Ligand 8-hydroxy-6-mercaptopurine
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Basic Ligand Information
Molecular Structure

C5H4N4OS
8-hydroxy-6-mercaptopurine
OIZCDCVIFRRJFF-UHFFFAOYSA-N
6-mercapto-7,9-dihydropurin-8-one
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (1 result)
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S-adenosyl-L-methionine + 8-hydroxy-6-mercaptopurine = S-adenosyl-L-homocysteine + 8-hydroxy-6-methylmercaptopurine
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Product in Enzyme-catalyzed Reactions (1 result)
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6-mercaptopurine + H2O + O2 = 6-mercapto-7,9-dihydropurin-8-one + H2O2
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Enzyme Kinetic Parameters
KM Value (1 result)
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References & Links
Literature References (2)
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Purine substrates for human thiopurine methyltransferase
1994
Deininger, M.; Szumlanski, C.L.; Otterness, D.M.; Van Loon, J.; Ferber, W.; Weinshilboum, R.M.
Biochem. Pharmacol.
48
2135-2138
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Purification and properties of xanthine oxidase from Enterobacter cloacae
1981
Machida, Y.; Nakanishi, T.
Agric. Biol. Chem.
45
425-432
Links to other databases for 8-hydroxy-6-mercaptopurine