• BRENDA home

• Basic Ligand Information
• • Molecular Structure
  • Sum Formula
  • BRENDA Name
  • Synonyms
  • InChIKey
  • Pathways
• Roles as Enzyme Ligand
• • In Vivo Substrate
  • In Vivo Product
  • Substrate
  • Product
  • Cofactor
  • Activator
  • Inhibitor
  • Metals and Ions
  • 3D Structure (PDB)
• Enzyme Kinetic Parameters
• • k_cat Value (Turnover Number)
  • K_M Value
  • K_i Value
  • IC₅₀ Value
• References & Links
• • References
  • Links

print visible entries

print all entries

Ligand 2-hydroxy-6-oxo-6-(2-hydroxyphenyl)hexa-2,4-dienoate

Basic Ligand Information

Molecular Structure

close all tables

open all tables

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

top print hide

Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.7.1.8

2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate + H2O = 2-hydroxypenta-2,4-dienoate + benzoate

755881

-

3.7.1.8

2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate + H2O = 2-oxopent-4-enoate + salicylate + H+

722479

-

3.7.1.8

2 entries

Substrate in Enzyme-catalyzed Reactions (4 results)

top print hide

Show Substrate (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.7.1.13

2-hydroxy-6-oxo-6-(2-hydroxyphenyl)hexa-2,4-dienoate + H2O = ?

707775

-

3.7.1.8

2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate + H2O = 2-hydroxypenta-2,4-dienoate + benzoate

755881, 757447

-

3.7.1.8

2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate + H2O = 2-oxopent-4-enoate + salicylate + H+

722479

-

3.7.1.8

2-hydroxy-6-oxo-6-(2-hydroxyphenyl)hexa-2,4-dienoate + H2O = 2-oxopent-4-enoate + salicylate

247042

-

3.7.1.8

3 entries

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

top print hide

Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

3.7.1.8

11.61

-

pH 7.0, 30°C

755881

K_M Value (1 result)

top print hide

Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.7.1.8

0.14

-

pH 7.0, 30°C

755881

References & Links

Literature References (5)

top print hide

Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

247042

7764304

Purification of two isofunctional hydrolases (EC 3.7.1.8) in the degradative pathway for dibenzofuran in Sphingomonas sp. strain RW1

1993

Buenz, P.V.; Falchetto, R.; Cook, A.M.

Biodegradation

4

171-178

707775

12619671

Purification and characterization of meta-cleavage compound hydrolase from a carbazole degrader Pseudomonas resinovorans strain CA10

2003

Nojiri, H.; Taira, H.; Iwata, K.; Morii, K.; Nam, J.W.; Yoshida, T.; Habe, H.; Nakamura, S.; Shimizu, K.; Yamane, H.; Omori, T.

Biosci. Biotechnol. Biochem.

67

36-45

722479

8449871

Metabolism of 2,2'-dihydroxybiphenyl by Pseudomonas sp. strain HBP1: production and consumption of 2,2',3-trihydroxybiphenyl

1993

Kohler, H.P.; Schmid, A.; van der Maarel, M.

J. Bacteriol.

175

1621-8

755881

31240368

Identification and characterization of a meta-cleavage product hydrolase involved in biphenyl degradation from Arthrobacter sp. YC-RL1

2019

Jia, Y.; Wang, J.; Ren, C.; Nahurira, R.; Khokhar, I.; Wang, J.; Fan, S.; Yan, Y.

Appl. Microbiol. Biotechnol.

103

6825-6836

757447

28783597

A water-assisted nucleophilic mechanism utilized by BphD, the meta-cleavage product hydrolase in biphenyl degradation

2017

Dong, L.; Zhang, S.; Liu, Y.

J. Mol. Graph. Model.

76

448-455

Links to other databases for 2-hydroxy-6-oxo-6-(2-hydroxyphenyl)hexa-2,4-dienoate

top print hide

Show Links (1 entry)

ChEBI

PubChem

-