Ligand Leu-NH2

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Basic Ligand Information

Molecular Structure
Picture of Leu-NH2 (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H14N2O
Leu-NH2
XMOCLSLCDHWDHP-IUODEOHRSA-N
Synonyms:
H-Leu-NH3, L-Leu-NH2, L-Leu amide, L-Leucinamide, L-Leucine amide, L-leucineamide, L-leucylamide, Leu-amide, leucinamide

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (28 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl-D-phenyl methyl ester + L-leucine amide = acetyl-D-phenyl-L-leucine + methanol
show the reaction diagram
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Leu-amide + H2O = Leu + NH3
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Leu-amide + H2O = Leu + NH3
show the reaction diagram
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Leu-NH2 + H2O = L-Leu + NH3
show the reaction diagram
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L-Leu-NH2 + H2O = L-Leu + NH3
show the reaction diagram
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benzoyl-Arg ethyl ester + leucinamide = benzoyl-Arg leucinamide + ethanol
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benzoyl-Arg-ethyl ester + Leu-NH2 = ?
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L-Leu amide + H2O = Leu + NH3
show the reaction diagram
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L-leucine amide + H2O = ?
show the reaction diagram
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L-leucine amide + H2O = L-leucine + NH3
show the reaction diagram
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Leu-NH2 + H2O = Leu + NH3
show the reaction diagram
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L-leucine amide + H2O = L-Leu + NH3
show the reaction diagram
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L-leucinamide + H2O = L-leucine + NH3
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L-leucine amide = D-leucine amide
show the reaction diagram
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L-leucine amide = D-leucine amide
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Product in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Pro-Leu-NH2 + H2O = Pro + Leu-NH2
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Acetyl-Pro-Ala-Pro-Phe-Leu-NH2 + H2O = Acetyl-Pro-Ala-Pro-Phe + Leu-NH2
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benzyloxycarbonyl-Gly-Leu-NH + H2O = L-leucine amide + N-benzyloxycarbonyl-glycine
show the reaction diagram
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furylacryloyl-Gly-Leu-NH2 + H2O = furylacryloyl-Gly + Leu-NH2
show the reaction diagram
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furylacryloyl-Gly-Leu-NH2 + H2O = furylacryloyl-Gly + Leu-NH2
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibition of the reaction with Gly-Gly-ethyl ester or Gly-L-Phe-NH2
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (6 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
112
-
native enzyme, pH 8.0, 25°C
220
-
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12
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pH 7.5, 30°C

KM Value (12 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
5.1
-
-
4.9
-
pH 7.5, 30°C
1.3
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acyl transfer reaction on hydroxylamine, pH = 7

References & Links

Links to other databases for Leu-NH2

ChEBI
PubChem
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PubChem