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Ligand prostaglandin G2
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Basic Ligand Information
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open all tablesRoles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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EC NUMBER 
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
In Vivo Product in Enzyme-catalyzed Reactions (2 results)
EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Substrate in Enzyme-catalyzed Reactions (7 results)
EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2 prostaglandin G2 + H2O = 15-hydroperoxythromboxane B2 + 12-hydroperoxy-5,8,10-heptadecatrienoic acid
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2 prostaglandin G2 = 15-hydroperoxythromboxane A2 + 12-hydroperoxy-5,8,10-heptadecatrienoic acid
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Product in Enzyme-catalyzed Reactions (4 results)
EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
arachidonate + reduced N,N,N',N'-tetramethylphenylenediamine + 2 O2 = prostaglandin G2 + oxidized N,N,N',N'-tetramethylphenylenediamine + ?
Inhibitor in Enzyme-catalyzed Reactions (1 result)
EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)
Enzyme Kinetic Parameters
kcat Value (Turnover Number) (3 results)
EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
KM Value (2 results)
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
IC50 Value (2 results)
EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0092
-
pH not specified in the publication, 37°C, inhibition of human THP-1 cells
References & Links
Literature References (12)
Links to other databases for prostaglandin G2
ChEBI
PubChem
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Release 2023.1 (January 2023)
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