Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Solubilization and partial characterization of rat liver squalene epoxidase
1975
Ono, T.; Bloch, K.
J. Biol. Chem.
250
1571-1579
Squalene epoxidase and oxidosqualene lanosterol-cyclase activities in cholesterogenic and non-cholesterogenic tissues
1977
Astruc, M.; Tabacik, C.; Descomps, B.; Crastes de Paulet, A.
Biochim. Biophys. Acta
487
204-211
-
Squalene oxidase: the elusive flavoenzyme of sterol biosynthesis
1991
Jordan, D.B.
Flavins and Flavoproteins (Proc. Int. Symp. , 10th, Meeting Date 1990, Curti, B. , Ronchi S. , Zanetti, G. , eds. ) de Gruyter, Berlin, New York
-
865-868
Purification and partial characterization of squalene epoxidase from rat liver microsomes
1982
Ono, T.; Nakazono, K.; Kosaka, H.
Biochim. Biophys. Acta
709
84-90
Squalene epoxidase from rat liver microsomes
1985
Ono, T.; Imai, Y.
Methods Enzymol.
110
375-380
In vitro assay of squalene epoxidase of Saccharomyces cerevisiae
1987
M'Baya, B.; Karst, F.
Biochem. Biophys. Res. Commun.
147
556-564
Inhibition of squalene epoxidase by allylamine antimycotic compounds. A comparative study of the fungal and mammalian enzymes
1985
Ryder, N.S.; Dupont, M.C.
Biochem. J.
230
765-770
Properties of a particulate squalene epoxidase from Candida albicans
1984
Ryder, N.S.; Dupont, M.C.
Biochim. Biophys. Acta
794
466-471
Enzymic properties of squalene epoxidase from Saccharomyces cerevisiae
1993
Satoh, T.; Horie, M.; Watanabe, H.; Tsuchiya, Y.; Kamei, T.
Biol. Pharm. Bull.
16
349-352
Purification and characterization of recombinant squalene epoxidase
1995
Nagumo, A.; Kamei, T.; Sakakibara, J.; Ono, T.
J. Lipid Res.
36
1489-1497
Characterization of squalene epoxidase activity from the dermatophyte Trichophyton rubrum and its inhibition by terbinafine and other antimycotic agents
1996
Favre, B.; Ryder, N.S.
Antimicrob. Agents Chemother.
40
443-447
Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase
2000
Laden, B.P.; Tang, Y.; Porter, T.D.
Arch. Biochem. Biophys.
374
381-388
Green tea polyphenols: novel and potent inhibitors of squalene epoxidase
2000
Abe, I.; Seki, T.; Umehara, K.; Miyase, T.; Noguchi, H.; Sakakibara, J.; Ono, T.
Biochem. Biophys. Res. Commun.
268
767-771
Site-directed mutagenesis of squalene-hopene cyclase: altered substrate specificity and product distribution
2000
Dang, T.; Prestwich, G.D.
Chem. Biol.
7
643-649
Site-directed mutagenesis of putative active-site residues in squalene-hopene cyclase
1996
Feil, C.; Suessmuth, R.; Jung, G.; Poralla, K.
Eur. J. Biochem.
242
51-55
Bicyclic triterpenes as new main products of squalene-hopene cyclase by mutation at conserved tyrosine residues
2001
Full, C.
FEBS Lett.
509
361-364
-
Functional analysis of Phe605, a conserved aromatic amino acid in squalene-hopene cyclases
2000
Hoshino, T.; Kouda, M.; Abe, T.; Sato, T.
Chem. Commun. (Camb.)
2000
1485-1486
-
Squalene-hopene cyclase: catalytic mechanism and substrate recognition
2002
Hoshino, T.; Sato, T.
Chem. Commun. (Camb.)
2000
291-301
Purification and properties of the squalene-hopene cyclase from Rhodopseudomonas palustris, a purple non-sulfur bacterium producing hopanoids and tetrahymanol
1994
Kleemann, G.; Kellner, R.; Poralla, K.
Biochim. Biophys. Acta
1210
317-320
Thiol-modifying inhibitors for understanding squalene cyclase function
2002
Milla, P.; Lenhart, A.; Grosa, G.; Viola, F.; Weihofen, W.A.; Schulz, G.E.; Balliano, G.
Eur. J. Biochem.
269
2108-2116
Properties of purified squalene-hopene cyclase from Bacillus acidocaldarius
1990
Ochs, D.; Tappe, C.H.; Gaertner, P.; Kellner, R.; Poralla, K.
Eur. J. Biochem.
194
75-80
Functional analysis of the DXDDTA motif in squalene-hopene cyclase by site-directed mutagenesis experiments: initiation site of the polycyclization reaction and stabilization site of the carbocation intermediate of the initially cyclized A-ring
1999
Sato, T.; Hoshino, T.
Biosci. Biotechnol. Biochem.
63
2189-2198
Kinetic studies on the function of all the conserved tryptophans involved inside and outside the QW motifs of squalene-hopene cyclase: stabilizing effect of the protein structure against thermal denaturation
1999
Sato, T.; Hoshino, T.
Biosci. Biotechnol. Biochem.
63
1171-1180
Functional analyses of Tyr420 and Leu607 of Alicyclobacillus acidocaldarius squalene-hopene cyclase. Neoachillapentaene, a novel triterpene with the 1,5,6-trimethylcyclohexene moiety produced through folding of the constrained boat structure
2002
Sato, T.; Sasahara, S.; Yamakami, T.; Hoshino, T.
Biosci. Biotechnol. Biochem.
66
1660-1670
-
Characterization and partial purification of squalene-hopene cyclase from Bacillus acidocaldarius
1986
Seckler, B.; Poralla, K.
Biochim. Biophys. Acta
881
356-363
Squalene synthetase. Solubilization and partial purification of squalene synthetase, copurification of presqualene pyrophosphate and squalene synthetase activities
1987
Kuswik-Rabiega, G.; Rilling, H.C.
J. Biol. Chem.
262
1505-1509
Squalene synthetase
1985
Agnew, W.S.
Methods Enzymol.
110
359-373
Formation of 12-cis-dehydrosqualene catalyzed by squalene synthetase
1985
Nishino, T.; Katsuki, H.
Methods Enzymol.
110
373-375
Squalene synthetase. I. Dissociation and reassociation of enzyme complex
1972
Qureshi, A.A.; Beytia, E.D.; Porter, J.W.
Biochem. Biophys. Res. Commun.
48
1123-1128
Purification to homogeneity and some properties of squalene synthetase
1988
Sasiak, K.; Rilling, H.C.
Arch. Biochem. Biophys.
260
622-627
-
Investigations of substrate specificity of squalene synthase
1977
Washburn, W.N.; Kow, R.
Tetrahedron Lett.
18
1555-1558
-
Squalene synthetase. Inhibition by ammonium analogues of carbocationic intermediates in the conversion of presqualene diphosphate to squalene
1989
Poulter, C.D.; Capson, T.L.; Thompson, M.D.; Bard, R.S.
J. Am. Chem. Soc.
111
3734-3739
Substrate selectivity of squalene synthetase
1977
Ortiz de Montellano, P.R.; Wei, J.S.; Vinson, W.A.; Castillo, R.; Boparai, A.S.
Biochemistry
16
2680-2685
Molecular cloning, expression, and characterization of the cDNA for the rat hepatic squalene synthase
1992
McKenzie, T.L.; Jiang, G.; Straubhaar, J.R.; Conrad, D.G.; Shechter, I.
J. Biol. Chem.
267
21368-21374
Solubilization and partial purification of squalene synthase from daffodil microsomal membranes
1991
Belingheri, L.; Beyer, P.; Kleinig, H.; Gleizes, M.
FEBS Lett.
292
34-36
Formation of dehydrosqualene catalyzed by squalene synthetase in Saccharomyces cerevisiae
1982
Takatsuji, H.; Nishino, T.; Izui, K.; Katsuki, H.
J. Biochem.
91
911-921
Yeast squalene synthase: expression, purification, and characterization of soluble recombinant enzyme [published erratum appears in Arch Biochem Biophys 1993 Sep;305(2):622]
1993
Zhang, D.; Jennnings, S.M.; Robinson, G.W.; Poulter, C.D.
Arch. Biochem. Biophys.
304
133-143
Overexpression, purification, and kinetic characterization of a carboxyl-terminal-truncated yeast squalene synthetase
1993
LoGrasso, P.V.; Soltis, D.A.; Boettcher, B.R.
Arch. Biochem. Biophys.
307
193-199
Isoprenoid biosynthesis in rat liver peroxisomes. Characterization of cis-prenyltransferase and squalene synthetase
1992
Ericsson, J.; Appelkvist, E.L.; Thelin, A.; Chojnacki, T.; Dallner, G.
J. Biol. Chem.
267
18708-18714
Solubilization, partial purification, and immunodetection of squalene synthetase from tobacco cell suspension cultures
1992
Hanley, K.; Chappell, J.
Plant Physiol.
98
215-220
Solubilization, purification, and characterization of a truncated form of rat hepatic squalene synthetase
1992
Shechter, I.; Klinger, E.; Rucker, M.L.; Engstrom, R.G.; Spirito, J.A.; Islam, M.A.; Boettcher, B.R.; Weinstein, D.B.
J. Biol. Chem.
267
8628-8635
Solubilization and purification of trans-farnesyl pyrophosphate-squalene synthetase
1971
Shechter, I.; Bloch, K.
J. Biol. Chem.
246
7690-7696
Squalene synthetase. Stoichiometry and kinetics of presqualene pyrophosphate and squalene synthesis by yeast microsomes
1978
Agnew, W.S.; Popjak, G.
J. Biol. Chem.
253
4566-4573
Squalene synthetase. Solubilization from yeast microsomes of a phospholipid-requiring enzyme
1978
Agnew, W.S.; Popjak, G.
J. Biol. Chem.
253
4574-4583
-
Selective inhibition activity on 15-lipoxygenase of squalene isolated from Prunus persica (L.) Batsch
1992
Lin, B.B.; Lin, Y.S.
Chem. Express
7
297-300
Photoaffinity labeling identifies the substrate-binding site of mammalian squalene epoxidase
2004
Lee, H.K.; Zheng, Y.F.; Xiao, X.Y.; Bai, M.; Sakakibara, J.; Ono, T.; Prestwich, G.D.
Biochem. Biophys. Res. Commun.
315
1-9
Squalene epoxidase encoded by ERG1 affects morphogenesis and drug susceptibilities of Candida albicans
2005
Pasrija, R.; Krishnamurthy, S.; Prasad, T.; Ernst, J.F.; Prasad, R.
J. Antimicrob. Chemother.
55
905-913
Cytochrome P450 17alpha hydroxylase/17,20 lyase (CYP17) function in cholesterol biosynthesis: identification of squalene monooxygenase (epoxidase) activity associated with CYP17 in Leydig cells
2005
Liu, Y.; Yao, Z.X.; Papadopoulos, V.
Mol. Endocrinol.
19
1918-1931
Novel 3-phenylprop-2-ynylamines as inhibitors of mammalian squalene epoxidase
2003
Musso, D.L.; Clarke, M.J.; Kelley, J.L.; Boswell, G.E.; Chen, G.
Org. Biomol. Chem.
1
498-506
Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from Alicyclobacillus acidocaldarius
2004
Sato, T.; Kouda, M.; Hoshino, T.
Biosci. Biotechnol. Biochem.
68
728-738
Access of the substrate to the active site of yeast oxidosqualene cyclase: an inhibition and site-directed mutagenesis approach
2005
Oliaro-Bosso, S.; Schulz-Gasch, T.; Balliano, G.; Viola, F.
ChemBioChem
6
2221-2228
Umbelliferone aminoalkyl derivatives, a new class of squalene-hopene cyclase inhibitors
2004
Cravotto, G.; Balliano, G.; Tagliapietra, S.; Palmisano, G.; Penoni, A.
Eur. J. Med. Chem.
39
917-924
Conjugated methyl sulfide and phenyl sulfide derivatives of oxidosqualene as inhibitors of oxidosqualene and squalene-hopene cyclases
2003
Rocco, F.; Bosso, S.O.; Viola, F.; Milla, P.; Roma, G.; Grossi, G.; Ceruti, M.
Lipids
38
201-207
Synthesis and biological activity of new iodoacetamide derivatives on mutants of squalene-hopene cyclase
2005
Ceruti, M.; Balliano, G.; Rocco, F.; Lenhart, A.; Schulz, G.E.; Castelli, F.; Milla, P.
Lipids
40
729-735
Characterization of squalene epoxidase of Saccharomyces cerevisiae by applying terbinafine-sensitive variants
2007
Ruckenstuhl, C.; Lang, S.; Poschenel, A.; Eidenberger, A.; Baral, P.K.; Kohut, P.; Hapala, I.; Gruber, K.; Turnowsky, F.
Antimicrob. Agents Chemother.
51
275-284
Sterol biosynthesis by a prokaryote: first in vitro identification of the genes encoding squalene epoxidase and lanosterol synthase from Methylococcus capsulatus
2007
Nakano, C.; Motegi, A.; Sato, T.; Onodera, M.; Hoshino, T.
Biosci. Biotechnol. Biochem.
71
2543-2550
Cation-pi interaction in the polyolefin cyclization cascade uncovered by incorporating unnatural amino acids into the catalytic sites of squalene cyclase
2006
Morikubo, N.; Fukuda, Y.; Ohtake, K.; Shinya, N.; Kiga, D.; Sakamoto, K.; Asanuma, M.; Hirota, H.; Yokoyama, S.; Hoshino, T.
J. Am. Chem. Soc.
128
13184-13194
Structure-function correlations of two highly conserved motifs in Saccharomyces cerevisiae squalene epoxidase
2008
Ruckenstuhl, C.; Poschenel, A.; Possert, R.; Baral, P.K.; Gruber, K.; Turnowsky, F.
Antimicrob. Agents Chemother.
52
1496-1499
Hepatic cytochrome P450 reductase-null mice reveal a second microsomal reductase for squalene monooxygenase
2007
Li, L.; Porter, T.D.
Arch. Biochem. Biophys.
461
76-84
Site-directed mutagenesis of conserved aromatic residues in rat squalene epoxidase
2007
Abe, I.; Abe, T.; Lou, W.; Masuoka, T.; Noguchi, H.
Biochem. Biophys. Res. Commun.
352
259-263
A squalene epoxidase is involved in biosynthesis of both the antitumor compound clavaric acid and sterols in the basidiomycete H. sublateritium
2007
Godio, R.P.; Fouces, R.; Martin, J.F.
Chem. Biol.
14
1334-1346
Molecular cloning and characterization of the gene encoding squalene epoxidase in Panax notoginseng
2008
He, F.; Zhu, Y.; He, M.; Zhang, Y.
DNA Seq.
19
270-273
Molecular characterization of a Squalene epoxidase gene in dermatophyte pathogen Trichophyton tonsurans
2008
Motavaze, K.; Namvar, Z.; Emami, M.; Noorbakhsh, F.; Rezaie, S.
Iran. Biomed. J.
12
55-58
Arabidopsis thaliana squalene epoxidase 1 is essential for root and seed development
2007
Rasbery, J.M.; Shan, H.; LeClair, R.J.; Norman, M.; Matsuda, S.P.; Bartel, B.
J. Biol. Chem.
282
17002-17013
Computational study of the mechanism and the relative free energies of binding of anticholesteremic inhibitors to squalene-hopene cyclase
2008
Schwab, F.; van Gunsteren, W.F.; Zagrovic, B.
Biochemistry
47
2945-2951
Reviewing the polyolefin cyclization reaction of the C(35) polyprene catalyzed by squalene-hopene cyclase
2009
Hoshino, T.; Kumai, Y.; Sato, T.
Chemistry
15
2091-2100
GRIND-based 3D-QSAR to predict inhibitory activity for similar enzymes, OSC and SHC
2008
Ermondi, G.; Caron, G.
Eur. J. Med. Chem.
43
1462-1468
Pharmacologic inhibition of squalene synthase and other downstream enzymes of the cholesterol synthesis pathway: a new therapeutic approach to treatment of hypercholesterolemia
2009
Seiki, S.; Frishman, W.H.
Cardiol. Rev.
17
70-76
Squalene-hopene cyclase (Spterp25) from Streptomyces peucetius: Sequence analysis, expression and functional characterization
2009
Ghimire, G.; Oh, T.; Lee, H.; Sohng, J.
Biotechnol. Lett.
31
565-569
Diversity of hopanoids and squalene-hopene cyclases across a tropical land-sea gradient
2009
Pearson, A.; Leavitt, W.; Saenz, J.; Summons, R.; Tam, M.; Close, H.
Environ. Microbiol.
11
1208-1223
Cyclization cascade of the C33-bisnorheptaprenoid catalyzed by recombinant squalene cyclase
2009
Cheng, J.; Hoshino, T.
Org. Biomol. Chem.
7
1689-1699
Dammaradiene synthase, a squalene cyclase, from Dryopteris crassirhizoma Nakai
2008
Shinozaki, J.; Shibuya, M.; Masuda, K.; Ebizuka, Y.
Phytochemistry
69
2559-2564
Purification and some properties of the squalene-tetrahymanol cyclase from Tetrahymena thermophila
1991
Saar, J.; Kader, J.; Poralla, K.; Ourisson, G.
Biochim. Biophys. Acta
1075
93-101
-
Detection of 1,2-hydride shifts in the formation of euph-7-ene by the squalene-tetrahymanol cyclase of Tetrahymena pyriformis
2005
Giner, J.; Rocchetti, S.; Neunlist, S.; Rohmer, M.; Arigoni, D.
Chem. Commun. (Camb. )
2005
3089-3091
Functional identification of triterpene methyltransferases from Botryococcus braunii race B
2012
Niehaus, T.D.; Kinison, S.; Okada, S.; Yeo, Y.S.; Bell, S.A.; Cui, P.; Devarenne, T.P.; Chappell, J.
J. Biol. Chem.
287
8163-8173
Gene regulation patterns in triterpene biosynthetic pathway driven by overexpression of squalene synthase and methyl jasmonate elicitation in Bupleurum falcatum
2011
Kim, Y.S.; Cho, J.H.; Park, S.; Han, J.Y.; Back, K.; Choi, Y.E.
Planta
233
343-355
Squalene-hopene cyclases
2011
Siedenburg, G.; Jendrossek, D.
Appl. Environ. Microbiol.
77
3905-3915
Prokaryotic squalene-hopene cyclases can be converted to citronellal cyclases by single amino acid exchange
2013
Siedenburg, G.; Breuer, M.; Jendrossek, D.
Appl. Microbiol. Biotechnol.
97
1571-1580
Synthesis of heterocyclic terpenoids by promiscuous squalene-hopene cyclases
2013
Seitz, M.; Syren, P.; Steiner, L.; Klebensberger, J.; Nestl, B.; Hauer, B.
ChemBioChem
14
436-439
Squalene hopene cyclases: highly promiscuous and evolvable catalysts for stereoselective CC and CX bond formation
2013
Hammer, S.C.; Syren, P.O.; Seitz, M.; Nestl, B.M.; Hauer, B.
Curr. Opin. Chem. Biol.
17
293-300
-
Substrate specificity of a novel squalene-hopene cyclase from Zymomonas mobilis
2012
Seitz, M.; Klebensberger, J.; Siebenhaller, S.; Breuer, M.; Siedenburg, G.; Jendrossek, D.; Hauer, B.
J. Mol. Catal. B
84
72-77
Chemo-enzymatic syntheses of drimane-type sesquiterpenes and the fundamental core of hongoquercin meroterpenoid by recombinant squalene-hopene cyclase
2012
Yonemura, Y.; Ohyama, T.; Hoshino, T.
Org. Biomol. Chem.
10
440-446
-
Stereoselective Friedel-Crafts alkylation catalyzed by squalene hopene cyclases
2012
Hammer, S.; Dominicus, J.; Syrén, P.; Nestl, B.; Hauer, B.
Tetrahedron
68
7624-7629
Lateral transfer of tetrahymanol-synthesizing genes has allowed multiple diverse eukaryote lineages to independently adapt to environments without oxygen
2012
Takishita, K.; Chikaraishi, Y.; Leger, M.M.; Kim, E.; Yabuki, A.; Ohkouchi, N.; Roger, A.J.
Biol. Direct
7
0000
Cyclization of squalene from both termini: identification of an onoceroid synthase and enzymatic synthesis of ambrein
2013
Ueda, D.; Hoshino, T.; Sato, T.
J. Am. Chem. Soc.
135
18335-18338
Squalene mono-oxygenase, a key enzyme in cholesterol synthesis, is stabilized by unsaturated fatty acids
2014
Stevenson, J.; Luu, W.; Kristiana, I.; Brown, A.J.
Biochem. J.
461
435-442
The regulatory domain of squalene monooxygenase contains a re-entrant loop and senses cholesterol via a conformational change
2015
Howe, V.; Chua, N.K.; Stevenson, J.; Brown, A.J.
J. Biol. Chem.
290
27533-27544
Production of squalene by lactose-fermenting yeast Kluyveromyces lactis with reduced squalene epoxidase activity
2015
Drozdikova, E.; Garaiova, M.; Csaky, Z.; Obernauerova, M.; Hapala, I.
Lett. Appl. Microbiol.
61
77-84
Arabidopsis squalene epoxidase 3 (SQE3) complements SQE1 and is important for embryo development and bulk squalene epoxidase activity
2015
Laranjeira, S.; Amorim-Silva, V.; Esteban, A.; Arro, M.; Ferrer, A.; Tavares, R.M.; Botella, M.A.; Rosado, A.; Azevedo, H.
Mol. Plant
8
1090-1102
Squalene epoxidase as hypocholesterolemic drug target revisited
2003
Chugh, A.; Ray, A.; Gupta, J.B.
Prog. Lipid Res.
42
37-50
Rubber oxygenase and latex clearing protein cleave rubber to different products and use different cleavage mechanisms
2014
Birke, J.; Jendrossek, D.
Appl. Environ. Microbiol.
80
5012-5020
Molecular cloning and promoter analysis of squalene synthase and squalene epoxidase genes from Betula platyphylla
2016
Zhang, M.; Wang, S.; Yin, J.; Li, C.; Zhan, Y.; Xiao, J.; Liang, T.; Li, X.
Protoplasma
253
1347-1363
Biosynthesis of squalene from farnesyl diphosphate in Bacteria Three steps catalyzed by three enzymes
2015
Pan, J.; Solbiati, J.; Ramamoorthy, G.; Hillerich, B.; Seidel, R.; Cronan, J.; Almo, S.; Poulter, C.
ACS Cent. Sci.
1
77-82
-
Biocatalytic process for (-)-ambrox production using squalene hopene cyclase
2018
Eichhorn, E.; Locher, E.; Guillemer, S.; Wahler, D.; Fourage, L.; Schilling, B.
Adv. Synth. Catal.
360
2339-2351
Heterologous biosynthesis of triterpenoid ambrein in engineered Escherichia coli
2018
Ke, D.; Caiyin, Q.; Zhao, F.; Liu, T.; Lu, W.
Biotechnol. Lett.
40
399-404
On the reversibility of parasitism adaptation to a free-living lifestyle via gene acquisitions in the diplomonad Trepomonas sp. PC1
2016
Xu, F.; Jerlstroem-Hultqvist, J.; Kolisko, M.; Simpson, A.; Roger, A.; Svaerd, S.; Andersson, J.
BMC Biol.
14
62
Analysis of the catalytic mechanism of bifunctional triterpene/sesquarterpene cyclase Tyr167 functions to terminate cyclization of squalene at the bicyclic step
2017
Tenkovskaia, L.; Murakami, M.; Okuno, K.; Ueda, D.; Sato, T.
ChemBioChem
18
1910-1913
Enzymatic addition of alcohols to terpenes by squalene hopene cyclase variants
2017
Kuehnel, L.C.; Nestl, B.M.; Hauer, B.
ChemBioChem
18
2222-2225
Alicyclobacillus acidocaldarius squalene-hopene cyclase the critical role of steric bulk at Ala306 and the first enzymatic synthesis of epoxydammarane from 2,3-oxidosqualene
2018
Ideno, N.; Umeyama, S.; Watanabe, T.; Nakajima, M.; Sato, T.; Hoshino, T.
ChemBioChem
19
1873-1886
-
Selectivity in the cyclization of citronellal introduced by squalene hopene cyclase variants
2017
Bastian, S.; Hammer, S.; KreÃ, N.; Nestl, B.; Hauer, B.
ChemCatChem
9
4364-4368
Squalene-hopene cyclase mechanistic insights into the polycyclization cascades of squalene analogs bearing ethyl and hydroxymethyl groups at the C-2 and C-23 positions
2018
Kaneko, I.; Terasawa, Y.; Hoshino, T.
Chemistry
24
11139-11157
Activity of squalene-hopene cyclases in bicontinuous microemulsions
2015
Steudle, A.K.; Nestl, B.M.; Hauer, B.; Stubenrauch, C.
Colloids Surf. B Biointerfaces
135
735-741
Squalene-hopene cyclases-evolution, dynamics and catalytic scope
2016
Syren, P.O.; Henche, S.; Eichler, A.; Nestl, B.M.; Hauer, B.
Curr. Opin. Struct. Biol.
41
73-82
-
Squalene-hopene cyclase on the polycyclization reactions of squalene analogues bearing ethyl groups at positions C-6, C-10, C-15, and C-19
2018
Takahashi, K.; Sasaki, Y.; Hoshino, T.
Eur. J. Org. Chem.
2018
1477-1490
Cyclization of squalene from both termini Identification of an onoceroid synthase and enzymatic synthesis of ambrein
2013
Ueda, D.; Hoshino, T.; Sato, T.
J. Am. Chem. Soc.
135
18335-18338
Whole-cell (+)-ambrein production in the yeast Pichia pastoris
2018
Moser, S.; Strohmeier, G.A.; Leitner, E.; Plocek, T.J.; Vanhessche, K.; Pichler, H.
Metab. Eng. Commun.
7
e00077
Squalene hopene cyclases are protonases for stereoselective Bronsted acid catalysis
2015
Hammer, S.C.; Marjanovic, A.; Dominicus, J.M.; Nestl, B.M.; Hauer, B.
Nat. Chem. Biol.
11
121-126
Further insight into polycyclization cascades of acyclic geranylfarnesol and its acetate by squalene-hopene cyclase from Alicyclobacillus acidocaldarius
2016
Cheng, J.; Nakano, C.; Shi, G.L.; Hoshino, T.
Nat. Prod. Commun.
11
163-167
A distinct pathway for tetrahymanol synthesis in bacteria
2015
Banta, A.B.; Wei, J.H.; Welander, P.V.
Proc. Natl. Acad. Sci. USA
112
13478-13483