Ligand 15-ketoprostaglandin E1

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Basic Ligand Information

Molecular Structure
Picture of 15-ketoprostaglandin E1 (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C20H32O5
15-ketoprostaglandin E1
VXPBDCBTMSKCKZ-XQHNHVHJSA-N
Synonyms:
(13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate, (13E)-11alpha-Hydroxy-9,15-dioxoprosta-13-enoate, 15-ketoprostaglandin E, 15-oxoprostaglandin E1

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
15-ketoprostaglandin E + NAD(P)H = ?
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
11alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ = (13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate + NAD(P)H + H+
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
15-oxoprostaglandin E1 + NAD(P)H = ? + NAD(P)+
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
11alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ = (13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate + NAD(P)H + H+
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (6 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
40
-
30°C

KM Value (9 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0521
-
at pH 7.0
0.001
-
30°C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.26
-
substrate prostaglandin E1

References & Links

Links to other databases for 15-ketoprostaglandin E1

ChEBI
PubChem
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PubChem