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Ligand dehydroepiandrosterone sulfate

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Natural Substrate (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.6.2

dehydroepiandrosterone 3-sulfate + H2O = dehydroepiandrosterone + sulfate

681104

-

3.1.6.2

dehydroepiandrosterone sulfate + H2O = dehydroepiandrosterone + sulfate

694116, 690441, 691817, 693555, 691323, 690451, 656443, 656646, 656370, 716214

-

3.1.6.2

2 entries

7.6.2.2

ATP + H2O + dehydroepiandrosterone sulfate/in = ADP + phosphate + dehydroepiandrosterone sulfate/out

701356

-

In Vivo Product in Enzyme-catalyzed Reactions (14 results)

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Show Natural Product (14 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.8.2.1

3'-phosphoadenylyl sulfate + dehydroepiandrosterone = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate

0

-

2.8.2.14

3'-phosphoadenylyl sulfate + dehydroepiandrosterone = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate

0

-

2.8.2.15

3'-phosphoadenylyl sulfate + dehydroepiandrosterone = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate

0

-

2.8.2.15

3'-phosphoadenylyl sulfate + dehydroepiandrosterone = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate

0

-

2.8.2.15

3'-phosphoadenylylsulfate + dehydroepiandrosterone = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate

0, 645735, 645733, 645724, 645739, 645730, 645722, 645731

-

2.8.2.15

3'-phosphoadenylyl sulfate + dehydroepiandrosterone = adenosine 3',5'-bisphosphate + dehydroepiandrosterone O-sulfate

0

-

2.8.2.15

3'-phosphoadenylyl sulfate + dehydroepiandrosterone = adenosine 3',5'-bisphosphate + dehydroepiandrosterone sulfate

0

-

2.8.2.2

3'-phosphoadenylyl sulfate + dehydroepiandrosterone = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate

0

-

2.8.2.2

3'-phosphoadenylyl sulfate + dehydroepiandrosterone = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate

0

-

2.8.2.2

3'-phosphoadenylylsulfate + dehydroepiandrosterone = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate

0

-

2.8.2.2

3'-phosphoadenylyl sulfate + dehydroepiandrosterone = adenosine 3',5'-bisphosphate + dehydroepiandrosterone sulfate

0

-

2.8.2.15

5 entries

2.8.2.2

4 entries

2.8.2.34

3'-phosphoadenylyl 5'-phosphosulfate + dehydroepiandrosterone = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate

0

-

2.8.2.4

3'-phosphoadenylyl sulfate + dehydroepiandrosterone = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate

0

-

7.6.2.2

ATP + H2O + dehydroepiandrosterone sulfate/in = ADP + phosphate + dehydroepiandrosterone sulfate/out

0

-

Substrate in Enzyme-catalyzed Reactions (10 results)

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Show Substrate (10 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.149

dehydroepiandrosterone 3-sulfate + NADPH + H+ = ?

740126

-

3.1.6.1

dehydroepiandrosterone 3-sulfate + H2O = dehydroepiandrosterone + sulfate

750395

-

3.1.6.2

3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate

135595, 135598

-

3.1.6.2

7-dehydroepiandrosterone sulfate + H2O = 7-dehydroepiandrosterone + sulfate

654540

-

3.1.6.2

dehydroepiandrosterone 3-sulfate + H2O = dehydroepiandrosterone + sulfate

135627, 135598, 135603, 135604, 135611, 135614, 135616, 135617, 135624, 135628, 681648, 681650, 135613, 135623, 135621, 135620, 135521, 666931, 135608, 681104, 751417, 750395, 135615

-

3.1.6.2

dehydroepiandrosterone sulfate + H2O = dehydroepiandrosterone + sulfate

701998, 656370, 656443, 656590, 656641, 656646, 656653, 702979, 716214, 656638, 656637, 694116, 690441, 691817, 693555, 691323, 690451, 656643

-

3.1.6.2

4 entries

3.1.6.8

dehydroisoandrosterone sulfate + H2O = dehydroisoandrosterone + sulfate

135683, 135684

-

7.6.2.2

ATP + H2O + dehydroepiandrosterone sulfate/in = ADP + phosphate + dehydroepiandrosterone sulfate/out

701356

-

7.6.2.2

ATP + H2O + dehydroepiandrosterone sulfate[side 1] = ADP + phosphate + dehydroepiandrosterone sulfate[side 2]

747619

-

7.6.2.2

ATP + H2O + dehydroepiandrosterone-3-sulfate/in = ADP + phosphate + dehydroepiandrosterone-3-sulfate/out

670491

-

7.6.2.2

3 entries

Product in Enzyme-catalyzed Reactions (22 results)

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Show Product (22 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.15.6

cholesterol sulfate + reduced adrenodoxin + O2 = pregnenolone sulfate + 17-hydroxy-pregnenolone + dehydroisoandrosterone sulfate + oxidized adrenodoxin + H2O

285426

-

2.8.2.1

3'-phosphoadenylyl sulfate + dehydroepiandrosterone = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate

0

-

2.8.2.1

3'-phosphoadenylylsulfate + dehydroepiandrosterone = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate

0

-

2.8.2.14

3'-phosphoadenylyl sulfate + (S)-dehydroepiandrosterone = adenosine 3',5'-bisphosphate + (S)-dehydroepiandrosterone 3-sulfate

0

-

2.8.2.14

3'-phosphoadenylyl sulfate + dehydroepiandrosterone = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate

0

-

2.8.2.14

3'-phosphoadenylyl-sulfate + dehydroepiandrosterone = adenosine 3',5'-bisphosphate + dehydroepiandrosterone sulfate

0

-

2.8.2.15

3'-phosphoadenylyl sulfate + dehydroepiandrosterone = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate

0

-

2.8.2.15

3'-phosphoadenylyl sulfate + dehydroepiandrosterone = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate

0

-

2.8.2.15

3'-phosphoadenylylsulfate + dehydroepiandrosterone = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate

0, 645735, 645733, 645722, 645730, 645739, 645724, 645731

-

2.8.2.15

3'-phosphoadenylyl sulfate + dehydroepiandrosterone = adenosine 3',5'-bisphosphate + dehydroepiandrosterone O-sulfate

0

-

2.8.2.15

3'-phosphoadenylyl sulfate + dehydroepiandrosterone = adenosine 3',5'-bisphosphate + dehydroepiandrosterone sulfate

0

-

2.8.2.2

3'-phosphoadenylyl sulfate + (S)-dehydroepiandrosterone = adenosine 3',5'-bisphosphate + (S)-dehydroepiandrosterone 3-sulfate

0

-

2.8.2.2

3'-phosphoadenylyl sulfate + dehydroepiandrosterone = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate

0

-

2.8.2.2

3'-phosphoadenylyl sulfate + dehydroepiandrosterone = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate

0

-

2.8.2.2

3'-phosphoadenylylsulfate + dehydroepiandrosterone = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate

0

-

2.8.2.2

3'-phosphoadenylyl sulfate + dehydroepiandrosterone = adenosine 3',5'-bisphosphate + dehydroepiandrosterone sulfate

0

-

2.8.2.1

2 entries

2.8.2.14

3 entries

2.8.2.15

5 entries

2.8.2.2

5 entries

2.8.2.34

3'-phosphoadenylyl 5'-phosphosulfate + dehydroepiandrosterone = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate

0

-

2.8.2.4

3'-phosphoadenylyl sulfate + dehydroepiandrosterone = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate

0

-

2.8.2.4

3'-phosphoadenylylsulfate + dehydroepiandrosterone = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate

645899, 645900, 645906, 645876, 645884, 645902

-

7.6.2.2

ATP + H2O + dehydroepiandrosterone sulfate/in = ADP + phosphate + dehydroepiandrosterone sulfate/out

0

-

7.6.2.2

ATP + H2O + dehydroepiandrosterone sulfate[side 1] = ADP + phosphate + dehydroepiandrosterone sulfate[side 2]

0

-

7.6.2.2

ATP + H2O + dehydroepiandrosterone-3-sulfate/in = ADP + phosphate + dehydroepiandrosterone-3-sulfate/out

0

-

2.8.2.4

2 entries

7.6.2.2

3 entries

Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.33

about 8% residual activity at 0.1 mM (isoform PanK3)

722018

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (2 results)

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Show Turnover Number (2 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

1.1.1.149

0.08

-

at pH 7.4 and 37°C

740126

3.1.6.2

6.48

-

pH 8, 37°C

656641

K_M Value (22 results)

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Show KM Value (22 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.1.1.149

0.0042

-

at pH 7.4 and 37°C

740126

3.1.6.2

0.0017

-

-

656443

3.1.6.2

0.0029

-

pH 7.0, 37°C

751417

3.1.6.2

0.003

-

-

135603

3.1.6.2

0.0036

-

37°C, MCF-7 cells

656646

3.1.6.2

0.00385

-

-

135614

3.1.6.2

0.0043

-

pH 7.5, 37°C, subcortical white matter, female

656590

3.1.6.2

0.0044

-

pH 7.5, 37°C, cerebral neocortex, male

656590

3.1.6.2

0.0059

-

pH 7.5, 37°C, cerebral neocortex, female

656590

3.1.6.2

0.0074

-

pH 7.5, 37°C, subcortical white matter, male

656590

3.1.6.2

0.0078

-

-

135616

3.1.6.2

0.008

-

-

135603

3.1.6.2

0.00944

-

37°C

681648

3.1.6.2

0.00959

-

pH 8, 37°C

656641

3.1.6.2

0.013

-

37°C, mammary myoepithelial cells

656646

3.1.6.2

0.0154

0.0268

in presence or absence of phosphate

135617

3.1.6.2

0.0157

-

pH 7.0, 37°C

751417

3.1.6.2

0.0194

-

pH 7.0, 28°C

751417

3.1.6.2

0.033

-

-

681650

3.1.6.2

0.036

-

pH 7.4, 50°C

666931

3.1.6.2

0.05

-

-

135604

3.1.6.2

0.113

-

-

135621

3.1.6.2

21 entries

IC₅₀ Value (1 result)

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Show IC50 Value (1 entry)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

2.7.1.33

0.0035

-

isoform PanK3, at pH 7.5 and 37°C

722018

References & Links

Literature References (64)

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Show Reference (64 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

135521

3657554

Sulfatases from Helix pomatia

1987

Roy, A.B.

Methods Enzymol.

143

361-366

135595

3886594

Arylsulfatase C and the streroid sulfatases

1985

Daniel, W.L.

Isozymes Curr. Top. Biol. Med. Res.

12

189-228

135598

6576810

Purification and partial characterization of arylsulphatase C from human placental microsomes

1983

Burns, G.R.J.

Biochim. Biophys. Acta

759

199-204

135603

6220952

Human placental steroid-sulfatase. Kinetics of the in-vitro hydrolysis of dehydroepiandrosterone 3-sulfate and of 16 alpha-hydroxydehydroepiandrosterone 3-sulfate

1983

Dibbelt, L.; Kuss, E.

Hoppe-Seyler's Z. Physiol. Chem.

364

187-191

135604

2953589

Purification and properties of arylsulfatase C from human placenta

1987

Vaccaro, A.M.; Salvioli, R.; Muscillo, M.; Renola, L.

Enzyme

37

115-126

135608

13208702

The steroid sulphatase of Patella vulgata

1954

Roy, A.B.

Biochim. Biophys. Acta

15

300-301

135611

6594315

Human placental steroid-sulfatase solubilized with a cholic-acid derivative: molecular mass, kinetic properties and susceptibility to glycosidases [retracted by Dibbelt L, Kuss E. In: Biol Chem Hoppe Seyler 1991 Mar;372(3):186]

1984

Dibbelt, L.; Kuss, E.

Hoppe-Seyler's Z. Physiol. Chem.

365

1145-1153

135613

7200

Solubilization and partial purification of steroid sulfatase from rat liver: characterization of estrone sulfatase

1976

Iwamori, M.; Moser, H.W.; Kishimoto, Y.

Arch. Biochem. Biophys.

174

199-208

135614

4258696

Gonadal steroid sulfates and sulfatase. V. Human testicular steroid sulfatase: partial characterization and possible regulation by free steroids

1972

Payne, A.H.

Biochim. Biophys. Acta

258

473-483

135615

2065092

Characterization of arylsulfatase C isozymes from human liver and placenta

1991

Shankaran, R.; Ameen, M.; Daniel, W.L.; Davidson, R.G.; Chang, P.L.

Biochim. Biophys. Acta

1078

251-257

135616

1606923

Purification and properties of steroid sulfatase from human placenta

1992

Suzuki, T.; Hirato, K.; Yanaihara, T.; Kadofuku, T.; Sato, T.; Hoshino, M.; Yanaihara, N.

Endocrinol. Jpn.

39

93-101

135617

1571052

Steroid sulfatase in the human ovary and placenta: enzyme kinetics and phosphate inhibition

1992

Haning, R.V., Jr.; Hackett, R.J.; Canick, J.A.

J. Steroid Biochem. Mol. Biol.

41

161-165

135620

9168894

Daidzein sulfoconjugates are potent inhibitors of sterol sulfatase (EC 3.1.6.2)

1997

Wong, C.K.; Keung, W.M.

Biochem. Biophys. Res. Commun.

233

579-583

135621

9408085

Distribution and characterization of neurosteroid sulfatase from the bovine brain

1997

Park, I.H.; Han, B.K.; Jo, D.H.

J. Steroid Biochem. Mol. Biol.

62

315-320

135623

9409701

Enhanced plasma DHEAS, brain acetylcholine and memory mediated by steroid sulfatase inhibition

1997

Rhodes, M.E.; Li, P.K.; Burke, A.M.; Johnson, D.A.

Brain Res.

773

28-32

135624

9566745

Steroid sulphatase: expression, isolation and inhibition for active-site identification studies

1998

Purohit, A.; Potter, B.V.; Parker, M.G.; Reed, M.J.

Chem. Biol. Interact.

109

183-193

135627

3479751

Linkage of the murine steroid sulfatase locus, Sts, to sex reversed, Sxr: a genetic and molecular analysis

1987

Nagamine, C.M.; Michot, J.L.; Roberts, C.; Guenet, J.L.; Bishop, C.E.

Nucleic Acids Res.

15

9227-9238

135628

6584688

The nature of placental steroid sulphatase deficiency in man

1983

Van der Loos, C.M.; van Breda, A.J.; van den Berg, F.M.; Jobsis, A.C.

J. Steroid Biochem.

19

1743-1746

135683

40545

Isolation, characterization and the role of rabbit testicular arysulphatase A in fertilization

1979

Farooqui, A.A.; Srivastava, P.N.

Biochem. J.

181

331-337

135684

6104985

Chemical characterization and substrate specificity of rabbit liver aryl sulfatase A

1980

Waheed, A.; Van Etten, R.L.

Biochim. Biophys. Acta

614

92-101

285426

6572949

Modulation of the kinetics of cholesterol side-chain cleavage by an activator and by an inhibitor isolated from the cytosol of the cortex of bovine adrenals

1983

Warne, P.A.; Greenfield, N.J.; Lieberman, S.

Proc. Natl. Acad. Sci. USA

80

1877-1881

645722

737567

Enzymatic sulfation of steroids. V. Partial purification and some properties of sulfotransferase III, the major glucocorticoid sulfotransferase of liver cytosol from male rats

1978

Singer, S.S.; Gebhart, J.; Hess, E.

Can. J. Biochem.

56

1028-1035

645724

6932974

Enzymic synthesis of steroid sulphates. XIII. Isolation and properties of dehydroepiandrosterone sulphotransferase from human foetal adrenals

1980

Adams, J.B.; McDonald, D.

Biochim. Biophys. Acta

615

275-278

645730

-

Purification and immunochemical charcterization of a male-specific rat liver oestrogen sulphotransferase

1993

Borthwick, E.B.; Burchell, A.; Coughtrie, M.W.H.

Biochem. J.

289

719-725

645731

8297382

Identification of a new adult human liver sulfotransferase with specificity for endogenous and xenobiotic estrogens

1994

Forbes-Bamforth, K.J.; Coughtrie, M.W.H.

Biochem. Biophys. Res. Commun.

198

707-711

645733

8943792

Steroid sulfotransferases

1996

Luu-The, V.; Bernier, F.; Dufort, I.

J. Endocrinol.

150

87-97

645735

9484797

Mouse steroid sulfotransferases. Substrate specificity and preliminary X-ray crystallographic analysis

1998

Kakuta, Y.; Pedersen, L.C.; Chae, K.; Song, W.C.; Leblanc, D.; London, R.; Carter, C.W.; Negishi, M.

Biochem. Pharmacol.

55

313-317

645739

11457664

Expression and characterization of the human 3b-hydroxysteroid sulfotransferases (SULT2B1alpha and SULT2B1beta)

2001

Meloche, C.A.; Falany, C.N.

J. Steroid Biochem. Mol. Biol.

77

261-269

645876

3859706

Estrogen sulfotransferase in human placenta

1985

Tseng, L.; Lee, L.Y.; Mazella, J.

J. Steroid Biochem.

22

611-615

645884

8185618

Human liver estrogen sulfotransferase: identification by cDNA cloning and expression

1994

Aksoy, I.A.; Wood, T.C.; Weinshilboum, R.

Biochem. Biophys. Res. Commun.

200

1621-1629

645899

10514486

Substrate gating confers steroid specificity to estrogen sulfotransferase

1999

Petrotchenko, E.V.; Doerflein, M.E.; Kakuta, Y.; Pedersen, L.C.; Negishi, M.

J. Biol. Chem.

274

30019-30022

645900

10659700

Correlation between PAP-dependent steroid binding activity and substrate specificity of mouse and human estrogen sulfotransferases

1999

Qian, Y.; Song, W.C.

J. Steroid Biochem. Mol. Biol.

71

123-131

645902

11006110

Site-directed mutagenesis of the substrate-binding cleft of human estrogen sulfotransferase

2000

Hempel, N.; Barnett, A.C.; Bolton-Grob, R.M.; Liyou, N.E.; McManus, M.E.

Biochem. Biophys. Res. Commun.

276

224-230

645906

11795394

Biochemistry and reproductive endocrinology of estrogen sulfotransferase

2001

Song, W.C.

Ann. N. Y. Acad. Sci.

948

43-50

654540

14969586

The potential function of steroid sulphatase activity in steroid production and steroidogenic acute regulatory protein expression

2004

Sugawara, T.; Fujimoto, S.

Biochem. J.

380

153-160

656370

11115773

Human granulosa cells are a site of sulphatase activity and are able to utilize dehydroepiandrosterone sulphate as a precursor for oestradiol production

2000

Bonser, J.; Walker, J.; Purohit, A.; Reed, M.J.; Potter, B.V.L.; Willis, D.S.; Franks, S.; Mason, H.D.

J. Endocrinol.

167

465-471

656443

11886493

Steroid sulfatase in the human hair follicle concentrates in the dermal papilla

2001

Hoffmann, R.; Rot, A.; Niiyama, S.; Billich, A.

J. Invest. Dermatol.

117

1342-1348

656590

15056284

Steroid sulfatase (STS) expression in the human temporal lobe: enzyme activity, mRNA expression and immunohistochemistry study

2004

Steckelbroeck, S.; Nassen, A.; Ugele, B.; Ludwig, M.; Watzka, M.; Reissinger, A.; Clusmann, H.; Lütjohann, D.; Siekmann, L.; Klingmüller, D.; Hans, V.H.

J. Neurochem.

89

403-417

656637

10925212

Subunits of neurosteroid sulfatase from bovine brain

2000

Park, I.H.; Han, B.K.; Baek, J.H.; Ryu, Y.W.; Park, Y.H.; Jo, D.H.

J. Steroid Biochem. Mol. Biol.

73

135-139

656638

11282278

Steroid sulfatase activity in the rat ovary, cultured granulosa cells, and a granulosa cell line

2000

Clemens, J.W.; Kabler, H.L.; Sarap, J.L.; Beyer, A.R.; Li, P.K.; Selcer, K.W.

J. Steroid Biochem. Mol. Biol.

75

245-252

656641

11738554

Purification, characterization and crystallization of human placental estrone/dehydroepiandrosterone sulfatase, a membrane-bound enzyme of the endoplasmic reticulum

2001

Hernandez-Guzman, F.G.; Higashiyama, T.; Osawa, Y.; Ghosh, D.

J. Steroid Biochem. Mol. Biol.

78

441-450

656643

12163138

Sterolsulphate sulphohydrolase from human placenta microsomes--30 kDa molecular weight form of cholesterol sulphate sulphohydrolase

2002

Norkowska, M.; Gniot-Szulzycka, J.

J. Steroid Biochem. Mol. Biol.

81

263-271

656646

12127043

Steroid sulfatase activity and expression in mammary myoepithelial cells

2002

Tobacman, J.K.; Hinkhouse, M.; Khalkhali-Ellis, Z.

J. Steroid Biochem. Mol. Biol.

81

65-68

656653

14623544

Role of steroid sulfatase in local formation of estrogen in post-menopausal breast cancer patients

2003

Nakata, T.; Takashima, S.; Shiotsu, Y.; Murakata, C.; Ishida, H.; Akinaga, S.; Li, P.K.; Sasano, H.; Suzuki, T.; Saeki, T.

J. Steroid Biochem. Mol. Biol.

86

455-460

666931

16157357

Steroid sulfatase and sulfuryl transferase activity in monkey brain tissue

2005

Kriz, L.; Bicikova, M.; Hill, M.; Hampl, R.

Steroids

70

960-969

670491

15083066

Identification and functional characterization of the natural variant MRP3-Arg1297His of human multidrug resistance protein 3 (MRP3/ABCC3)

2004

Lee, Y.M.; Cui, Y.; Koenig, J.; Risch, A.; Jaeger, B.; Drings, P.; Bartsch, H.; Keppler, D.; Nies, A.T.

Pharmacogenetics

14

213-223

681104

16837617

Tissue-specific transcriptional initiation and activity of steroid sulfatase complementing dehydroepiandrosterone sulfate uptake and intracrine steroid activations in human adipose tissue

2006

Valle, L.D.; Toffolo, V.; Nardi, A.; Fiore, C.; Bernante, P.; Di Liddo, R.; Parnigotto, P.P.; Colombo, L.

J. Endocrinol.

190

129-139

681648

17945483

Inactivation of recombinant human steroid sulfatase by KW-2581

2008

Ishida, H.; Sato, N.; Hosogi, J.; Tanaka, H.; Kuwabara, T.

J. Steroid Biochem. Mol. Biol.

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Dehydroepiandrosterone sulphate sulphohydrolase from human placenta microsomes - properties of the purified enzyme

2006

Niewiadomska, I.; Gniot-Szulzycka, J.

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99

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690441

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The development of steroid sulfatase inhibitors for hormone-dependent cancer therapy

2009

Day, J.M.; Purohit, A.; Tutill, H.J.; Foster, P.A.; Woo, L.W.; Potter, B.V.; Reed, M.J.

Ann. N. Y. Acad. Sci.

1155

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690451

18630506

Inhibition of steroid sulphatase activity via the percutaneous route: a new option for breast cancer therapy

2008

Purohit, A.; Chander, S.K.; Woo, L.W.; Parsons, M.F.; Jhalli, R.; Potter, B.V.; Reed, M.J.

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Estradiol dimers as a new class of steroid sulfatase reversible inhibitors

2009

Fournier, D.; Poirier, D.

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691817

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Synthesis of aromatase inhibitors and dual aromatase steroid sulfatase inhibitors by linking an arylsulfamate motif to 4-(4H-1,2,4-triazol-4-ylamino)benzonitrile: SAR, crystal structures, in vitro and in vivo activities

2008

Bubert, C.; Woo, L.W.; Sutcliffe, O.B.; Mahon, M.F.; Chander, S.K.; Purohit, A.; Reed, M.J.; Potter, B.V.

ChemMedChem

3

1708-1730

693555

18590272

Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activity

2008

Wood, P.M.; Woo, L.W.; Labrosse, J.R.; Trusselle, M.N.; Abbate, S.; Longhi, G.; Castiglioni, E.; Lebon, F.; Purohit, A.; Reed, M.J.; Potter, B.V.

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Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography

2008

Woo, L.W.; Fischer, D.S.; Sharland, C.M.; Trusselle, M.; Foster, P.A.; Chander, S.K.; Di Fiore, A.; Supuran, C.T.; De Simone, G.; Purohit, A.; Reed, M.J.; Potter, B.V.

Mol. Cancer Ther.

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701356

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Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules

2008

Russel, F.G.; Koenderink, J.B.; Masereeuw, R.

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29

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701998

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Brain pathways mediating the pro-aggressive effect of the steroid sulfatase (Sts) gene

2010

Mortaud, S.; Nicolas, L.; Pinoteau, W.; Tordjman, S.; Carlier, M.; Roubertoux, P.L.

Behav. Genet.

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702979

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Expression of estrogenicity genes in a lineage cell culture model of human breast cancer progression

2010

Fu, J.; Weise, A.M.; Falany, J.L.; Falany, C.N.; Thibodeau, B.J.; Miller, F.R.; Kocarek, T.A.; Runge-Morris, M.

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Steroid sulfatase: a pivotal player in estrogen synthesis and metabolism

2011

Purohit, A.; Woo, L.W.; Potter, B.V.

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Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain

2010

Leonardi, R.; Zhang, Y.M.; Yun, M.K.; Zhou, R.; Zeng, F.Y.; Lin, W.; Cui, J.; Chen, T.; Rock, C.O.; White, S.W.; Jackowski, S.

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Substrate specificity and inhibitor sensitivity of rabbit 20alpha-hydroxysteroid dehydrogenase

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Endo, S.; Arai, Y.; Hara, A.; Kitade, Y.; Bunai, Y.; El-Kabbani, O.; Matsunaga, T.

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ATP-binding cassette exporters structure and mechanism with a focus on P-glycoprotein and MRP1

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Arana, M.R.; Altenberg, G.

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Pseudomonas aeruginosa arylsulfatase a purified enzyme for the mild hydrolysis of steroid sulfates

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Stevenson, B.J.; Waller, C.C.; Ma, P.; Li, K.; Cawley, A.T.; Ollis, D.L.; McLeod, M.D.

Drug Test. Anal.

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Identification of zebrafish steroid sulfatase and comparative analysis of the enzymatic properties with human steroid sulfatase

2019

Kurogi, K.; Yoshihama, M.; Williams, F.E.; Kenmochi, N.; Sakakibara, Y.; Suiko, M.; Liu, M.C.

J. Steroid Biochem. Mol. Biol.

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Links to other databases for dehydroepiandrosterone sulfate

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