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Ligand 3-oxodecanoyl-CoA

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (9 results)

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Show Substrate (9 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.100

3-oxodecanoyl-CoA + NADPH = (R)-3-hydroxydecanoyl-CoA + NADP+

667257

-

1.1.1.211

3-oxodecanoyl-CoA + NADH = 3-hydroxydecanoyl-CoA + NAD+

286270, 486411, 286269

-

2.3.1.155

3-oxodecanoyl-CoA + CoA = acetyl-CoA + octanoyl-CoA

288678

-

2.3.1.16

3-oxodecanoyl-CoA + CoA = acetyl-CoA + octanoyl-CoA

735368

-

2.3.1.16

CoA + 3-oxodecanoyl-CoA = acetyl-CoA + octanoyl-CoA

2206, 288678, 486412, 486417, 486404, 486427

-

2.3.1.16

2 entries

2.3.1.211

4-coumaroyl-CoA + 3-oxodecanoyl-CoA = (1E,4Z)-5-hydroxy-1-(4-hydroxyphenyl)dodeca-1,4-dien-3-one + CoA + CO2 + H2O

722042

-

2.3.1.230

3-oxodecanoyl-CoA + 2-aminobenzoyl-CoA = 2 CoA + 2-heptyl-3-hydroxy-4(1H)-quinolone + CO2

722047

-

3.1.2.2

3-oxodecanoyl-CoA + H2O = CoA + 3-oxodecanoate

646180

-

3.1.2.20

3-oxodecanoyl-CoA + H2O = CoA + 3-oxodecanoate

646180

-

Product in Enzyme-catalyzed Reactions (9 results)

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Show Product (9 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.35

(S)-3-hydroxydecanoyl-CoA + NAD+ = 3-ketodecanoyl-CoA + NADH

286601, 286612

5omo, 3D-view

1.1.1.35

(S)-3-hydroxydecanoyl-CoA + NAD+ = 3-ketodecanoyl-CoA + NADH

286601, 286612

6z5f, 3D-view

1.1.1.35

(S)-3-hydroxydecanoyl-CoA + NAD+ = 3-ketodecanoyl-CoA + NADH

286601, 286612

6z5v, 3D-view

1.1.1.35

(S)-3-hydroxydecanoyl-CoA + ? = 3-oxodecanoyl-CoA + NADH + H+

0

5omo, 3D-view

1.1.1.35

(S)-3-hydroxydecanoyl-CoA + ? = 3-oxodecanoyl-CoA + NADH + H+

0

6z5f, 3D-view

1.1.1.35

(S)-3-hydroxydecanoyl-CoA + ? = 3-oxodecanoyl-CoA + NADH + H+

0

6z5v, 3D-view

1.1.1.36

(3R)-3-hydroxydecanoyl-CoA + NADP+ = 3-oxodecanoyl-CoA + NADPH + H+

0

-

1.1.1.36

(3R)-hydroxydecanoyl-CoA + NAD+ = 3-oxodecanoyl-CoA + NADH

0

-

1.1.1.36

(R)-3-hydroxydecanoyl-CoA + NAD+ = 3-oxodecanoyl-CoA + NADH + H+

0

-

1.1.1.35

6 entries

1.1.1.36

3 entries

Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.3.8.7

medium- and long-chain acyl-CoA dehydrogenase

391283

-

3D Structure of Enzyme-Ligand-Complex (PDB) (18 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (18 entries)

EC NUMBER

ENZYME 3D STRUCTURE

1.1.1.35

5omo, 3D-view

1.1.1.35

6z5f, 3D-view

1.1.1.35

6z5v, 3D-view

1.1.1.35

5omo, 3D-view

1.1.1.35

6z5f, 3D-view

1.1.1.35

6z5v, 3D-view

4.2.1.17

5omo, 3D-view

4.2.1.17

6z5f, 3D-view

4.2.1.17

6z5v, 3D-view

4.2.1.17

5omo, 3D-view

4.2.1.17

6z5f, 3D-view

4.2.1.17

6z5v, 3D-view

5.3.3.8

5omo, 3D-view

5.3.3.8

6z5f, 3D-view

5.3.3.8

6z5v, 3D-view

5.3.3.8

5omo, 3D-view

5.3.3.8

6z5f, 3D-view

5.3.3.8

6z5v, 3D-view

1.1.1.35

6 entries

4.2.1.17

6 entries

5.3.3.8

6 entries

Enzyme Kinetic Parameters

K_M Value (3 results)

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Show KM Value (3 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.3.1.155

0.008

-

-

288678

2.3.1.16

0.0018

-

-

486412

2.3.1.16

0.0021

-

-

486404

2.3.1.16

2 entries

K_i Value (1 result)

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Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.3.8.7

0.0007

-

-

391283

References & Links

Literature References (17)

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Show Reference (17 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

2206

368024

Five different enzymatic activities are associated with the multienzyme complex of fatty acid oxidation from Escherichia coli

1979

Pramanik, A.; Pawar, S.; Antonian, E.; Schulz, H.

J. Bacteriol.

137

469-473

286269

7150615

The existence of an inner-membrane-bound, long acyl-chain-specific 3-hydroxyacyl-CoA dehydrogenase in mammalian mitochondria

1982

El-Fakhri, M.; Middleton, B.

Biochim. Biophys. Acta

713

270-279

286270

1550553

Human liver long-chain 3-hydroxyacyl-coenzyme A dehydrogenase is a multifunctional membrane-bound beta-oxidation enzyme of mitochondria

1992

Carpenter, K.; Pollitt, R.J.; Middleton, B.

Biochem. Biophys. Res. Commun.

183

443 - 448

286601

6773478

Purification and properties of mitochondrial and peroxisomal 3-hydroxyacyl-CoA dehydrogenase from rat liver

1980

Osumi, T.; Hashimoto, T.

Arch. Biochem. Biophys.

203

372-383

286612

13163047

Studies on the fatty acid oxidizing system of animal tissues. IV. beta-hydroxyacyl coenzyme A dehydrogenase

1954

Wakil, S.J.; Green, D.E.; Mil, S.; Mahler, H.R.

J. Biol. Chem.

207

631-638

288678

6117552

Properties of peroxisomal 3-ketoacyl-CoA thiolase from rat liver

1981

Miyazawa, S.; Furuta, S.; Osumi, T.; Hashimoto, T.; Ui, N.

J. Biochem.

90

511-519

391283

7059177

Separation, properties, and regulation of acyl coenzyme A dehydrogenases from bovine heart and liver

1982

Davidson, B.; Schulz, H.

Arch. Biochem. Biophys.

213

155-162

486404

-

3-Ketoacyl-Co-A-thiolase with broad chain length specificity from pig heart muscle

1981

Schulz, H.; Staack, H.

Methods Enzymol.

71

389-403

486411

8449315

A unique, membrane-bound, multifunctional enzyme from human liver mitochondria catalysing three steps of fatty acid beta-oxidation

1992

Carpenter, K.; Pollitt, R.J.; Middleton, B.

Biochem. Soc. Trans.

21

35S

486412

344310

Purification and properties of a pig heart thiolase with broad chain length specificity and comparison of thiolases from pig heart and Escherichia coli

1978

Staack, H.; Binstock, J.F.; Schulz, H.

J. Biol. Chem.

253

1827-1831

486417

2048733

An acyl-coenzyme A chain length dependent assay for 3-oxoacyl-coenzyme A thiolases employing acetyldithio-coenzyme A

1991

Wrensford, L.V.; Coppola, C.; Anderson, V.E.

Anal. Biochem.

192

49-54

486427

-

Characterization of two 3-ketothiolases possessing differing substrate specificities in the polyhydroxyalkanoate synthesizing organism Alcaligenes eutrophus

1988

Haywood, G.H.; Anderson, A.J.; Chu, L.; Dawes, E.A.

FEMS Microbiol. Lett.

52

91-96

646180

35538

Isolation, properties, and regulation of a mitochondrial acyl coenzyme A thioesterase from pig heart

1979

Lee, K.Y.; Schulz, H.

J. Biol. Chem.

254

4516-4523

667257

16085817

Expression of 3-ketoacyl-acyl carrier protein reductase (fabG) genes enhances production of polyhydroxyalkanoate copolymer from glucose in recombinant Escherichia coli JM109

2005

Nomura, C.T.; Taguchi, K.; Gan, Z.; Kuwabara, K.; Tanaka, T.; Takase, K.; Doi, Y.

Appl. Environ. Microbiol.

71

4297-4306

722042

20836122

Production of dehydrogingerdione derivatives in Escherichia coli by exploiting a curcuminoid synthase from Oryza sativa and a beta-oxidation pathway from Saccharomyces cerevisiae

2010

Katsuyama, Y.; Ohnishi, Y.; Horinouchi, S.

ChemBioChem

11

2034-2041

722047

21425231

Biosynthesis of 2-Alkyl-4(1H)-quinolones in Pseudomonas aeruginosa: potential for therapeutic interference with pathogenicity

2011

Pistorius, D.; Ullrich, A.; Lucas, S.; Hartmann, R.W.; Kazmaier, U.; Müller, R.

Chembiochem

12

850-853

735368

25478839

The crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase (T1): insight into the reaction mechanism of its thiolase and thioesterase activities

2014

Kiema, T.R.; Harijan, R.K.; Strozyk, M.; Fukao, T.; Alexson, S.E.; Wierenga, R.K.

Acta Crystallogr. Sect. D

70

3212-3225

Links to other databases for 3-oxodecanoyl-CoA

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Show Links (1 entry)

ChEBI

PubChem