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BRENDA support

Ligand 2,4-D

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Basic Ligand Information

Molecular Structure
Picture of 2,4-D (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C8H6ClO3
2,4-D
OVSKIKFHRZPJSS-UHFFFAOYSA-N
Synonyms:
(2,4-dichlorophenoxy)acetic acid, 2,4-dichlorophenoxyacetate, 2,4-Dichlorophenoxyacetic acid, 2,4-dichlorophenoxy acetic acid, 2,4-Dichlorophenoxyethanoic acid, 2,4-dichlorphenoxyacetic acid, 2,4-PA, Aminopielik 50SL, Amoxone, B-Selektonon, Basalcoat, D-2,4 dichlorophenoxyacetate, Deherban, Dichlorophenoxyacetic acid, Diclordon, Dicopu, Esterone, Fernimine, Foredex 75, Hedonal, Ipaner, Isadiamineyeom, NSC 190751, phenoxyalacanoic herbicide 2,4-D

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2,4-dichlorophenoxyacetate + NADH = ?
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + dichlorophenoxyacetic acid = S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
2,4-dichlorophenoxyacetic acid + UDP-glucose = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
methyl-2,4-dichlorophenoxyacetate + H2O = 2,4-dichlorophenoxyacetic acid + methanol
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
induction of MAR activity in wild type strain
-
0.005 mM, 10fold activation
-
activates CAS expression at 10 mM, 2,4-D is a synthetic auxin
-

Inhibitor in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibits the enzyme, in vivo treatment of the animals with 2,4-dichlorophenoxyacetic acid leads to strong decrease of triglycerides level and HDL cholesterol and an increase in GOT level and LDL cholesterol, and necrosis of seminiferous tubules cells in testis, hyperplasia of hepatocytes in liver and presence of multinucleated giant cells in brain, overview
-
decreases the enzyme activity by about 70% at 2 mM
-
inhibits the enzyme by up to 31%
-
reduced activity in microsomes and mitochondria
-
reduced activity in microsomes and mitochondria
-
concentration dependent inhibitor
-

Enzyme Kinetic Parameters

Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
12
-
-
0.002
-
-

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
1.6
-
pH and temperature not specified in the publication

References & Links

Links to other databases for 2,4-D

ChEBI
PubChem
ChEBI
PubChem