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Ligand (D-mannose)6-(N-acetyl-D-glucosaminyl)2-dolichyl-diphosphate Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C1 5 2 H2 5 2 N2 O4 7 P2
(D-mannose)6-(N-acetyl-D-glucosaminyl)2-dolichyl-diphosphate
VLJNJYBJSIFAMC-MEHMYDNKSA-N
Man6GlcNAc2 dolichyl diphosphate, Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)(Manalpha(1-3)Manalpha(1-6))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-PP-dolichol
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (1 result)
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Man6GlcNAc2 dolichyl diphosphate + GAYNSTSV = dolichyl diphosphate + GAY-(Man6GlcNAc2)NSTSV
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Product in Enzyme-catalyzed Reactions (1 result)
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GDP-alpha-D-mannose + Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)(Manalpha(1-6))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-PP-dolichol = GDP + Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)(Manalpha(1-3)Manalpha(1-6))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-PP-dolichol
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Enzyme Kinetic Parameters
References & Links Literature References (2)
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The accumulation of Man6GlcNAc2-PP-dolichol in the Saccharomyces cerevisiae deltaalg9 mutant reveals a regulatory role for the Alg3p alpha1,3-Man middle-arm addition in downstream oligosaccharide-lipid and glycoprotein glycan processing
2000
Cipollo, J.F.; Trimble, R.B.
J. Biol. Chem.
275
4267-4277
The yeast oligosaccharyltransferase complex can be replaced by STT3 from Leishmania major
2008
Hese, K.; Otto, C.; Routier, F.H.; Lehle, L.
Glycobiology
19
160-171
Links to other databases for (D-mannose)6-(N-acetyl-D-glucosaminyl)2-dolichyl-diphosphate