Ligand glycochenodeoxycholic acid

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Basic Ligand Information

Molecular Structure
Picture of glycochenodeoxycholic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C26H43NO5
glycochenodeoxycholic acid
GHCZAUBVMUEKKP-GYPHWSFCSA-M
Synonyms:
3alpha,7alpha-Dihydroxy-5beta-cholanoyl glycine, glycine conjugated chenodeoxycholate, glycochenodeoxycholate, N-(3alpha,7alpha-dihydroxy-5beta-cholan-24-oyl)-glycine


Show all pahtways known for Show all BRENDA pathways known for glycochenodeoxycholic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3'-phosphoadenylyl 5'-phosphosulfate + glycochenodeoxycholate = adenosine 3',5'-bisphosphate + ?
show the reaction diagram
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glycochenodeoxycholic acid + H2O = chenodeoxycholate + glycine
show the reaction diagram
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ATP + H2O + chenodeoxycholylglycine/in = ADP + phosphate + chenodeoxycholylglycine/out
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + H2O + chenodeoxycholylglycine/in = ADP + phosphate + chenodeoxycholylglycine/out
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
glycochenodeoxycholic acid + NAD(P)+ = N[7alpha-hydroxy-3-oxo-5beta-cholan-24-oyl]glycine + NAD(P)H
show the reaction diagram
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glycochenodeoxycholic acid + NAD+ = 7alpha-hydroxy-3-oxo-5-beta-cholanoyl glycine + NADH
show the reaction diagram
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3'-phosphoadenylyl 5'-phosphosulfate + glycochenodeoxycholate = adenosine 3',5'-bisphosphate + ?
show the reaction diagram
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ATP + H2O + chenodeoxycholylglycine/in = ADP + phosphate + chenodeoxycholylglycine/out
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
chenodeoxycholoyl-CoA + glycine = CoA + glycochenodeoxycholate
show the reaction diagram
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ATP + H2O + chenodeoxycholylglycine/in = ADP + phosphate + chenodeoxycholylglycine/out
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
bile salt regulation of lipid metabolism via both activation and inhibition of PLA2, interaction and binding structure analysis, overview

Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
bile salt regulation of lipid metabolism via both activation and inhibition of PLA2, interaction and binding structure analysis, overview

3D Structure of Enzyme-Ligand-Complex (PDB) (15 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (8 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.2
-
-
0.02
-
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KM Value (18 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0075
-
-

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0071
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C

References & Links

Links to other databases for glycochenodeoxycholic acid

ChEBI
PubChem
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PubChem