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Ligand diethanolamine

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (5 results)

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Show Substrate (5 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.3.17

diethanolamine + O2 = ?

389716

-

2.7.1.32

diethanolamine + ATP = ADP + O-phospho-diethanolamine

685011

-

2.7.1.82

ATP + diethanolamine = ADP + O2-[(2-hydroxyethyl)amino]ethyl phosphate

685011

-

3.1.4.4

1,2-dioleoyl-sn-glycerophosphocholine + diethanolamine = choline + 1,2-dioleoyl-sn-glycerophospho-diethanolamine

691771

-

3.1.4.4

2 1,2-dioleoyl-sn-glycerophosphocholine + diethanolamine = 2 choline + bis(1,2-dioleoyl-sn-glycerophospho)-diethanolamine

691771

-

3.1.4.4

2 entries

Activator in Enzyme-catalyzed Reactions (2 results)

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Show Activating Compound (2 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.1.3.1

highly activates BIALP. Km values increase with increasing concentrations of diethanolamine and N-methylethanolamine, but not triethanolamine

714864

-

3.1.8.2

-

751964

-

Inhibitor in Enzyme-catalyzed Reactions (8 results)

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Show Inhibitors (8 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.2.1.23

causes 40% inhibition of the enzyme activated by L-2-aminopropan-1-ol at a concentration of 50 mM

288143

-

2.8.2.6

-

643827

-

3.2.1.10

about 80% inhibition of isomaltase activity by 50 mM

136520

-

3.2.1.33

-

171379

-

3.2.1.37

-

707563

-

3.2.1.48

-

136520

-

3.4.24.75

-

752549

-

4.2.1.27

-

644460

-

Enzyme Kinetic Parameters

K_i Value (2 results)

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Show KI Value (2 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.2.1.37

0.205

-

substrate 4-nitrophenyl-beta-D-xylopyranoside, 25°C, pH 7.0

707563

3.2.1.37

0.22

-

substrate 4-nitrophenyl-alpha-L-arabinofuranoside, 25°C, pH 7.0

707563

3.2.1.37

2 entries

References & Links

Literature References (12)

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Show Reference (12 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

136520

8924896

Inhibition of purified human sucrase and isomaltase by ethanolamine derivatives

1996

Kano, T.; Usami, Y.; Adachi, T.; Tatematsu, M.; Hirano, K.

Biol. Pharm. Bull.

19

341-344

171379

5805288

Purification and properties of rabbit muscle amylo-1,6-glucosidase-oligo-1,4->1,4-transferase

1969

Nelson, T.E.; Kolb, E.; Larner, J.

Biochemistry

8

1419-1428

288143

998

Purification of 2-oxoaldehyde dehydrogenase and its dependence on unusual amines

1975

Dunkerton, J.; James, S.P.

Biochem. J.

149

609-617

389716

599154

Purification and characterization of choline oxidase from Arthrobacter globiformis

1977

Ikuta, S.; Imamura, S.; Misaki, H.; Horiuti, Y.

J. Biochem.

82

1741-1749

643827

14202240

Choline sulphokinase (sulfotransferase)

1964

Orsi, B.A.; Spencer, B.

J. Biochem.

56

81-91

644460

13654296

Enzymatic utilization of acetylenic compounds. II. Acetylenemonocarboxylc acid hydrase

1959

Yamada, E.W.; Jakoby, W.B.

J. Biol. Chem.

234

941-945

685011

18489261

Biochemical characterization of the initial steps of the Kennedy pathway in Trypanosoma brucei: the ethanolamine and choline kinases

2008

Gibellini, F.; Hunter, W.N.; Smith, T.K.

Biochem. J.

415

135-144

691771

18302938

Phospholipase D-catalyzed synthesis of new phospholipids with polar head groups

2008

Dippe, M.; Mrestani-Klaus, C.; Schierhorn, A.; Ulbrich-Hofmann, R.

Chem. Phys. Lipids

152

71-77

707563

18973836

Aminoalcohols as probes of the two-subsite active site of beta-D-xylosidase from Selenomonas ruminantium

2009

Jordan, D.; Mertens, J.; Braker, J.

Biochim. Biophys. Acta

1794

144-158

714864

22112405

Effects of amines and aminoalcohols on bovine intestine alkaline phosphatase activity

2011

Sekiguchi, S.; Hashida, Y.; Yasukawa, K.; Inouye, K.

Enzyme Microb. Technol.

49

171-176

751964

28085964

Aminoalcohol-induced activation of organophosphorus hydrolase (OPH) towards diisopropylfluorophosphate (DFP)

2017

Li, D.; Zhang, Y.; Song, H.; Lu, L.; Liu, D.; Yuan, Y.

PLoS ONE

12

e0169937

752549

29728390

Unprotonated short-chain alkylamines inhibit staphylolytic activity of lysostaphin in a wall teichoic acid-dependent manner

2018

Wu, X.; Kwon, S.J.; Kim, D.; Zha, J.; Mora-Pale, M.; Dordick, J.S.

Appl. Environ. Microbiol.

84

e00693-18

Links to other databases for diethanolamine

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ChEBI

PubChem