Ligand kynurenic acid

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Basic Ligand Information

Molecular Structure
Picture of kynurenic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H7NO3
kynurenic acid
HCZHHEIFKROPDY-UHFFFAOYSA-N
Synonyms:
4-Hydroxy-2-quinolinecarboxylate, 4-hydroxy-2-quinolinecarboxylic acid, 4-hydroxyquinoline-2-carboxylic acid, Kynurenate

Show all pahtways known for Show all pathways known for kynurenic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-kynurenine + 2-oxoglutarate = kynurenic acid + L-glutamate + H2O
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Product in Enzyme-catalyzed Reactions (37 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
quinaldate + acceptor = kynurenate + reduced acceptor
show the reaction diagram
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L-kynurenine + ? = kynurenic acid + ?
show the reaction diagram
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-
kynurenine + 2-oxoglutarate = kynurenic acid + L-glutamate
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.1 mM, 57.2% inhibition. 1 mM, 99.4% inhibition
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13% inhibition at 2 mM and 5% inhibition at 0.2 mM
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competitive inhibition at 0.2 mM
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40% inhibition at 0.002 mM
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IC50: 0.67 mM
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weak inhibition
1 mM, 59% residual activity
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.008
-
-

IC50 Value (8 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.67
-
IC50: 0.67 mM

References & Links

Links to other databases for kynurenic acid

ChEBI
PubChem
ChEBI
PubChem