Ligand Insulin B-chain

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Basic Ligand Information

Molecular Structure
Picture of Insulin B-chain (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C157H232N40O41S2
Insulin B-chain
HWHYREAUUKYVGA-MEAGCGGSSA-N
Synonyms:
Insulin B chain

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
insulin B chain + H2O = ?
show the reaction diagram
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insulin B chain + H2O = ?
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (51 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Insulin B-chain + H2O = ?
show the reaction diagram
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insulin B chain + H2O = ?
show the reaction diagram
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insulin B-chain + H2O = peptide fragments
show the reaction diagram
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Insulin B-chain + H2O = ?
show the reaction diagram
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Insulin B-chain + H2O = Hydrolyzed insulin B-chain
show the reaction diagram
-
Insulin B-chain + H2O = ?
show the reaction diagram
-
Insulin B-chain + H2O = ?
show the reaction diagram
-
Insulin B-chain + H2O = Fragments of insulin B-chain
show the reaction diagram
-
insulin B chain + H2O = ?
show the reaction diagram
-
Insulin B-chain + H2O = ?
show the reaction diagram
-
Insulin B-chain + H2O = ?
show the reaction diagram
-
insulin B chain + H2O = fragments of insulin B chain
show the reaction diagram
-
Insulin B-chain + H2O = More
show the reaction diagram
-
Insulin B-chain + H2O = ?
show the reaction diagram
-
insulin B chain + H2O = ?
show the reaction diagram
-
Insulin B-chain + H2O = ?
show the reaction diagram
-
insulin B chain + H2O = ?
show the reaction diagram
-
insulin B chain + H2O = ?
show the reaction diagram
-
insulin B chain + H2O = ?
show the reaction diagram
-
insulin B chain + H2O = ?
show the reaction diagram
-
Insulin B-chain + H2O = ?
show the reaction diagram
-
insulin B chain + H2O = ?
show the reaction diagram
-
Insulin B-chain + H2O = ?
show the reaction diagram
-
Insulin B-chain + H2O = Hydrolyzed insulin B-chain
show the reaction diagram
-
insulin B chain + H2O = ?
show the reaction diagram
-
insulin B chain + H2O = ?
show the reaction diagram
-
Insulin B-chain + H2O = ?
show the reaction diagram
-
Insulin B-chain + H2O = ?
show the reaction diagram
-
Insulin B-chain + H2O = ?
show the reaction diagram
-
Insulin B-chain + H2O = ?
show the reaction diagram
-
insulin B chain + H2O = ?
show the reaction diagram
-
Insulin B-chain + H2O = ?
show the reaction diagram
-
Insulin B-chain + H2O = ?
show the reaction diagram
-
Insulin B-chain + H2O = ?
show the reaction diagram
-
Insulin B-chain + H2O = ?
show the reaction diagram
-
insulin B chain + H2O = ?
show the reaction diagram
-
Insulin B-chain + H2O = ?
show the reaction diagram
-
insulin B chain + H2O = ?
show the reaction diagram
-
Insulin B-chain + H2O = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
reduced insulin B chain + O2 = insulin B chain + H2O
show the reaction diagram
-
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Pro-insulin + H2O = Insulin A-chain + insulin B-chain
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibits the activity with substrate N-(4-carboxy-1-oxobutyl)-L-alanyl-L-alanyl-N-(4-methoxy-2-naphthalenyl)-L-phenylalaninamide
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (4 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0725
-
scissile bond Phe24-Phe25
0.014
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pH 8, 37°C

Ki Value (5 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for Insulin B-chain

ChEBI
PubChem
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PubChem