Ligand 4-hydroxyacetophenone

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Basic Ligand Information

Molecular Structure
Picture of 4-hydroxyacetophenone (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C8H8O2
4-hydroxyacetophenone
TXFPEBPIARQUIG-UHFFFAOYSA-N
Synonyms:
(4-hydroxyphenyl)ethan-1-one, 1-(4-hydroxy-phenyl)-ethanone, 1-(4-hydroxyphenyl)-ethanone, 1-(4-hydroxyphenyl)ethanone, 4'-hydroxyacetophenone, 4-acetylphenol, 4-hydroxy-acetophenone, 4-hydroxyphenylmethyl ketone, p-acetylphenol, p-hydroxyacetophenone

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
4'-hydroxyacetophenone + NADH + H+ = (S)-4-(1-hydroxyethyl)phenol + NAD+
show the reaction diagram
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4'-hydroxyacetophenone + NADH + H+ = (S)-4-(1-hydroxyethyl)phenol + NAD+
show the reaction diagram
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4-hydroxyacetophenone + H2O2 + H+ = ?
show the reaction diagram
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4-hydroxyacetophenone + NADPH + O2 = acetic acid 4-hydroxyphenyl ester + NADP+ + O2
show the reaction diagram
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UDP-glucose + 4-hydroxyacetophenone = UDP + (4-acetophenyl)-beta-D-glucopyranoside
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (26 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
4-ethylphenol + O2 = 1-(4'-hydroxyphenyl)ethanol + 4-vinylphenol + 4-hydroxyacetophenone
show the reaction diagram
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4-methoxyacetophenone + AH2 + O2 = 4-hydroxyacetophenone + formaldehyde + A + H2O
show the reaction diagram
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4-acetoxyacetophenone + H2O = 4-hydroxyacetophenone + acetate
show the reaction diagram
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4-acetylphenyl sulfate + H2O = 4-acetylphenol + sulfate
show the reaction diagram
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p-acetylphenyl sulfate + H2O = p-acetylphenol + sulfate
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
weak inhibitor with 20.8% inhibition at 0.1 mM
-
IC50: 1.70892 mM
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0.25 mM causes 46% inhibition
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (4 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.34
-
30°C, pH 7.5, 0.1 mM NADPH

KM Value (5 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2.2
-
30°C, pH 7.5, 0.1 mM NADPH

IC50 Value (15 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
1.70892
-
IC50: 1.70892 mM

References & Links

Links to other databases for 4-hydroxyacetophenone

ChEBI
PubChem
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PubChem