Ligand D-glycerate

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Basic Ligand Information

Molecular Structure
Picture of D-glycerate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C3H6O4
D-glycerate
RBNPOMFGQQGHHO-UWTATZPHSA-N
Synonyms:
(R)-glycerate, D-(-)-glycerate


Show all pahtways known for Show all BRENDA pathways known for D-glycerate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-glycerate + NAD+ = hydroxypyruvate + NADH + H+
show the reaction diagram
ADP-glucose + D-glycerate = 2-O-(alpha-D-glucopyranosyl)-D-glycerate + ADP
show the reaction diagram
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alpha-D-glucopyranose 1-phosphate + D-glycerate = 2-O-(alpha-D-glucopyranosyl)-D-glycerate + phosphate
show the reaction diagram
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ATP + D-glycerate = ADP + 3-phospho-D-glycerate
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In Vivo Product in Enzyme-catalyzed Reactions (18 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
hydroxypyruvate + NADH = D-glycerate + NAD+
show the reaction diagram
-
-
hydroxypyruvate + NAD(P)H = D-glycerate + NAD(P)+ + H+
show the reaction diagram
-
2-hydroxy-3-oxosuccinate + NAD(P)H = D-glycerate + NAD(P)+ + CO2
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-
D-glyceraldehyde + NADP+ + H2O = D-glycerate + NADPH + H+
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-
-
D-glyceraldehyde + H2O + acceptor = D-glycerate + reduced acceptor
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-
-
2-O-(alpha-D-glucopyranosyl)-D-glycerate + phosphate = alpha-D-glucopyranose 1-phosphate + D-glycerate
show the reaction diagram
-
-
L-tartrate = D-glycerate + CO2
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-

Substrate in Enzyme-catalyzed Reactions (44 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-glycerate + NADP+ = ?
show the reaction diagram
-
D-glycerate + NADP+ = ?
show the reaction diagram
-
D-glycerate + NAD+ = ?
show the reaction diagram
-
D-glycerate + NAD+ = hydroxypyruvate + NADH + H+
show the reaction diagram
D-glycerate + ferricytochrome c = ?
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-
D-glycerate + acceptor = hydroxypyruvate + reduced acceptor
show the reaction diagram
-
alpha-D-glucopyranose 1-phosphate + D-glycerate = 2-O-(alpha-D-glucopyranosyl)-D-glycerate + phosphate
show the reaction diagram
-
D-glycerate = pyruvate + H2O
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (42 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
hydroxypyruvate + NADH + H+ = D-glycerate + NAD+
show the reaction diagram
-
-
D-glyceraldehyde + NAD+ + H2O = D-glycerate + NADH + H+
show the reaction diagram
-
-
2-O-(alpha-D-glucopyranosyl)-D-glycerate + phosphate = alpha-D-glucopyranose 1-phosphate + D-glycerate
show the reaction diagram
-
-
D-glycerate 2-phosphate + H2O = D-glycerate + phosphate
show the reaction diagram
-
D-glycerate 3-phosphate + H2O = D-glycerate + phosphate
show the reaction diagram
-
2-O-(6-phospho-alpha-D-mannosyl)-D-glycerate + H2O = D-mannose 6-phosphate + D-glycerate
show the reaction diagram
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-

Inhibitor in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
the enzyme shows product inhibition
product inhibition, 10 mM, 65% inhibition
-
competitive. Presence of 20 mM D-glycerate decreases catalytic activity towards D-gluconate drastically to 5% residual activity
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3D Structure of Enzyme-Ligand-Complex (PDB) (4 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (35 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
2.01
-
pH 9.0, 30°C
5.8
-
pH 11.0, 37°C, wild-type enzyme
0.1
-
-
128
-
at pH 6.5 and 42°C

KM Value (60 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
56
-
pH 9.0, 30 °C
50
-
pH 9.0, 30°C
10.8
-
pH 11.0, 37°C, wild-type enzyme
0.522
-
D-glycerate oxidation, 50 mM, NaCl, pH 9
8.871
-
-
2.6
-
at pH 6.5 and 42°C

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.1
-
in 100 mM HEPES/KOH, pH 7.0, at 37°C; pH 6.5, 80°C
2.3
-
50°C, pH 7

References & Links

Links to other databases for D-glycerate

ChEBI
PubChem
ChEBI
PubChem