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Ligand 1,2,3,5-Tetrahydroxybenzene

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for 1,2,3,5-Tetrahydroxybenzene

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.97.1.2

1,2,3,5-tetrahydroxybenzene + pyrogallol = ?

437674, 437677, 437680, 4734

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Substrate in Enzyme-catalyzed Reactions (6 results)

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Show Substrate (6 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.97.1.2

1,2,3,5-tetrahydroxybenzene + 1,2,3,5-tetrahydroxybenzene = phloroglucinol + pentahydroxybenzene

437676, 437674

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1.97.1.2

1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,3,5-trihydroxybenzene + 1,2,3,5-tetrahydroxybenzene

673091

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1.97.1.2

1,2,3,5-tetrahydroxybenzene + hydroxyhydroquinone = phloroglucinol + 1,2,4,5-tetrahydroxybenzene

437679, 437676, 437674

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1.97.1.2

1,2,3,5-tetrahydroxybenzene + pyrogallol = ?

437674, 437677, 437680, 4734

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1.97.1.2

1,2,3,5-tetrahydroxybenzene + pyrogallol = phloroglucinol + 1,2,3,5-tetrahydroxybenzene

4734, 437677, 437678, 437679, 437680, 437674, 437676

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1.97.1.2

1,2,3,5-tetrahydroxybenzene + resorcinol = phloroglucinol + hydroxyhydroquinone

437674, 437676

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1.97.1.2

6 entries

Product in Enzyme-catalyzed Reactions (4 results)

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Show Product (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.97.1.2

1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,3,5-trihydroxybenzene + 1,2,3,5-tetrahydroxybenzene

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1.97.1.2

1,2,3,5-tetrahydroxybenzene + pyrogallol = phloroglucinol + 1,2,3,5-tetrahydroxybenzene

4734, 437677, 437678, 437679, 437680, 437674, 437676

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1.97.1.2

1,2,4,5-tetrahydroxybenzene + pyrogallol = hydroxyhydroquinone + 1,2,3,5-tetrahydroxybenzene

437676

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1.97.1.2

hydroxyhydroquinone + pyrogallol = resorcinol + 1,2,3,5-tetrahydroxybenzene

437676, 437674

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1.97.1.2

4 entries

Enzyme Kinetic Parameters

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.97.1.2

0.71

-

-

437674

References & Links

Literature References (8)

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Show Reference (8 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

4734

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Phloroglucinol pathway in the strictly anaerobic Pelobacter acidigallici: fermentation of trihydroxybenzenes to acetate via triacetic acid

1992

Brune, A.; Schink, B.

Arch. Microbiol.

157

417-424

437674

2298693

Pyrogallol-to-phloroglucinol conversion and other hydroxyl-transfer reactions catalyzed by cell extracts of Pelobacter acidigallici

1990

Brune, A.; Schink, B.

J. Bacteriol.

172

1070-1076

437676

16348719

Sequential transhydroxylations converting hydroxyhydroquinone to phloroglucinol in the strictly anaerobic, fermentative bacterium Pelobacter massiliensis

1992

Brune, A.; Schnell, S.; Schink, B.

Appl. Environ. Microbiol.

58

1861-1868

437677

10518782

Cloning, sequencing and heterologous expression of pyrogallol-phloroglucinol transhydroxylase from Pelobacter acidigallici

1999

Baas, D.; Retey, J.

Eur. J. Biochem.

265

896-901

437678

8647079

One molecule of molybdopterin guanine dinucleotide is associated with each subunit of the heterodimeric Mo-Fe-S protein transhydroxylase of Pelobacter acidigallici as determined by SDS/PAGE and mass spectrometry

1996

Reichenbecher, W.; Ruediger, A.; Kroneck, P.M.H.; Schink, B.

Eur. J. Biochem.

237

406-413

437679

10082952

Towards the reaction mechanism of pyrogallol-phloroglucinol transhydroxylase of Pelobacter acidigallici

1999

Reichenbecher, W.; Schink, B.

Biochim. Biophys. Acta

1430

245-253

437680

11807272

Crystallization and preliminary x-ray analysis of the molybdenum-dependent pyrogallol-phloroglucinol transhydroxylase of Pelobacter acidigallici

2002

Abt, D.J.; Einsle, O.; Niessen, H.; Krieger, R.; Messerschmidt, A.; Schink, B.; Kroneck, P.M.H.

Acta Crystallogr. Sect. D

58

343-345

673091

17201004

Investigation of the mechanism of action of pyrogallol-phloroglucinol transhydroxylase by using putative intermediates

2007

Paizs, C.; Bartlewski-Hof, U.; Retey, J.

Chemistry

13

2805-2811

Links to other databases for 1,2,3,5-Tetrahydroxybenzene

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Show Links (1 entry)

ChEBI

PubChem

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