Ligand cob(I)alamin

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Basic Ligand Information

Molecular Structure
Picture of cob(I)alamin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C62H90CoN13O14P
cob(I)alamin
ASARMUCNOOHMLO-PPDMUPKDSA-L

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
NADH + cob(II)alamine = NAD+ + cob(I)alamin
show the reaction diagram
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NADPH + cyanocob(III)alamin = NADP+ + cob(I)alamin + cyanide
show the reaction diagram
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HSCoM + methylcobalamin = CH3-SCoM + cob(I)alamin + H+
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (29 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
glycine betaine + cob(I)alamin = dimethylglycine + methylcob(III)alamin
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
NADH + cob(II)alamine = NAD+ + cob(I)alamin
show the reaction diagram
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NADPH + cyanocob(III)alamin = NADP+ + cob(I)alamin + cyanide
show the reaction diagram
-
HSCoM + methylcobalamin = CH3-SCoM + cob(I)alamin + H+
show the reaction diagram
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cob(II)alamin = cob(I)alamin
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
substrate inhibition at more than 0.008 mM in presence of subsaturating concentrations of ATP (0.003 mM)
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (73 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (46 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for cob(I)alamin

ChEBI
PubChem
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PubChem