Ligand dihydroxyacetone

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Basic Ligand Information

Molecular Structure
Picture of dihydroxyacetone (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C3H6O3
dihydroxyacetone
RXKJFZQQPQGTFL-UHFFFAOYSA-N
Synonyms:
1,3-dihydroxy-2-propanone, 1,3-dihydroxyacetone, 1,3-dihydroxypropan-2-one, dihydroxypropanone, dioxyacetone, Glycerone

Show all pahtways known for Show all pathways known for dihydroxyacetone

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dihydroxyacetone + NAD(P)H + H+ = ?
show the reaction diagram
-
dihydroxyacetone + O2 = 3-hydroxy-2-oxo-propionaldehyde + H2O2
show the reaction diagram
-
phosphoenolpyruvate + glycerone = pyruvate + glycerone phosphate
show the reaction diagram
ATP + dihydroxyacetone = ADP + dihydroxyacetone phosphate
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
glycerol + NADP+ = dihydroxyacetone + NADPH
show the reaction diagram
-
glycerol + NADP+ = dihydroxyacetone + NADPH + H+
show the reaction diagram
-
-
D-xylulose 5-phosphate + formaldehyde = glyceraldehyde 3-phosphate + dihydroxyacetone
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (68 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dihydroxyacetone + NADH + H+ = glycerol + NAD+
show the reaction diagram
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dihydroxyacetone + NADPH = propanetriol + NADP+
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dihydroxyacetone + NADH + H+ = ? + NAD+
show the reaction diagram
-
dihydroxyacetone + NAD(P)H = glycerol + NAD(P)+
show the reaction diagram
-
dihydroxyacetone + NADPH = glycerol + NADP+
show the reaction diagram
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dihydroxyacetone + NADPH = glycerol + NADP+
show the reaction diagram
-
dihydroxyacetone + NADPH + H+ = ? + NADP+
show the reaction diagram
-
dihydroxyacetone + NADPH + H+ = ?
show the reaction diagram
-
dihydroxyacetone + NADH = ? + NAD+
show the reaction diagram
-
glycerone + NADH + H+ = glycerol + NAD+
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-
dihydroxyacetone + NAD(P)H + H+ = ?
show the reaction diagram
-
1,3-dihydroxyacetone + NADH + H+ = ?
show the reaction diagram
-
dihydroxyacetone + NADH = glycerol + NAD+
show the reaction diagram
-
dihydroxyacetone + O2 = 3-hydroxy-2-oxopropanal + H2O2
show the reaction diagram
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dihydroxyacetone + nitro blue tetrazolium = ? + reduced nitro blue tetrazolium
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D-Glucose + dihydroxyacetone = ?
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1,3-dihydroxyacetone + NAD+ + H2O = ? + NADH + H+
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1,3-dihydroxyacetone + NAD+ + H2O = ? + NADH + H+
show the reaction diagram
-
dihydroxyacetone + H2O + O2 = ?
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-
dihydroxyacetone + NADPH = ?
show the reaction diagram
ATP + dihydroxyacetone = ?
show the reaction diagram
-
ATP + dihydroxyacetone = ADP + ?
show the reaction diagram
-
ATP + dihydroxyacetone = ADP + dihydroxyacetone phosphate
show the reaction diagram
-
ATP + dihydroxyacetone = ADP + dihydroxyacetone phosphate
show the reaction diagram
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4-nitrophenyl sulfate + dihydroxyacetone = 4-nitrophenol + ?
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Product in Enzyme-catalyzed Reactions (31 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
DL-glyceraldehyde + NADPH = dihydroxyacetone + NADP+
show the reaction diagram
-
-
glycerol + NAD+ = dihydroxyacetone + NADH + H+
show the reaction diagram
-
-
glycerol + NAD+ = dihydroxyacetone + NADH
show the reaction diagram
-
-
glycerol + NADP+ = dihydroxyacetone + NADPH
show the reaction diagram
-
glycerol + NAD+ = dihydroxyacetone + NADH + H+
show the reaction diagram
-
-
glycerol + NAD+ = dihydroxyacetone + NADH
show the reaction diagram
-
-
glycerol + NADP+ = dihydroxyacetone + NADPH + H+
show the reaction diagram
-
-
glycerol + acceptor = dihydroxyacetone + reduced acceptor
show the reaction diagram
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-
dihydroxyacetone phosphate + H2O = dihydroxyacetone + phosphate
show the reaction diagram
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dihydroxyacetone phosphate + H2O = dihydroxyacetone + phosphate
show the reaction diagram
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dihydroxyacetone phosphate + H2O = dihydroxyacetone + phosphate
show the reaction diagram
-
-
dihydroxyacetone phosphate + H2O = dihydroxyacetone + phosphate
show the reaction diagram
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-
L-fuculose 1-phosphate = dihydroxyacetone + (S)-lactaldehyde
show the reaction diagram
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D-glyceraldehyde = dihydroxyacetone
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation, used as carbon source in wild type cell cultures, greater activity compared to activity in glucose-grown cells
-
increase of activity
-

Inhibitor in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
weak
-
2% residual activity at 10 mM
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3D Structure of Enzyme-Ligand-Complex (PDB) (4 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (21 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
98.44
-
pH 6.0, 60°C, recombinant enzyme
5.5
-
-
2.12
-
pH and temperature not specified in the publication
0.063
-
pH and temperature not specified in the publication

KM Value (56 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
160
-
-
160
-
at pH 6.4 and 25°C
5.8
-
at pH 7.0 and 30°C
48
-
-
0.137
-
pH 7.6, 25°C
49.5
-
at pH 7.0 and 30°C
5.4
-
-
0.52
-
-
0.1
-
30°C, enzyme II
0.0378
-
pH and temperature not specified in the publication
0.339
-
pH and temperature not specified in the publication

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
11.1
-
-

References & Links

Links to other databases for dihydroxyacetone

ChEBI
PubChem
ChEBI
PubChem