Ligand 7,8-dihydromethanopterin
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Basic Ligand Information
Molecular Structure

C30H43N6O16P
7,8-dihydromethanopterin
WTMBWYHMZCVPRJ-WJBIZLLUSA-N
Show all BRENDA pathways known for 7,8-dihydromethanopterin
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)
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7,8-dihydromethanopterin + NAD(P)H + H+ = 5,6,7,8-tetrahydromethanopterin + NAD(P)+
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7,8-dihydromethanopterin + NADPH + H+ = 5,6,7,8-tetrahydromethanopterin + NADP+
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7,8-dihydromethanopterin + FMNH2 = 5,6,7,8-tetrahydromethanopterin + FMN
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7,8-dihydromethanopterin + reduced acceptor = 5,6,7,8-tetrahydromethanopterin + oxidized acceptor
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7,8-dihydromethanopterin + reduced ferredoxin = 5,6,7,8-tetrahydromethanopterin + ferredoxin
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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5,6,7,8-tetrahydromethanopterin + oxidized acceptor = 7,8-dihydromethanopterin + reduced acceptor
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Substrate in Enzyme-catalyzed Reactions (6 results)
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7,8-dihydromethanopterin + NAD(P)H + H+ = 5,6,7,8-tetrahydromethanopterin + NAD(P)+
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7,8-dihydromethanopterin + NADPH + H+ = 5,6,7,8-tetrahydromethanopterin + NADP+
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7,8-dihydromethanopterin + FMNH2 = 5,6,7,8-tetrahydromethanopterin + FMN
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7,8-dihydromethanopterin + reduced acceptor = 5,6,7,8-tetrahydromethanopterin + oxidized acceptor
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7,8-dihydromethanopterin + reduced dithiothreitol = 5,6,7,8-tetrahydromethanopterin + oxidized dithiothreitol
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7,8-dihydromethanopterin + reduced ferredoxin = 5,6,7,8-tetrahydromethanopterin + ferredoxin
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Product in Enzyme-catalyzed Reactions (1 result)
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5,6,7,8-tetrahydromethanopterin + oxidized acceptor = 7,8-dihydromethanopterin + reduced acceptor
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (1 result)
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1.5
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pH 5.3, 23°C, recombinant C-terminally His4-tagged enzyme
KM Value (1 result)
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0.193
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pH 5.3, 23°C, recombinant C-terminally His4-tagged enzyme
References & Links
Literature References (5)
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Biochemical characterization of a dihydromethanopterin reductase involved in tetrahydromethanopterin biosynthesis in Methylobacterium extorquens AM1
2004
Caccamo, M.A.; Malone, C.S.; Rasche, M.E.
J. Bacteriol.
186
2068-2073
Discovery and characterization of the first archaeal dihydromethanopterin reductase, an iron-sulfur flavoprotein from Methanosarcina mazei
2014
Wang, S.; Tiongson, J.; Rasche, M.E.
J. Bacteriol.
196
203-209
Discovery and characterization of the first archaeal dihydromethanopterin reductase, an iron-sulfur flavoprotein from Methanosarcina mazei
2014
Wang, S.; Tiongson, J.; Rasche, M.E.
J. Bacteriol.
196
203-209
Structure of dihydromethanopterin reductase, a cubic protein cage for redox transfer
2014
McNamara, D.E.; Cascio, D.; Jorda, J.; Bustos, C.; Wang, T.C.; Rasche, M.E.; Yeates, T.O.; Bobik, T.A.
J. Biol. Chem.
289
8852-8864
Substrate specificity analysis of dihydrofolate/dihydromethanopterin reductase homologs in methylotrophic alpha-proteobacteria
2018
Burton, M.; Abanobi, C.; Wang, K.; Ma, Y.; Rasche, M.
Front. Microbiol.
9
2439
Links to other databases for 7,8-dihydromethanopterin