Ligand 2'-deoxyguanosine

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Basic Ligand Information

Molecular Structure
Picture of 2'-deoxyguanosine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H13N5O4
2'-deoxyguanosine
YKBGVTZYEHREMT-KVQBGUIXSA-N
Synonyms:
2'-deoxy-guanosine, 2'deoxyguanosine, 9-(2'-deoxyribofuranosyl)guanine, deoxyguanosine


Show all pahtways known for Show all BRENDA pathways known for 2'-deoxyguanosine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2'-deoxyguanosine + 2 O2 + H2O = 2'-deoxy-9-riburonosylguanine + 2 H2O2
show the reaction diagram
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ATP + 2'-deoxyguanosine = ADP + 2'-deoxyguanosine 5'-phosphate
show the reaction diagram
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2'-deoxyguanosine + H2O = 2'-deoxyxanthosine + NH3
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5'-dGMP + H2O = deoxyguanosine + phosphate
show the reaction diagram
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dGTP + H2O = deoxyguanosine + triphosphate
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Substrate in Enzyme-catalyzed Reactions (69 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
deoxyguanosine + O2 = 9-riburonosyldeoxyguanine + H2O
show the reaction diagram
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2'-deoxyguanosine + 2 O2 + H2O = 2'-deoxy-9-riburonosylguanine + 2 H2O2
show the reaction diagram
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deoxyguanosine + phosphate = guanine + deoxyribose 1-phosphate
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ATP + deoxyguanosine = ADP + dGMP
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ATP + deoxyguanosine = ADP + dGMP
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2'-deoxyguanosine + H2O = guanine + 2-deoxy-D-ribose
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2'-deoxyguanosine + H2O = 2'-deoxyxanthosine + NH3
show the reaction diagram
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2'-deoxyguanosine + H2O = 2'-deoxyxanthosine + NH3
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (24 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5'-dGMP + thymidine = TMP + 2'-deoxyguanosine
show the reaction diagram
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dGMP + H2O = deoxyguanosine + phosphate
show the reaction diagram
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-
5'-dGMP + H2O = deoxyguanosine + phosphate
show the reaction diagram
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5'-dGMP + H2O = deoxyguanosine + phosphate
show the reaction diagram
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3'-dGMP + H2O = deoxyguanosine + phosphate
show the reaction diagram
dGTP + H2O = deoxyguanosine + triphosphate
show the reaction diagram
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dGTP + H2O = deoxyguanosine + triphosphate
show the reaction diagram
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N2-phenylacetyl-2'-deoxyguanosine + H2O = phenylacetic acid + 2'-deoxyguanosine
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2,6-diaminopurine-2'-deoxyriboside + H2O = 2'-deoxyguanosine + NH3
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5'-dGMP + H2O = deoxyguanosine + phosphate
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation, deoxycytidine as substrate, mitochondrial isozyme

Inhibitor in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
substrate deoxyadenosine
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competitive
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3D Structure of Enzyme-Ligand-Complex (PDB) (13 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (59 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.34
-
full-length enzyme, at pH 7.8 and 37°C
0.61
-
pH 7.6, 37°C, recombinant enzyme
0.611
-
at pH 8.0 and 40°C

KM Value (113 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.016
-
-
0.21
-
-
2.6
-
full-length enzyme, at pH 7.8 and 37°C

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

IC50 Value (3 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0015
-
pH 4.8

References & Links

Links to other databases for 2'-deoxyguanosine

ChEBI
PubChem
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PubChem