Ligand D-mannitol

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Basic Ligand Information

Molecular Structure
Picture of D-mannitol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H14O6
D-mannitol
FBPFZTCFMRRESA-KVTDHHQDSA-N
Synonyms:
D-mannitol[side 1], mannitol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-mannitol + NAD+ = D-mannose + NADH + H+
show the reaction diagram
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D-mannitol + ferricytochrome c = D-fructose + ferrocytochrome c
show the reaction diagram
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D-mannitol + O2 = ?
show the reaction diagram
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D-mannitol + O2 = mannose + H2O2
show the reaction diagram
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D-mannitol + O2 = ?
show the reaction diagram

In Vivo Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-fructose + NADPH = D-mannitol + NADP+
show the reaction diagram
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D-fructose + NADH + H+ = D-mannitol + NAD+
show the reaction diagram
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[protein]-L-histidine + D-mannitol 1-phosphate[side 2] = [protein]-Npi-phospho-L-histidine + D-mannitol[side 1]
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (56 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
mannitol + NAD+ = ? + NADH + H+
show the reaction diagram
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D-mannitol + NAD+ = D-fructose + NADH + H+
show the reaction diagram
-
D-mannitol + NAD+ = D-mannose + NADH + H+
show the reaction diagram
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D-mannitol + NAD+ = ? + NADH + H+
show the reaction diagram
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D-mannitol + NAD+ = D-mannose + NADH + H+
show the reaction diagram
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D-mannitol + NAD+ = ? + NADH + H+
show the reaction diagram
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D-mannitol + NAD+ = ?
show the reaction diagram
-
D-mannitol + NAD+ = ? + NADH
show the reaction diagram
-
mannitol + NADP+ = D-mannose + NADPH
show the reaction diagram
-
mannitol + NADP+ = ?
show the reaction diagram
-
D-mannitol + ferricytochrome c = D-fructose + ferrocytochrome c
show the reaction diagram
-
D-mannitol + O2 = ?
show the reaction diagram
-
D-mannitol + O2 = mannose + H2O2
show the reaction diagram
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mannitol + phenazine methosulfate = ?
show the reaction diagram
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D-mannitol + pyrroloquinoline quinone = ?
show the reaction diagram
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D-mannitol + acceptor = D-fructose + reduced acceptor
show the reaction diagram
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phosphohistidinoprotein + D-mannitol = histidine-containing protein + D-mannitol phosphate
show the reaction diagram
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D-mannitol + acetyl phosphate = ?
show the reaction diagram
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mannitol + phenyl alpha-D-galactoside = ?
show the reaction diagram
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2-nitrophenyl beta-D-galactopyranoside + D-mannitol = beta-D-galactopyranosyl-(1-1)-D-mannitol + 2-nitrophenol
show the reaction diagram
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di-N-acetylchitobiose + mannitol = ?
show the reaction diagram
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mannitol + H2O = ?
show the reaction diagram
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Galbeta(1-3)GalNAcalpha(1-)p-nitrophenyl + mannitol = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (25 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-fructose + NADH + H+ = D-mannitol + NAD+
show the reaction diagram
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D-mannose + NAD(P)H = mannitol + NAD(P)+
show the reaction diagram
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[protein]-L-histidine + D-mannitol 1-phosphate[side 2] = [protein]-Npi-phospho-L-histidine + D-mannitol[side 1]
show the reaction diagram
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D-mannitol 6-phosphate + H2O = D-mannitol + phosphate
show the reaction diagram
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mannitol 1-phosphate + H2O = mannitol + phosphate
show the reaction diagram
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mannitol-1-phosphate + H2O = D-mannitol + phosphate
show the reaction diagram
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mannobiosylmannitol + H2O = mannobiose + mannitol
show the reaction diagram
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1-O-alpha-D-glucopyranosyl-D-mannitol + H2O = alpha-D-glucose + D-mannitol
show the reaction diagram
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Manbeta(1-4)Manbeta(1-4)Manbeta(1-4)Manbeta(1-4)Man-ol + H2O = D-mannitol + Manbeta(1-4)Man-ol + D-mannose + Manbeta(1-4)Manbeta(1-4)Man-ol + Manbeta(1-4)Manbeta(1-4)Manbeta(1-4)Man-ol + Manbeta(1-4)Man + Manbeta(1-4)Manbeta(1-4)Manbeta(1-4)Manbeta(1-4)Man-ol + Manbeta(1-4)Manbeta(1-4)Man
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
osmotic activation of nasal tissue with mannitol activates 15-LO-1 leading to increased amounts of 15(S)-hydroxyeicosatetranoic acid in nasal lavage, and the levels of 15(S)-hydroxyeicosatetranoic acid are associated with nasal symptoms
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favores CGTase synthesis
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induces production of the protein
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induces reduction in height and dry weight in seedlings due to increased enzyme activity in the initial growth stages followed by a decrease in subsequent days
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drought treatment
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enhances activity to 105%
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300 mM, induces expression of the enzyme
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Inhibitor in Enzyme-catalyzed Reactions (23 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
significant decrease in rate of oxidation of dibromoacetonitrile by the hypoxanthine/xanthine oxidase/Fe system
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only with O2 as electron acceptor
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strong substrate inhibition at pH 7.0
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inhibition of 50% or more
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competitive
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competitive
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competitive
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weak inhibitor
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competitive
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50 mM, slight inhibition
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4 mM
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3D Structure of Enzyme-Ligand-Complex (PDB) (44 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (29 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
9.2
-
pH 7.5, 30°C
38
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pH 7.5, 70°C, wild-type enzyme

KM Value (88 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
7.3
-
pH 10.0, 25°C
36
-
pH 7.5, 30°C
0.00009
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pH 7.5, 70°C, wild-type enzyme
67
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pH 7.5, 25°C

Ki Value (5 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
9
-
at pH 5.5 and 55°C

References & Links

Links to other databases for D-mannitol

ChEBI
PubChem
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PubChem