Ligand 5-guanidino-2-oxopentanoate

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Basic Ligand Information

Molecular Structure
Picture of 5-guanidino-2-oxopentanoate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H11N3O3
5-guanidino-2-oxopentanoate
ARBHXJXXVVHMET-UHFFFAOYSA-N
Synonyms:
2-keto-5-guanidinovalerate, 2-oxo-5-guanidino-pentanoate, 2-oxo-5-guanidinopentanoate, 2-oxo-5-guanidinopentanoic acid, 2-oxo-5-guanidinovaleric acid, 2-oxo-5-guanodinopentanoate, 2-oxoarginine, 5-carbamidamido-2-oxopentanoate, 5-guanidine-2-oxopentanoate, 5-guanidino-2-oxo-pentanoate, 5-guanidino-2-oxopentanoic acid


Show all pahtways known for Show all BRENDA pathways known for 5-guanidino-2-oxopentanoate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + 5-guanidino-2-oxopentanoate = S-adenosyl-L-homocysteine + 5-guanidino-3-methyl-2-oxopentanoate
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5-Guanidino-2-oxopentanoate = ?
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In Vivo Product in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-arginine + O2 + H2O = 5-carbamidamido-2-oxopentanoate + NH3 + H2O2
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L-arginine + H2O + O2 = 5-guanidino-2-oxopentanoate + NH3 + H2O2
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L-arginine + pyruvate = 5-guanidino-2-oxopentanoate + L-alanine
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Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5-guanidino-2-oxopentanoate + NH3 + NAD(P)H + H+ = L-arginine + H2O + NAD(P)+
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S-adenosyl-L-methionine + 5-guanidino-2-oxopentanoate = S-adenosyl-L-homocysteine + 5-guanidino-3-methyl-2-oxopentanoate
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L-histidinol phosphate + 2-oxo-5-guanidinopentanoate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-arginine
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Product in Enzyme-catalyzed Reactions (33 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-arginine + phenazine methosulfate = 2-keto-5-guanidinovalerate + NH3 + reduced phenazine methosulfate
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L-arginine + H2O + NAD(P)+ = 5-guanidino-2-oxopentanoate + NH3 + NAD(P)H + H+
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L-arginine + H2O + O2 = 5-guanidino-2-oxopentanoate + NH3 + H2O2
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L-arginine + H2O + 2 cytochrome b = 2-oxo-5-guanidinopentanoic acid + NH3 + 2 reduced cytochrome b
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D-arginine + oxidized 2,6-dichloroindophenol + H2O = 2-oxo-5-guanidinopentanoate + NH3 + reduced 2,6-dichloroindophenol
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arginine + pyruvate = 2-oxo-5-guanidinovaleric acid + L-alanine
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L-arginine + 2-oxoglutarate = 2-oxo-5-guanidinopentanoate + L-glutamate
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L-arginine + 4,5-dioxopentanoate = 5-aminolevulinate + 5-guanidino-2-oxopentanoate
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L-arginine + pyruvate = 5-guanidino-2-oxopentanoate + L-alanine
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arginine + pyruvate = 5-guanidino-2-oxopentanoate + L-alanine
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L-arginine + pyruvate = 5-guanidino-2-oxopentanoate + L-alanine
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L-arginine + pyruvate = 5-guanidino-2-oxopentanoate + L-alanine
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3-(imidazol-4-yl)-2-oxopropyl phosphate + L-arginine = L-histidinol phosphate + 2-oxo-5-guanidinopentanoate
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L-arginine + pyridoxal 5'-phosphate = 2-oxo-5-guanidinopentanoate + pyridoxamine 5'-phosphate
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates
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Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
167
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References & Links

Links to other databases for 5-guanidino-2-oxopentanoate

ChEBI
PubChem
ChEBI
PubChem