Ligand 2'-deoxycytidine

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Basic Ligand Information

Molecular Structure
Picture of 2'-deoxycytidine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C9H13N3O4
2'-deoxycytidine
CKTSBUTUHBMZGZ-SHYZEUOFSA-N
Synonyms:
2'-dC, 2'-deoxy-cytidine, 2-deoxycytidine, cytosine desoxyriboside, D-2'-deoxycytidine, D-deoxycytidine, deoxcytidine, deoxycytidine


Show all pahtways known for Show all BRENDA pathways known for 2'-deoxycytidine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (44 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2'-deoxycytidine + 2 O2 + H2O = 2'-deoxy-1-riburonosylcytosine + 2 H2O2
show the reaction diagram
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ATP + 2'-deoxycytidine = ADP + 2'-deoxycytidine 5'-phosphate
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ATP + 2'-deoxycytidine = ADP + 2'-deoxycytidine 5'-phosphate
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deoxycytidine + H2O = deoxyuridine + NH3
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2'-deoxycytidine + H2O = 2'-deoxyuridine + NH3
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5'-dCMP + H2O = 2'-deoxycytidine + phosphate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (194 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
deoxycytidine + O2 = 1-riburonosylcytosine + H2O
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2'-deoxycytidine + 2 O2 + H2O = 2'-deoxy-1-riburonosylcytosine + 2 H2O2
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p-nitrophenyl phosphate + 2'-deoxycytidine = ?
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deoxycytidine + H2O = D-deoxyribose + cytosine
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2'-deoxycytidine + H2O = cytosine + 2-deoxy-D-ribose
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deoxycytidine + H2O = deoxyuridine + NH3
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deoxycytidine + H2O = ?
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2'-deoxycytidine + H2O = 2'-deoxyuridine + NH3
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Product in Enzyme-catalyzed Reactions (24 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5'-dCMP + thymidine = 2'-deoxycytidine + TMP
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5'-dCMP + H2O = deoxycytidine + phosphate
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5'-dCMP + H2O = deoxycytidine + phosphate
show the reaction diagram
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dCTP + H2O = deoxycytidine + triphosphate
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
30 mM, 584% activation of deoxyadenosine phosphorylation, half-maximal activation at 0.1 mM
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Inhibitor in Enzyme-catalyzed Reactions (44 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
binding modelling, overview
competitive
-

3D Structure of Enzyme-Ligand-Complex (PDB) (12 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (62 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
3.5
-
in 50 mM Tris-HCl buffer pH 7.5 at 25C

KM Value (135 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.32
-
-
0.34
-
pH 7.6, recombinant mitochondrial deoxyguanosine kinase

Ki Value (8 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
TABLE ID
3
-
pH 7.5, 37C, wild-type enzyme, versus uridine
21218

References & Links

Links to other databases for 2'-deoxycytidine

ChEBI
PubChem
ChEBI
PubChem