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Ligand CDP-dipalmitin

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (7 results)

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Show Substrate (7 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.8.11

CDP-dipalmitin + myo-inositol = ?

645306

-

2.7.8.11

CDP-dipalmitoyl-sn-glycerol + myo-inositol = CMP + dipalmitoylphosphatidylinositol

210005, 645297

-

2.7.8.11

CDP-dipalmitoylglycerol + D-myo-inositol = CMP + 1,2-dipalmitoyl-phosphatidyl-1D-myo-inositol

690824

-

2.7.8.11

CDPdipalmitoyl-sn-glycerol + myo-inositol = CMP + dipalmitoylphosphatidylinositol

210005

-

2.7.8.11

4 entries

2.7.8.41

CDP-dipalmitoylglycerol + 1,2-dioleoylphosphatidylglycerol = 1-(1-oleoyl-2-oleoyl-sn-glycero-3-phospho)-3-(1-palmitoyl-2-palmitoyl-sn-glycero-3-phospho)-sn-glycerol + CMP

727509

-

2.7.8.8

CDP-dipalmitoylglycerol + L-serine = CMP + (3-sn-phosphatidyl)-L-serine

761843

-

3.6.1.26

CDPdipalmitoylglycerol + H2O = CMP + 1,2-dipalmitoyl-sn-glycerol-3-phosphate

210005

-

Product in Enzyme-catalyzed Reactions (1 result)

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Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.7.41

CTP + 1,2-dipalmitoyl phosphatidic acid = diphosphate + CDP-dipalmitoylglycerol

0

-

Activator in Enzyme-catalyzed Reactions (1 result)

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Show Activating Compound (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.7.8.B10

stimulates the reaction but does not participate as phosphatidyl donor

728702

-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.7.7.41

inhibits diphosphorolysis of CDP-dipalmitin

643314

-

Enzyme Kinetic Parameters

K_M Value (4 results)

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Show KM Value (4 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.7.8.11

0.01929

-

pH 6.8, 37°C, 0.010 mM Ca2+

645306

2.7.8.11

0.0195

-

pH 6.8, 37°C, 0.0001 mM Ca2+

645306

2.7.8.11

0.05

-

pH 8.3, 37°C

210005

2.7.8.11

3 entries

3.6.1.26

0.063

-

-

210005

References & Links

Literature References (8)

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Show Reference (8 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

210005

6127112

Stereospecific synthesis and enzyme studies of CDP-diacylglycerols

1982

Murthy, P.P.N.; Agranoff, B.W.

Biochim. Biophys. Acta

712

473-483

643314

30751

Partial purification and properties of CTP:phosphatidic acid cytidylyltransferase from membranes of Escherichia coli

1978

Langley, K.E.; Kennedy, E.P.

J. Bacteriol.

136

85-95

645297

-

Properties of cytidinediphosphodiacyl-sn-glycerol:myoinositol transferase of bovine mammary tissue

1977

Wootton, J.A.; Kinsella, J.E.

Int. J. Biochem.

8

449-456

645306

2840949

Presence of a Ca2+-sensitive CDPdiglyceride-inositol transferase in canine cardiac sarcoplasmic reticulum

1988

Kasinathan, C.; Kirchberger, M.A.

Biochemistry

27

2834-2839

690824

18402553

Alternative metabolic fates of phosphatidylinositol produced by phosphatidylinositol synthase isoforms in Arabidopsis thaliana

2008

Loefke, C.; Ischebeck, T.; Koenig, S.; Freitag, S.; Heilmann, I.

Biochem. J.

413

115-124

727509

16678169

Identification and characterization of human cardiolipin synthase

2006

Houtkooper, R.H.; Akbari, H.; van Lenthe, H.; Kulik, W.; Wanders, R.J.; Frentzen, M.; Vaz, F.M.

FEBS Lett.

580

3059-3064

728702

4551982

Mechanism of the enzymatic synthesis of cardiolipin in Escherichia coli

1972

Hirschberg, C.B.; Kennedy, E.P.

Proc. Natl. Acad. Sci. USA

69

648-651

761843

30854712

Molecular and functional evidence of phosphatidylserine synthase in Vibrio parahaemolyticus

2019

Huang, R.Y.; Lee, C.Y.

Microbiol. Immunol.

63

119-129

Links to other databases for CDP-dipalmitin

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Show Links (1 entry)

ChEBI

PubChem

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