Ligand 1-Methylxanthine

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Basic Ligand Information

Molecular Structure
Picture of 1-Methylxanthine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H6N4O2
1-Methylxanthine
NHXYSAFTNPANFK-HDMCBQFHSA-N
Synonyms:
Methylxanthine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1-methylxanthine + H2O + O2 = 1-methylurate + H2O2
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1-methylxanthine + O2 + NADH + H+ = xanthine + NAD+ + H2O + formaldehyde
show the reaction diagram
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1-methylxanthine + H2O + O2 = 1-methylurate + H2O2
show the reaction diagram
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S-adenosyl-L-methionine + 1-methylxanthine = S-adenosyl-L-homocysteine + 1,3-dimethylxanthine
show the reaction diagram
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S-adenosyl-L-methionine + 1-methylxanthine = S-adenosyl-L-homocysteine + 1,3-dimethylxanthine
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
theophylline + O2 + NADH + H+ = 1-methylxanthine + NAD+ + H2O + formaldehyde
show the reaction diagram
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theophylline + O2 + NADH + H+ = 1-methylxanthine + NAD+ + H2O + formaldehyde
show the reaction diagram
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1-methylhypoxanthine + NAD+ + H2O = 1-methylxanthine + NADH
show the reaction diagram
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1-methylxanthosine + H2O = 1-methylxanthine + D-ribose
show the reaction diagram
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1-methylguanine + H2O = 1-methylxanthine + NH3
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
10 mM, 35.9% inhibition
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weak competitive inhibitor
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.27
-
pH 7.5, 30C

KM Value (2 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.27
-
pH 7.5, 30C
0.13
-
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References & Links

Links to other databases for 1-Methylxanthine

ChEBI
PubChem
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PubChem