Ligand phenylalanine benzyl ester
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Basic Ligand Information
Molecular Structure

C16H17NO2
phenylalanine benzyl ester
FPRSPUHXEPWUBZ-HNNXBMFYSA-N
Benzyl ester of phenylalanine, L-Phe benzyl ester
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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L-Phe benzyl ester + H2O = benzyl alcohol + L-phenylalanine
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Substrate in Enzyme-catalyzed Reactions (3 results)
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L-Phe benzyl ester + H2O = L-Phe + benzoic acid
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phenylalanine benzyl ester + H2O = L-phenylalanine + benzyl alcohol
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L-Phe benzyl ester + H2O = benzyl alcohol + L-phenylalanine
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (1 result)
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395
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pH 7.4, 37°C, recombinant enzyme
KM Value (1 result)
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0.099
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pH 7.4, 37°C, recombinant enzyme
References & Links
Literature References (3)
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Partial purification, and some properties and reactivities of cetraxate benzyl ester hydrochloride-hydrolyzing enzyme
1989
Kuroda, H.; Miyadera, A.; Imura, A.; Suzuki, A.
Chem. Pharm. Bull.
37
2929-2932
Molecular basis of prodrug activation by human valacyclovirase, an alpha-amino acid ester hydrolase
2008
Lai, L.; Xu, Z.; Zhou, J.; Lee, K.D.; Amidon, G.L.
J. Biol. Chem.
283
9318-9327
Specificity of a prodrug-activating enzyme hVACVase: the leaving group effect
2010
Sun, J.; Dahan, A.; Walls, Z.F.; Lai, L.; Lee, K.D.; Amidon, G.L.
Mol. Pharm.
7
2362-2368
Links to other databases for phenylalanine benzyl ester