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New reactions in clavulanic acid biosynthesis
2002
Townsend, C.A.
Curr. Opin. Chem. Biol.
6
583-589
Purification and characterization of clavaminate synthase from Streptomyces clavuligerus: an unusual oxidative enzyme in natural product biosynthesis
1990
Salowe, S.P.; Marsh, E.N.; Townsend, C.A.
Biochemistry
29
6499-6508
Elucidation of the order of oxidations and identification of an intermediate in the multistep clavaminate synthase reaction
1991
Salowe, S.P.; Krol, W.J.; Iwata-Reuyl, D.; Townsend, C.A.
Biochemistry
30
2281-2292
-
Studies on the substrate specificity of clavaminic acid synthase and associated enzymes
1992
Elson, S.W.; Baggaley, K.H.; Holland, S.; Nicholson, N.H.; Sime, J.T.; Woroniecki, S.R.
Bioorg. Med. Chem. Lett.
2
1503-1508
Synthesis and reaction of potential alternate substrates and mechanism-based inhibitors of clavaminate synthase
1993
Iwata-Reuyl, D.; Basak, A.; Silverman, L.S.; Engle, C.A.; Townsend, C.A.
J. Nat. Prod.
56
1373-1396
Purification and characterization of clavaminate synthase from Streptomyces antibioticus. A multifunctional enzyme of clavam biosynthesis
1995
Janc, J.W.; Egan, L.A.; Townsend, C.A.
J. Biol. Chem.
270
5399-5404
Expression and purification of two isoenzymes of clavaminate synthase and initial characterization of the iron binding site. General error analysis in polymerase chain reaction amplification
1995
Busby, R.W.; Chang, M.D.T.; Busby, R.C.; Wimp, J.; Townsend, C.A.
J. Biol. Chem.
270
4262-4269
Functional analysis of the gene encoding the clavaminate synthase 2 isoenzyme involved in clavulanic acid biosynthesis in Streptomyces clavuligerus
1995
Paradkar, A.S.; Jensen, S.E.
J. Bacteriol.
177
1307-1314
A single monomeric iron center in clavaminate synthase catalyzes three nonsuccessive oxidative transformations
1996
Busby, R.W.; Townsend, C.A.
Bioorg. Med. Chem.
4
1059-1064
-
Chemo-enzymic synthesis of bicyclic gamma-lactams using clavaminic acid synthase
1997
Baldwin, J.E.; Adlington, R.M.; Bryans, J.S.; Lloyd, M.D.; Sewell, T.J.; Schofield, C.J.; Baggaley, K.H.; Cassels, R.
Tetrahedron
53
7011-7020
-
Substrate binding to the alpha-ketoglutarate-dependent non-heme iron enzyme clavaminate synthase 2: coupling mechanism of oxidative decarboxylation and hydroxylation
1998
Zhou, J.; Gunsior, M.; Bachmann, B.O.; Townsend, C.A.; Solomon, E.I.
J. Am. Chem. Soc.
120
13539-13540
-
Product-substrate engineering by bacteria: studies on clavaminate synthase, a trifunctional dioxygenase
1999
Lloyd, M.D.; Merritt, K.D.; Lee, V.; Sewell, T.J.; Wha-Son, B.; Baldwin, J.E.; Schofield, C.J.; Elson, S.W.; Baggaley, K.H.; Nicholson, N.H.
Tetrahedron
55
10201-10220
Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase
2000
Zhang, Z.; Ren, J.; Stammers, D.K.; Baldwin, J.E.; Harlos, K.; Schofield, C.J.
Nat. Struct. Biol.
7
127-133
Site-directed mutagenesis and biochemical analysis of the endogenous ligands in the ferrous active site of clavaminate synthase. The His-3 variant of the 2-His-1-carboxylate model
2000
Khaleeli, N.; Busby, R.W.; Townsend, C.A.
Biochemistry
39
8666-8673
Mutagenesis studies on the iron binding ligands of clavaminic acid synthase
2000
Doan, L.X.; Hassan, A.; Lipscomb, S.J.; Dhanda, A.; Zhang, Z.; Schofield, C.J.
Biochem. Biophys. Res. Commun.
279
240-244
Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional a-KG-dependent non-heme iron enzyme: correlation with mchanisms and reactivities
2001
Zhou, J.; Kelly, W.L.; Bachmann, B.O.; Gunsior, M.; Townsend, C.A.; Solomon, E.I.
J. Am. Chem. Soc.
123
7388-7398
Crystal structure of a clavaminate synthase-Fe(II)-2-oxoglutarate-substrate-NO complex: evidence for metal centred rearrangements
2002
Zhang, Z.; Ren, J.s.; Harlos, K.; McKinnon, C.H.; Clifton, I.J.; Schofield, C.J.
FEBS Lett.
517
7-12
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