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Ligand ManGlcNAc

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.2.1.152

Man-beta-(1-4)GlcNAc + H2O = ?

659383, 659098, 658680, 659075

-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.2.1.24

alpha-D-mannosidosis fibroblasts + H2O = Manbeta(1-4)GlcNAc + ?

135962

-

Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.2.1.152

Man-beta-(1-4)GlcNAc + H2O = ?

659383, 659098, 658680, 659075

-

3.2.1.152

Man-beta-1-4GlcNAc + H2O = ?

658680

-

3.2.1.152

2 entries

3.2.1.25

Man-(beta1-4)GlcNAc + H2O = mannose + GlcNAc

136040, 136038, 136041

-

Product in Enzyme-catalyzed Reactions (4 results)

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Show Product (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.2.1.114

D-Manalpha(1-3)Manbeta(1-4)GlcNAc + H2O = D-Manbeta(1-4)GlcNAc + alpha-D-mannose

0, 586942

-

3.2.1.24

alpha-D-mannosidosis fibroblasts + H2O = Manbeta(1-4)GlcNAc + ?

135962

-

3.2.1.96

beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-Asn = beta-D-Man-(1->4)-beta-D-GlcNAc + beta-D-GlcNAc-Asn

0

-

3.2.1.96

N4-(beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-N2-dansyl-L-Asn + H2O = beta-D-Man-(1->4)-beta-D-GlcNAc + N4-(beta-D-GlcNAc)-N2-dansyl-L-Asn

0

-

3.2.1.96

2 entries

Enzyme Kinetic Parameters

References & Links

Literature References (9)

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Show Reference (9 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

135962

9305783

Cloning, expression, purification, and characterization of the murine lysosomal acid alpha-mannosidase

1997

Merkle, R.K.; Zhang, Y.; Ruest, P.J.; Lal, A.; Liao, Y.F.; Moremen, K.W.

Biochim. Biophys. Acta

1336

132-146

136038

26672

Purification and characterization of beta-D-mannosidase and beta-N-acetyl-D-hexosaminidase of Tremella fuciformis

1978

Sone, Y.; Misaki, A.

J. Biochem.

83

1135-1144

136040

845158

Purification and properties of a beta-mannosidase from Aspergillus niger

1977

Elbein, A.D.; Adya, S.; Lee, Y.C.

J. Biol. Chem.

252

2026-2031

136041

6478

beta-Mannosidase from the mushroom Polyporus sulfureus

1976

Wan, C.C.; Muldrey, J.E.; Li, S.C.; Li, Y.T.

J. Biol. Chem.

251

4384-4388

586942

3745139

Purification and characterization of a novel alpha-mannosidase from Aspergillus saitoi

1986

Amano, J.; Kobata, A.

J. Biochem.

99

1645-1654

658680

15794753

Synthesis of beta-mannosides using the transglycosylation activity of endo-beta-mannosidase from Lilium longiflorum

2005

Sasaki, A.; Ishimizu, T.; Geyer, R.; Hase, S.

FEBS J.

272

1660-1668

659075

9990135

Partial purification and characterization of a novel endo-beta-mannosidase acting on N-linked sugar chains from Lilium longflorum thumb

1999

Sasaki, A.; Yamagishi, M.; Mega, T.; Norioka, S.; Natsuka, S.; Hase, S.

J. Biochem.

125

363-367

659098

15713887

Substrate specificity and molecular cloning of the lily endo-beta-mannosidase acting on N-glycan

2005

Sasaki, A.; Ishimizu, T.; Hase, S.

J. Biochem.

137

87-93

659383

15247239

Endo-beta-mannosidase, a plant enzyme acting on N-glycan: purification, molecular cloning, and characterization

2004

Ishimizu, T.; Sasaki, A.; Okutani, S.; Maeda, M.; Yamagishi, M.; Hase, S.

J. Biol. Chem.

279

38555-38562

Links to other databases for ManGlcNAc

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Show Links (1 entry)

ChEBI

PubChem