Ligand dADP

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Basic Ligand Information

Molecular Structure
Picture of dADP (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H15N5O9P2
dADP
DAEAPNUQQAICNR-RRKCRQDMSA-N
Synonyms:
2'-dADP, 2'-deoxy-ADP, 2'-deoxyadenosine 5'-diphosphate, 2'-deoxyadenosine 5'-pyrophosphate, 2'-deoxyADP, 2-deoxy-ADP, deoxyADP, dNDP


Show all pahtways known for Show all BRENDA pathways known for dADP

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dADP + (phosphate)n+1 = dATP + (phosphate)n
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ATP + dNDP = ADP + dNTP
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dADP + H2O = dAMP + phosphate
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In Vivo Product in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dATP + (R)-pantothenate = dADP + (R)-4'-phosphopantothenate
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ATP + dAMP = ADP + dADP
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ATP + dAMP = ADP + dADP
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dATP + H2O = dADP + phosphate
show the reaction diagram
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dNTP + H2O = dNDP + phosphate
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Substrate in Enzyme-catalyzed Reactions (19 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dimethylallyl diphosphate + dADP = ?
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dimethylallyl diphosphate + dADP = diphosphate + N6-(dimethylallyl)dADP
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dADP + adenosine = dAMP + AMP
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dADP + phosphoenolpyruvate = dATP + pyruvate
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dADP + phosphocreatine = ?
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dADP + phospholombricine = dATP + lombricine
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dADP + phosphoramide = dATP + NH3
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dADP + H2O = dIDP + NH3
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dADP + H2O = dIDP + NH3
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dADP + H2O = dAMP + phosphate
show the reaction diagram
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dADP + H2O = dAMP + phosphate
show the reaction diagram
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dADP + H2O = dAMP + phosphate
show the reaction diagram
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dADP + H2O = dAMP + phosphate
show the reaction diagram
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dADP + phosphate + acetyl-CoA = dATP + acetate + CoA
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Product in Enzyme-catalyzed Reactions (136 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ADP + reduced thioredoxin = dADP + oxidized thioredoxin + H2O
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peroxiredoxin-(S-hydroxy-S-oxocysteine) + dATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + dADP + phosphate + R-S-S-R
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dATP + citrate + CoA = dADP + phosphate + acetyl-CoA + oxaloacetate
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dADPglucose + alpha-1,4-polyglucan = dADP + alpha-1,4-polyglucan
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2'-dATP + D-glucose = 2'-dADP + D-glucose 6-phosphate
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dATP + 5-methylthioribose = dADP + 5-methylthioribose 1-phosphate
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2'-deoxy-ATP + sn-1,2-dihexanoylglycerol = 2'-deoxy-ADP + sn-1,2-dihexanoylglycerol 3-phosphate
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dATP + D-fructose 6-phosphate = dADP + D-fructose 1,6-bisphosphate
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dATP + D-ribose = dADP + D-ribose 5-phosphate
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dATP + adenosylcobinamide = adenosylcobinamide phosphate + dADP
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dATP + L-seryl-tRNASec = dADP + O-phospho-L-seryl-tRNASec
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dATP + 2-deoxy-D-ribose = dADP + 2-deoxy-D-ribose 5-phosphate
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dATP + adenosine 5-phosphosulfate = dADP + 3'-phosphoadenosine 5'-phosphosulfate
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dATP + mevalonate = dADP + phosphomevalonate
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dATP + D-fructose = dADP + D-fructose 6-phosphate
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dATP + D-glucuronate = dADP + 1-phospho-D-glucuronate
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dATP + 4-methyl-5-(2-hydroxyethyl)thiazole = dADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole
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dATP + N-acetyl-D-glucosamine = dADP + N-acetyl-D-glucosamine 6-phosphate
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dATP + glucose = dADP + D-glucose 6-phosphate
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2'-deoxy-ATP + scyllo-inosamine = 2'-deoxy-ADP + scyllo-inosamine phosphate
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dATP + D-mannose = dADP + D-mannose 6-phosphate
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2'-deoxyATP + shikimate = 2'-deoxyADP + shikimate 3-phosphate
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dATP + streptomycin = dADP + streptomycin 6-phosphate
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dATP + deoxycytidine = dADP + dCMP
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dATP + deoxyadenosine = dADP + dAMP
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dATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] = dADP + ?
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dATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = dADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
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dATP + carbamate = dADP + carbamoyl phosphate
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dATP + N-acetyl-L-glutamate = dADP + N-acetyl-L-glutamate 5-phosphate
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dGTP + dAMP = dGDP + dADP
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ATP + dAMP = ADP + dADP
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ATP + dAMP = ADP + dADP
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2'-deoxy-adenosine 5'-triphosphate + trans-farnesyl diphosphate = 2'-deoxyadenosine 5'-diphosphate + trans-farnesyl triphosphate
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dATP + 5-methyldeoxycytidine 5'-phosphate = dADP + 5-methyldeoxycytidine diphosphate
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dATP + CMP = dADP + CDP
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ATP + dAMP = ADP + dADP
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dATP + UMP = dADP + UDP
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dADP-alpha-D-glucose + phosphate = dADP + alpha-D-glucose 1-phosphate
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dATP + H2O = dADP + phosphate
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dATP + H2O = dADP + phosphate
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dATP + N-methylimidazolidine-2,4-dione + H2O = dADP + phosphate + N-carbamoylsarcosine
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dATP + H2O = dADP + phosphate
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dATP + H2O = dADP + phosphate
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P1,P4-bis(5'-(2'-deoxy)adenosyl)tetraphosphate + H2O = 2 dADP
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dATP + H2O = dADP + phosphate
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dATP + H2O = dADP + phosphate
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dATP + 5-diphosphomevalonate = dADP + phosphate + isopentenyl diphosphate + CO2
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2'-dATP + H2O + a dynein associated with a microtubule at position n = 2'-dADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
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2'-dATP + H2O + a kinesin associated with a microtubule at position n = 2'-dADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
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dATP + H2O + closed Cl- channel = dADP + phosphate + open Cl- channel
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dATP + negatively supercoiled circular DNA = dADP + phosphate + relaxed circular DNA
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dATP + 7,8-dihydropteroate + L-Glu = dADP + phosphate + 7,8-dihydrofolate
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dATP + gamma-Glu-L-Cys + Gly = dADP + phosphate + glutathione
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dATP + 5-formyltetrahydrofolate = dADP + phosphate + 5,10-methylenetetrahydrofolate
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deoxyATP + UTP + NH4+ = deoxyADP + phosphate + CTP
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dATP + formate + tetrahydrofolate = dADP + phosphate + 10-formyltetrahydrofolate
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dATP + acetyl-CoA + HCO3- = dADP + phosphate + malonyl-CoA
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dATP + hydrogenobyrinic acid a,c-diamide + Co2+ = dADP + phosphate + cob(II)yrinic acid a,c-diamide + H+
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dATP + H2O + H+/in = dADP + phosphate + H+/out
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2'-deoxyATP + H2O + H+/in + K+/out = 2'-deoxyADP + phosphate + H+/out + K+/in
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dATP + H2O = dADP + H2O
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Enzyme Cofactor/Cosubstrate (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation
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activation, can replace ADP
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation
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Inhibitor in Enzyme-catalyzed Reactions (21 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
1 mM, 49% inhibition at pH 6.0
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weak
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strong
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0.05 mM, 70% inhibition
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weak
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mixture of competitive and noncompetitive inhibition, binding to the substrate site excludes the substrate GTP, whereas binding to the noncompetitive site has no effect on GTP binding, although the resulting complex is catalytically inactive. It binds to the high and low affinity sites with equivalent affinities. BAY 41-2272, which shares an analogous core structure to YC-1, fully inhibits 2'-dADP binding to the low affinity site, whereas the inhibition by YC-1 is incomplete
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3D Structure of Enzyme-Ligand-Complex (PDB) (40 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.52
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substrate concentration between 0.01 and 4.0 mM, 37°C
0.143
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in the presence of 5 mM Mg2+, at pH 8.0 and 37°C
0.006
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pH 8.0, 30°C

KM Value (4 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.145
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substrate concentration between 0.01 and 4.0 mM, 37°C
0.447
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in the presence of 5 mM Mg2+, at pH 8.0 and 37°C
0.0126
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pH 8.0, 30°C
1.09
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Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.003
0.004
pH 9.0, 37°C, inhibition of ADP polymerization

References & Links

Links to other databases for dADP

ChEBI
PubChem
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PubChem