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Purification and characterization of a neutral ceramidase from mouse liver
2000
Tani, M.; Okino, N.; Mitsutake, S.; Tanigawa, T.; Izu, H.; Ito, M.
J. Biol. Chem.
275
3462-3468
Purification and characterization of a novel ceramidase from Pseudomonas aeruginoa
1998
Okino, N.; Tani, M.; Imayama, S.; Ito, M.
J. Biol. Chem.
273
14368-14373
Properties of rat liver N-acylethanolamine amidohydrolase
1985
Schmid, P.C.; Zuzarte-Augustin, M.L.; Schmid, H.H.O.
J. Biol. Chem.
260
14145-14149
Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity
2004
Monick, M.M.; Mallampalli, R.K.; Bradford, M.; McCoy, D.; Gross, T.J.; Flaherty, D.M.; Powers, L.S.; Cameron, K.; Kelly, S.; Merrill, A.H.; Hunninghake, G.W.
J. Immunol.
173
123-135
The N-acylethanolamine-hydrolyzing acid amidase (NAAA)
2007
Tsuboi, K.; Takezaki, N.; Ueda, N.
Chem. Biodivers.
4
1914-1925
A second fatty acid amide hydrolase with variable distribution among placental mammals
2006
Wei, B.Q.; Mikkelsen, T.S.; McKinney, M.K.; Lander, E.S.; Cravatt, B.F.
J. Biol. Chem.
281
36569-36578
Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase
1999
Lang, W.; Qin, C.; Lin, S.; Khanolkar, A.D.; Goutopoulos, A.; Fan, P.; Abouzid, K.; Meng, Z.; Biegel, D.; Makriyannis, A.
J. Med. Chem.
42
898-902
Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase
2009
Karbarz, M.J.; Luo, L.; Chang, L.; Tham, C.S.; Palmer, J.A.; Wilson, S.J.; Wennerholm, M.L.; Brown, S.M.; Scott, B.P.; Apodaca, R.L.; Keith, J.M.; Wu, J.; Breitenbucher, J.G.; Chaplan, S.R.; Webb, M.
Anesth. Analg.
108
316-329
Radiochromatographic assay of N-acyl-phosphatidylethanolamine-specific phospholipase D activity
2005
Fezza, F.; Gasperi, V.; Mazzei, C.; Maccarrone, M.
Anal. Biochem.
339
113-120
Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA
2011
Novgorodov, S.A.; Wu, B.X.; Gudz, T.I.; Bielawski, J.; Ovchinnikova, T.V.; Hannun, Y.A.; Obeid, L.M.
J. Biol. Chem.
286
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Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases
2011
Canals, D.; Perry, D.M.; Jenkins, R.W.; Hannun, Y.A.
Br. J. Pharmacol.
163
694-712
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Ceramide, a crucial functional lipid, and its metabolic regulation by acid ceramidase
2010
Park, J.; Yoon, S.
Food Sci. Biotechnol.
19
859-864
Discovery and evaluation of inhibitors of human ceramidase
2011
Draper, J.M.; Xia, Z.; Smith, R.A.; Zhuang, Y.; Wang, W.; Smith, C.D.
Mol. Cancer Ther.
10
2052-2061
Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain
2010
Leonardi, R.; Zhang, Y.M.; Yun, M.K.; Zhou, R.; Zeng, F.Y.; Lin, W.; Cui, J.; Chen, T.; Rock, C.O.; White, S.W.; Jackowski, S.
Chem. Biol.
17
892-902
Novel amide- and sulfonamide-based aromatic ethanolamines: Effects of various substituents on the inhibition of acid and neutral ceramidases
2012
Bhabak, K.; Arenz, C.
Bioorg. Med. Chem.
20
6162-6170
Effective inhibition of acid and neutral ceramidases by novel B-13 and LCL-464 analogues
2013
Bhabak, K.P.; Kleuser, B.; Huwiler, A.; Arenz, C.
Bioorg. Med. Chem.
21
874-882
Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL)
2014
Korhonen, J.; Kuusisto, A.; van Bruchem, J.; Patel, J.Z.; Laitinen, T.; Navia-Paldanius, D.; Laitinen, J.T.; Savinainen, J.R.; Parkkari, T.; Nevalainen, T.J.
Bioorg. Med. Chem.
22
6694-6705
Discovery of a new class of highly potent inhibitors of acid ceramidase: synthesis and structure-activity relationship (SAR)
2013
Pizzirani, D.; Pagliuca, C.; Realini, N.; Branduardi, D.; Bottegoni, G.; Mor, M.; Bertozzi, F.; Scarpelli, R.; Piomelli, D.; Bandiera, T.
J. Med. Chem.
56
3518-3530
Advances in the discovery of N-acylethanolamine acid amidase inhibitors
2014
Bandiera, T.; Ponzano, S.; Piomelli, D.
Pharmacol. Res.
86
11-17
Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity
2013
Realini, N.; Solorzano, C.; Pagliuca, C.; Pizzirani, D.; Armirotti, A.; Luciani, R.; Costi, M.P.; Bandiera, T.; Piomelli, D.
Sci. Rep.
3
1035
N-acylethanolamines bind to SIRT6
2016
Rahnasto-Rilla, M.; Kokkola, T.; Jarho, E.; Lahtela-Kakkonen, M.; Moaddel, R.
ChemBioChem
17
77-81
A potent systemically active N-acylethanolamine acid amidase inhibitor that suppresses inflammation and human macrophage activation
2015
Ribeiro, A.; Pontis, S.; Mengatto, L.; Armirotti, A.; Chiurchiu, V.; Capurro, V.; Fiasella, A.; Nuzzi, A.; Romeo, E.; Moreno-Sanz, G.; Maccarrone, M.; Reggiani, A.; Tarzia, G.; Mor, M.; Bertozzi, F.; Bandiera, T.; Piomelli, D.
ACS Chem. Biol.
10
1838-1846
In vitro and in vivo pharmacological characterization of ASP8477 A novel highly selective fatty acid amide hydrolase inhibitor
2017
Watabiki, T.; Tsuji, N.; Kiso, T.; Ozawa, T.; Narazaki, F.; Kakimoto, S.
Eur. J. Pharmacol.
815
42-48
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