Ligand cephalosporin C

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Basic Ligand Information

Molecular Structure
Picture of cephalosporin C (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C16H21N3O8S
cephalosporin C
HOKIDJSKDBPKTQ-GLXFQSAKSA-N

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
cephalosporin C + H2O + O2 = 7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
show the reaction diagram
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cephalosporin C + H2O = deacetylcephalosporin C + acetate
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
cephalosporin C + H2O + O2 = ?
show the reaction diagram
-
cephalosporin C + 2-oxoglutarate = 7-(5-carboxy-5-oxopentanoyl)aminocephalosporinate + D-glutamate
show the reaction diagram
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cephalosporin C + H2O = ?
show the reaction diagram
-
cephalosporin C + H2O = deacetylcephalosporin C + acetate
show the reaction diagram
-
cephalosporin C + H2O = 7-aminocephalosporanic acid
show the reaction diagram
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cephalosporin C + H2O = N6-[(R)-{(2R)-5-[(acetyloxy)methyl]-4-carboxy-3,6-dihydro-2H-1,3-thiazin-2-yl}(carboxy)methyl]-6-oxo-D-lysine
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N-acetyl cephalosporin C + H2O = acetate + cephalosporin C
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
50% inhibition at 0.014 mg/ml
-
zinc salt, inhibition is largely attributable to zinc
-
classical non-specific beta-lactam
-
65% inhibition; 65% inhibition at 1 mM
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3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (45 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
1370
-
-

KM Value (113 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0011
-
pH 7.5, temperature not specified in the publication

References & Links

Links to other databases for cephalosporin C

ChEBI
PubChem
ChEBI
PubChem