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Ligand 4-methylene-L-glutamate

Basic Ligand Information

Molecular Structure

Related pathways

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

6.3.1.7

ATP + 4-methylene-L-glutamate + NH3 = ?

960

-

Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Substrate (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

6.3.1.7

ATP + 4-methylene-L-glutamate + glutamine = AMP + diphosphate + glutamate + 4-methylene-L-glutamine

960

-

6.3.1.7

ATP + 4-methylene-L-glutamate + hydroxylamine = AMP + diphosphate + 4-methylene-L-glutamylhydroxamate

960

-

6.3.1.7

ATP + 4-methylene-L-glutamate + NH3 = ?

960

-

6.3.1.7

ATP + 4-methylene-L-glutamate + NH4+ = AMP + diphosphate + 4-methylene-L-glutamine

960, 961

-

6.3.1.7

4 entries

Product in Enzyme-catalyzed Reactions (1 result)

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Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.5.1.67

4-methylene-L-glutamine + H2O = 4-methylene-L-glutamate + NH3

172073, 172074, 172075

-

Inhibitor in Enzyme-catalyzed Reactions (5 results)

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Show Inhibitors (5 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.5.1.67

non-competitive, Ki: 5.4 mM

172073

-

3.5.1.67

slight inhibition

172074

-

6.3.2.2

-

1118

-

6.3.2.2

no inhibition

1118

-

6.3.2.2

weak, competitive

649263

-

3.5.1.67

2 entries

6.3.2.2

3 entries

Enzyme Kinetic Parameters

K_M Value (2 results)

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Show KM Value (2 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

6.3.1.7

2.7

-

-

961

6.3.1.7

8

-

about

960

6.3.1.7

2 entries

K_i Value (1 result)

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Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

6.3.2.2

2.5

-

-

649263

References & Links

Literature References (7)

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Show Reference (7 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

960

6838571

4-Methyleneglutamine synthetase: a new amide synthetase present in germinating peanuts

1983

Winter, H.C.; Ti-Zhi Su; Dekker, E.E.

Biochem. Biophys. Res. Commun.

111

484-489

961

3015960

Purification and characterization of a novel 4-methyleneglutamine synthetase from germinating peanut cotyledons (Arachis hypogaea)

1986

Winter, H.C.; Dekker, E.E.

J. Biol. Chem.

261

11189-11193

1118

2895925

On the active site thiol of gamma-glutamylcysteine synthetase: relationship to catalysis, inhibition, and regulation

1988

Huang, C.S.; Moore, W.R.; Meister, A.

Proc. Natl. Acad. Sci. USA

85

2464-2468

172073

-

Purification and properties of 4-methyleneglutaminase from the leaves of peanut (Arachis hypogaea)

1984

Ibrahim, S.A.; Lea, P.J.; Fowden, L.

Phytochemistry

23

1545-1549

172074

16667952

4-Methyleneglutamine amidohydrolase from peanut leaves. Preparation, catalytic properties, and immunological responses of a highly purified form of the enzyme

1991

Winter, H.C.; Dekker, E.E.

Plant Physiol.

95

206-212

172075

6863306

Purification and properties of a 4-methylene-L-glutamine amidohydrolase from peanut leaves

1983

Powell, G.K.; Dekker, E.E.

J. Biol. Chem.

258

8677-8683

649263

10218110

The enzymes of glutathione synthesis: gamma-glutamylcysteine synthetase

1999

Griffith, O.W.; Mulcahy, R.T.

Adv. Enzymol. Relat. Areas Mol. Biol.

73

209-267

Links to other databases for 4-methylene-L-glutamate

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Show Links (1 entry)