Ligand phosphatidylinositol

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Basic Ligand Information

Molecular Structure
Picture of phosphatidylinositol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C17H29O13PR2
phosphatidylinositol
SNFSYLYCDAVZGP-OHWKOEMOSA-N
Synonyms:
(3-phosphatidyl)-1-D-inositol, 1,2-diacyl-sn-glycero-3-phosphoinositol, 1-phosphatidyl-1D-myo-inositol, 1-phosphatidyl-D-myo-inositol, 1-phosphatidylinositol, phosphatidyl-1D-myo-inositol, phosphatidyl-myo-inositol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
show the reaction diagram
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1-phosphatidyl-1D-myo-inositol + a very-long-chain mannosylinositol phospho-(2'R)-2'-hydroxyphytoceramide = 1,2-diacyl-sn-glycerol + a very-long-chain mannosyl-diphosphoinositol-(2'R)-2'-hydroxyphytoceramide
show the reaction diagram
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1-phosphatidyl-1D-myo-inositol + H2O = 1D-myo-inositol 1-phosphate + diacylglycerol
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
phosphatidylinositol 4-phosphate + H2O = phosphatidylinositol + phosphate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (69 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + phosphatidylinositol = S-adenosyl-L-homocysteine + ?
show the reaction diagram
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Phosphatidylinositol + lyso-phosphatidylcholine = lyso-Phosphatidylcholine + phosphatidylinositol
show the reaction diagram
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ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 5-phosphate
show the reaction diagram
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1-phosphatidyl-1D-myo-inositol + a very-long-chain mannosylinositol phospho-(2'R)-2'-hydroxyphytoceramide = 1,2-diacyl-sn-glycerol + a very-long-chain mannosyl-diphosphoinositol-(2'R)-2'-hydroxyphytoceramide
show the reaction diagram
-
phosphatidylinositol + H2O = ?
show the reaction diagram
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phosphatidylinositol + H2O = diacylglycerol + inositol phosphate
show the reaction diagram
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phosphatidylinositol = inositol 1,2-cyclic phosphate + inositol phosphate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (19 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
phosphatidylinositol 4-phosphate + H2O = phosphatidylinositol + phosphate
show the reaction diagram
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phosphatidylinositol 3-phosphate + H2O = phosphatidylinositol + phosphate
show the reaction diagram
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phosphatidylinositol 4-phosphate + H2O = phosphatidylinositol + phosphate
show the reaction diagram
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-

Activator in Enzyme-catalyzed Reactions (45 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation of mitochondrial enzyme
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stimulates
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highly required for activity of GlcAT-P and GlcAT-S with paraglobosid and other glycolipids
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strong activation in the presence of 1,2-dioleoylphosphatidylglycerol
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activation of partially purified, delipidated enzyme
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activation
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stimulation
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activates, phosphorylation of beta2-AR, 6fold activation of phosphorylation of RRREEEEESAAA
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required for CMP-dependent incorporation of glycerol 3-phosphate
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slight activation, 0.2 mM
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enhances arylesterase activity, but slightly decreases paraoxonase activity
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1.5fold stimulation of hydrophilic enzyme form
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allosteric activation
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stimulation
-
activates 99% at 1 mM
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acidic, unsaturated phospholipid interfaces interact with acid beta-glucosidase to conform the enzyme into an active structure
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from 0.02 mg to 0.05 mg
-
activates
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stimulates
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2.1fold activation of horse heart cytochrome c mediated reaction, 2.4fold activation of Candida krusei cytchrome c mediated reaction
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Inhibitor in Enzyme-catalyzed Reactions (31 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
3 mM, 68% inhibition
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inhibition of microsomal enzyme
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relative activity: 70%
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effectiveness of various ligands in protection against inhibition, effect of pH and temperature
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2.5 mol% results in 50% inhibition of the phosphatidylcholine-dependent kinase activity
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substrate inhibition
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0.1 mM, 125% stimulation
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strong
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inhibitory if included as aqueous sonicated dispersions at 2.5 mg/ml
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phosphatidic acid is the most effective inhibitor among acidic phospholipids, followed by phosphatidylserine and phosphatidylinositol, phosphorylated myosin as substrate
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strong
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enhances arylesterase activity, but slightly decreases paraoxonase activity
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CaCl2 or NaCl restores
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addition of 0.05 mM phosphatidic acid decreases PEPC activity to approximately 40% of the control activity
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3D Structure of Enzyme-Ligand-Complex (PDB) (11 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (48 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.4
-
-
0.037
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IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.588
-
CHAPS-washed membranes, pH 7.5, 23°C

References & Links

Links to other databases for phosphatidylinositol

ChEBI
PubChem
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PubChem