydroxypyruvate + NADH + H+ = D-glycerate + NAD+

0

-

1.1.1.81

3-hydroxypyruvate + NADPH + H+ = D-glycerate + NADP+

0

-

1.1.1.81

hydroxypyruvate + NAD(P)H + H+ = D-glycerate + NAD(P)+

0

-

1.1.1.81

hydroxypyruvate + NAD(P)H = D-glycerate + NAD(P)+ + H+

287375, 0, 287380, 287376, 287377, 287378, 287379, 287383, 287368, 287371, 286505, 286510, 287372, 287373, 287374, 287370, 287381, 287382, 287364, 286508, 287369, 287365

-

1.1.1.81

hydroxypyruvate + NADH + H+ = D-glycerate + NAD+

0

-

1.1.1.81

hydroxypyruvate + NADH = D-glycerate + NAD+

0

-

1.1.1.81

hydroxypyruvate + NADPH + H+ = D-glycerate + NADP+

0

-

1.1.1.81

hydroxypyruvate + NADPH = D-glycerate + NADP+

0

-

1.1.1.92

2,3-dihydroxysuccinate + NAD(P)H = D-glycerate + NAD(P)+ + CO2

287510

-

1.1.1.92

2-hydroxy-3-oxosuccinate + NAD(P)H = D-glycerate + NAD(P)+ + CO2

287509, 287510

-

1.1.1.92

2-hydroxy-3-oxosuccinate + NADH + H+ = D-glycerate + NAD+ + CO2

0

-

1.1.1.92

hydroxypyruvate + NAD(P)H = D-glycerate + NAD(P)+ + H+

287510

-

1.1.1.237

2 entries

1.1.1.26

3 entries

1.1.1.29

3 entries

1.1.1.60

4 entries

1.1.1.79

5 entries

1.1.1.81

8 entries

1.1.1.92

4 entries

1.1.3.41

D-glyceraldehyde + O2 = D-glycerate + H2O2

0

-

1.2.1.3

D-glyceraldehyde + NAD+ + H2O = D-glycerate + NADH + H+

0

-

1.2.1.4

D-glyceraldehyde + NADP+ = D-glycerate + NADPH + H+

0

-

1.2.1.5

D-glyceraldehyde + NAD+ + H2O = D-glycerate + NADH + H+

0

-

1.2.1.5

D-glyceraldehyde + NADP+ + H2O = D-glycerate + NADPH

0

-

1.2.1.89

D-glyceraldehyde + NAD+ + H2O = D-glycerate + NADH + H+

0

-

1.2.1.89

D-glyceraldehyde + NAD+ = D-glycerate + NADH + H+

0

-

1.2.1.89

D-glyceraldehyde + NADP+ + H2O = D-glycerate + NADPH + H+

0

-

1.2.99.8

D-glyceraldehyde + H2O + 2,6-dichlorophenolindophenol = D-glycerate + reduced 2,6-dichlorophenolindophenol

0

-

1.2.99.8

D-glyceraldehyde + H2O + acceptor = D-glycerate + reduced acceptor

0

-

1.2.99.8

D-glyceraldehyde + H2O + methyl viologen = D-glycerate + reduced methyl viologen

0

-

1.3.1.7

meso-tartrate + 3-acetylpyridine-NAD+ = D-glycerate + CO2 + ?

349358

-

1.3.1.7

meso-tartrate + NAD+ = D-glycerate + CO2 + NADH + H+

0, 349358

-

1.2.1.5

2 entries

1.2.1.89

3 entries

1.2.99.8

3 entries

1.3.1.7

2 entries

2.4.1.352

2-O-(alpha-D-glucopyranosyl)-D-glycerate + phosphate = alpha-D-glucopyranose 1-phosphate + D-glycerate

0

-

3.1.3.20

D-glycerate 2-phosphate + H2O = D-glycerate + phosphate

81021, 81022, 81024, 81023

-

3.1.3.38

D-glycerate 3-phosphate + H2O = D-glycerate + phosphate

81096, 81090, 81092, 81097, 81098, 81051, 81091, 81093, 81094, 81095

-

3.2.1.170

2-O-(6-phospho-alpha-D-mannosyl)-D-glycerate + H2O = D-mannose 6-phosphate + D-glycerate

0

-

3.2.1.208

2-O-(alpha-D-glucopyranosyl)-D-glycerate + H2O = D-glucopyranose + D-glycerate

0

-

3.2.1.208

2-O-(alpha-D-mannopyranosyl)-D-glycerate + H2O = D-mannopyranose + D-glycerate

0

-

4.1.1.73

L-tartrate = D-glycerate + CO2

0, 648378, 648380

-

4.1.1.73

meso-tartrate = D-glycerate + CO2

0, 648380

-

3.2.1.208

2 entries

4.1.1.73

2 entries

Inhibitor in Enzyme-catalyzed Reactions (9 results)

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Show Inhibitors (9 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.79

the enzyme shows product inhibition

669886

2gcg, 3D-view

1.1.1.81

5 mM, 20% inhibition of NADH linked hydroxypyruvate reduction, 40% of NADPH linked reduction

286508

-

1.1.1.81

the enzyme shows product inhibition

669886

-

1.1.1.81

2 entries

1.20.1.1

-

287853

-

2.7.1.165

substrate inhibition at high glycerate concentrations

685823

-

2.7.1.165

substrate inhibition is observed at higher glycerate concentrations

672800

-

2.7.1.165

substrate inhibition; substrate inhibition at glycerate concentrations higher than 2 mM at 80°C, above 2 mM at 70°C and 5 mM at 65°C

722247

-

2.7.1.165

3 entries

4.1.1.73

product inhibition, 10 mM, 65% inhibition

648380

-

4.2.1.9

competitive. Presence of 20 mM D-glycerate decreases catalytic activity towards D-gluconate drastically to 5% residual activity

732214

-

3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (2 entries)

EC NUMBER

ENZYME 3D STRUCTURE

1.1.1.79

2gcg, 3D-view

1.2.1.12

3vaz, 3D-view

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (44 results)

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Show Turnover Number (44 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

1.1.1.381

2.01

-

pH 9.0, 30°C

639084

1.1.1.387

5.8

-

pH 11.0, 37°C, wild-type enzyme

725474

1.1.2.4

0.1

-

-

698932

1.1.5.10

8

-

pH 7.4, 30°C

763205

1.1.5.12

0.78

-

isolated FAD-containing dehydrogenase domain, pH 7.4. 30°C

761384

1.1.5.12

8

-

pH 7.4, 30°C

763205

1.1.5.12

8

-

pH 7.4, 30°C, acceptor: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide

763205

1.1.5.12

8

-

pH 7.4. 30°C

761384

1.2.1.89

12

-

pH 6.9, 58°C

724992

1.2.1.89

20

-

pH 6.9, 58°C

724992

2.4.1.269

0.017

-

mutant T139A, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

0.023

-

mutant E166A, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

0.023

-

mutant Q66A, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

0.032

-

wild-type, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

0.055

-

mutant R73A, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

0.06

-

mutant R73G, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

0.065

-

mutant D135A, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

0.067

-

mutant Y220A, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

0.07

-

mutant Y220F, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

0.075

-

mutant K76A, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

0.077

-

mutant W189A, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

0.083

-

mutant H217A, pH 7.0, 23°C, presence of 3 mM Mg2+

722705

2.4.1.269

0.115

-

mutant K9A, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

0.135

-

mutant M229A, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

0.183

-

mutant Y37A, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

0.25

-

mutant R218A, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

0.267

-

mutant H217A, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

0.6

-

wild-type, pH 7.0, 23°C, presence of 3 mM Ca2+

722705

2.4.1.269

1.02

-

pH 7.8, 25°C, cosubstrate: GDP-mannose

710045

2.4.1.269

1.92

-

wild-type, pH 7.0, 23°C, presence of 3 mM Mg2+

722705

2.4.1.269

6.5

-

pH 7.8, 65°C, cosubstrate: GDP-mannose

710045

1.1.5.12

4 entries

1.2.1.89

2 entries

2.4.1.269

21 entries

2.4.1.352

128

-

at pH 6.5 and 42°C

744114

2.7.1.165

0.054

-

recombinant enzyme, pH 7.0, 37°C

759053

2.7.1.165

2.5

-

pH 7.5, 22°C

5083

2.7.1.165

3.6

-

-

685823

2.7.1.165

24.5

-

in 100 mM HEPES/KOH, pH 7.0, at 37°C

722247

2.7.1.165

24.5

-

pH 6.5, 80°C, Hill equation

722247

2.7.1.165

360

-

the reaction mixture contains 1 mM (R)-glycerate, 1 mM ATP, 10 mM MgCl2, 0.3 mM NADH, 1 mM phosphoenolpyruvate, 10 nM purified glycerate kinase, 3.5 units pyruvate kinase and 5 units lactate dehydrogenase in 50 mM potassium phosphate (pH 7.0), at 45°C

673501

2.7.1.165

489.2

-

-

673501

2.7.1.165

533.3

-

pH 6.5, 80°C, kinetic model

722247

2.7.1.31

200

-

-

641341

2.7.1.31

350

-

-

641287

4.2.1.9

0.011

-

pH 7, 50°C, non-activated enzyme

732214

4.2.1.9

0.03

-

pH 7, 50°C, enzyme activated by 2-mercaptoethanol

732214

2.7.1.165

8 entries

2.7.1.31

2 entries

4.2.1.9

2 entries

K_M Value (67 results)

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Show KM Value (67 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.1.1.276

56

-

pH 9.0, 30 °C

639082

1.1.1.381

50

-

pH 9.0, 30°C

639084

1.1.1.387

10.8

-

pH 11.0, 37°C, wild-type enzyme

725474

1.1.1.60

0.0177

-

pH 8.5, 40°C

726270

1.1.1.60

0.05

0.4

-

287164, 287165, 287166

1.1.1.60

0.28

-

-

287167

1.1.1.60

3.7

-

-

287167

1.1.1.60

4 entries

1.1.1.81

0.522

-

D-glycerate oxidation, 50 mM, NaCl, pH 9

287383

1.1.2.4

8.871

-

-

698932

1.1.5.10

1.38

-

pH 7.4, 30°C

763205

1.1.5.12

1.38

-

pH 7.4, 30°C

763205

1.1.5.12

1.38

-

pH 7.4, 30°C, acceptor: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide

763205

1.1.5.12

1.38

-

pH 7.4. 30°C

761384

1.1.5.12

1.67

-

isolated FAD-containing dehydrogenase domain, pH 7.4. 30°C

761384

1.2.1.89

5.1

-

pH 6.9, 58°C

724992

1.2.1.89

18.3

-

pH 6.9, 58°C

724992

2.4.1.268

0.9

-

pH 6.7, 60°C, native enzyme

708933

2.4.1.268

1.9

-

pH 6.7, 70°C, native enzyme

708933

2.4.1.268

2.2

-

pH 6.5, 70°C

680490

2.4.1.268

3.4

-

pH 6.7, 60°C, recombinant enzyme

708933

2.4.1.269

0.0014

-

mutant K9A, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

0.0022

-

wild-type, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

0.0038

-

mutant R73A, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

0.0041

-

mutant R73G, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

0.0058

-

mutant R218A, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

0.0078

-

mutant M229A, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

0.015

-

mutant W189A, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

0.017

-

mutant Y37A, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

0.03

-

mutant K76A, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

0.032

-

mutant E166A, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

0.07

-

mutant Q66A, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

0.6

-

pH 7.6, 90°C, native enzyme

393091

2.4.1.269

0.9

-

pH 7.6, 90°C, recombinant enzyme

393091

2.4.1.269

1.1

-

mutant Y220A, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

1.2

-

cosubstrate GDP-mannose, pH 8.0, 25°C

723506

2.4.1.269

1.3

-

mutant D135A, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

1.6

-

cosubstrate GDP-glucose, pH 8.0, 25°C

723506

2.4.1.269

1.9

-

mutant H217A, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

3.3

-

mutant T139A, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

3.4

-

cosubstrate GDP-glucose, pH 8.0, 50°C

723506

2.4.1.269

3.8

-

mutant Y220F, pH 7.0, 23°C, presence of Mn2+

722705

2.4.1.269

4.4

-

cosubstrate GDP-mannose, pH 8.0, 50°C

723506

2.4.1.269

96.5

-

pH 7.8, 65°C, cosubstrate: GDP-mannose

710045

2.4.1.269

121.9

-

pH 7.8, 25°C, cosubstrate: GDP-mannose

710045

1.1.5.12

4 entries

1.2.1.89

2 entries

2.4.1.268

4 entries

2.4.1.269

24 entries

2.4.1.352

2.6

-

at pH 6.5 and 42°C

744114

2.7.1.165

0.02

-

-

685823

2.7.1.165

0.02

-

at 70°C

672800

2.7.1.165

0.043

-

-

686769

2.7.1.165

0.044

-

the reaction mixture contains 1 mM (R)-glycerate, 1 mM ATP, 10 mM MgCl2, 0.3 mM NADH, 1 mM phosphoenolpyruvate, 10 nM purified glycerate kinase, 3.5 units pyruvate kinase and 5 units lactate dehydrogenase in 50 mM potassium phosphate (pH 7.0), at 45°C

673501

2.7.1.165

0.044

-

-

673501

2.7.1.165

0.051

-

pH 7.5, 22°C

5083

2.7.1.165

0.056

-

-

686769

2.7.1.165

0.086

-

-

686769

2.7.1.165

0.13

-

recombinant enzyme, pH 7.0, 37°C

759053

2.7.1.165

0.34

-

-

673730

2.7.1.165

0.56

-

in 100 mM Tris-HCl (pH 8), 5 mM EGTA, 1 mM (R)-glycerate, 1 mM ATP, 10 mM MgCl2, at 55°C

672720

2.7.1.165

0.56

-

pH 8.0, 55°C

672720

2.7.1.31

0.104

-

-

686769

2.7.1.31

0.11

-

pH 7.8, 25°C

641343

2.7.1.31

0.17

-

-

641332

2.7.1.31

0.208

-

-

686769

2.7.1.31

0.25

-

25°C

641341

2.7.1.31

0.266

-

-

686769

2.7.1.31

0.285

-

25°C, pH 7.8

641337

2.7.1.31

0.358

-

oxidized recombinant enzyme, pH and temperature not specified in the publication

723461

2.7.1.31

0.399

-

reduced recombinant enzyme, pH and temperature not specified in the publication

723461

2.7.1.31

0.45

-

-

686769

2.7.1.165

12 entries

2.7.1.31

10 entries

K_i Value (3 results)

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Show KI Value (3 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.7.1.165

0.1

-

in 100 mM HEPES/KOH, pH 7.0, at 37°C

722247

2.7.1.165

0.1

-

pH 6.5, 80°C

722247

2.7.1.165

2 entries

4.2.1.9

2.3

-

50°C, pH 7

732214

References & Links

Literature References (100)

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Show Reference (100 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

4589

623498

Metabolic regulation in Pseudomonas oxalaticus OX1. Autotrophic and heterotrophic growth on mixed substrates

1978

Dijkhuizen, L.; Knight, M.; Harder, W.

Arch. Microbiol.

116

77-83

5083

9772162

Evolution of enzymatic activities in the enolase superfamily: characterization of the (D)-glucarate/galactarate catabolic pathway in Escherichia coli

1998

Hubbard, B.K.; Koch, M.; Palmer, D.R.J.; Babbitt, P.C.; Gerlt, J.A.

Biochemistry

37

14369-14375

81021

-

Differential regulation of phosphoglycolate and phosphoglycerate phosphatases in Euglena

1982

James, L.; Schwartzbach, S.D.

Plant Sci. Lett.

27

223-232

81022

1191301

Biochemical components of the photosynthetic CO2 compensation point of higher plants

1975

Kestler, D.P.; Mayne, B.C.; Ray, T.B.; Goldstein, L.D.; Brown, R.H.; Black, C.C.

Biochem. Biophys. Res. Commun.

66

1439-1446

81023

6271379

2-Phosphoglycerate phosphatase and serine biosynthesis in Veillonella alcalescens

1981

Pestka, J.J.; Delwiche, E.A.

Can. J. Microbiol.

27

808-814

81024

4284998

2-Phosphoglyceric acid phosphatase: identification and properties of the beef-liver enzyme

1965

Fallon, H.J.; Byrne, W.L.

Biochim. Biophys. Acta

105

43-53

81051

24241741

Enzymes of serine and glycine metabolism in leaves and non-photosynthetic tissues of Pisum sativum L.

1986

Walton, N.J.; Woolhouse, H.W.

Planta

167

119-128

81090

16662549

3-Phosphoglycerate phosphatase activity in chloroplast preparation as a result of contamination by acid phosphatase

1982

Robinson, S.P.

Plant Physiol.

70

645-648

81091

-

Activity of PEP carboxylase and some photorespiratory enzymes in C3 and C4 plants grown at two temperatures

1980

Pandey, O.P.; Saxena, P.K.; Todaria, N.P.; Purohit, A.N.

Plant Sci. Lett.

19

121-127

81092

16661597

Properties of a membrane-bound phosphatase from the thylakoids of spinach chloroplasts

1980

Mulligan, R.M.; Tolbert, N.E.

Plant Physiol.

66

1169-1173

81093

-

Chlorophyll and enzymes of photorespiration in Dendrophthoe falcata seeds

1979

Kachru, D.N.; Krishnan, P.S.

Plant Sci. Lett.

16

165-170

81094

-

3-Phosphoglycerate phosphatase

1975

Randall, D.D.; Tolbert, N.E.

Methods Enzymol.

42C

405-409

81095

10970181

3-Phosphoglycerate phosphatase in plants. I. Isolation and characterization from sugarcane leaves

1971

Randall, D.D.; Tolbert, N.E.

J. Biol. Chem.

246

5510-5517

81096

16657822

3-Phosphoglycerate phosphatase in plants. II. Distribution, physiological considerations, and comparison with P-glycolate phosphatase

1971

Randall, D.D.; Tolbert, N.E.; Gremel, D.

Plant Physiol.

48

480-487

81097

16657823

3-Phosphoglycerate phosphatase in plants. III. Activity associated with starch particles

1971

Randall, D.D.; Tolbert, N.E.

Plant Physiol.

48

488-492

81098

4335962

Glycolate metabolism in mesophyll cells and bundle sheath cells isolated from crabgrass, Digitaria sanguinalis (L.) Scop., leaves

1972

Liu, A.Y.

Arch. Biochem. Biophys.

149

269-280

286505

2039466

Oxalate as a potent and selective inhibitor of spinach (Spinacia oleracea) leaf NADPH-dependent hydroxypyruvate reductase

1991

Kleczkowski, L.A.; Randall, D.D.; Edwards, G.E.

Biochem. J.

276

125-127

286508

1657886

Purification and characterization of hydroxypyruvate reductase from the facultative methylotroph Methylobacterium extorquens AM1

1991

Chistoserdova, L.V.; Lidstrom, M.E.

J. Bacteriol.

173

7228-7232

286510

8759789

Immunological characterization of serine-glyoxylate aminotransferase and hydroxypyruvate reductase from a methylotrophic bacterium, Hyphomicrobium methylovorum GM2

1996

Hagishita, T.; Yoshida, T.; Izumi, Y.; Mitsunaga, T.

FEMS Microbiol. Lett.

142

49-52

287162

6614900

Glyoxylate conversion by Hyphomicrobium species grown on allantoin as nitrogen source

1983

Van der Drift, C.; de Windt, F.E.

Antonie van Leeuwenhoek

49

167-172

287164

4300866

Tartaric acid metabolism. 8. Crystalline tartronic semialdehyde reductase

1968

Kohn, L.

J. Biol. Chem.

243

4426-4433

287165

-

Tartronic semialdehyde reductase (crystalline)

1966

Kornberg, H.L.; Gotto, A.M.

Methods Enzymol.

9

240-247

287166

13900766

The metabolism of C2 compounds in micro-organisms

1961

Gotto, A.M.; Kornberg, H.L.

Biochem. J.

81

273-284

287167

10978349

Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus infuenzae

2000

Ijau, R.K.; Herndon, C.A.; Hawes, J.W.

J. Biol. Chem.

275

38780-38786

287168

11306094

New developments in our understanding of the beta-hydroxyacid dehydrogenases

2001

Njau, R.K.; Herndon, C.A.; Hawes, J.W.

Chem. Biol. Interact.

130-132

785-791

287364

8055948

Cloning and expression of the gene for hydroxypyruvate reductase (D-glycerate dehydrogenase) from an obligate methylotroph Hyphomicrobium methyovorum GM2

1994

Yoshida, T.; Yamaguchi, K.; Hagishata, T.; Miyata, T.; Tanabe, T.; Toh, H.; Oshiro, T.; Shimao, M.; Itumi, Y.

Eur. J. Biochem.

223

727-732

287365

8316213

Inhibition of tobacco NADH-hydroxypyruvate reductase by expression of a heterologous antisense RNA derived from a cucumber cDNA: implications for the mechanism of action of antisense RNAs

1993

Oliver, M.J.; Ferguson, D.L.; Burke, J.J.; Velten, J.

Mol. Gen. Genet.

239

425-434

287368

16667783

Enzymology of the reduction of hydroxypyruvate and glyoxylate in a mutant of barley lacking peroxisomal hydroxypyruvate reductase

1990

Kleczkowski, L.A.; Edwards, G.E.; Blackwell, R.D.; Lea, P.J.; Givan, C.V.

Plant Physiol.

94

819-825

287369

-

Hydroxypyruvate reductase from Methylobacterium extorquens AM1

1990

Krema, C.; Lidstrom, M.E.

Methods Enzymol.

188

373-378

287370

16667010

Identification of hydroxypyruvate and glyoxylate reductase in maize leaves

1989

Kleczkowski, L.A.; Edwards, G.E.

Plant Physiol.

91

278-288

287371

16667032

Metabolism of hydroxypyruvate in a mutant of barley lacking NADH-dependent hydroxypyruvate reductase, an important photorespiratory enzyme activity

1989

Murray, A.J.S.; Blackwell, R.D.; Lea, P.J.

Plant Physiol.

91

395-400

287372

24220768

Import of peroxisomal hydroxypyruvate reductase into glyoxysomes

1988

Sautter, C.; Sautter, E.; Hock, B.

Planta

176

149-158

287373

16666441

Subcellular location of NADPH-dependent hydroxypyruvate reductase activity in leaf protoplasts of Pisum sativum L. and its role in photorespiratory metabolism

1988

Kleczkowski, L.A.; Givan, C.V.; Hodgson, J.M.; Randall, D.D.

Plant Physiol.

88

1182-1185

287374

3281657

Purification and characterization of a novel NADPH(NADH)-dependent hydroxypyruvate reductase from spinach leaves. Comparison of immunological properties of leaf hydroxypyruvate reductases

1988

Kleczkowski, L.A.; Randall, D.D.

Biochem. J.

250

145-152

287375

-

Hydroxypyruvate reductase activity in Paracoccus denitrificans

1977

Bamforth, C.W.; Quayle, J.R.

J. Gen. Microbiol.

101

259-267

287376

804293

Comparison of D-glycerate dehydrogenases from beef liver, beef spinal cord and hog spinal cord

1975

Feld, R.D.; Sallach, H.J.

Arch. Biochem. Biophys.

166

417-425

287377

236450

D-Glycerate dehydrogenase from hog spinal cord

1975

Feld, R.D.; Sallach, H.J.

Methods Enzymol.

41B

289-293

287378

4352623

Mechanisms of inhibition and activation of beef liver D-glycerate dehydrogenase by inorganic anions

1972

Sugimoto, E.; Kitagawa, Y.; Hirose, M.; Chiba, H.

J. Biochem.

72

1317-1325

287379

4146372

Purification and properties of beef liver D-glycerate dehydrogenase

1972

Sugimoto, E.; Kitagawa, Y.; Nakanishi, K.; Chiba, H.

J. Biochem.

72

1307-1315

287380

11946015

Glycine and serine inhibition of D-glycerate dehydrogenase and 3-phosphoglycerate dehydrogenase of rat brain

1971

Uhr, M.L.; Sneddon, M.K.

FEBS Lett.

17

137-140

287381

4385077

Tartaric acid metabolism. VII. Crystalline hydroxypyruvate reductase (D-glycerate dehydrogenase)

1968

Kohn, L.D.; Jakoby, W.B.

J. Biol. Chem.

243

2494-2499

287382

-

Hydroxypyruvate reductase (D-glycerate dehydrogenase; crystalline) Pseudomonas

1966

Kohn, L.D.; Jakoby, W.B.

Methods Enzymol.

9

229-232

287383

31939

Effect of salts on D-glycerate dehydrogenase kinetic behavior

1979

Coderch, R.; Lluis, C.; Bozal, J.

Biochim. Biophys. Acta

566

21-31

287509

1200995

The stereospecificity of sequential nicotinamide-adenine dinucleotide-dependent oxidoreductases in relation to the evolution of metabolic sequences

1975

Do Nascimento, K.H.; Davies, D.D.

Biochem. J.

149

553-557

287510

4385076

Tartaric acid metabolism. VI. Crystalline oxaloglcolate reductive decarboxylase

1968

Kohn, L.D.; Jakoby W., B.

J. Biol. Chem.

243

2486-2493

287840

236454

D-2-hydroxy acid dehydrogenase from animal tissue

1975

Cammack, R.

Methods Enzymol.

41

323-329

287853

11278981

Purification and characterization of a novel phosphorus-oxidizing enzyme from Pseudomonas stutzeri WM88

2001

Costas, A.M.G.; White, A.K.; Metcalf, W.W.

J. Biol. Chem.

276

17429-17436

349358

7986065

Tartrate dehydrogenase-oxalate complexes: formation of a stable analog of a reaction intermediate complex

1994

Beecher, B.S.; Koder, R.L.; Tipton, P.A.

Arch. Biochem. Biophys.

315

255-261

393091

10585410

Biosynthesis of mannosylglycerate in the thermophilic bacterium Rhodothermus marinus. Biochemical and genetic characterization of a mannosylglycerate synthase

1999

Martins, L.O.; Empadinhas, N.; Marugg, J.D.; Miguel, C.; Ferreira, C.; Da Costa, M.S.; Santos, H.

J. Biol. Chem.

274

35407-35414

639082

9028042

A novel NADP+ dependent serine dehydrogenase from Agrobacterium tumefaciens

1997

Chowdhury, E.K.; Higuchi, K.; Nagata, S.; Misono, H.

Biosci. Biotechnol. Biochem.

61

152-157

639084

12535615

Characterization of short-chain dehydrogenase/reductase homologues of Escherichia coli (YdfG) and Saccharomyces cerevisiae (YMR226C)

2003

Fujisawa, H.; Nagata, S.; Misono, H.

Biochim. Biophys. Acta

1645

89-94

641287

-

Glycerol and glycerate kinases

1973

Thorner, J.W.; Paulus, H.

The Enzymes,3rd ed. (Boyer,P. D. ,ed. )

8

487-508

641329

13416296

Studies on the purification and properties of D-glyceric acid kinase of liver

1957

Ichihara, A.; Greenberg, D.M.

J. Biol. Chem.

225

949-958

641330

5325263

Purification and properties of D-glycerate 3-kinase from Escherichia coli

1966

Doughty, C.C.; Hayashi, J.A.; Guenther, H.L.

J. Biol. Chem.

241

568-572

641331

166273

D-glycerate 3-kinase from Escherichia coli

1975

Doughty, C.C.; Hayashi, J.A.

Methods Enzymol.

42

124-127

641332

-

Partial purification and characterization of glycerate kinase from immature pods of Brassica campestris

1993

Saharan, M.M.R.; Singh, R.

Plant Physiol. Biochem.

31

559-566

641333

-

Glycerate kinase from spinach leaves: partial purification, characterization and subcellular location

1985

Chaguturu, R.

Physiol. Plant.

63

19-24

641336

4370494

The purification of glycerate kinase from Hyphomicrobium sp. and Pseudomonas AM1: product identification

1974

Hill, B.; Attwood, M.M.

J. Gen. Microbiol.

83

187-190

641337

-

Purification and partial characterization of spinach leaf glycerate kinase

1983

Kleczkowski, L.A.; Randall, D.D.

FEBS Lett.

158

313-316

641338

1336459

Purification and characterization of glycerate kinase from a serine-producing methylotroph, Hyphomicrobium methylovorum GM2

1992

Yoshida, T.; Fukuta, K.; Mitsunaga, T.; Yamada, H.; Izumi, Y.

Eur. J. Biochem.

210

849-854

641340

6307152

Glycerate kinase from leaves of C3 plants

1983

Schmitt, M.R.; Edwards, G.E.

Arch. Biochem. Biophys.

224

332-341

641341

2981505

The substrate specificity, kinetics, and mechanism of glycerate-3-kinase from spinach leaves

1985

Kleczkowski, L.A.; Randall, D.D.; Zahler, W.L.

Arch. Biochem. Biophys.

236

185-194

641342

-

Substrate stereospecificity of leaf glycerate kinase from C3 and C4 plants

1988

Kleczkowski, L.A.; Randall, D.D.

Phytochemistry

27

1269-1273

641343

24226402

Purification and characterization of D-glycerate 3-kinase from maize leaves

1988

Kleczkowski, L.A.; Randall, D.D.

Planta

173

221-229

648378

-

Enzymic production of D-glycerate from L-tartrate

1989

Furuyoshi, S.; Kawabata, N.; Tanaka, H.; Soda, K.

Agric. Biol. Chem.

53

2101-2105

648380

1778975

Purification and characterization of a new NAD(+)-dependent enzyme, L-tartrate decarboxylase, from Pseudomonas sp. group Ve-2

1991

Furuyoshi, S.; Nawa, Y.; Kawabata, N.; Tanaka, H.; Soda, K.

J. Biochem.

110

520-525

660135

15980259

D-Glycerate 3-kinase, the last unknown enzyme in the photorespiratory cycle in Arabidopsis, belongs to a novel kinase family

2005

Boldt, R.; Edner, C.; Kolukisaoglu, U.; Hagemann, M.; Weckwerth, W.; Wienkoop, S.; Morgenthal, K.; Bauwe, H.

Plant Cell

17

2413-2420

669886

16756993

Structural basis of substrate specificity in human glyoxylate reductase/hydroxypyruvate reductase

2006

Booth, M.P.; Conners, R.; Rumsby, G.; Brady, R.L.

J. Mol. Biol.

360

178-189

672720

-

Purification and characterization of glycerate kinase from the thermoacidophilic archaeon Thermoplasma acidophilum: an enzyme belonging to the second glycerate kinase family

2006

Noh, M.; Jung, J.H.; Lee, S.B.

Biotechnol. Bioprocess Eng.

11

344-350

672800

17764545

Glycerate kinase of the hyperthermophilic archaeon Thermoproteus tenax: new insights into the phylogenetic distribution and physiological role of members of the three different glycerate kinase classes

2007

Kehrer, D.; Ahmed, H.; Brinkmann, H.; Siebers, B.

BMC Genet.

8

301

673501

17563835

A unique highly thermostable 2-phosphoglycerate forming glycerate kinase from the hyperthermophilic archaeon Pyrococcus horikoshii: gene cloning, expression and characterization

2007

Liu, B.; Hong, Y.; Wu, L.; Li, Z.; Ni, J.; Sheng, D.; Shen, Y.

Extremophiles

11

733-739

673730

16684110

Characterization of glycerate kinase (2-phosphoglycerate forming), a key enzyme of the nonphosphorylative Entner-Doudoroff pathway, from the thermoacidophilic euryarchaeon Picrophilus torridus

2006

Reher, M.; Bott, M.; Schoenheit, P.

FEMS Microbiol. Lett.

259

113-119

680490

17369297

Single-step pathway for synthesis of glucosylglycerate in Persephonella marina

2007

Fernandes, C.; Empadinhas, N.; da Costa, M.S.

J. Bacteriol.

189

4014-4019

685823

17764545

Glycerate kinase of the hyperthermophilic archaeon Thermoproteus tenax: new insights into the phylogenetic distribution and physiological role of members of the three different glycerate kinase classes

2007

Kehrer, D.; Ahmed, H.; Brinkmann, H.; Siebers, B.

BMC Genomics

8

301

686769

18675808

Only plant-type (GLYK) glycerate kinases produce d-glycerate 3-phosphate

2008

Bartsch, O.; Hagemann, M.; Bauwe, H.

FEBS Lett.

582

3025-3028

696906

19690808

A MOFRL family glycerate kinase from the thermophilic crenarchaeon, Sulfolobus tokodaii, with unique enzymatic properties

2009

Liu, B.; Wu, L.; Liu, T.; Hong, Y.; Shen, Y.; Ni, J.

Biotechnol. Lett.

31

1937-1941

698932

19586914

Two D-2-hydroxy-acid dehydrogenases in Arabidopsis thaliana with catalytic capacities to participate in the last reactions of the methylglyoxal and beta-oxidation pathways

2009

Engqvist, M.; Drincovich, M.F.; Fluegge, U.I.; Maurino, V.G.

J. Biol. Chem.

284

25026-25037

699594

-

Reed, G.H.: Method for the enzymatic synthesis of 2-phospho-D-glycerate from adenosine 5'-triphosphate and D-glycerate via D-glycerate-2-kinase

2005

Sims, P.A

J. Mol. Catal. B

32

77-81

708933

20061481

Two alternative pathways for the synthesis of the rare compatible solute mannosylglucosylglycerate in Petrotoga mobilis

2010

Fernandes, C.; Mendes, V.; Costa, J.; Empadinhas, N.; Jorge, C.; Lamosa, P.; Santos, H.; da Costa, M.S.

J. Bacteriol.

192

1624-1633

710045

15951819

Structural dissection and high-throughput screening of mannosylglycerate synthase

2005

Flint, J.; Taylor, E.; Yang, M.; Bolam, D.N.; Tailford, L.E.; Martinez-Fleites, C.; Dodson, E.J.; Davis, B.G.; Gilbert, H.J.; Davies, G.J.

Nat. Struct. Mol. Biol.

12

608-614

722247

23279921

Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic crenarchaeon Sulfolobus solfataricus P2

2013

Kouril, T.; Wieloch, P.; Reimann, J.; Wagner, M.; Zaparty, M.; Albers, S.V.; Schomburg, D.; Ruoff, P.; Siebers, B.

FEBS J.

280

1126-1138

722379

20949620

D-glyceric aciduria is caused by genetic deficiency of D-glycerate kinase (GLYCTK)

2010

Sass, J.O.; Fischer, K.; Wang, R.; Christensen, E.; Scholl-Buergi, S.; Chang, R.; Kapelari, K.; Walter, M.

Hum. Mutat.

31

1280-1285

722705

21288903

Substrate and metal ion promiscuity in mannosylglycerate synthase

2011

Nielsen, M.M.; Suits, M.D.; Yang, M.; Barry, C.S.; Martinez-Fleites, C.; Tailford, L.E.; Flint, J.E.; Dumon, C.; Davis, B.G.; Gilbert, H.J.; Davies, G.J.

J. Biol. Chem.

286

15155-15164

723461

20413649

An autoinhibitory domain confers redox regulation to maize glycerate kinase

2010

Bartsch, O.; Mikkat, S.; Hagemann, M.; Bauwe, H.

Plant Physiol.

153

832-840

723506

23179444

The plant Selaginella moellendorffii possesses enzymes for synthesis and hydrolysis of the compatible solutes mannosylglycerate and glucosylglycerate

2012

Nobre, A.; Empadinhas, N.; Nobre, M.; Lourenco, E.; Maycock, C.; Ventura, M.; Mingote, A.; da Costa, M.

Planta

237

891-901

724992

16458304

Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily

2006

Reher, M.; Schönheit, P.

FEBS Lett.

580

1198-1204

725474

22128181

Biochemical and structural studies of uncharacterized protein PA0743 from Pseudomonas aeruginosa revealed NAD+-dependent L-serine dehydrogenase

2012

Tchigvintsev, A.; Singer, A.; Brown, G.; Flick, R.; Evdokimova, E.; Tan, K.; Gonzalez, C.F.; Savchenko, A.; Yakunin, A.F.

J. Biol. Chem.

287

1874-1883

726270

21305026

Tartronate semialdehyde reductase defines a novel rate-limiting step in assimilation and bioconversion of glycerol in Ustilago maydis

2011

Liu, Y.; Koh, C.; Sun, L.; Ji, L.

PLoS ONE

6

e16438

732214

26102631

Characterization of recombinantly expressed dihydroxy-acid dehydratase from Sulfobus solfataricus - a key enzyme for the conversion of carbohydrates into chemicals

2015

Carsten, J.M.; Philipp, A.; Sieber, V.

J. Biotechnol.

211

31-41

737745

24076009

Identification of catalytically important amino acid residues for enzymatic reduction of glyoxylate in plants

2013

Hoover, G.J.; Jorgensen, R.; Rochon, A.; Bajwa, V.S.; Merrill, A.R.; Shelp, B.J.

Biochim. Biophys. Acta

1834

2663-2671

739242

26997491

Up regulation of glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is associated with intestinal epithelial cells apoptosis in TNBS-induced experimental colitis

2016

Zong, C.; Nie, X.; Zhang, D.; Ji, Q.; Qin, Y.; Wang, L.; Jiang, D.; Gong, C.; Liu, Y.; Zhou, G.

Pathol. Res. Pract.

212

365-371

739276

26791824

The redox control of photorespiration: From biochemical and physiological aspects to biotechnological considerations

2017

Keech, O.; Gardeström, P.; Kleczkowski, L.; Rouhier, N.

Plant Cell Environ.

40

553-569

739413

25823014

An in vivo metabolic approach for deciphering the product specificity of glycerate kinase proves that both E. colis glycerate kinases generate 2-phosphoglycerate

2015

Zelcbuch, L.; Razo-Mejia, M.; Herz, E.; Yahav, S.; Antonovsky, N.; Kroytoro, H.; Milo, R.; Bar-Even, A.

PLoS ONE

10

e0122957

744114

28754708

Glucosylglycerate phosphorylase, an enzyme with novel specificity involved in compatible solute metabolism

2017

Franceus, J.; Pinel, D.; Desmet, T.

Appl. Environ. Microbiol.

83

e01434-17

758811

29684280

Discovery of a kojibiose phosphorylase in Escherichia coli K-12

2018

Mukherjee, K.; Narindoshvili, T.; Raushel, F.M.

Biochemistry

57

2857-2867

759053

28421660

Biocatalytic asymmetric phosphorylation catalyzed by recombinant glycerate-2-kinase

2017

Hardt, N.; Kinfu, B.M.; Chow, J.; Schoenenberger, B.; Streit, W.R.; Obkircher, M.; Wohlgemuth, R.

ChemBioChem

18

1518-1522

759581

33057913

Production of d-Glyceric acid from d-Galacturonate in Escherichia coli

2020

Fox, K.; Prather, K.

J. Ind. Microbiol. Biotechnol.

47

1075-1081

759778

28462797

D-Glyceric aciduria does not cause nonketotic hyperglycinemia a historic co-occurrence

2017

Swanson, M.A.; Garcia, S.M.; Spector, E.; Kronquist, K.; Creadon-Swindell, G.; Walter, M.; Christensen, E.; Van Hove, J.L.K.; Sass, J.O.

Mol. Genet. Metab.

121

80-82

761384

28847921

A bacterial multidomain NAD-independent D-lactate dehydrogenase utilizes flavin adenine dinucleotide and Fe-S clusters as cofactors and quinone as an electron acceptor for D-lactate oxidization

2017

Jiang, T.; Guo, X.; Yan, J.; Zhang, Y.; Wang, Y.; Zhang, M.; Sheng, B.; Ma, C.; Xu, P.; Gao, C.

J. Bacteriol.

199

e00342

763205

28847921

A bacterial multidomain NAD-independent D-lactate dehydrogenase utilizes flavin adenine dinucleotide and Fe-S clusters as cofactors and quinone as an electron acceptor for D-lactate oxidization

2017

Jiang, T.; Guo, X.; Yan, J.; Zhang, Y.; Wang, Y.; Zhang, M.; Sheng, B.; Ma, C.; Xu, P.; Gao, C.

J. Bacteriol.

199

e00342-17

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