print visible entries

print all entries

Ligand 7,8-dihydromethanopterin

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for 7,8-dihydromethanopterin

close all tables

open all tables

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

top print hide

Show Natural Substrate (5 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.5.1.47

7,8-dihydromethanopterin + NAD(P)H + H+ = 5,6,7,8-tetrahydromethanopterin + NAD(P)+

719701

-

1.5.1.47

7,8-dihydromethanopterin + NADPH + H+ = 5,6,7,8-tetrahydromethanopterin + NADP+

764758

-

1.5.99.15

7,8-dihydromethanopterin + FMNH2 = 5,6,7,8-tetrahydromethanopterin + FMN

742870

-

1.5.99.15

7,8-dihydromethanopterin + reduced acceptor = 5,6,7,8-tetrahydromethanopterin + oxidized acceptor

727782

-

1.5.99.15

7,8-dihydromethanopterin + reduced ferredoxin = 5,6,7,8-tetrahydromethanopterin + ferredoxin

742781

-

1.5.1.47

2 entries

1.5.99.15

3 entries

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

top print hide

Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.5.99.15

5,6,7,8-tetrahydromethanopterin + oxidized acceptor = 7,8-dihydromethanopterin + reduced acceptor

0

-

Substrate in Enzyme-catalyzed Reactions (6 results)

top print hide

Show Substrate (6 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.5.1.47

7,8-dihydromethanopterin + NAD(P)H + H+ = 5,6,7,8-tetrahydromethanopterin + NAD(P)+

719701

-

1.5.1.47

7,8-dihydromethanopterin + NADPH + H+ = 5,6,7,8-tetrahydromethanopterin + NADP+

764758

-

1.5.99.15

7,8-dihydromethanopterin + FMNH2 = 5,6,7,8-tetrahydromethanopterin + FMN

742870

-

1.5.99.15

7,8-dihydromethanopterin + reduced acceptor = 5,6,7,8-tetrahydromethanopterin + oxidized acceptor

727782

-

1.5.99.15

7,8-dihydromethanopterin + reduced dithiothreitol = 5,6,7,8-tetrahydromethanopterin + oxidized dithiothreitol

727782

-

1.5.99.15

7,8-dihydromethanopterin + reduced ferredoxin = 5,6,7,8-tetrahydromethanopterin + ferredoxin

742781

-

1.5.1.47

2 entries

1.5.99.15

4 entries

Product in Enzyme-catalyzed Reactions (1 result)

top print hide

Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.5.99.15

5,6,7,8-tetrahydromethanopterin + oxidized acceptor = 7,8-dihydromethanopterin + reduced acceptor

0

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

top print hide

Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

1.5.1.47

1.5

-

pH 5.3, 23°C, recombinant C-terminally His4-tagged enzyme

764758

K_M Value (1 result)

top print hide

Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.5.1.47

0.193

-

pH 5.3, 23°C, recombinant C-terminally His4-tagged enzyme

764758

References & Links

Literature References (5)

top print hide

Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

719701

15028691

Biochemical characterization of a dihydromethanopterin reductase involved in tetrahydromethanopterin biosynthesis in Methylobacterium extorquens AM1

2004

Caccamo, M.A.; Malone, C.S.; Rasche, M.E.

J. Bacteriol.

186

2068-2073

727782

23995635

Discovery and characterization of the first archaeal dihydromethanopterin reductase, an iron-sulfur flavoprotein from Methanosarcina mazei

2014

Wang, S.; Tiongson, J.; Rasche, M.E.

J. Bacteriol.

196

203-209

742781

23995635

Discovery and characterization of the first archaeal dihydromethanopterin reductase, an iron-sulfur flavoprotein from Methanosarcina mazei

2014

Wang, S.; Tiongson, J.; Rasche, M.E.

J. Bacteriol.

196

203-209

742870

24523405

Structure of dihydromethanopterin reductase, a cubic protein cage for redox transfer

2014

McNamara, D.E.; Cascio, D.; Jorda, J.; Bustos, C.; Wang, T.C.; Rasche, M.E.; Yeates, T.O.; Bobik, T.A.

J. Biol. Chem.

289

8852-8864

764758

30364315

Substrate specificity analysis of dihydrofolate/dihydromethanopterin reductase homologs in methylotrophic alpha-proteobacteria

2018

Burton, M.; Abanobi, C.; Wang, K.; Ma, Y.; Rasche, M.

Front. Microbiol.

9

2439

Links to other databases for 7,8-dihydromethanopterin

top print hide

Show Links (1 entry)

ChEBI

PubChem