Ligand L-cysteic acid

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Basic Ligand Information

Molecular Structure
Picture of L-cysteic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C3H7NO5S
L-cysteic acid
XVOYSCVBGLVSOL-REOHCLBHSA-N
Synonyms:
cysteate, cysteic acid, cysteine sulfonate, L-cysteate, L-cysteinic acid

Show all pahtways known for Show all BRENDA pathways known for L-cysteic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-cysteate + H2O = pyruvate + bisulfite + NH3
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-cysteic acid + H2O + O2 = ? + NH3 + H2O2
show the reaction diagram
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L-Cysteic acid = ?
show the reaction diagram
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L-cysteate + H2O = pyruvate + bisulfite + NH3
show the reaction diagram
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L-Cysteate = D-Cysteate
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Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-phosphoserine + sulfite = L-cysteate + phosphate
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L-Cys + sulfite = L-cysteate + H2S
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Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
5 mM, 2fold stimulation
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1 mM, 151% of initial activity
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stimulates
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Inhibitor in Enzyme-catalyzed Reactions (18 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
weak inhibition
-
5.38 mM, 50% inhibition of brain KAT I, 1.55 mM, 50% inhibition of brain KAT II
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0.1 mM, 40% inhibition
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sulfo transition state mimic, competitive inhibitor
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50 mM, 25% inhibition
-
-
-
-
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poor
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3D Structure of Enzyme-Ligand-Complex (PDB) (813 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

KM Value (8 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
5.4
-
-
11.7
-
pH 9.0, 30°C

Ki Value (7 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.4
-
pH 5.8, 37°C

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
12.6
-
pH 7.0, 37°C

References & Links

Links to other databases for L-cysteic acid

ChEBI
PubChem
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PubChem