• BRENDA home

• Basic Ligand Information
• • Molecular Structure
  • Sum Formula
  • BRENDA Name
  • Synonyms
  • InChIKey
  • Pathways
• Roles as Enzyme Ligand
• • In Vivo Substrate
  • In Vivo Product
  • Substrate
  • Product
  • Cofactor
  • Activator
  • Inhibitor
  • Metals and Ions
  • 3D Structure (PDB)
• Enzyme Kinetic Parameters
• • k_cat Value (Turnover Number)
  • K_M Value
  • K_i Value
  • IC₅₀ Value
• References & Links
• • References
  • Links

print visible entries

print all entries

Ligand L-Rhamnonate

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for L-Rhamnonate

close all tables

open all tables

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

top print hide

Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

4.2.1.90

L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O

747418, 347736, 729795, 747890, 643844, 697897, 687737

-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

top print hide

Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.1.65

L-rhamnono-1,4-lactone + H2O = L-rhamnonate

643844, 347736

-

Substrate in Enzyme-catalyzed Reactions (2 results)

top print hide

Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.1.65

L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O

347736

-

4.2.1.90

L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O

729790, 747418, 643844, 687737, 347736, 697897, 729795, 747890, 696299

-

Product in Enzyme-catalyzed Reactions (1 result)

top print hide

Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.1.65

L-rhamnono-1,4-lactone + H2O = L-rhamnonate

347736, 643844

-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

top print hide

Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

4.2.1.68

10 mM, 95% inhibition

33953

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (4 results)

top print hide

Show Turnover Number (4 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

4.2.1.90

0.72

-

pH 7.0, 30°C

687737

4.2.1.90

3.2

-

pH 7.9, 25°C, wild-type enzyme

696299

4.2.1.90

3.9

-

pH 7.9, 25°C, wild-type enzyme

696299

4.2.1.90

49.3

-

pH 7.0, 30°C

687737

4.2.1.90

4 entries

K_M Value (6 results)

top print hide

Show KM Value (6 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

4.2.1.90

0.115

-

pH 7.0, 30°C

687737

4.2.1.90

0.15

-

pH 7.9, 25°C, wild-type enzyme

696299

4.2.1.90

0.25

-

pH 7.9, 25°C, wild-type enzyme

696299

4.2.1.90

1.37

-

pH 7.0, 30°C

687737

4.2.1.90

2.99

-

pH and temperature not specified in the publication

729790

4.2.1.90

3

-

recombinant enzyme, pH 7.0, temperature not specified in the publication

747890

4.2.1.90

6 entries

References & Links

Literature References (10)

top print hide

Show Reference (10 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

33953

-

L.Fuconate dehydratase: purification and properties of the enzyme from Pullularia pullulans

1991

Veiga, L.A.; Guimaes, M.F.

Arq. Biol. Tecnol.

34

537-553

347736

-

L-Rhamnose metabolism in Pichia stipitis and Debaryomyces polymorphus

1994

Twerdochlib, A.L.; Pedrosa, F.O.; Funayama, S.; Rigo, L.U.

Can. J. Microbiol.

40

896-902

643844

-

Oxidative pathway for L-rhamnose degradation in Pullularia pullulans

1985

Rigo, L.U.; Marechal, L.R.; Vieira, M.M.; Veiga, L.A.

Can. J. Microbiol.

31

817-822

687737

18505728

Eukaryotic and bacterial gene clusters related to an alternative pathway of non-phosphorylated L-rhamnose metabolism

2008

Watanabe, S.; Saimura, M.; Makino, K.

J. Biol. Chem.

283

20372-20382

696299

18754693

Evolution of enzymatic activities in the enolase superfamily: L-rhamnonate dehydratase

2008

Rakus, J.F.; Fedorov, A.A.; Fedorov, E.V.; Glasner, M.E.; Hubbard, B.K.; Delli, J.D.; Babbitt, P.C.; Almo, S.C.; Gerlt, J.A.

Biochemistry

47

9944-9954

697897

19187228

Novel modified version of nonphosphorylated sugar metabolism-an alternative L-rhamnose pathway of Sphingomonas sp

2009

Watanabe, S.; Makino, K.

FEBS J.

276

1554-1567

729790

24382357

Categorisation of sugar acid dehydratases in Aspergillus niger

2014

Motter, F.A.; Kuivanen, J.; Keraenen, H.; Hilditch, S.; Penttilae, M.; Richard, P.

Fungal Genet. Biol.

64

67-72

729795

22037608

Characterisation of the gene cluster for L-rhamnose catabolism in the yeast Scheffersomyces (Pichia) stipitis

2012

Koivistoinen, O.M.; Arvas, M.; Headman, J.R.; Andberg, M.; Penttilae, M.; Jeffries, T.W.; Richard, P.

Gene

492

177-185

747418

29110642

In vivo functional analysis of L-rhamnose metabolic pathway in Aspergillus niger a tool to identify the potential inducer of RhaR

2017

Khosravi, C.; Kun, R.S.; Visser, J.; Aguilar-Pontes, M.V.; de Vries, R.P.; Battaglia, E.

BMC Microbiol.

17

214-227

747890

24382357

Categorisation of sugar acid dehydratases in Aspergillus niger

2014

Motter, F.A.; Kuivanen, J.; Keraenen, H.; Hilditch, S.; Penttilae, M.; Richard, P.

Fungal Genet. Biol.

64

67-72

Links to other databases for L-Rhamnonate

top print hide

Show Links (1 entry)

ChEBI

PubChem