Ligand dNTP

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Basic Ligand Information

Molecular Structure
Picture of dNTP (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H13NO12P3R
dNTP
NBSCHQHZLSJFNQ-QTVWNMPRSA-N

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dNTP + n dNTP = dN(pdN)n + n diphosphate
show the reaction diagram
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NTP + 7 dNTP = N(pdN)7 + 7 diphosphate
show the reaction diagram
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dNTP + H2O = dNDP + phosphate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + dNDP = ADP + dNTP
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dNTP + H2O = dNDP + phosphate
show the reaction diagram
-
dNTP + H2O = dNDP + phosphate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + dNDP = ADP + dNTP
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
both GTP and dNTP are required for tetramer activation of the enzyme. SAMHD1 activation is regulated by the concentration of dNTP
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
1
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KM Value (5 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0105
-
-
0.028
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pH 8.0, 60°C, in presence of M13 ssDNA as template

References & Links

Links to other databases for dNTP

ChEBI
PubChem
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PubChem