Ligand (S)-coclaurine

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Basic Ligand Information

Molecular Structure
Picture of (S)-coclaurine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C17H19NO3
(S)-coclaurine
LVVKXRQZSRUVPY-HNNXBMFYSA-N


Show all pahtways known for Show all BRENDA pathways known for (S)-coclaurine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + (S)-norcoclaurine = S-adenosyl-L-homocysteine + (S)-coclaurine
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-coclaurine + ascorbate + O2 = (S)-3-hydroxycoclaurine + dehydroascorbate + H2O
show the reaction diagram
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(S)-coclaurine + [reduced NADPH-hemoprotein reductase] + O2 = ? + [oxidized NADPH-hemoprotein reductase] + 2 H2O
show the reaction diagram
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(S)-N-methylcoclaurine + (R)-N-methylcoclaurine + (S)-coclaurine + [reduced NADPH-hemoprotein reductase] + O2 = (R,S)-berbamunine + (R,R)-guattegaumerine + (R,S)-2'-norberbamunine + [oxidized NADPH-hemoprotein reductase] + H2O
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S-Adenosylmethionine + (S)-coclaurine = S-Adenosylhomocysteine + N-methylcoclaurine
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-N-methylcoclaurine + O2 = (S)-coclaurine + H2O2
show the reaction diagram
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S-adenosyl-L-methionine + (S)-norcoclaurine = S-adenosyl-L-homocysteine + (S)-coclaurine
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (7 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.022
-
pH 8.0, 30°C

KM Value (8 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.637
-
pH 8.0, 30°C

References & Links

Links to other databases for (S)-coclaurine

ChEBI
PubChem
ChEBI
PubChem