Ligand methyl-alpha-D-mannoside

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Basic Ligand Information

Molecular Structure
Picture of methyl-alpha-D-mannoside (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C7H14O6
methyl-alpha-D-mannoside
HOVAGTYPODGVJG-VEIUFWFVSA-N
Synonyms:
alpha-methyl-D-mannoside, alpha-methyl D-mannoside, alpha-methylmannose, alpha-methylmannoside, Man-alpha-O-CH3, methyl-alpha-D-mannnopyranose, methyl-alpha-D-mannopyranose, methyl-alpha-D-mannopyranoside, methyl-alpha-mannoside, methyl alpha-D-mannopyranoside, methyl alpha-D-mannose, methyl alpha-D-mannoside, methyl alpha-mannoside

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
methyl alpha-D-mannopyranoside + acceptor = ?
show the reaction diagram
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sucrose + methyl alpha-D-mannopyranoside = methyl alpha-D-glucopyranosyl-(1,6)-alpha-D-mannopyranoside + methyl-3,6-di-O-alpha-D-glucopyranosyl-alpha-D-mannopyranoside + beta-D-fructofuranose
show the reaction diagram
-
mannosylphosphodecaprenol + methyl-alpha-D-mannoside = decaprenol phosphate + ?
show the reaction diagram
-
GDP-mannose + methyl-alpha-D-mannoside = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
1.4fold enhancement of activity at 0.2 M
-

Inhibitor in Enzyme-catalyzed Reactions (16 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibits activity at 10 mM, 11.3% relative activity compared with activity without any addition of effector. Other sugars and sugar analogs do not inhibit with exception of methyl-alpha-D-mannose
-
competitive
-
concentration of 10 mM causes 25% inhibition
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3D Structure of Enzyme-Ligand-Complex (PDB) (33 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (9 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
28.6
-
-
0.34
-
-

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0008
-
at pH 7.5 and 30°C

References & Links

Links to other databases for methyl-alpha-D-mannoside

ChEBI
PubChem
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PubChem