Ligand 11beta,21dihydroxy-pregnan-3,11,20-trione
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Basic Ligand Information
Molecular Structure

C21H30O5
11beta,21dihydroxy-pregnan-3,11,20-trione
AMOBBQQIUGNCNP-YJELPYPSSA-N
17beta,21dihydroxy-pregnan-3,11,20-trione
Roles as Enzyme Ligand
In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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cortisone + NADPH + H+ = 11beta,21dihydroxy-pregnan-3,11,20-trione + NADP+
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Product in Enzyme-catalyzed Reactions (2 results)
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cortisone + NADPH + H+ = 11beta,21dihydroxy-pregnan-3,11,20-trione + NADP+
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cortisone + NADPH = 11beta,21dihydroxy-pregnan-3,11,20-trione + NADP+
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Enzyme Kinetic Parameters
References & Links
Literature References (3)
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Identification of cortisone 5beta-reductase as DELTA4-3-ketosteroid 5beta-reductase
1987
Furuebisu, M.; Deguchi, S.; Okuda, K.
Biochim. Biophys. Acta
912
110-114
The DELTA4-hydrogenases of guinea pig adrenal gland
1960
Brown-Grant, K.; Forchielli, E.; Dorfman, R.I.
J. Biol. Chem.
235
1317-1320
The enzymatic reduction of DELTA4-3-ketosteroids
1957
Tomkins, G.M.
J. Biol. Chem.
225
13-24
Links to other databases for 11beta,21dihydroxy-pregnan-3,11,20-trione