Ligand D-glucosamine 6-phosphate

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Basic Ligand Information

Molecular Structure
Picture of D-glucosamine 6-phosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H14NO8P
D-glucosamine 6-phosphate
XHMJOUIAFHJHBW-IVMDWMLBSA-N
Synonyms:
2-amino-2-deoxy-6-O-phosphono-D-glucopyranose, D-glucosaminate 6-phosphate[side 2], D-glucosamine phosphate, glucosamine 6-phosphate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate
show the reaction diagram
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D-glucosamine 6-phosphate = D-galactosamine 6-phosphate
show the reaction diagram
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D-glucosamine 6-phosphate = D-glucosamine 1-phosphate
show the reaction diagram
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D-glucosamine 6-phosphate = alpha-D-glucosamine 1-phosphate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate
show the reaction diagram
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[protein]-Npi-phospho-L-histidine + D-glucosaminate[side 1] = [protein]-L-histidine + D-glucosaminate 6-phosphate[side 2]
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-glucosamine 6-phosphate + oxidized coenzyme F420 = ?
show the reaction diagram
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acetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate
show the reaction diagram
-
glucosamine 6-phosphate + H2O = glucosamine + phosphate
show the reaction diagram
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D-glucosamine 6-phosphate + H2O = D-glucosamine + phosphate
show the reaction diagram
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D-glucosamine 6-phosphate + acetate = N-acetyl-D-glucosamine 6-phosphate + H2O
show the reaction diagram
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D-glucosamine 6-phosphate = D-galactosamine 6-phosphate
show the reaction diagram
-
D-glucosamine 6-phosphate = D-glucosamine 1-phosphate
show the reaction diagram
-
D-glucosamine 6-phosphate = alpha-D-glucosamine 1-phosphate
show the reaction diagram
-
glucosamine 6-phosphate = glucosamine 1-phosphate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (19 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate
show the reaction diagram
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ADP + D-glucosamine = AMP + D-glucosamine 6-phosphate
show the reaction diagram
-
-
[protein]-Npi-phospho-L-histidine + D-glucosaminate[side 1] = [protein]-L-histidine + D-glucosaminate 6-phosphate[side 2]
show the reaction diagram
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ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate
show the reaction diagram
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(phosphate)n + glucosamine = (phosphate)n-1 + D-glucosamine 6-phosphate
show the reaction diagram
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ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate
show the reaction diagram
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-
D-fructose 6-phosphate + NH3 = D-glucosamine 6-phosphate + H2O
show the reaction diagram
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glucosamine 1-phosphate = glucosamine 6-phosphate
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
allosteric, 0.003 mM, 5fold increase of activity, reversible by dialysis
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1.4 mM, 30C, pH7.5, relative activity 109% with glycogen synthase D as substrate, 117% with histone as substrate, and 102% with phosphorylase a as substrate compared to no addition
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Inhibitor in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
negative feedback-regulation at post-transcriptional level. The biological function of small RNA GlmZ is to positively control the enzyme's mRNA in response to D-glucosamine 6-phosphate concentrations. YhbJ, a gene of the rpoN operon, negatively regulates GlmZ
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0.004 M, 56% inhibition
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substrate inhibition
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competitive
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3D Structure of Enzyme-Ligand-Complex (PDB) (5 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (50 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
1.358
-
pH 8.0, 30C

KM Value (73 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.215
-
pH 8.0, 30C
3
-
-
25
-
-
0.05
-
-

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
4
-
22C, pH 8.0

References & Links

Links to other databases for D-glucosamine 6-phosphate

ChEBI
PubChem
ChEBI
PubChem