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Ligand phosphatidic acid

Basic Ligand Information

Molecular Structure

Pathway Source

Pathways

BRENDA

CDP-diacylglycerol biosynthesis, glycine betaine biosynthesis

KEGG

Biosynthesis of secondary metabolites, cAMP signaling pathway, Choline metabolism in cancer, Fat digestion and absorption, Fc gamma R-mediated phagocytosis, Glycerolipid metabolism, Glycerophospholipid metabolism, GnRH signaling pathway, Pancreatic cancer, Pathways in cancer, Phosphatidylinositol signaling system, Phospholipase D signaling pathway more

MetaCyc

anandamide biosynthesis I, CDP-diacylglycerol biosynthesis I, CDP-diacylglycerol biosynthesis II, CDP-diacylglycerol biosynthesis III, choline biosynthesis III, diacylglycerol and triacylglycerol biosynthesis, palmitoyl ethanolamide biosynthesis, phosphatidate metabolism, as a signaling molecule, phospholipases, type I lipoteichoic acid biosynthesis (S. aureus) more

Show all BRENDA pathways known for phosphatidic acid

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (14 results)

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Show Natural Substrate (14 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.7.41

CTP + phosphatidate = diphosphate + CDP-diacylglycerol

761129, 738826, 761504, 739305, 738000, 741020, 739033, 739396, 762084, 760639, 761476, 762488, 659064, 662589, 661820, 737701

-

2.7.7.41

CTP + phosphatidate = diphosphate + CDPdiacylglycerol

643302, 643321, 643319, 643320, 643316, 643328, 643323, 643297, 643300, 643314

-

2.7.7.41

dCTP + phosphatidate = diphosphate + dCDPdiacylglycerol

643319

-

3.1.1.32

phosphatidic acid + H2O = 2-acyl-lysophosphatidic acid + a carboxylate

730037, 652226, 652486, 652297

-

3.1.1.32

phosphatidic acid + H2O = 2-acylglycerophosphatidic acid + a carboxylate

650008

-

2.7.7.41

3 entries

3.1.1.32

2 entries

3.1.1.4

1,2-diacyl-sn-glycero-3-phosphatide + H2O = ?

133925, 133907

-

3.1.3.4

a 3-sn-phosphatidate + H2O = a 1,2-diacyl-sn-glycerol + phosphate

691109, 691384, 694357, 693521, 693238, 693251, 693153, 691685, 691076, 694740

-

3.1.3.4

phosphatidate + H2O = 1,2-diacyl-sn-glycerol + phosphate

752338, 134878

-

3.1.3.4

phosphatidate + H2O = diacyl-sn-glycerol + phosphate

678372, 680628

-

3.1.3.4

phosphatidic acid + H2O = 1,2-diacyl-sn-glycerol + phosphate

666452, 680849, 716166, 751277, 716574, 751842

-

3.1.3.4

phosphatidic acid + H2O = 1,2-diacylglycerol + phosphate

665748, 681768, 680723, 682952

-

3.1.3.4

phosphatidic acid + H2O = 1,2-sn-diacylglycerol + phosphate

680823

-

3.1.3.4

phosphatidic acid + H2O = diacylglycerol + phosphate

665748

-

3.1.3.4

7 entries

3.1.4.3

1,2-diacyl-sn-glycero-3-phosphatide + H2O = 1,2-diacylglycerol + phosphate

135298

-

In Vivo Product in Enzyme-catalyzed Reactions (25 results)

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Show Natural Product (25 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.51

acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate

0, 487198, 487179, 487180, 486338, 486486, 486341, 487184

-

2.3.1.51

acyl-[acyl-carrier protein] + 1-acyl-sn-glycerol 3-phosphate = ACP + 1,2-diacyl-sn-glycerol 3-phosphate

486339

-

2.3.1.51

acyl-[acyl-carrier protein] + 1-acyl-sn-glycerol 3-phosphate = acyl-carrier protein + 1,2-diacyl-sn-glycerol 3-phosphate

0

-

2.3.1.51

3 entries

2.3.1.52

acyl-CoA + 2-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate

0

-

2.7.1.107

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate

0

-

2.7.1.107

ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate

0

-

2.7.1.107

2 entries

2.7.1.174

CTP + 1,2-diacyl-sn-glycerol = CDP + 1,2-diacyl-sn-glycerol 3-phosphate

0

-

2.7.1.94

ATP + diacylglycerol = ADP + phosphatidic acid

0

-

2.7.7.41

diphosphate + CDP-diacylglycerol = CTP + phosphatidate

0

-

3.1.3.4

diacylglycerol diphosphate + H2O = phosphatidate + phosphate

0

-

3.1.4.4

phosphatidylcholine + H2O = 1,2-diacylglycerophosphate + choline

0

-

3.1.4.4

phosphatidylethanolamine + H2O = 1,2-diacylglycerophosphate + ethanolamine

0

-

3.1.4.4

phosphatidylcholine + H2O = choline + phosphatidate

0

-

3.1.4.4

phosphatidylcholine + H2O = choline + phosphatidic acid

0

-

3.1.4.4

phosphatidylethanolamine + H2O = ethanolamine + phosphatidic acid

0

-

3.1.4.4

phosphatidylglycerol + H2O = glycerol + phosphatidic acid

0

-

3.1.4.4

phosphatidylserine + H2O = serine + phosphatidic acid

0

-

3.1.4.4

phospholipid + H2O = phosphatidic acid + alcohol

0

-

3.1.4.50

membrane form of variant-surface-glycoprotein + H2O = phosphatidic acid + variant-surface-glycoprotein inositol

646473, 646472

-

3.1.4.50

phosphatidylinositol-glycan-anchored membrane form of acetylcholinesterase + H2O = soluble acetylcholinesterase + phosphatidic acid

646474

-

3.1.4.54

N-acylphosphatidylethanolamine + H2O = N-acylethanolamine + phosphatidate

0

-

3.1.4.54

N-arachidonoyl-phosphatidylethanolamine + H2O = N-arachidonoylethanolamine + phosphatidic acid

0

-

3.1.4.54

N-arachidonoylphosphatidylethanolamine + H2O = N-arachidonoylethanolamine + phosphatidic acid

0

-

3.1.4.4

8 entries

3.1.4.50

2 entries

3.1.4.54

3 entries

3.6.1.26

CDPdiacylglycerol + H2O = CMP + phosphatidate

210005, 210004

-

3.6.1.75

diacylglycerol diphosphate + H2O = phosphatidate + phosphate

0

-

Substrate in Enzyme-catalyzed Reactions (35 results)

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Show Substrate (35 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.7.41

CTP + phosphatidate = diphosphate + CDP-diacylglycerol

761129, 659064, 662589, 690426, 691056, 661820, 738826, 737701, 761504, 739305, 738000, 741020, 739033, 739396, 762084, 760639, 761476, 762488

-

2.7.7.41

CTP + phosphatidate = diphosphate + CDPdiacylglycerol

643319, 643306, 643317, 643316, 643314, 643318, 643302, 643304, 643305, 643313, 643322, 643301, 643321, 643328, 643310, 643324, 643303, 643307, 643320, 643327, 643323, 643309, 643312, 643299, 643300, 643311, 643325, 643308, 643298, 643297, 643315

-

2.7.7.41

dCTP + phosphatidate = diphosphate + dCDPdiacylglycerol

643319, 643306, 643300, 643314, 643321, 643297, 643308

-

2.7.7.41

3 entries

3.1.1.111

phosphatidic acid + H2O = lysophosphatidic acid + a fatty acid

754071

-

3.1.1.26

phosphatidic acid + H2O = ?

94293, 94294, 94291

-

3.1.1.3

phosphatidic acid + H2O = ?

80843

-

3.1.1.32

phosphatidic acid + H2O = 2-acyl-lysophosphatidic acid + a carboxylate

730037, 652226, 652486, 652297, 729743

-

3.1.1.32

phosphatidic acid + H2O = 2-acylglycerol-3-phosphate + a carboxylate

664829

-

3.1.1.32

phosphatidic acid + H2O = 2-acylglycerophosphatidic acid + a carboxylate

749810, 650008

-

3.1.1.32

phosphatidic acid + H2O = 2-acyllysophosphatidic acid + a carboxylate

678494

-

3.1.1.32

phosphatidic acid + H2O = ?

678494

-

3.1.1.32

phosphatidic acid + H2O = lysophosphatidic acid + a carboxylate

650395

-

3.1.1.4

1,2-diacyl-sn-glycero-3-phosphatide + H2O = 1-acyl-sn-glycero-3-phosphatide + fatty acid

133925, 133907

-

3.1.1.4

1,2-diacyl-sn-glycero-3-phosphatide + H2O = ?

133925, 133907

-

3.1.1.4

phosphatidic acid + H2O = 1-acylglycerophosphate + fatty acid

133911, 133925, 133931

-

3.1.1.32

6 entries

3.1.1.4

3 entries

3.1.1.5

phosphatidic acid + H2O = ?

678790, 94366

-

3.1.3.4

1,2-diacyl-sn-glycerol 3-phosphate + H2O = 1,2-diacyl-sn-glycerol + phosphate

694357

-

3.1.3.4

1,2-diacyl-sn-glycerol-3-phosphate + H2O = 1,2-diacyl-sn-glycerol + phosphate

730770

-

3.1.3.4

a 3-sn-phosphatidate + H2O = a 1,2-diacyl-sn-glycerol + phosphate

691109, 691685, 693153, 693238, 693251, 693521, 694740, 691384, 694357, 691076

-

3.1.3.4

phosphatidate + H2O = 1,2-diacyl-sn-glycerol + phosphate

650322, 653123, 751124, 752338, 134878, 678372

-

3.1.3.4

phosphatidate + H2O = diacyl-sn-glycerol + phosphate

678372, 680628

-

3.1.3.4

phosphatidate + H2O = diacylglycerol + phosphate

751935

-

3.1.3.4

phosphatidic acid + H2O = 1,2-diacyl-sn-glycerol + phosphate

134895, 690815, 666452, 680849, 709065, 709098, 710376, 710639, 716166, 134878, 134881, 134883, 134884, 134887, 134889, 134897, 708068, 709037, 134859, 134860, 134861, 134863, 134865, 134867, 134868, 134871, 134873, 134874, 134876, 134877, 134879, 134882, 134885, 134888, 134890, 134894, 134896, 134875, 134886, 134892, 715630, 716758, 751277, 134862, 134893, 134869, 134870, 134898, 716574, 752337, 134880, 134891, 751135, 679998, 751842, 134866, 134872, 134864, 651209, 710418, 707555

-

3.1.3.4

phosphatidic acid + H2O = 1,2-diacylglycerol + phosphate

665748, 682952, 681768, 680723

-

3.1.3.4

phosphatidic acid + H2O = 1,2-sn-diacylglycerol + phosphate

680823, 691384

-

3.1.3.4

phosphatidic acid + H2O = ?

679521

-

3.1.3.4

phosphatidic acid + H2O = diacylglycerol + phosphate

665805, 663994, 666926, 680744, 681760, 680723, 665748, 681013

-

3.1.3.4

phosphatidic acid + H2O = phosphate + diacylglycerol

680814

-

3.1.3.4

12 entries

3.1.3.59

diacyl-glycerophosphate + H2O = dialkylglycerol + phosphate

646420

-

3.1.4.3

1,2-diacyl-sn-glycero-3-phosphatide + H2O = 1,2-diacylglycerol + phosphate

135298

-

3.1.4.3

phosphatidic acid + H2O = 1,2-diacyl-sn-glycerol + phosphate

715502

-

3.1.4.3

phosphatidic acid + H2O = 1,2-sn-diacylglycerol + phosphate

730853

-

3.1.4.3

phosphatidic acid + H2O = ?

135281, 135308, 135307, 668022

-

3.1.4.3

4 entries

3.1.4.4

doxorubicin + phosphatidate = phosphatidyl-doxorubicin + H2O

750001

-

3.6.1.27

phosphatidic acid + H2O = ?

687718

-

Product in Enzyme-catalyzed Reactions (67 results)

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Show Product (67 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.51

acyl-ACP + 1-acyl-sn-glycerol 3-phosphate = ACP + 1,2-diacyl-sn-glycerol 3-phosphate

486341, 486339

-

2.3.1.51

acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate

0, 487192, 486635, 486345, 486339, 486335, 487198, 487204, 486373, 487180, 486338, 486634, 487188, 487193, 487179, 486375, 486341, 487184, 487194, 486374, 486630, 487210, 487191, 486486

-

2.3.1.51

acyl-[acyl-carrier protein] + 1-acyl-sn-glycerol 3-phosphate = ACP + 1,2-diacyl-sn-glycerol 3-phosphate

486339

-

2.3.1.51

acyl-[acyl-carrier protein] + 1-acyl-sn-glycerol 3-phosphate = acyl-carrier protein + 1,2-diacyl-sn-glycerol 3-phosphate

0

-

2.3.1.51

oleoyl-CoA + lysophosphatidic acid = CoA + 1,2-diacyl-sn-glycerol 3-phosphate

0

-

2.3.1.51

5 entries

2.3.1.52

acyl-CoA + 2-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate

0

-

2.7.1.107

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate

0

-

2.7.1.107

ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate

0

-

2.7.1.107

GTP + 1,2-diacyl-sn-glycerol = GDP + 1,2-diacyl-sn-glycerol 3-phosphate

0

-

2.7.1.107

3 entries

2.7.1.138

ATP + diacylglycerol = ADP + diacylglycerol 1-phosphate

0

-

2.7.1.174

CTP + 1,2-diacyl-sn-glycerol = CDP + 1,2-diacyl-sn-glycerol 3-phosphate

0

-

2.7.1.174

dCTP + 1,2-diacyl-sn-glycerol = dCDP + 1,2-diacyl-sn-glycerol 3-phosphate

0

-

2.7.1.174

2 entries

2.7.1.94

ATP + diacylglycerol = ADP + phosphatidic acid

0

-

2.7.4.29

diacylglycerol diphosphate + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A = diacylglycerol phosphate + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A 1-diphosphate

0

-

2.7.7.41

diphosphate + CDP-diacylglycerol = CTP + phosphatidate

0

-

2.7.8.8

CDP-diacylglycerol + H2O = CMP + phosphatidic acid

643776, 643778

-

3.1.3.4

diacylglycerol diphosphate + H2O = phosphatidate + phosphate

0

-

3.1.4.3

phosphatidylinositol 4,5-bisphosphate + H2O = inositol 4,5-bisphosphate + phosphatidate

650878, 653351

-

3.1.4.4

phosphatidylcholine + H2O = 1,2-diacylglycerophosphate + choline

0, 652769

-

3.1.4.4

phosphatidylethanolamine + H2O = 1,2-diacylglycerophosphate + ethanolamine

0

-

3.1.4.4

phosphatidylglycerol + H2O = glycerol + 1,2-diacylglycerophosphate

0

-

3.1.4.4

phosphatidylinositol + H2O = 1,2-diacylglycerophosphate + inositol

0

-

3.1.4.4

phosphatidylserine + H2O = 1,2-diacylglycerophosphate + serine

0

-

3.1.4.4

phosphatidylcholine + H2O = choline + a phosphatidate

0

-

3.1.4.4

cardiolipin + H2O = sn-glycero-1-phosphate + diacylglycerophosphate

0

-

3.1.4.4

phosphatidylglycerol + H2O = glycerol + diacylglycerophosphate

0

-

3.1.4.4

dipalmitoyl phosphatidylcholine + H2O = choline + phosphatidate

0

-

3.1.4.4

N-acyl-phosphatidylethanolamine + H2O = N-acylethanolamine + phosphatidate

0

-

3.1.4.4

N-acylphosphatidylethanolamine + H2O = N-acylethanolamine + phosphatidate

0

-

3.1.4.4

phosphatidyl-doxorubicin + H2O = doxorubicin + phosphatidate

0

-

3.1.4.4

phosphatidyl-p-nitrophenol + H2O = phosphatidate + p-nitrophenol

0

-

3.1.4.4

phosphatidylcholine + H2O = choline + phosphatidate

0, 650910, 650848, 653523, 652644

-

3.1.4.4

phosphatidylcholine + H2O = phosphatidate + choline

0

-

3.1.4.4

phosphatidylethanolamine + H2O = ethanolamine + phosphatidate

651126, 0

-

3.1.4.4

phosphatidylethanolamine + H2O = phosphatidate + ethanolamine

0

-

3.1.4.4

phosphatidylglycerol + H2O = glycerol + phosphatidate

0

-

3.1.4.4

phosphatidylglycerol + H2O = phosphatidate + glycerol

0

-

3.1.4.4

phosphatidylinositol + H2O = phosphatidate + inositol

0

-

3.1.4.4

phosphatidylserine + H2O = L-serine + phosphatidate

651126, 0

-

3.1.4.4

phosphatidylserine + H2O = phosphatidate + serine

0

-

3.1.4.4

N-arachidonoyl-phosphatidylethanolamine + H2O = phosphatidic acid + N-arachidonoylethanolamine

650338

-

3.1.4.4

N-lauroyl-phosphatidylethanolamine + H2O = phosphatidic acid + N-lauroylethanolamine

0

-

3.1.4.4

N-palmitoyl-phosphatidylethanolamine + H2O = phosphatidic acid + N-palmitoylethanolamine

0, 650338

-

3.1.4.4

phosphatidyl-p-nitrophenol + H2O = phosphatidic acid + p-nitrophenol

0

-

3.1.4.4

phosphatidylcholine + H2O = choline + phosphatidic acid

0

-

3.1.4.4

phosphatidylcholine + H2O = phosphatidic acid + choline

0

-

3.1.4.4

phosphatidylethanolamine + H2O = ethanolamine + phosphatidic acid

0

-

3.1.4.4

phosphatidylglycerol + H2O = glycerol + phosphatidic acid

0

-

3.1.4.4

phosphatidylserine + H2O = serine + phosphatidic acid

0

-

3.1.4.4

phospholipid + H2O = phosphatidic acid + alcohol

0

-

3.1.4.4

32 entries

3.1.4.41

phosphatidylcholine + H2O = phosphatidic acid + choline

0

-

3.1.4.50

glycosylphosphatidylinositol-anchored proteins = phosphatidic acid + variant membrane protein

0

-

3.1.4.50

glycosylphosphatidylinositol-membrane anchor of Cripto-1 = soluble Cripto-1 + phosphatidic acid

0

-

3.1.4.50

membrane form of variant-surface-glycoprotein + H2O = phosphatidic acid + variant-surface-glycoprotein inositol

646473, 646472, 0

-

3.1.4.50

phosphatidylinositol-glycan-anchored membrane form of acetylcholinesterase + H2O = soluble acetylcholinesterase + phosphatidic acid

646474

-

3.1.4.54

N-acylphosphatidylethanolamine + H2O = N-acylethanolamine + phosphatidate

0

-

3.1.4.54

N-arachidonoylphosphatidylethanolamine + H2O = N-arachidonoylethanolamine + phosphatidate

0

-

3.1.4.54

N-oleoylphosphatidylethanolamine + H2O = N-oleoylethanolamine + phosphatidate

0

-

3.1.4.54

N-palmitoylphosphatidylethanolamine + H2O = N-palmitoylethanolamine + phosphatidate

0

-

3.1.4.54

N-stearoylphosphatidylethanolamine + H2O = N-stearoylethanolamine + phosphatidate

0

-

3.1.4.54

N-arachidonoyl-phosphatidylethanolamine + H2O = N-arachidonoylethanolamine + phosphatidic acid

0

-

3.1.4.54

N-arachidonoylphosphatidylethanolamine + H2O = N-arachidonoylethanolamine + phosphatidic acid

0

-

3.1.4.54

N-palmitoylphosphatidylethanolamine + H2O = N-palmitoylethanolamine + phosphatidic acid

0

-

3.1.4.50

4 entries

3.1.4.54

8 entries

3.6.1.26

CDPdiacylglycerol + H2O = CMP + phosphatidate

210005, 210004

-

3.6.1.27

diacylglycerol diphosphate + H2O = diacylglycerol phosphate + phosphate

0

-

3.6.1.75

diacylglycerol diphosphate + H2O = diacylglycerol phosphate + phosphate

0

-

3.6.1.75

diacylglycerol diphosphate + H2O = phosphatidate + phosphate

0

-

3.6.1.75

2 entries

Activator in Enzyme-catalyzed Reactions (51 results)

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Show Activating Compound (51 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.3.3.3

2.3fold activation at 0.5 mg/ml

390964

-

1.3.3.3

activation in sonicated mitochondria up to 150%

390943

-

2.3.1.20

-

486509

-

2.3.1.20

PA, Feed-forward activation of BnaDGAT1 by phosphatidate, PA facilitates the transition of the enzyme into the more active state. PA may also relieve possible autoinhibition of BnaDGAT1 brought about by the N-terminal regulatory domain, which is shown to interact with PA. The soluble domain of BnaDGAT1 is likely to interact with the small highly charged head group of PA. 18:1/18:1-PA and 16:0/18:1-PA activated BnaDGAT1 by about 4.7fold and 2.4fold, respectively. 16:0/16:0-PA only activates the enzyme by about 1.24fold, while 18:0/18:0-PA has a minimal effect on enzyme activity. Truncated enzyme BnaDGAT11-113, comprising the N-terminus, interacts with increasing amounts of PA, allowing the soluble domain to be recovered together with the liposomes upon centrifugation

758018

-

2.3.1.20

a feedforward activator of plant DGAT1. PtdOH is suggested to aid in relieving possible autoinhibition by interacting with the N-terminal regulatory domain spanning the autoinhibitory motif and converts DGAT1 to a more active state that is also less sensitive to substrate inhibition

757544

-

1.3.3.3

2 entries

2.3.1.20

3 entries

2.3.1.22

stimulates

486606

-

2.3.1.23

182% activation

486651

-

2.4.1.142

-

636890

-

2.4.1.46

-

736153

-

2.4.1.46

allosterically activates MGD1, half-maximal activation at about 0.2 mol%. With 0.15 mol% of phosphatidic acid, the enzyme velocity versus substrate curve is sigmoid, whereas with 1.5 mol% of phosphatidic acid, the curve is hyperbolic. MGDG synthase activity of leaf homogenates is dependent on the constant presence of phosphatidic acid, decrease of phosphatidic acid production leads to a decrease of the MGDG synthase activity. Molecular discrimination of phosphatidic acid and phosphatidylglycerol binding sites, overview

704698

-

2.4.1.46

2 entries

2.4.1.88

activation

489482

-

2.5.1.31

enhancement factor: 0.8 in absence of Triton X-100, 1.0 in presence of 0.1% Triton X-100

637484

-

2.5.1.31

from egg, good activator in absence of detergent

637475, 637484

-

2.7.1.107

the enzyme apoprotein is attributed to a novel feedback activation involving diacylglycerol 3-phosphate

640360

-

2.7.1.107

activates only in presence of Triton X-100

640361

-

2.7.1.107

good activator of DGK IV, no effect on DGK I activity

640364

-

2.7.1.107

highly stimulating

661157

-

2.7.1.107

more effective activator than phosphatidylserine. Phosphatidic acid decreases the apparent surface KM of DGKtheta for dioleoylglycerol and promotes binding to vesicles in a dose-dependent manner

672275

-

2.7.1.107

phosphatidic acid is more effective than phosphatidiylserine. Both decreases the apparent surface KM value for dioleoylglycerol and promote binding to vesicles, but through different mechanisms

672275

-

2.7.1.107

production of oxidative burst and hypersensitive cell death. Activation of the epxression of diacylglycerol kinase and transcritional factor gene OsBIERF3. Neomycin partially inhibits the poduction of oxidatve burst, hypersensitive cell death, and expression of both genes

677073

-

2.5.1.31

2 entries

2.7.1.107

7 entries

2.7.1.137

enhances activity more markedly for PI 3-kinase II than for PI 3-kinase I

640854

-

2.7.1.174

-

687738

-

2.7.1.68

-

722784, 738288

-

2.7.1.68

0.14 mM, potent activator, the enzyme is unable to produce 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate unless phosphatidic acid is bound

675019

-

2.7.1.68

activates enzyme form 1 by 2.1fold

661757

-

2.7.1.68

activates isozyme alpha by 2.0fold

661757

-

2.7.1.68

activation

660875

-

2.7.1.68

stimulates

641851

-

2.7.1.68

stimulates in a concentration-dependent manner up to 20fold when an equal molar ratio of phosphatidic acid to phosphatidylinositol 4-phosphate is attained

641835

-

2.7.1.91

-

674380

-

2.7.1.91

0.01 mM, isoform SphK2, 102% of initial activity, isoform SphK1, 265% of initial activity

702037

-

2.7.1.68

7 entries

2.7.1.91

2 entries

2.7.11.15

activates, phosphorylation of beta2-AR

645028

-

2.7.11.17

activating at low concentrations, inhibitory at high concentrations

490759

-

3.1.1.118

-

760614

-

3.1.1.4

highly activating

729999

-

3.1.2.1

activates mutant form lacking START domain

732297

-

3.1.4.11

activates the hydrolysis at a physiological pH

285224

-

3.1.4.11

enhances hyrolysis of phosphatidylinositol 4,5-diphosphate, membrane bound enzyme and cytosolic enzyme

135123

-

3.1.4.11

increases the film pressure of the phosphatidylinositol monolayer at an air/water interface at which cut-off occurs, as well as increases the rate of hydrolysis at lower pressure

285223

-

3.1.4.11

PLC-beta1 activation, Ca2+-dependent, relatively independent of acyl chain length, stimulates basal and receptor-G protein-regulated PLC-beta1 activity, activation occurs through an C-terminal-dependent and an independent mechanism

649997

-

3.1.4.11

stimulating

285228

-

3.1.4.12

-

135176, 135183

-

3.1.4.12

anionic phospholipids required for activity, maximal activation at 1 mM, 33% of activation with phosphatidylserine

649682

-

3.1.4.4

interaction of phospholipase D with the lipidic activator at the air-water interface

664164

-

3.1.4.4

only with addition of lecithin and SDS

135438

-

3.1.4.4

the Streptomyces chromofuscus PLD seems to be dependent on presence of phosphatidic acid for activity on phospholipids

708211

-

3.1.4.4

up to 2fold

653805

-

3.1.4.11

5 entries

3.1.4.12

2 entries

3.1.4.4

4 entries

3.1.6.8

at a relative concentration of 30 mol% the lipid stimulates the reaction rate by a factor of 3.1

693260

-

3.4.22.B36

activates

648418

-

3.6.1.75

slight activation of the DGPP phosphatases activity

680603

-

4.6.1.13

binding to nonsubstrate anionic interfaces enhances the catalytic activity of PI-PLC, interfacial binding studies, activation mechanism

650231

-

Inhibitor in Enzyme-catalyzed Reactions (43 results)

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Show Inhibitors (43 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.14.18.2

3 mM, 20% inhibition

639334

-

1.8.4.2

-

394810, 394811, 394847

-

2.3.1.15

-

486351, 486378

-

2.3.1.15

i.e. phosphatidic acid, inhibition of mitochondrial enzyme

486348

-

2.3.1.15

2 entries

2.3.1.42

-

486953

-

2.3.1.67

-

487386

-

2.4.1.38

-

489511, 489513

-

2.4.1.90

-

489511, 489513

-

2.7.1.107

moderate

640370

-

2.7.1.107

competitive inhibition

704564

-

2.7.1.107

2 entries

2.7.1.137

-

640851

-

2.7.1.67

slight

641789

-

2.7.1.68

0.1 mM, 125% stimulation

641844

-

2.7.1.68

2-3fold activation of the brain cytosol enzyme, 30fold enhancement of the activation by GTPgammaS, even higher activation by addition of recombinant mouse isozyme alpha

660641

-

2.7.1.68

2 entries

2.7.11.17

at high concentrations, activates at low concentrations

490759

-

2.7.8.1

-

644406

-

2.7.8.17

-

645369

-

2.7.8.B10

MgCl2 partially offsets inhibition by phosphatidate

727058

-

3.1.1.13

slight inhibition

133829

-

3.1.1.5

-

94396

-

3.1.1.5

0.5 mM, 24% inhibition at pH 5.0, 66% inhibition at pH 7.0, LPL1; 0.5 mM, 58% inhibition of phospholipase B activity, 92% inhibition of lysophospholipase at pH 5.0, 87% inhibition of lysophospholipase at pH 7.0

663943

-

3.1.1.5

2 entries

3.1.2.1

-

732297

-

3.1.3.4

conpetitive versus diacylglycerol diphosphate

678372

-

3.1.3.4

competitive inhibition

134897

-

3.1.3.4

competitive with respect to diacylglycerol diphosphate

650322

-

3.1.3.4

substrate inhibition

681768

-

3.1.3.51

-

134910

-

3.1.3.51

0.00006 mg, 50% inhibition

134915

-

3.1.3.51

0.1 mM or 1 mM, competitive

134920

-

3.1.3.4

4 entries

3.1.3.51

3 entries

3.1.3.53

most effective inhibitor among acidic phospholipids, followed by phosphatidylserine and phosphatidylinositol, phosphorylated myosin as substrate

646357

-

3.1.3.59

38% inhibition in presence of 0.2 mM 1-alkyl-2-acetyl-sn-glycero-3-phosphate, mitochondrial fraction

646420

-

3.1.4.3

monomeric and micellar, poor substrate, inhibitor

135281

-

3.1.4.4

-

135449

-

3.1.4.42

0.45 mM, 43% inhibition

81113

-

3.1.4.50

-

646476, 646486

-

3.1.4.50

50% inhibition at 0.1 mM

646483

-

3.1.4.50

2 entries

3.4.21.39

from bovine brain

29374, 81368

-

3.5.1.23

ceramide synthesis activity, 2.5-5 mol%, total inhibition

655998

-

3.5.1.23

complete inhibition

733984

-

3.5.1.23

2 entries

3.6.1.43

70% inhibition at 60 mM

134917

-

3.6.1.75

competitive versus diacylglycerol diphosphate

680603

-

4.1.1.31

addition of 0.05 mM phosphatidic acid decreases PEPC activity to approximately 40% of the control activity. Inclusion of D-glucose 6-phosphate or L-malate do not change the effect of phosphatidic acid on PEPC, preincubation of the enzyme with 5 mM phosphoenolpyruvate prior to the addition of phosphatidic acid did not prevent inactivation either. The incubation of phosphatidic acid-inactivated PEPC with protein kinase A does not restore PEPC activity

706331

-

7.4.2.1

ATP-binding subunit HisP with a carboxy-terminal extension of 8 amino acids

246888

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (3 results)

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Show Turnover Number (3 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.7.7.41

8.92

-

pH 6.5, 30°C

643309

3.1.1.32

630

-

pH 7.2, 50°C, recombinant enzyme

729743

3.6.1.27

61

-

pH 7.5, 37°C, recombinant enzyme

687718

K_M Value (36 results)

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Show KM Value (36 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.7.7.41

0.067

-

NBD-phosphatidate, pH and temperature not specified in the publication

738000

2.7.7.41

0.08

-

pH 7.2, 37°C

643307

2.7.7.41

0.094

-

at pH 7.5 and 30°C

762488

2.7.7.41

0.138

-

pH 7.5, 30°C

643325

2.7.7.41

0.22

-

pH 7.0, 30°C

643303

2.7.7.41

0.28

-

-

643300

2.7.7.41

0.28

-

pH 7, 37°C

643314

2.7.7.41

0.28

-

pH 7.4, 30°C

643308

2.7.7.41

0.3

-

pH 7.5, 25°C, with 0.45 mM CTP

643306

2.7.7.41

0.5

-

-

643301

2.7.7.41

0.5

-

pH 6.5, 30°C

643309

2.7.7.41

0.65

-

pH 7.0, 37°C

643311

2.7.7.41

2.5

-

-

643319

2.7.7.41

13 entries

3.1.1.32

2.38

-

pH 7.2, 50°C, recombinant enzyme

729743

3.1.3.4

0.0054

-

-

134874

3.1.3.4

0.032

-

enzyme form PAP2B

134896

3.1.3.4

0.05

-

-

134879, 134866

3.1.3.4

0.062

-

-

134887

3.1.3.4

0.08

-

enzyme form PT

134861

3.1.3.4

0.098

-

in presence of various polyamines

134871

3.1.3.4

0.1

-

phosphatidate dispersed in sonicated microsomal lipid

134864

3.1.3.4

0.14

-

-

134888

3.1.3.4

0.16

-

enzyme forms D250 and E

134861

3.1.3.4

0.16

-

phosphatidate bound to microsomal membrane

134864

3.1.3.4

0.16

-

without polyamines

134871

3.1.3.4

0.277

-

pH 6.5, 37°C, recombinant isozyme DPPL1

679998

3.1.3.4

0.284

-

pH 6.5, 37°C

751935

3.1.3.4

0.355

-

pH 6.5, 37°C

751935

3.1.3.4

0.369

-

pH 6.5, 37°C

751935

3.1.3.4

0.43

-

wild type enzyme, pH and temperature not specified in the publication

716758

3.1.3.4

0.506

-

pH 6.5, 37°C, recombinant isozyme DPPL2

679998

3.1.3.4

0.5954

-

pH 6.5, 53°C

730770

3.1.3.4

0.67

-

-

134862

3.1.3.4

0.67

-

without ATP

134859

3.1.3.4

1.2

-

in presence of 2 mM ATP

134859

3.1.3.4

21 entries

3.6.1.27

1.7

-

pH 7.5, 37°C, recombinant enzyme

687718

K_i Value (1 result)

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Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.1.3.51

0.00006

-

-

134915

References & Links

Literature References (301)

top print hide

Show Reference (301 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

29374

3890754

Chymotrypsin- and trypsin-type serine proteases in rat mast cells: properties and functions

1985

Kido, H.; Fukusen, N.; Katunuma, N.

Arch. Biochem. Biophys.

239

436-443

80843

2051929

Purification and substrate specificity of rat hepatic lipase

1991

Waite, M.; Thuren, T.Y.; Wilcox, R.W.; Sisson, P.J.; Kucera, G.L.

Methods Enzymol.

197

331-339

81113

212014

rac-Glycerol 1:2-cyclic phosphate 2-phosphodiesterase, a new soluble phosphodiesterase of mammalian tissues

1978

Clarke, N.; Dawson, R.M.C.

Biochem. J.

173

579-589

81368

3882053

Inhibition of chymase activity by phosphoglycerides

1985

Fukusen, N.; Kido, H.; Katunuma, N.

Arch. Biochem. Biophys.

237

118-123

94291

-

Purification of a lipolytic acyl-hydrolase from Phaseolus vulgaris leaves by affinity chromatography on palmitolyated gauze and its properties

1979

Matsuda, H.; Tanaka, G.; Morita, K.; Hirayama, O.

Agric. Biol. Chem.

43

563-570

94293

454635

Purification and properties of a lipolytic acyl-hydrolase from potato leaves

1979

Matsuda, H.; Hirayama, O.

Biochim. Biophys. Acta

573

155-165

94294

236765

Purification and properties of a lipid acyl-hydrolase from potato tubers

1975

Hirayama, O.; Matsuda, H.; Takeda, H.; Maenaka, K.; Takatsuka, H.

Biochim. Biophys. Acta

384

127-137

94366

8782402

Purification and some properties of phospholipase B from Schizosaccharomyces pombe

1996

Oishi, H.; Tsuda, S.; Watanabe, Y.; Tamai, Y.

Biosci. Biotechnol. Biochem.

60

1087-1092

94396

8119970

Purification, characterization, and inhibition by phosphatidic acid of lysophospholipase transacylase from rat liver

1994

Sugimoto, H.; Yamashita, S.

J. Biol. Chem.

269

6252-6258

133829

8468334

Hydrolysis of cholesteryl oleate liquid crystals by hormon-sensitive lipase

1993

Tsujita,T.; Okuda, H.

J. Biochem.

113

264-269

133907

7278678

Phospholipase A2 from bee venom

1981

Cottrell, R.C.

Methods Enzymol.

71

698-702

133911

7325675

Phospholipase A2 activity on mixed lipid monolayers: Activation of phospholipase A2 from porcine pancreas and Crotalus adamanteus by anionic and neutral amphophiles

1981

Hendrickson, H.S.; Trygstad, W.M.; Loftness, T.L.; Sailer, S.L.

Arch. Biochem. Biophys.

212

508-514

133925

4475346

Phospholipase A2 (phosphatide acylhydrolase, EC 3.1.1.4) from porcine pancreas

1974

Nieuwenhuizen, W.; Kunze, H.; de Haas, G.H.

Methods Enzymol.

32

147-154

133931

-

Phospholipases

1971

Hanahan, D.J.

The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )

5

71-85

134859

2540828

Activation of rat liver cytosolic phosphatidic acid phosphatase by nucleoside diphosphates

1989

Berglund, L.; Björkhem, I.; Angelin, B.; Einarsson, K.

Biochim. Biophys. Acta

1002

382-387

134860

2822021

A rapid assay for measuring the activity and the Mg2+ and Ca2+ requirements of phosphatidate phosphohydrolase in cytosolic and microsomal fractions of rat liver

1987

Martin, A.; Hales, P.; Brindley, D.N.

Biochem. J.

245

347-355

134861

3019411

Isolation and characterization of multiple forms of Mg2+-dependent phosphatidate phosphohydrolase from rat adipose cytosol

1986

Wells, G.N.; Osborne, L.J.; Jamdar, S.C

Biochim. Biophys. Acta

878

225-237

134862

3002481

Phosphatidate phosphatase activity in isolated rod outer segment from bovine retina

1986

Pasquare de Garcia, S.J.; Giusto, N.M.

Biochim. Biophys. Acta

875

195-202

134863

2998883

Presence of membrane-associated phosphatidate phosphohydrolase activity in cultured islets and its stimulation by glucose

1985

Dunlop, M.; Larkins, R.G.

FEBS Lett.

193

231-235

134864

2987202

Phosphatidate phosphatase in rat liver: the relationship between the activities with membrane-bound phosphatidate and aqueous dispersion of phosphatidate

1985

Ide, H.; Nakazawa, Y.

J. Biochem.

97

45-54

134865

6095917

The role of Mg2+-dependent phosphatidate phosphohydrolase in pulmonary glycerolipid biosynthesis

1984

Walton, P.A.; Possmeyer, F.

Biochim. Biophys. Acta

796

364-372

134866

6091767

Partial purification and properties of phosphatidate phosphatase in Saccharomyces cerevisiae

1984

Hosaka, K.; Yamashita, S.

Biochim. Biophys. Acta

796

102-109

134867

6091551

Glycerolipid biosynthesis in rat adipose tissue 12. Properties of Mg2+-dependent and -independent phosphatidate phosphohydrolase

1984

Jamdar, S.C.; Osborne, L.J.; Wells, G.N.

Arch. Biochem. Biophys.

233

370-377

134868

6087797

Partial purification and characterization of the soluble phosphatidate phosphohydrolase of rat liver

1984

Butterwith, S.C.; Hopewell, R.; Brindley, D.N.

Biochem. J.

220

825-833

134869

37120

Characterization of phosphatidate phosphohydrolase activity associated with chloroplast envelope membranes

1979

Joyard, J.; Douce, R.

FEBS Lett.

102

147-150

134870

-

The phosphatidic acid phosphatase of the chloroplast envelope is located on the inner envelope membrane

1983

Block, M.A.; Dorne, A.J.; Joyard, J.; Douce, R.

FEBS Lett.

164

111-115

134871

6303437

Glycerolipid biosynthesis in rat adipose tissue. 11. Effects of polyamines on Mg2+-dependent phosphatidate phosphohydrolase

1983

Jamdar, S.C.; Osborne, L.J.

Biochim. Biophys. Acta

752

79-88

134872

6264964

Separation and characterization of the membrane-bound and aqueously dispersed phosphatidate phosphatidic acid phosphohydrolase activities in rat lung

1981

Casola, P.G.; Possmayer, F.

Biochim. Biophys. Acta

664

298-315

134873

226152

Pulmonary phosphatidic acid phosphatase. A comparative study of the aqueously dispersed phosphatidate-dependent and membrane-bound phosphatidate-dependent phosphatidic acid phosphatase activities of rat lung

1979

Yeung, A.; Casola, P.G.; Wong, C.; Fellows, J.F.; Possmayer, F.

Biochim. Biophys. Acta

574

226-239

134874

226151

Pulmonary phosphatidic acid phosphatase. Properties of membrane-bound phosphatidate-dependent phosphatidic acid phosphatase in rat lung

1979

Casola, P.G.; Possmayer, F.

Biochim. Biophys. Acta

574

212-225

134875

216393

Characterization of phosphatidate phosphohydrolase activity associated with isolated lamellar bodies

1978

Spitzer, H.L.; Johnston, J.M.

Biochim. Biophys. Acta

531

275-285

134876

212108

Phosphatidate phosphatase: activity and properties in fetal and adult rat lung

1978

Ravinuthala, H.R.; Miller, J.C.; Weinhold, P.A.

Biochim. Biophys. Acta

530

347-356

134877

200224

The effects of amphiphilic cationic drugs and inorganic cations on the activity of phosphatidate phosphohydrolase

1977

Bowley, M.; Cooling, J.; Burditt, S.L.; Brindley, D.N.

Biochem. J.

165

447-454

134878

9370315

Phosphatidate phosphatases and diacylglycerol pyrophosphate phosphatases in Saccharomyces cerevisiae and Escherichia coli

1997

Carman, G.M.

Biochim. Biophys. Acta

1348

45-55

134879

238959

Partial purification, properties, and subcellular distribution of rat liver phosphatidate phosphatase

1975

Hosaka, K.; Yamashita, S.; Numa, S.

J. Biochem.

77

501-509

134880

4335251

Localization of phosphatidic acid phosphatase activity in granular pneumocytes

1972

Meban, C.

J. Cell Biol.

53

249-252

134881

9705349

Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform

1998

Roberts, R.; Sciorra, V.A.; Morris, A.J.

J. Biol. Chem.

273

22059-22067

134882

8053903

Properties of phosphatidate phosphohydrolase in rat adipose tissue

1994

Jamdar, S.C.; Cao, W.F.

Biochem. J.

301

793-799

134883

9516474

Involvement of phosphatidate phosphohydrolase in arachidonic acid mobilization in human amniotic WISH cells

1998

Balboa, M.A.; Balsinde, J.; Dennis, E.A.

J. Biol. Chem.

273

7684-7690

134884

9305923

Cloning and characterization of two human isozymes of Mg2+-independent phosphatidic acid phosphatase

1997

Kai, M.; Wada, I.; Imai, S.; Sakane, F.; Kanoh, H.

J. Biol. Chem.

272

24572-24578

134885

7642624

Purification and characterization of a novel plasma membrane phosphatidate phosphohydrolase from rat liver

1995

Waggoner, D.W.; Martin, A.; Dewald, J.; Gomez-Munoz, A.; Brindley, D.N.

J. Biol. Chem.

270

19422-19429

134886

1334090

Purification and properties of phosphatidic acid phosphatase from porcine thymus membranes

1992

Kanoh, H.; Imai, S.; Yamada, K.; Sakane, F.

J. Biol. Chem.

267

25309-25314

134887

8418897

Characterization of phosphatidic acid phosphohydrolase in neutrophil subcellular fractions

1993

Taylor, G.S.; Ladd, A.; James, J.; Greene, B.; English, D.

Biochim. Biophys. Acta

1175

219-224

134888

2163615

Properties of phosphatidate phosphohydrolase and diacylglycerol acyltransferase activities in the isolated rat heart

1990

Schoonderwoerd, K.; Broekhoven-Schokker, S.; Hulsmann, W.C.; Stam, H.

Biochem. J.

268

487-492

134889

8403799

Plasma membrane form of phosphatidate phosphohydrolase: a possible role in signal transduction during liver fibrogenesis

1993

Day, C.P.; Burt, A.D.; Brown, A.S.M.; Bennett, M.K.; Farrell, D.J.; James, O.F.W.; Yeaman, S.J.

Clin. Sci.

85

281-287

134890

2051944

Characterization and assay of phosphatidate phosphatase

1991

Martin, A.; Gomez-Munoz, A.; Jamal, Z.; Brindley, D.N.

Methods Enzymol.

197

553-563

134891

9408176

Purification of a phosphatase which hydrolyzes phosphatidic acid, a key intermediate in glucolipid synthesis in Acholeplasma laidlawii A membranes

1997

Berg, S.; Wieslander, A.

Biochim. Biophys. Acta

1330

225-232

134892

1995619

Phosphatidate phosphatase from Saccharomyces cerevisiae. Isolation of 45- and 104-kDa forms of the enzyme that are differentially regulated by inositol

1991

Morlock, K.R.; McLaughlin, J.J.; Lin, Y.P.; Carman, G.M.

J. Biol. Chem.

266

3586-3593

134893

8448987

Differential properties of phosphatidate phosphohydrolase and diacylglyceride lipase activities in retinal subcellular fractions and rod outer segments

1993

Pasquare, S.J.; Giusto, N.M.

Comp. Biochem. Physiol. B

104

141-148

134894

1770306

Stimulation and inhibition of the activity of rat liver cytosolic phosphatidate phosphohydrolase by various phospholipids

1991

Humble, E.; Berglund, L.

J. Lipid Res.

32

1869-1873

134895

8869881

Phosphatidate phosphatases of mammals, yeast, and higher plants

1996

Kocsis, M.G.; Weselake, R.J.

Lipids

31

785-802

134896

8948459

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