print visible entries

print all entries

Ligand phosphatidylinositol

Basic Ligand Information

Molecular Structure

Pathway Source

Pathways

KEGG

Autophagy - animal, Autophagy - other, Autophagy - yeast, Glycerophospholipid metabolism, Glycosylphosphatidylinositol (GPI)-anchor biosynthesis, Inositol phosphate metabolism, Lipoarabinomannan (LAM) biosynthesis, Phosphatidylinositol signaling system, Salmonella infection, Tuberculosis more

MetaCyc

3-phosphoinositide biosynthesis, 3-phosphoinositide degradation, D-myo-inositol (1,4,5)-trisphosphate biosynthesis, phosphatidylinositol biosynthesis I (bacteria), phosphatidylinositol biosynthesis II (eukaryotes), phosphatidylinositol mannoside biosynthesis, sphingolipid biosynthesis (plants), sphingolipid biosynthesis (yeast), superpathway of phospholipid biosynthesis II (plants) more

close all tables

open all tables

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (14 results)

top print hide

Show Natural Substrate (14 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.198

UDP-N-acetyl-alpha-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol

759489, 758711, 759061

-

2.4.1.198

UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol

723140, 736462

-

2.4.1.198

UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol

703374, 638133, 638129, 638131, 638132, 638134, 638135, 288963, 638128

-

2.4.1.345

GDP-alpha-D-mannose + 1-phosphatidyl-1D-myo-inositol = GDP + 2-O-(alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol

660449

-

2.4.1.345

GDP-mannose + phosphatidyl-myo-inositol = GDP + phosphatidyl-(2-O-alpha-D-manno-pyranosyl)-myo-inositol

660449

-

2.4.1.345

GDP-mannose + phosphatidylinositol = GDP + phosphatidyl-(2-O-alpha-D-manno-pyranosyl)-myo-inositol

659183, 680790

-

2.7.1.137

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate

708146, 709003, 709207, 708336, 707877, 760521, 760661, 739359, 761826, 762179, 738465, 761792, 708568, 708996

-

2.7.1.137

ATP + 1-phosphatidylinositol = ADP + phosphatidylinositol 3-phosphate

675009

-

2.4.1.198

3 entries

2.4.1.345

3 entries

2.7.1.137

2 entries

2.7.1.153

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate

708568

-

2.7.1.228

1-phosphatidyl-1D-myo-inositol + a very-long-chain mannosylinositol phospho-(2'R)-2'-hydroxyphytoceramide = 1,2-diacyl-sn-glycerol + a very-long-chain mannosyl-diphosphoinositol-(2'R)-2'-hydroxyphytoceramide

754049

-

2.7.1.67

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

723136, 722098, 760073, 721555, 721713, 721967, 722121, 723072, 723609, 723790, 723791, 737789, 738845, 738939, 739030, 758569, 758912, 759586, 759590, 759597, 759752, 760068, 641812, 722857, 723392, 758648, 759276, 760009, 739027, 758572, 759607, 759289, 759796, 737350, 759678, 760185, 738109, 758830, 641806, 641814, 641818, 641807, 641821, 641816, 641817, 641796, 641780, 662885, 662444, 662328, 662815, 662676, 660950, 661041, 662814

-

3.1.4.11

1-phosphatidyl-1D-myo-inositol + H2O = 1D-myo-inositol 1-phosphate + diacylglycerol

751269

-

4.6.1.13

1-phosphatidyl-1D-myo-inositol = 1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol

729728, 729401, 729893

-

4.6.1.13

1-phosphatidyl-1D-myo-inositol = 1D-myo-inositol 1,2-cyclic phosphate + diacylglycerol

650586, 650573

-

4.6.1.13

2 entries

In Vivo Product in Enzyme-catalyzed Reactions (8 results)

top print hide

Show Natural Product (8 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.8.11

CDP-diacylglycerol + myo-inositol = CMP + 1-phosphatidyl-1D-myo-inositol

0

-

2.7.8.11

CDP-diacylglycerol + D-myo-inositol = CMP + phosphatidyl-1D-myo-inositol

0

-

2.7.8.11

CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol

645316, 0, 210005, 645293, 645295, 645321, 645309, 645307, 645313, 645318, 645305, 645308, 645310, 645299, 645320, 645322, 645325, 645312, 645304, 645306, 645323, 645315, 645319, 643323, 645302, 645294, 645296, 645297, 645314, 645301, 645303, 645298, 645311, 645324

-

3.1.3.64

1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate

0

-

3.1.3.64

phosphatidylinositol 3-phosphate + H2O = phosphatidylinositol + phosphate

646449, 646448, 646451

-

3.1.3.95

1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate

0

-

3.1.3.95

1-phosphatidyl-1D-myo-inositol 5-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate

0

-

2.7.8.11

3 entries

3.1.3.64

2 entries

3.1.3.95

2 entries

3.1.3.B4

phosphatidylinositol 4-phosphate + H2O = phosphatidylinositol + phosphate

0

-

Substrate in Enzyme-catalyzed Reactions (67 results)

top print hide

Show Substrate (67 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.16

S-adenosyl-L-methionine + phosphatidylinositol = S-adenosyl-L-homocysteine + ?

485163

-

2.3.1.148

Phosphatidylinositol + lyso-phosphatidylcholine = lyso-Phosphatidylcholine + phosphatidylinositol

16276

-

2.4.1.198

UDP-N-acetyl-alpha-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol

759489, 758711, 759061

-

2.4.1.198

UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol

685820, 723140, 736462

-

2.4.1.198

UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol

638133, 638130, 288963, 703374, 703326, 638129, 638128, 638131, 638132, 638134, 638135

-

2.4.1.345

GDP-alpha-D-mannose + 1-phosphatidyl-1D-myo-inositol = GDP + 2-O-(alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol

659183, 660449

-

2.4.1.345

GDP-mannose + phosphatidyl-myo-inositol = GDP + phosphatidyl-(2-O-alpha-D-manno-pyranosyl)-myo-inositol

660449

-

2.4.1.345

GDP-mannose + phosphatidylinositol = GDP + phosphatidyl-(2-O-alpha-D-manno-pyranosyl)-myo-inositol

659183, 680790

-

2.4.1.345

GDP-mannose + phosphatidylinositol = GDP + phosphatidyl-(2-O-alpha-D-mannopyranosyl)-myo-inositol

680790

-

2.4.1.346

GDP-alpha-D-mannopyranose + phosphatidyl-myo-inositol = GDP + ?

719899

-

2.4.1.346

GDP-Man + phosphatidyl-myo-inositol = ?

704533

-

2.7.1.137

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate

708146, 708568, 709003, 709207, 640851, 708336, 707877, 760521, 760661, 739359, 761826, 762179, 738465, 761792, 708996

-

2.7.1.137

ATP + 1-phosphatidylinositol = ADP + phosphatidylinositol 3-phosphate

640884, 640914, 640925, 640907, 393230, 640904, 640859, 640865, 640870, 640874, 640876, 640881, 640889, 640890, 640892, 640895, 640897, 640900, 640901, 640902, 640921, 640923, 640924, 640926, 640861, 640862, 640864, 640866, 640868, 640869, 640872, 640877, 640880, 640885, 640886, 640887, 640893, 640894, 640896, 640899, 640909, 640910, 640911, 640916, 640922, 640927, 640928, 640929, 690219, 694255, 640849, 640851, 640853, 640858, 640860, 640863, 640871, 640873, 640878, 640883, 640891, 640898, 640905, 640906, 640908, 640913, 640919, 640920, 640917, 640848, 640850, 640852, 640854, 640855, 640856, 640857, 640875, 640882, 640888, 640903, 640879, 640918, 640931, 532753, 640932, 640935, 587104, 640934, 640936, 640953, 491211, 640940, 640957, 640941, 640942, 640943, 640944, 640945, 640946, 640947, 640949, 640950, 640951, 640952, 640954, 640955, 640959, 640960, 640961, 640963, 675009

-

2.7.1.137

ATP + phosphatidylinositol = ADP + phosphatidylinositol 3-phosphate

661892

-

2.4.1.198

3 entries

2.4.1.345

4 entries

2.4.1.346

2 entries

2.7.1.137

3 entries

2.7.1.150

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 5-phosphate

660790

-

2.7.1.153

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate

708746, 708568

-

2.7.1.153

ATP + phosphatidylinositol = ADP + phosphatidylinositol 3-phosphate

393230, 393232, 587104, 640876

-

2.7.1.154

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate

645036, 660945

-

2.7.1.154

ATP + phosphatidylinositol = ?

671183

-

2.7.1.154

ATP + phosphatidylinositol = ADP + phosphatidylinositol 3-phosphate

640880, 640862, 672858, 640950, 640904

-

2.7.1.227

1-phosphatidyl-1D-myo-inositol + 6-((N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-hexanoyl)-sphingosine = ?

752588, 752503, 752745

-

2.7.1.227

1-phosphatidyl-1D-myo-inositol + C6-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)ceramide = ?

754674

-

2.7.1.227

1-phosphatidyl-1D-myo-inositol + hydroxy fatty acid-containing ceramide = hydroxy fatty acid-containing inositolphosphoylceramide

752588

-

2.7.1.227

1-phosphatidyl-1D-myo-inositol + N-[(2R,4E)-1-hydroxyoctadec-4-en-2-yl]octanamide = 1,2-diacyl-sn-glycerol + ?

754973

-

2.7.1.227

1-phosphatidyl-1D-myo-inositol + N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphingosine = ?

752502

-

2.7.1.227

1-phosphatidyl-1D-myo-inositol + nonhydroxy fatty acid-containing ceramide = nonhydroxy fatty acid-containing inositolphosphoylceramide

752588

-

2.7.1.153

2 entries

2.7.1.154

3 entries

2.7.1.227

6 entries

2.7.1.228

1-phosphatidyl-1D-myo-inositol + a very-long-chain mannosylinositol phospho-(2'R)-2'-hydroxyphytoceramide = 1,2-diacyl-sn-glycerol + a very-long-chain mannosyl-diphosphoinositol-(2'R)-2'-hydroxyphytoceramide

754049

-

2.7.1.67

2'-dATP + 1-phosphatidyl-1D-myo-inositol = 2'-dADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

641771

-

2.7.1.67

ADP + 1-phosphatidyl-1D-myo-inositol = AMP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

641787

-

2.7.1.67

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

723136, 722098, 641788, 641806, 641821, 662815, 676001, 760073, 641768, 641776, 641778, 641779, 641780, 641793, 641794, 641797, 641801, 641809, 641819, 662814, 672995, 673232, 674704, 674715, 674878, 721555, 721713, 721967, 722121, 723072, 723609, 723790, 723791, 737789, 738845, 738939, 739030, 758569, 758912, 759586, 759590, 759597, 759752, 760068, 641769, 641770, 641773, 641789, 641790, 641796, 641802, 641807, 641812, 641817, 641820, 662444, 662885, 641791, 641775, 641783, 641784, 641785, 641795, 641818, 660950, 674864, 722857, 677233, 641771, 641777, 641782, 641786, 641787, 641792, 641800, 641810, 672504, 641772, 641774, 641798, 641815, 674801, 676541, 676635, 723392, 758648, 759276, 760009, 673414, 641816, 739027, 641781, 641805, 641811, 758572, 759607, 641804, 759289, 641799, 759796, 641813, 641814, 661041, 737350, 641808, 759678, 760185, 738109, 758830, 641803, 662328, 662676

-

2.7.1.67

CTP + 1-phosphatidyl-1D-myo-inositol = CDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

641787

-

2.7.1.67

dATP + 1-phosphatidyl-1D-myo-inositol = dADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

641787

-

2.7.1.67

GTP + 1-phosphatidyl-1D-myo-inositol = GDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

641788, 641771, 641802, 641787

-

2.7.1.67

ITP + 1-phosphatidyl-1D-myo-inositol = IDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

641787

-

2.7.1.67

TTP + 1-phosphatidyl-1D-myo-inositol = TDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

641787

-

2.7.1.67

UTP + 1-phosphatidyl-1D-myo-inositol = UDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

641787

-

2.7.1.67

9 entries

3.1.1.118

phosphatidylinositol + H2O = lysophosphatidylinositol + ?

760595

-

3.1.1.26

phosphatidylinositol + H2O = ?

94294

-

3.1.1.32

phosphatidylinositol + H2O = ?

94303, 94335, 94332, 716165

-

3.1.1.32

phosphatidylinositol + H2O = lysophosphatidylinositol + a carboxylate

650395

-

3.1.1.4

phosphatidylinositol + arachidonic acid = arachidonoyl phosphatidylinositol + fatty acid

133894, 133888

-

3.1.1.4

phosphatidylinositol + linoleic acid = lineoyl phosphatidylinositol + fatty acid

133888

-

3.1.1.5

phosphatidylinositol + H2O = lysophophatidylinositol + a carboxylate

678790, 649683

-

3.1.1.5

phosphatidylinositol + H2O = lysophosphatidylinositol + glycerophosphorylinositol + a carboxylate

94373, 94386, 94366

-

3.1.4.11

1-phosphatidyl-1D-myo-inositol + H2O = 1D-myo-inositol 1-phosphate + diacylglycerol

751269, 750062, 749960, 750911, 285220

-

3.1.4.11

1-phosphatidyl-1D-myo-inositol = 1D-myo-inositol 1-phosphate + diacylglycerol

285220

-

3.1.4.11

phosphatidylinositol + H2O = 1,2-diacylglycerol + 1D-myo-inositol 1-phosphate

285233

-

3.1.4.11

phosphatidylinositol + H2O = 1D-myo-inositol 1-phosphate + diacylglycerol

285224, 285231, 285221, 285214, 285218, 285213

-

3.1.4.11

phosphatidylinositol + H2O = 1D-myo-inositol 1-phosphate + glycerophosphoinositol + phosphate + ?

285222

-

3.1.4.11

phosphatidylinositol + H2O = 1D-myo-inositol-1-phosphate + diacylglycerol

285227

-

3.1.4.11

phosphatidylinositol + H2O = ?

285217, 135119, 135133, 653348, 135137, 285216, 667524, 134812, 135136, 135123, 135141, 135143, 285223, 649330, 135140

-

3.1.4.11

phosphatidylinositol + H2O = diacylglycerol + 1D-myo-inositol 1-phosphate

285228, 285219, 285237

-

3.1.4.11

phosphatidylinositol + H2O = diacylglycerol + inositol 1,2-(cyclic)-phosphate

691015

-

3.1.4.11

phosphatidylinositol + H2O = diacylglycerol + myo-inositol 1-phosphate

649641

-

3.1.4.11

phosphatidylinositol + H2O = myo-inositol 1-phosphate + diacylglycerol

653195, 651282, 652082

-

3.1.4.3

phosphatidylinositol + H2O = 1,2-sn-diacylglycerol + phosphoinositol

730009

-

3.1.4.3

phosphatidylinositol + H2O = inositol monophosphate + diacylglycerol

135288, 135301, 135287, 135289, 135286, 135299, 135308, 135307, 653351

-

3.1.4.4

phosphatidylinositol + H2O = 1,2-diacylglycerophosphate + inositol

135449, 135446, 664423

-

3.1.4.4

phosphatidylinositol + H2O = phosphatidate + inositol

694606

-

3.1.1.32

2 entries

3.1.1.4

2 entries

3.1.1.5

2 entries

3.1.4.11

11 entries

3.1.4.3

2 entries

3.1.4.4

2 entries

3.1.4.50

phosphatidylinositol + H2O = diacylglycerol + inositol phosphate

681627

-

4.6.1.13

1-phosphatidyl-1D-myo-inositol = 1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol

729728, 729401, 729893

-

4.6.1.13

1-phosphatidyl-1D-myo-inositol = 1D-myo-inositol 1,2-cyclic phosphate + diacylglycerol

651281, 650586, 650093, 650390, 650064, 652552, 650231, 650204, 652411, 652257, 650573

-

4.6.1.13

1-phosphatidyl-1D-myo-inositol = 1D-myo-inositol 1,2-cyclic phosphate + sn-1,2-diacylglycerol

650573

-

4.6.1.13

phosphatidylinositol + H2O = diacylglycerol + myo-inositol 1,2-cyclic phosphate

285229, 285232, 285236, 285239, 285242, 285241, 285238, 285230, 285225, 285235, 670066

-

4.6.1.13

phosphatidylinositol + H2O = diacylglycerol + myo-inositol 1,2-cyclic phosphate + D-myo-inositol 1-phosphate

670066

-

4.6.1.13

phosphatidylinositol = diacylglycerol + myo-inositol 1,2-cyclic phosphate

691015, 707504, 709019

-

4.6.1.13

6 entries

4.6.1.14

phosphatidylinositol = inositol 1,2-cyclic phosphate + inositol phosphate

648778, 648781, 648770, 648776, 648769

-

Product in Enzyme-catalyzed Reactions (19 results)

top print hide

Show Product (19 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.148

lyso-Phosphatidylinositol + phospholipid = Phosphatidylinositol + lyso-phospholipid

0

-

2.3.1.148

Phosphatidylcholine + lyso-phosphatidylinositol = lyso-Phosphatidylcholine + phosphatidylinositol

0

-

2.3.1.148

Phosphatidylinositol + lyso-phosphatidylcholine = lyso-Phosphatidylcholine + phosphatidylinositol

0

-

2.7.8.11

CDP-diacylglycerol + myo-inositol = CMP + 1-phosphatidyl-1D-myo-inositol

0

-

2.7.8.11

CDP-diacylglycerol + D-myo-inositol = CMP + phosphatidyl-1D-myo-inositol

0

-

2.7.8.11

CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol

645316, 0, 210005, 645293, 645324, 645295, 645321, 645309, 645311, 645294, 645296, 645307, 645313, 645318, 645302, 645305, 645308, 645310, 645297, 645299, 645314, 645301, 645320, 645322, 645325, 645312, 645303, 645304, 645306, 645323, 645298, 645315, 645319, 643323

-

2.7.8.11

CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-myo-inositol

0

-

2.3.1.148

3 entries

2.7.8.11

4 entries

3.1.3.25

phosphatidylinositol 4-phosphate + H2O = phosphatidylinositol + phosphate

0

-

3.1.3.64

1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate

0

-

3.1.3.64

phosphatidylinositol 3-phosphate + H2O = phosphatidylinositol + phosphate

0, 646450, 646449, 646448, 646451

-

3.1.3.64

2 entries

3.1.3.67

phosphatidylinositol 3-phosphate + H2O = phosphatidylinositol + phosphate

651881

-

3.1.3.78

phosphatidylinositol 3-phosphate + H2O = phosphatidylinositol + phosphate

0

-

3.1.3.78

phosphatidylinositol 4-phosphate + H2O = phosphatidylinositol + phosphate

0

-

3.1.3.95

1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate

0

-

3.1.3.95

1-phosphatidyl-1D-myo-inositol 5-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate

0

-

3.1.3.78

2 entries

3.1.3.95

2 entries

3.1.3.B4

phosphatidylinositol 4-phosphate + H2O = phosphatidylinositol + phosphate

0

-

3.1.4.4

dioleoyl-phosphatidylcholine + myo-inositol = phosphatidylinositol + choline

0

-

3.1.4.4

phosphatidylcholine + inositol = phosphatidylinositol + choline

0

-

3.1.4.4

phosphatidylcholine + myo-inositol = phosphatidylinositol + choline

0

-

3.1.4.4

3 entries

Activator in Enzyme-catalyzed Reactions (45 results)

top print hide

Show Activating Compound (45 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.14.16.2

0.1 mg/ml activates

438690, 438696

-

1.14.16.2

no stimulation

438698

-

1.14.16.2

2 entries

2.3.1.15

activation of mitochondrial enzyme

486378

-

2.3.1.23

212% activation

486651

-

2.3.1.23

incorporation in membrane elevates acyltransferase activity

486641

-

2.3.1.23

2 entries

2.4.1.109

-

657566

-

2.4.1.16

stimulates

488645

-

2.4.1.17

highly required for activity of GlcAT-P and GlcAT-S with paraglobosid and other glycolipids

660431

-

2.4.1.208

strong activation in the presence of 1,2-dioleoylphosphatidylglycerol

488888

-

2.4.1.46

activation of partially purified, delipidated enzyme

489231

-

2.4.1.83

increases activity 2.3fold at the optimal concentration

489447

-

2.4.1.83

relative activity: 70%

692257

-

2.4.1.83

2 entries

2.4.1.88

activation

489482

-

2.7.1.107

effective stimulation

640355

-

2.7.1.107

enhances activity of DGK I and DGK IV

640364

-

2.7.1.107

enzyme type II has a preference for phosphatidylcholine as cofactor, enzyme type I can utilize both phosphatidylserine and phosphatidylinositol, but has a lower preference for phosphatidylcholine

640366

-

2.7.1.107

3 entries

2.7.1.174

-

687738

-

2.7.1.91

-

674380

-

2.7.1.91

0.01 mM, isoform SphK2,187% of initial activity

702037

-

2.7.1.91

2 entries

2.7.11.1

stimulation

491415

-

2.7.11.15

activates, phosphorylation of beta2-AR, 6fold activation of phosphorylation of RRREEEEESAAA

645028

-

2.7.11.7

-

640782, 640798

-

2.7.11.7

10fold activation of autophosphorylation and kinase activity

640797

-

2.7.11.7

2 entries

2.7.7.15

-

690911

-

2.7.8.15

solubilized enzyme is stimulated by exogenously added phospholipids in order of increasing activity: phosphatidylglycerol, phosphatidylinositol, phosphatidylserine

645351

-

2.7.8.15

stimulates

645354

-

2.7.8.15

2 entries

2.7.8.5

required for CMP-dependent incorporation of glycerol 3-phosphate

644285

-

2.8.2.20

slight activation, 0.2 mM

645807

-

3.1.1.2

enhances arylesterase activity, but slightly decreases paraoxonase activity

678376

-

3.1.3.1

1.5fold stimulation of hydrophilic enzyme form

94623

-

3.1.3.4

-

751022, 751277

-

3.1.3.4

activation, antagonized by sphinganine

134878

-

3.1.3.4

PAH1-encoded PAP activity is enhanced by the phospholipids CDP-diacylglycerol, phosphatidylinositol, and cardiolipin

693238

-

3.1.3.4

3 entries

3.1.3.B4

allosteric activation

731293

-

3.1.4.12

-

135176, 135183

-

3.1.4.12

anionic phospholipids required for activity, maximal activation at 1 mM, 53% of activation with phosphatidylserine

649682

-

3.1.4.12

2 entries

3.1.4.17

stimulation

135218

-

3.1.4.4

-

650910

-

3.1.4.54

activates 99% at 1 mM

708110

-

3.2.1.45

acidic, unsaturated phospholipid interfaces interact with acid beta-glucosidase to conform the enzyme into an active structure

657208

-

3.2.1.46

from 0.02 mg to 0.05 mg

171506

-

3.4.22.B36

activates

648418

-

3.6.1.75

-

680601

-

3.6.5.5

stimulates

644187

-

7.1.1.9

2.1fold activation of horse heart cytochrome c mediated reaction, 2.4fold activation of Candida krusei cytchrome c mediated reaction

396045

-

Inhibitor in Enzyme-catalyzed Reactions (31 results)

top print hide

Show Inhibitors (31 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.101

-

285690

-

1.14.18.2

3 mM, 68% inhibition

639334

-

2.3.1.15

inhibition of microsomal enzyme

486348, 486349

-

2.3.1.20

-

735573

-

2.3.1.26

-

486677, 486682

-

2.3.1.42

-

486953

-

2.3.1.84

2 mM, 97% inhibition

487555

-

2.3.1.84

strong inhibition

662479

-

2.3.1.84

2 entries

2.4.1.109

-

638330

-

2.4.1.83

relative activity: 70%

692257

-

2.7.1.1

effectiveness of various ligands in protection against inhibition, effect of pH and temperature

640221

-

2.7.1.107

2.5 mol% results in 50% inhibition of the phosphatidylcholine-dependent kinase activity

640370

-

2.7.1.227

substrate inhibition

752745

-

2.7.1.68

0.1 mM, 125% stimulation

641844

-

2.7.11.17

strong

490759

-

2.7.7.41

15-20% inhibition by soybean and liver phosphatidylinositol, inhibition of CDS2 by phosphatidylinositol is acyl chain-dependent, with the strongest inhibition seen with the 1-stearoyl-2-arachidonoyl species; CDS1 shows no acyl chain-dependent inhibition; significant inhibition of isoform CDS2 by both soybean and liver PI, with 15?20% residual activity

737701

-

2.7.7.41

2 mM, 23% inhibition

643311

-

2.7.7.41

2 entries

3.1.1.13

inhibitory if included as aqueous sonicated dispersions at 2.5 mg/ml

133842

-

3.1.3.4

-

134894

-

3.1.3.51

-

134915

-

3.1.3.53

phosphatidic acid is the most effective inhibitor among acidic phospholipids, followed by phosphatidylserine and phosphatidylinositol, phosphorylated myosin as substrate

646357

-

3.1.3.9

-

134947

-

3.1.4.12

-

135149, 135172

-

3.1.4.4

-

135449

-

3.1.4.50

strong

646486

-

3.1.8.1

enhances arylesterase activity, but slightly decreases paraoxonase activity

678376

-

3.2.1.114

CaCl2 or NaCl restores

646584

-

3.4.21.39

-

29374, 81368

-

4.1.1.31

addition of 0.05 mM phosphatidic acid decreases PEPC activity to approximately 40% of the control activity

706331

-

4.1.1.65

-

727905

-

4.6.1.14

-

648769

-

3D Structure of Enzyme-Ligand-Complex (PDB) (23 results)

top print hide

Show 3D Structure of Enzyme-Ligand-Complex (PDB) (23 entries)

EC NUMBER

ENZYME 3D STRUCTURE

1.10.2.2

1kb9, 3D-view

1.14.13.1

5hym, 3D-view

1.6.5.3

6rfq, 3D-view

1.6.5.3

6rfr, 3D-view

1.6.5.3

6y79, 3D-view

1.6.5.3

7o6y, 3D-view

1.6.5.3

7o71, 3D-view

1.6.99.3

6rfq, 3D-view

1.6.99.3

6rfr, 3D-view

1.6.99.3

6y79, 3D-view

1.6.99.3

7o6y, 3D-view

1.6.99.3

7o71, 3D-view

1.97.1.12

7bgi, 3D-view

1.97.1.12

7blz, 3D-view

7.1.1.2

6rfq, 3D-view

7.1.1.2

6rfr, 3D-view

7.1.1.2

6y79, 3D-view

7.1.1.2

7aqq, 3D-view

7.1.1.2

7ar7, 3D-view

7.1.1.2

7ar8, 3D-view

7.1.1.2

7arb, 3D-view

7.1.1.2

7o6y, 3D-view

7.1.1.2

7o71, 3D-view

1.6.5.3

5 entries

1.6.99.3

5 entries

1.97.1.12

2 entries

7.1.1.2

9 entries

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (2 results)

top print hide

Show Turnover Number (2 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.7.1.67

2.77

-

-

641775

2.7.1.67

2.77

-

pH 8.0, 30°C

641803

2.7.1.67

2 entries

K_M Value (48 results)

top print hide

Show KM Value (48 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.7.1.137

0.034

-

sonicated

640850

2.7.1.137

0.06

-

-

640851

2.7.1.137

64

-

-

640917

2.7.1.154

0.064

-

pH 7.5, 30°C, in presence of phosphatidylserine

640880

2.7.1.154

0.122

-

pH 7.5, 30°C, without phosphatidylserine

640880

2.7.1.227

0.13

-

pH 7.0, 23°C

752503

2.7.1.227

0.138

-

CHAPS-washed membranes, pH 7.5, 23°C

752745

2.7.1.227

0.2

-

pH 8.0, 30°C

752588

2.7.1.227

0.555

-

pH 7.0, 23°C

752503

2.7.1.67

0.016

-

pH 7.2, 30°C

641768

2.7.1.67

0.017

-

pH 7.0, 25°C

641800

2.7.1.67

0.017

-

room temperature, enzyme type 2

641786

2.7.1.67

0.02

0.06

-

677233

2.7.1.67

0.022

-

-

641820

2.7.1.67

0.022

-

pH 7.4, 30°C

641798

2.7.1.67

0.027

-

pH 7.8, 28°C, at 0.75 mM Triton X-100

641804

2.7.1.67

0.04

-

-

641800

2.7.1.67

0.04

-

pH 7.5, 30°C

641794

2.7.1.67

0.05

-

pH 7.5, 34°C

641784

2.7.1.67

0.055

-

pH 7.8, 28°C, at 1.5 mM Triton X-100

641804

2.7.1.67

0.07

-

pH 8.0, 30°C

641803

2.7.1.67

0.071

-

pH 8.5, 30°C

641783

2.7.1.67

0.1

-

-

677233

2.7.1.67

0.115

-

pH 7.4, 30°C

641802

2.7.1.67

0.12

-

pH 7.5, 30°C

641791

2.7.1.67

0.127

-

room temperature, enzyme type 3

641786

2.7.1.67

0.17

-

pH 7.5, enzyme form QII

641815

2.7.1.67

0.2

-

pH 7.2, 37°C

641797

2.7.1.67

0.23

-

pH 7.5, enzyme form QI

641815

2.7.1.67

1

-

37°C

641808

3.1.4.11

0.012

-

isoenzyme PLC-gamma

135136

3.1.4.11

0.031

-

isoenzyme PLC-gamma

135136

3.1.4.11

0.035

-

isoenzyme PLC-beta1

135136

3.1.4.11

0.058

-

in the presence of diacylglycerol and dimyristoyl phosphatidylcholine, at pH 7.5 and 39°C

750062

3.1.4.11

0.079

-

recombinant enzyme

667524

3.1.4.11

0.08

-

in the presence of diacylglycerol and sphingomyelin, at pH 7.5 and 39°C

750062

3.1.4.11

0.1

0.15

-

285220

3.1.4.11

0.125

-

in the presence of diacylglycerol and distearoyl phosphatidylcholine, at pH 7.5 and 39°C

750062

3.1.4.11

0.143

-

-

135141

3.1.4.11

0.44

-

in the presence of diacylglycerol, at pH 7.5 and 39°C

750062

3.1.4.11

0.93

-

at pH 7.5 and 39°C

750062

3.1.4.11

12.5

-

at the lower PI-PLC concentration (3.6 microg/ml)

691015

3.1.4.11

18.7

-

in the presence of diacylglycerol and galactosylceramide, at pH 7.5 and 39°C

750062

3.1.4.11

100

-

at double the enzyme concentration

691015

3.1.4.3

0.087

-

PLC-beta1a, 2mM free Ca2+

135288

3.1.4.3

0.369

-

PLC-beta1b, 2mM free Ca2+

135288

2.7.1.137

3 entries

2.7.1.154

2 entries

2.7.1.227

4 entries

2.7.1.67

21 entries

3.1.4.11

14 entries

3.1.4.3

2 entries

4.6.1.13

1.4

-

-

285230

4.6.1.14

0.037

-

-

648778

IC₅₀ Value (1 result)

top print hide

Show IC50 Value (1 entry)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

2.7.1.227

0.588

-

CHAPS-washed membranes, pH 7.5, 23°C

752745

References & Links

Literature References (491)

top print hide

Show Reference (491 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

16276

526311

Transfer of arachidonic acid between phospholipids in rat liver microsomes

1979

Irvine, R.L.; Dawson, R.M.C.

Biochem. Biophys. Res. Commun.

91

1399-1405

29374

3890754

Chymotrypsin- and trypsin-type serine proteases in rat mast cells: properties and functions

1985

Kido, H.; Fukusen, N.; Katunuma, N.

Arch. Biochem. Biophys.

239

436-443

81368

3882053

Inhibition of chymase activity by phosphoglycerides

1985

Fukusen, N.; Kido, H.; Katunuma, N.

Arch. Biochem. Biophys.

237

118-123

94294

236765

Purification and properties of a lipid acyl-hydrolase from potato tubers

1975

Hirayama, O.; Matsuda, H.; Takeda, H.; Maenaka, K.; Takatsuka, H.

Biochim. Biophys. Acta

384

127-137

94303

6692000

Substrate specificity of two cationic lipases with high phospholipase A1 activity purified from guinea pig pancreas. II. Studies on glycerophospholipids

1984

Fauvel, J.; Chap, H.; Roques, V.; Douste-Blazy, L.

Biochim. Biophys. Acta

792

72-78

94332

8216258

The presence of Ca2+-independent phospholipase A1 highly specific for phosphatidylinositol in bovine brain

1993

Ueda, H.; Kobayashi, T.; Kishimoto, M.; Tsusumi, T.; Watanabe, S.; Okuyama, H.

Biochem. Biophys. Res. Commun.

195

1272-1279

94335

7786901

Phospholipid interactions affect substrate hydrolysis by bovine brain phospholipase A1

1995

Pete, M.J.; Exton, J.H.

Biochim. Biophys. Acta

1256

367-373

94366

8782402

Purification and some properties of phospholipase B from Schizosaccharomyces pombe

1996

Oishi, H.; Tsuda, S.; Watanabe, Y.; Tamai, Y.

Biosci. Biotechnol. Biochem.

60

1087-1092

94373

-

Purification and some properties of soluble phospholipase B from baker's yeast (Saccharomyces cerevisiae)

1985

Ichimasa, M.; Shiobara, M.

Agric. Biol. Chem.

49

1083-1089

94386

8816850

Kashiwabara, Y.: Purification and properties of a membrane-bound phospholipase B from Mycobacterium lepraemurium

1996

Maeda, S

Biochim. Biophys. Acta

1303

31-38

94623

1815949

Properties of amphiphilic and hydrophilic forms of alkaline phosphatase from human liver

1991

Kihn, L.; Rutkowski, D.; Nakatsui, T.; Stinson, R.A.

Enzyme

45

155-164

133842

4066668

Human lysosomal acid lipase/cholesteryl ester hydrolase. Purification and properties of the form secreted by fibroblasts in microcarrier culture

1985

Sando, G.N.; Rosenbaum, L.M.

J. Biol. Chem.

260

15186-15193

133888

8328965

Cytosolic phospholipase A2 from human monocytic cells: characterization of substrate specificity and Ca2+-dependent membrane association

1993

Rehfeldt, W.; Resch, K.; Goppelt-Struebe, M.

Biochem. J.

293

255-261

133894

1910288

Localization and characterization of phospholipase A2 in mouse mammary gland-derived cells

1991

Steiner, M.

Arch. Biochem. Biophys.

286

293-299

134812

214133

Studies on the properties of triphosphoinositide phosphomonoesterase and phosphodiesterase of rabbit iris smooth muscle

1978

Akhtar, R.A.; Abdel-Latif, A.A.

Biochim. Biophys. Acta

527

159-170

134878

9370315

Phosphatidate phosphatases and diacylglycerol pyrophosphate phosphatases in Saccharomyces cerevisiae and Escherichia coli

1997

Carman, G.M.

Biochim. Biophys. Acta

1348

45-55

134894

1770306

Stimulation and inhibition of the activity of rat liver cytosolic phosphatidate phosphohydrolase by various phospholipids

1991

Humble, E.; Berglund, L.

J. Lipid Res.

32

1869-1873

134915

6329308

Dolichyl phosphate phosphatase in rat liver microsomes. Avoidance of the use of detergent in testing the effect of phospholipids on dolichyl phosphate phosphatase

1984

Boscoboinik, D.O.; Morera, S.; Belocopitow, E.

Biochim. Biophys. Acta

794

41-48

134947

9417039

Liver microsomal glucose-6-phosphatase is competitively inhibited by the lipid products of phosphatidylinositol 3-kinase

1998

Mithieux, G.; Daniele, N.; Payrastre, B.; Zitoun, C.

J. Biol. Chem.

273

17-19

135119

2829827

Characterization of partially purified phospholipase C from human platelet membranes

1987

Banno, Y.; Nozawa, Y.

Biochem. J.

248

95-101

135123

3493241

Partial purification and characterization of membrane-bound and cytosolic phosphatidylinositol-specific phospholipases C from murine thymocytes

1986

Wang, P.; Toyoshima, S.; Osawa, T.

J. Biochem.

100

1015-1022

135133

1325785

Discrete subcellular localization of phosphoinositidase C beta, gamma and delta in PC12 rat pheochromocytoma cells

1992

Mazzoni, M.; Bertagnolo, V.; Neri, L.M.; Carini, C.; Marchisio, M.; Milani, D.; Manzoli, F.A.; Capitani, S.

Biochem. Biophys. Res. Commun.

187

114-120

135136

1646858

Purification, properties, and phosphorylation by protein kinase C of two phosphoinositidase C isoenzymes from rat brain

1991

Blank, J.L.; Foster, K.A.; Hawthorne, J.N.

J. Neurochem.

57

15-21

135137

-

A comparison of properties of species of phospholipase C isolated from porcine lymphocytes

1986

Carter, H.R.; Smith, A.D.

Biochem. Soc. Trans.

14

1159-1160

135140

1651335

Characterization of phosphatidylinositol-specific phospholipase C from cultured vascular smooth muscle cells

1991

Griendling, K.K.; Taubman, M.B.; Akers, M.; Mendlowitz, M.; Alexander, R.W.

J. Biol. Chem.

266

15498-15504

135141

1332858

Expression, purification and characterisation of a functional phosphatidylinositol-specific phospholipase C-delta1 protein in Escherichia coli

1992

Ginger, R.S.; Parker, P.J.

Eur. J. Biochem.

210

155-160

135143

8395015

Genetic and biochemical characterization of a phosphatidylinositol-specific phospholipase C in Saccharomyces cerevisiae

1993

Flick, J.S.; Thorner, J.

Mol. Cell. Biol.

13

5861-5876

135149

2825797

Acid sphingomyelinase from human urine: purification and characterization

1987

Quintern, L.E.; Weitz, G.; Nehrkorn, H.; Tager, J.M.; Schram, A.W.; Sandhoff, K.

Biochim. Biophys. Acta

922

323-336

135172

5916388

Enzymatic hydrolysis of sphingolipids. II. Hydrolysis of sphingomyelin by an enzyme from rat brain

1966

Barnholz, Y.; Roitman, A.; Gatt, S.

J. Biol. Chem.

241

3731-3737

135176

8307965

Characteristics and partial purification of a novel cytosolic, magnesium-independent, neutral sphingomyelinase activated in the early signal transduction of 1alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation

1994

Okazaki, T.; Bielawska, A.; Domae, N.; Bell, R.M.; Hannun, Y.A.

J. Biol. Chem.

269

4070-4077

135183

9852115

Purification and characterization of a membrane bound neutral pH optimum magnesium-dependent and phosphatidylserine-stimulated sphingomyelinase from rat brain

1998

Liu, B.; Hassler, D.F.; Smith, G.K.; Weaver, K.; Hannun, Y.A.

J. Biol. Chem.

273

34472-34479

135218

6329099

Properties of a cyclic nucleotide phosphodiesterase of amphibian oocytes that is activated by calmodulin and calcium, by tryptic proteolysis, and by phospholipids

1984

Orellana, O.; Jedlicki, E.; Allende, C.C.; Allende, J.E.

Arch. Biochem. Biophys.

231

345-354

135286

8722307

Characterization of a phospholipase C produced by Pseudomaonas fluorescens

1996

Ivanov, A.; Titibali, R.W.; Kostadinova, S.

New Microbiol.

19

113-121

135287

7799788

Characterization of phospholipase C isoenzymes in bovine retina: Purification of phospholipase C-beta 4

1994

Lee, C.W.; Lee, K.H.; Rhee, S.G.

Methods Enzymol.

238

227-237

135288

-

Overexpression and biochemical characterization of phospholipase C-beta 1a and -beta 1b

1994

Bahk, Y.Y.; Lee, Y.H.; Ryu, S.H.; Suh, P.G.

Mol. Cells

4

361-367

135289

8292995

Purification and characterization of phospholipase C preferentially hydrolysing phosphatidylcholine in Tetrahymena membranes

1993

Alam, S.; Banno, Y.; Nozawa, Y.

J. Eukaryot. Microbiol.

40

775-781

135299

-

Phospholipase C from Bacillus cereus

1981

Little, C.

Methods Enzymol.

71

725-730

135301

7356635

Properties of phospholipase C isolated from rat liver lysosomes

1980

Matsuzawa, Y.; Hostetler, K.Y.

J. Biol. Chem.

255

646-652

135307

5411

Studies on phospholipases from Streptomyces. Purification and properties of Streptomyces hachijoensis phospholipase C

1975

Okawa, Y.; Yamaguchi, T.

J. Biochem.

78

537-545

135308

4216738

Phospholipase C (phosphatidylcholine cholinephosphohydrolase, EC 3.1.4.3) from Bacillus cereus

1974

Zwaal, R.F.A.; Roelofsen, B.

Methods Enzymol.

32

154-161

135446

10425392

Molecular and biochemical properties and physiological roles of plant phospholipase D

1999

Pappan, K.; Wang, X.

Biochim. Biophys. Acta

1439

151-166

135449

7983063

Purification and characterization of phosphatidylcholine phospholipase D from pig lung

1994

Okamura, S.; Yamashita, S.

J. Biol. Chem.

269

31207-31213

171506

3111543

Hydrolysis of galactosylsphingosine and lactosylsphingosine by beta-galactosidases in human brain and cultured fibroblasts

1987

Goda, S.; Kobayashi, T.; Goto, I.

Biochim. Biophys. Acta

920

259-265

210005

6127112

Stereospecific synthesis and enzyme studies of CDP-diacylglycerols

1982

Murthy, P.P.N.; Agranoff, B.W.

Biochim. Biophys. Acta

712

473-483

285213

3089288

Phospholipase C and diacylglycerol lipase activities associated with plasma membranes of chromaffin cells isolated from bovine adrenal medulla

1986

Zahler, P.; Reist, M.; Pilarska, M.; Rosenheck, K.

Biochim. Biophys. Acta

877

372-379

285214

2996496

The inhibition of diacylglycerol-stimulated intracellular phospholipases by phospholipids with a phosphocholine-containing polar group. A possible physiological role for sphingomyelin

1985

Dawson, R.M.C.; Hemington, N.; Irvine, R.F.

Biochem. J.

230

61-68

285216

6316925

Resolution of myocardial phospholipase C into several forms with distinct properties

1983

Low, M.G.; Weglicki, W.B.

Biochem. J.

215

325-334

285217

-

Phosphatidylinositol phosphodiesterase in isolated plasma membranes of rodent skeletal muscle

1985

Shute, J.K.; Smith, M.E.

Biochem. Soc. Trans.

13

193-194

285218

6089765

Soluble phosphatidylinositol phosphodiesterase in normal and denervated fast and slow muscles of the rat

1984

Shute, J.K.; Smith, M.E.

Biochem. J.

222

299-305

285219

6307156

Characterization of rat kidney proximal tubule brush border membrane-associated phosphatidylinositol phosphodiesterase

1983

Schwertz, D.W.; Kreisberg, J.I.; Venkatachalam, M.A.

Arch. Biochem. Biophys.

224

555-567

285220

6860706

Properties and distribution of phosphatidylinositol-specific phospholipase C in human and horse platelets

1983

Sies, W.; Lapetina, E.G.

Biochim. Biophys. Acta

752

329-338

285221

6291509

Heterogeneity of the calcium-dependent phosphatidylinositol phosphodiesterase in rat brain

1982

Hirasawa, K.; Irvine, R.F.; Dawson, R.M.C.

Biochem. J.

205

437-442

285222

6273169

The catabolism of phosphatidylinisitol by an EDTA-insensitive phospholipase A1 and calcium-dependent phosphatidylinositol phosphodiesterase in rat brain

1981

Hirasawa, K.; Irvine, R.F.; Dawson, R.M.C.

Eur. J. Biochem.

120

53-58

285223

6272711

The hydrolysis of phosphatidylinositol monolayers at an air/water interface by the calcium-ion-dependent phosphatidylinositol phosphodiesterase of pig brain

1981

Hirasawa, K.; Irvine, R.F.; Dawson, R.M.C.

Biochem. J.

193

607-614

285224

6256168

The inhibition and activation of Ca2+-dependent phosphatidylinositol phosphodiesterase by phospholipids and blood plasma

1980

Dawson, R.M.C.; Hemington, N.; Irvine, R.F.

Eur. J. Biochem.

112

33-38

285225

7417468

Purification and properties of phosphatidylinositol-specific phospholipase C of Bacillus thuringiensis

1980

Taguchi, R.; Asahi, Y.; Ikezawa, H.

Biochim. Biophys. Acta

619

48-57

285227

37116

Characterization and properties of a phosphatidylinositol phosphodiesterase (phospholipase C) from platelet cytosol

1979

Mauco, G.; Chap, H.; Douste-Blazy, L.

FEBS Lett.

100

367-370

285228

6272700

Phosphatidylinositol phosphodiesterase in higher plants

1980

Irvine, R.F.; Letcher, A.J.; Dawson, R.M.C.

Biochem. J.

192

279-283

285229

207692

Enzymatic properties of phosphatidylinositol inositolphosphohydrolase from Bacillus cereus. Substrate dilution in detergent-phospholipid micelles and bilayer vesicles

1978

Sundler, R.; Alberts, A.W.; Vagelos, P.R.

J. Biol. Chem.

253

4175-4179

285230

10986

Studies on phosphatidylinositol phosphodiesterase (phospholipase C type) of Bacillus cereus. I. purification, properties and phosphatase-releasing activity

1976

Ikezawa, H.; Yamanegi, M.; Taguchi, R.; Miyashita, T.; Ohyabu, T.

Biochim. Biophys. Acta

450

154-164

285231

242322

A comparison of the activity of phosphatidylinositol phosphodiesterase against substrate in dispersions and as monolayers at the air-water interface

1975

Quinn, P.J.; Barenholz, Y.

Biochem. J.

149

199-208

285232

1668269

High-level expression in Escherichia coli and rapid purification of phosphatidylinositol-specific phospholipase C from Bacillus cereus and Bacillus thuringiensis

1991

Koke, J.A.; Yang, M.; Henner, D.J.; Volwerk, J.J.; Griffith, O.H.

Protein Expr. Purif.

2

51-58

285233

4377210

Phosphatidylinositol cleavage catalysed by the soluble fraction from lymphocytes. Activity at pH 5.5 and pH 7.0

1974

Allan, D.; Michell, R.H.

Biochem. J.

142

591-597

285235

7918603

Purification and properties of phosphatidylinositol-specific phospholipase C from Streptomyces antibioticus

1994

Iwasaki, Y.; Niwa, S.; Nakano, H.; Nagasawa, T.; Yamane, T.

Biochim. Biophys. Acta

1214

221-228

285236

8386017

Crystallization of phosphatidylinositol-specific phospholipase C from Bacillus cereus

1993

Bullock, T.L.; Ryan, M.; Kim, S.L.; Remington, S.J.; Griffith, O.H.

Biophys. J.

64

784-791

285237

1646808

Purification and properties of membrane and cytosolic phosphatidylinositol-specific phospholipase C from human spleen

1991

Roy, G.; Villar, L.M.; Lazaro, I.; Gonzalez, M.; Bootello, A.; Gonzalez-Porque, P.

J. Biol. Chem.

266

11495-11501

285238

9178552

Growth inhibition, morphological change, and ectoenzyme release of LLC-PK1 cells by phosphatidylinositol-specific phospholipase C of Bacillus thuringiensis

1997

Itami, C.; Kimura, Y.; Taguchi, R.; Ikezawa, H.; Nakayashi, T.

Biosci. Biotechnol. Biochem.

61

776-781

285239

8877813

Inhibition of phosphatidylinositol-specific phospholipase C: studies on synthetic substrates, inhibitors and a synthetic enzyme

1996

Vizitiu, D.; Kriste, A.G.; Campbell, A.S.; Thatcher, G.R.J.

J. Mol. Recognit.

9

197-209

285241

9367761

Crystal structure of the phosphatidylinositol-specific phospholipase C from the human pathogen Listeria monocytogenes

1997

Moser, J.; Gerstel, B.; Meyer, J.E.; Chakraborty, T.; Wehland, L.; Heinz, D.W.

J. Mol. Biol.

273

269-282

285242

7664726

Crystal structure of the phosphatidylinositol-specific phospholipase C from Bacillus cereus in complex with myo-inositol

1995

Heinz, D.W.; Ryan, M.; Bullock, T.L.; Griffith, O.H.

EMBO J.

14

3855-3863

285690

2335525

Purification and properties of acyl/alkyl dihydroxyacetone-phosphate reductase from guinea pig liver peroxisomes

1990

Datta, S.C.; Ghosh, M.K.; Hajra, A.K.

J. Biol. Chem.

265

8268-8274

288963

2525555

Biosynthesis of the glycosyl phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein. Origin of the non-acetylated glucosamine

1989

Doering, T.L.; Masterson, W.J.; Englund, P.T.; Hart, G.W.

J. Biol. Chem.

264

11168-11173

393230

11395417

Synthesis and function of 3-phosphorylated inositol lipids

2001

Vanhaesebroeck, B.; Leevers, S.J.; Ahmadi, K.; Timms, J.; Katso, R.; Driscoll, P.C.; Woscholski, R.; Parker, P.J.; Waterfield, M.D.

Annu. Rev. Biochem.

70

535-602

393232

9255069

Phosphoinositide 3-kinases: a conserved family of signal transducers

1997

Vanhaesebroeck, B.; Leevers, S.J.; Panayotou, G.; Waterfield, M.D.

Trends Biochem. Sci.

22

267-272

396045

2839468

Catalytic properties of cytochrome c oxidase purified from Nitrosomonas europaea

1988

Yamazaki, T.; Fukumori, Y.; Yamanaka, T.

J. Biochem.

103

499-503

438690

2885720

Tyrosine 3-monooxygenase from rat pheochromocytoma

1987

Tank, A.W.; Weiner, N.

Methods Enzymol.

142

71-82

438696

2861203

Purification and characterization of rat striatal tyrosine hydroxylase. Comparison of the activation by cyclic AMP-dependent phosphorylation and by other effectors

1985

Richtand, N.M.; Inagami, T.; Misono, K.; Kuczenski, R.

J. Biol. Chem.

260

8465-8473

438698

6120836

Purification and some properties of tyrosine 3-monooxygenase from rat adrenal

1982

Okuno, S.; Fujisawa, H.

Eur. J. Biochem.

122

49-55

485163

4313604

Enzymatic alkylenation of phospholipid fatty acid chains by extracts of Mycobacterium phlei

1970

Akamatsu, Y.; Law, J.H.

J. Biol. Chem.

245

701-708

486348

1495436

Glycerophosphate acyltransferase from liver

1992

Haldar, D.; Vancura, A.

Methods Enzymol.

209

64-72

486349

4650158

Partial purification and properties of glycerophosphate acyltransferase from rat liver. Formation of 1-acylglycerol 3-phosphate from sn-glycerol 3-phosphate and palmityl coenzyme A

1972

Yamashita, S.; Numa, S.

Eur. J. Biochem.

31

565-573

486378

7961630

Purification and characterization of glycerophosphate acyltransferase from rat liver mitochondria

1994

Vancura, A.; Haldar, D.

J. Biol. Chem.

269

27209-27215

486641

1793566

Phospholipid modifications influence acyl-CoA:1-acyl-glycero-3-phosphocholine O-acyltransferase in rat liver plasma membranes

1991

Momchilova, A.B.; Markovska, T.T.; Koshlukova, S.E.; Koumanov, K.S.; Pankov, R.G.

Biochem. Cell Biol.

69

643-648

486651

9930410

Lysophosphatidylcholine acyltransferase activity in Saccharomyces cerevisiae: regulation by a high-affinity Zn2+ binding site

1998

Richard, M.G.; McMaster, C.R.

Lipids

33

1229-1234

486677

-

Acyl coenzyme A:cholesterol O-acyltransferase

1983

Chang, T.Y.; Doolittle, G.M.

The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )

16

523-539

486682

7074032

Solubilization, partial purification, and reconstitution in phosphatidylcholine-cholesterol liposomes of acyl-CoA:cholesterol acyltransferase

1982

Doolittle, G.M.; Chang, T.Y.

Biochemistry

21

674-679

486953

6639048

Solubilization and partial purification of dihydroxyacetone-phosphate acyltransferase from guinea pig liver

1983

Jones, C.L.; Hajra, A.K.

Arch. Biochem. Biophys.

226

155-165

487555

-

Ester formation by alcohol acetyltransferase from brewer's yeast

1981

Yoshioka, K.; Hashimoto, N.

Agric. Biol. Chem.

45

2183-2190

488645

159723

Chitin synthase activity from the slime variant of Neurospora crassa

1979

Selitrennikoff, C.P.

Biochim. Biophys. Acta

571

224-232

488888

10734070

The nonbilayer/bilayer lipid balance in membranes: Regulatory enzyme in Acholeplasma laidlawii is stimulated by metabolic phosphates, activator phospholipids, and double-stranded DNA

2000

Vikstrom, S.; Li, L.; Wieslander, A.

J. Biol. Chem.

275

9296-9302

489231

16593955

Lipid requirement and kinetic studies of solubilized UDP-galactose:diacylglycerol galactosyltransferase activity from spinach chloroplast envelope membranes

1988

Coves, J.; Joyard, J.; Douce, R.

Proc. Natl. Acad. Sci. USA

85

4966-4970

489447

11159922

Partial purification and characterization of dolichol phosphate mannose synthase from Entamoeba histolytica

2000

Villagomez-Castro, J.C.; Calvo-Mendez, C.; Flores-Carreon, A.; Lopez-Romero, E.

Glycobiology

10

1311-1316

489482

19076

Solubilization and partial characterization of UDP-N-acetylgalactosamine: globoside alpha-N-acetylgalactosaminyltransferase from dog spleen microsomes

1977

Ishibashi, T.; Ohkubo, I.; Makita, A.

Biochim. Biophys. Acta

484

24-34

490759

3121601

Phosphorylation of tau proteins to a state like that in Alzheimers brain is catalyzed by a calcium/calmodulin-dependent kinase and modulated by phospholipids

1987

Baudier, J.; Cole, R.D.

J. Biol. Chem.

262

17577-17583

491211

11859360

The genome sequence of Schizosaccharomyces pombe

2002

Wood, V.; Gwilliam, R.; Rajandream, M.A.; Lyne, M.; Lyne, R.; et al.

Nature

415

871-880

491415

7916621

Calcium and lipid regulation of an Arabidopsis protein kinase expressed in Escherichia coli

1993

Harper, J.F.; Binder, B.M.; Sussman, M.R.

Biochemistry

32

3282-3290

532753

8840504

Analysis of a 62 kb DNA sequence of chromosome X reveals 36 open reading frames and a gene cluster with a counterpart on chromosome XI

1996

Huang, M.E.; Manus, V.; Chuat, J.C.; Galibert, F.

Yeast

12

869-875

587104

9113989

P110delta, a novel phosphoinositide 3-kinase in leukocytes

1997

Vanhaesebroeck, B.; Welham, M.J.; Kotani, K.; Stein, R.; Warne, P.H.; Zvelebil, M.J.; Higashi, K.; Volinia, S.; Downward, J.; Waterfield, M.D.

Proc. Natl. Acad. Sci. USA

94

4330-4335

638128

1325903

Inhibition of the GlcNAc transferase of the glycosylphosphatidylinositol anchor biosynthesis in African trypanosomes

1992

Milne, K.G.; Ferguson, M.A.J.; Masterson, W.J.

Eur. J. Biochem.

208

309-314

638129

8389477

Specific defect in N-acetylglucosamine incorporation in the biosynthesis of the glycosylphosphatidylinositol anchor in cloned cell lines from patients with paroxysmal nocturnal hemoglobinuria

1993

Hillmen, P.; Bessler, M.; Mason, P.J.; Watkins, W.M.; Luzzatto, L.

Proc. Natl. Acad. Sci. USA

90

5272-5276

638130

-

Activity of phosphatidylinositol/UDP-GlcNAc:GlcNAc transferase in midgut tissue of Bombyx mori

2003

Takano, D.; Kishimoto, T.; Hayakawa, T.; Mitsui, T.; Hori, H.

Niigata Daigaku Nogakubu Kenkyu Hokoku

55

123-131

638131

9463366

The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1

1998

Watanabe, R.; Inoue, N.; Westfall, B.; Taron, C.H.; Orlean, P.; Takeda, J.; Kinoshita, T.

EMBO J.

17

877-885

638132

10373468

GPI1 stabilizes an enzyme essential in the first step of glycosylphosphatidylinositol biosynthesis

1999

Hong, Y.; Oshihi, K.; Watanabe, R.; Endo, Y.; Maeda, Y.; Kinoshita, T.

J. Biol. Chem.

274

18582-18588

638133

-

Segregation of glycosylphosphatidylinositol biosynthetic reactions in a subcompartment of the endoplasmic reticulum

1999

Vidugiriene, J.; Sharma, D.K.; Smith, T.K.; Baumann, N.A.; Menon, A.K.

J. Biol. Chem.

274

15202-15212

638134

10944123

Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2

2000

Watanabe, R.; Murakami, Y.; Marmor, M.; Inoue, N.; Maeda, Y.; Hino, J.; Kangawa, K.; Julius, M.; Kinoshita, T.

EMBO J.

19

4402-4411

638135

-

Photoaffinity labelling with P3-(4-azidoanilido)uridine 5'-triphosphate identifies Gpi3p as the UDP-GlcNAc-binding subunit of the enzyme that catalyses formation of GlcNAc-phosphatidylinositol, the first glycolipid intermediate in glycosylphosphatidylinositol synthesis

2000

Kostova, Z.; Rancour, D.M.; Menon, A.K.; Orlean, P.

Biochem. J.

350

815-822

638330

8354289

Protein O-mannosylation in Candida albicans. Determination of the amino acid sequences of peptide acceptors for protein O-mannosyltransferase

1993

Weston, A.; Nassau, P.M.; Henley, C.; Marriott, M.S.

Eur. J. Biochem.

215

845-849

639334

1587278

Mouse liver cytidine-5-monophosphate-N-acetylneuraminic acid hydroxylase. Catalytic function and regulation

1992

Shaw, L.; Schneckenburger, P.; Carlsen, J.; Christiansen, K.; Schauer, R.

Eur. J. Biochem.

206

269-277

640221

3966791

Acidic phospholipids may inhibit rat brain hexokinase by interaction at the nucleotide binding site

1985

Nemat-Gorgani, M.; Wilson, J.E.

Arch. Biochem. Biophys.

236

220-227

640355

16668739

Diacylglycerol kinase from suspension cultured plant cells

1992

Wissing, J.B.; Wagner, K.G.

Plant Physiol.

98

1148-1153

640364

2153114

Purification and characterization of membrane-bound and cytosolic forms of diacylglycerol kinase from rat brain

1990

Kato, M.; Takenawa, T.

J. Biol. Chem.

265

794-800

640366

2176468

Identification of two cytosolic diacylglycerol kinase isoforms in rat brain, and in NIH-3T3 and ras-transformed fibroblasts

1990

Stathopoulos, V.M.; Coco-Maroney, A.; Wei, C.W.; Goth, M.; Zaricznyj, C.; Macara, I.G.

Biochem. J.

272

569-575

640370

6296111

Diacylglycerol kinase from pig brain. Purification and phospholipid dependencies

1983

Kanoh, H.; Kondoh, H.; Ono, T.

J. Biol. Chem.

258

1767-1774

640782

2168881

Substrate specificity of Acanthamoeba myosin I heavy chain kinase as determined with synthetic peptides

1990

Brzeska, H.; Lynch, T.J.; Martin, B.; Corigliano-Murphy, A.; Korn, E.D.

J. Biol. Chem.

265

16138-16144

640797

9774403

Regulation of the p21-activated kinase-related Dictyostelium myosin I heavy chain kinase by autophosphorylation, acidic phospholipids, and Ca2+-calmodulin

1998

Lee, S.F.; Mahasneh, A.; de la Roche, M.; Cote, G.P.

J. Biol. Chem.

273

27911-27917

640798

9892644

Myosin I heavy chain kinase: cloning of the full-length gene and acidic lipid-dependent activation by Rac and Cdc42

1999

Brzeska, H.; Young, R.; Knaus, U.; Korn, E.D.

Proc. Natl. Acad. Sci. USA

96

394-399

640848

1850737

Two types of phosphatidylinositol 3-kinase from bovine thymus. Monomer and heterodimer form

1991

Shibasaki, F.; Homma, Y.; Takenawa, T.

J. Biol. Chem.

266

8108-8114

640849

7520748

Potent activation of phosphatidylinositol 3-kinase by simple phosphotyrosine peptides derived from insulin receptor substrate 1 containing two YMXM motifs for binding SH2 domains

1994

Herbst, J.J.; Andrews, G.; Contillo, L.; Lamphere, L.; Gardner, J.; Lienhard, G.E.; Gibbs, E.M.

Biochemistry

33

9376-9381

640850

2167854

Purification and characterization of bovine brain type I phosphatidylinositol kinase

1990

Morgan, S.J.; Smith, A.D.; Parker, P.J.

Eur. J. Biochem.

191

761-767

640851

2174051

Purification and characterization of phosphoinositide 3-kinase from rat liver

1990

Carpenter, C.L.; Duckworth, B.C.; Auger, K.R.; Cohen, B.; Schaffhausen, B.S.; Cantley, L.C.

J. Biol. Chem.

265

19704-19711

640852

-

Purification and characterization of a phosphatidylinositol 3-kinase complex from bovine brain by using phosphopeptide affinity columns

1992

Fry, M.J.; Panayotou, G.; Dhand, R.; Ruiz-Larrea, F.; Gout, I.; Nguyen, O.; Courtneidge, S.A.; Waterfield, M.D.

Biochem. J.

288

383-393

640853

8131938

Characterisation of phosphatidylinositol 3-kinase in PC12 cell extracts and isolation of the enzyme from rat brain extracts

1993

Baxter, R.M.; Bramham, J.; Thomason, P.A.; Downes, C.P.; Carter, A.N.

Biochem. Soc. Trans.

21

359S

640854

-

Different properties of monomer and heterodimer forms of phosphatidylinositol 3-kinases

1993

Shibasaki, F.; Fukui, Y.; Takenawa, T.

Biochem. J.

289

227-231

640855

-

Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system

1992

Gout, I.; Dhand, R.; Panayotou, G.; Fry, M.J.; Hiles, I.; Otsu, M.; Waterfield, M.D.

Biochem. J.

288

395-405

640856

-

Characterization of the bovine brain cytosolic phosphatidylinositol 3-kinase complex

1993

Ruiz-Larrea, F.; Vicendo, P.; Yaish, P.; End, P.; Panayotou, G.; Fry, M.J.; Morgan, S.J.; Thompson, A.; Parker, P.J.; Waterfield, M.D.

Biochem. J.

290

609-616

640857

1322797

Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit

1992

Hiles, I.D.; Otsu, M.; Volinia, S.; Fry, M.J.; Gout, I.; Dhand, R.; Panayotou, G.; Ruiz-Larrea, F.; Thompson, A.; Totty, N.F.; Hsuan, J.J.; Courtneidge, S.A.; Parker, P.J.; Waterfield, M.D.

Cell

70

419-429

640858

7544790

Osmotic loading of neutralizing antibodies demonstrates a role of protein-tyrosine phosphatase 1B in negative regulation of the insulin action pathway

1995

Ahmad, F.; Li, P.M.; Meyerovitch, J.; Goldstein, B.J.

J. Biol. Chem.

270

20503-20508

640859

10462494

Mouse Phosphoinositide 3-Kinase p110a Gene: Cloning, Structural Organization, and Localization to Chromosome 3 Band B

1999

Aksoy, I.A.; Ramsey, M.J.; Fruman, D.A.; Aksoy, S.; Cantley, L.C.; Tucker, J.D.; Roberts, T.M.

Biochem. Biophys. Res. Commun.

262

438-442

640860

12089355

Short-term leptin-dependent inhibition of hepatic gluconeogenesis is mediated by insulin receptor substrate-2

2002

Anderwald, C.; Muller, G.; Koca, G.; Furnsinn, C.; Waldhausl, W.; Roden, M.

Mol. Endocrinol.

16

1612-1628

640861

10805725

Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors

2000

Arcaro, A.; Zvelebil, M.J.; Wallasch, C.; Ullrich, A.; Waterfield, M.D.; Domin, J.

Mol. Cell. Biol.

20

3817-3830

640862

9830063

Human phosphoinositide 3-kinase C2b, the role of calcium and the C2 domain in enzyme activity

1998

Arcaro, A.; Volinia, S.; Zvelebil, M.J.; Stein, R.; Watton, S.J.; Layton, M.J.; Gout, I.; Ahmadi, K.; Downward, J.; Waterfield, M.D.

J. Biol. Chem.

273

33082-33090

640863

10748220

p110b is up-regulated during differentiation of 3T3-L1 cells and contributes to the highly insulin-responsive glucose transport activity

2000

Asano, T.; Kanda, A.; Katagiri, H.; Nawano, M.; Ogihara, T.; Inukai, K.; Anai, M.; Fukushima, Y.; Yazaki, Y.; Kikuchi, M.; Hooshmand-Rad, R.; Heldin, C.H.; Oka, Y.; Funaki, M.

J. Biol. Chem.

275

17671-17676

640864

10739672

Clustering of b2-Integrins on Human Neutrophils Activates Dual Signaling Pathways to PtdIns 3-Kinase

2000

Axelsson, L.; Hellberg, C.; Melander, F.; Smith, D.; Zheng, L.; Andersson, T.

Exp. Cell Res.

256

257-263

640865

10213474

Differential mRNA expression and subcellular locations of PI3-kinase isoforms in sympathetic and sensory neurons

1999

Bartlett, S.E.; Reynolds, A.J.; Tan, T.; Heydon, K.; Hendry, I.A.

J. Neurosci. Res.

56

44-53

640866

-

Phosphatidylinositol 3-kinase translocation to the nucleus is induced by interleukin 1 and prevented by mutation of interleukin 1 receptor in human osteosarcoma Saos-2 cells

1999

Bavelloni, A.; Santi, S.; Sirri, A.; Riccio, M.; Faenza, I.; Zini, N.; Cecchi, S.; Ferri, A.; Auron, P.; Maraldi, N.M.; Marmiroli, S.

J. Cell Sci.

112

631-640

640868

10768093

Natural variants of human p85a phosphoinositide 3-kinase in severe insulin resistance: a novel variant with impaired insulin-stimulated lipid kinase activity

2000

Baynes, K.C.R.; Beeton, C.A.; Panayotou, G.; Stein, R.; Soos, M.; Hansen, T.; Simpson, H.; O'Rahilly, S.; Shepherd, P.R.; Whitehead, J.P.

Diabetologia

43

321-331

640869

8547643

Phosphatidylinositol-3-kinase activity is required for the anti-Ig-mediated growth inhibition of a human b-lymphoma cell line

1996

Beckwith, M.; Fenton, R.G.; Katona, I.M.; Longo, D.L.

Blood

87

202-210

640870

8395981

Inhibition of the signalling enzyme phosphatidylinositol-3-kinase by antitumor ether lipid analogs

1993

Berggren, M.I.; Gallegos, A.; Dressler, L.A.; Modest, E.J.; Powis, G.

Cancer Res.

53

4297-4302

640871

10827205

A high fructose diet affects the early steps of insulin action in muscle and liver of rats

2000

Bezerra, R.M.N.; Ueno, M.; Silva, M.S.; Tavares, D.Q.; Carvalho, C.R.O.; Saad, M.J.A.

J. Nutr.

130

1531-1535

640872

11001925

Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway

2000

Blondeau, F.; Laporte, J.; Bodin, S.; Superti-Furga, G.; Payrastre, B.; Mandel, J.L.

Hum. Mol. Genet.

9

2223-2229

640873

11181519

Involvement of both phosphatidylinositol 3-kinase and p44/p42 mitogen-activated protein kinase pathways in the short-term regulation of pyruvate kinase L by insulin

2001

Carrillo, J.J.; Ibares, B.; Esteban-Gamboa, A.; Feliu, J.E.

Endocrinology

142

1057-1064

640874

11080619

Phosphatidylinositol-3-kinase activation and atypical protein kinase C z phosphorylation characterize the DMSO signaling in erythroleukemia cells

2000

Cataldi, A.; Di Pietro, R.; Centurione, L.; Grilli, A.; Cutroneo, G.; Miscia, S.

Cell. Signal.

12

667-672

640875

8396016

Characterization of insulin and insulin-like growth factor-I actions in the bovine luteal cell: Regulation of receptor tyrosine kinase activity, phosphatidylinositol 3-kinase, and deoxyribonucleic acid synthesis

1993

Chakravorty, A.; Joslyn, M.I.; Davis, J.S.

Endocrinology

133

1331-1340

640876

9235916

p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes

1997

Chantry, D.; Vojtek, A.; Kashishian, A.; Holtzman, D.A.; Wood, C.; Gray, P.W.; Cooper, J.A.; Hoekstra, M.F.

J. Biol. Chem.

272

19236-19241

640877

7520779

Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor is dependent on protein tyrosine kinase activity

1994

Dadi, H.; Ke, S.; Roifman, C.M.

Blood

84

1579-1586

640878

9920907

Phosphatidylinositol 3-kinase translocates onto liver endoplasmic reticulum and may account for the inhibition of glucose-6-phosphatase during refeeding

1999

Daniele, N.; Rajas, F.; Payrastre, B.; Mauco, G.; Zitoun, C.; Mithieux, G.

J. Biol. Chem.

274

3597-3601

640879

9111325

SIP/SHIP inhibits Xenopus oocyte maturation induced by insulin and phosphatidylinositol 3-kinase

1997

Deuter-Reinhard, M.; Apell, G.; Pot, D.; Klippel, A.; Williams, L.T.; Kavanaugh, W.M.

Mol. Cell. Biol.

17

2559-2565

640880

-

Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin

1997

Domin, J.; Pages, F.; Volinia, S.; Rittenhouse, S.E.; Zvelebil, M.J.; Stein, R.C.; Waterfield, M.D.

Biochem. J.

326

139-147

640881

8702949

Binding to the platelet-derived growth factor receptor transiently activates the p85a-p110a phosphoinositide 3-kinase complex in vivo

1996

Domin, J.; Dhand, R.; Waterfield, M.D.

J. Biol. Chem.

271

21614-21621

640882

7683666

A biosensor approach to probe the structure and function of the p85a subunit of the phosphatidylinositol 3-kinase complex

1993

End, P.; Gout, I.; Fry, M.J.; Panayotou, G.; Dhand, R.; Yonezawa, K.; Kasuga, M.; Waterfield, M.D.

J. Biol. Chem.

268

10066-10075

640883

11121098

Involvement of insulin receptor substrates in epidermal growth factor induced activation of phosphatidylinositol 3-kinase in rat hepatocyte primary culture

2001

Fujioka, T.; Ui, M.

Eur. J. Biochem.

268

25-34

640884

7713890

Cooperation of Src homology domains in the regulated binding of phosphatidylinositol 3-kinase. A role for the Src homology 2 domain

1995

Haefner, B.; Baxter, R.; Fincham, V.J.; Downes, C.P.; Frame, M.C.

J. Biol. Chem.

270

7937-7943

640885

11103797

Oleate activates phosphatidylinositol 3-kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite effects

2000

Hardy, S.; Langelier, Y.; Prentki, M.

Cancer Res.

60

6353-6358

640886

11950599

Differentiated HL-60 cells are a valid model system for the analysis of human neutrophil migration and chemotaxis

2002

Hauert, A.B.; Martinelli, S.; Marone, C.; Niggli, V.

Int. J. Biochem. Cell Biol.

34

838-854

640887

8557993

Bacterial lipopolysaccharide induces the association and coordinate activation of p53/56lyn and phosphatidylinositol 3-kinase in human monocytes

1996

Herrera-Velit, P.; Reiner, N.E.

J. Immunol.

156

1157-1165

640888

7937816

A phosphatidylinositol 3-kinase is induced during soybean nodule organogenesis and is associated with membrane proliferation

1994

Hong, Z.; Verma, D.P.S.

Proc. Natl. Acad. Sci. USA

91

9617-9621

640889

7515100

The Src-Family Kinase, Fyn, Regulates the Activation of Phosphatidylinositol 3-Kinase in an Interleukin 2-responsive T cell Line

1994

Karnitz, L.M.; Sutor, S.L.; Abraham, R.T.

J. Exp. Med.

179

1799-1808

640890

9399964

Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse

1997

Kerouz, N.J.; Horsch, D.; Pons, S.; Kahn, C.R.

J. Clin. Invest.

100

3164-3172

640891

11120660

Diversification of cardiac insulin signaling involves the p85a/b subunits of phosphatidylinositol 3-kinase

2001

Kessler, A.; Uphues, I.; Ouwens, D.M.; Till, M.; Eckel, J.

Am. J. Physiol.

280

E65-E74

640892

11574397

Insulin activates ATP-sensitive K+ channels in pancreatic b-cells through a phosphatidylinositol 3-kinase-dependent pathway

2001

Khan, F.A.; Goforth, P.B.; Zhang, M.; Satin, L.S.

Diabetes

50

2192-2198

640893

8576262

Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils

1996

Knall, C.; Young, S.; Nick, J.A.; Buhl, A.M.; Worthen, G.S.; Johnson, G.L.

J. Biol. Chem.

271

2832-2838

640894

9950886

EGF activates ErbB-2 and stimulates phosphatidylinositol 3-kinase in human airway smooth muscle cells

1999

Krymskaya, V.P.; Hoffman, R.; Eszterhas, A.; Kane, S.; Ciocca, V.; Panettieri, R.A., Jr.

Am. J. Physiol.

276

L246-L255

640895

7476306

Effect of insulin and insulin-like growth factor-I on glucose transport and its transporters in soleus muscle of lean and obese mice

1995

Le Marchand-Brustel, Y.; Heydrick, S.J.; Jullien, D.; Gautier, N.; Van Obberghen, E.

Metab. Clin. Exp.

44

18-23

640896

8648629

Crystal structure of PI3K SH3 domain at 2.0.ANG. resolution

1996

Liang, J.; Chen, J.K.; Schreiber, S.L.; Clardy, J.

J. Mol. Biol.

257

632-643

640897

9548960

Phosphoinositide 3-kinase in rat liver nuclei

1998

Lu, P.J.; Hsu, A.L.; Wang, D.S.; Yan, H.Y.; Yin, H.L.; Chen, C.S.

Biochemistry

37

5738-5745

640898

11208545

Insulin signal transduction in rat small intestine: role of MAP kinases in expression of mucosal hydrolases

2001

Marandi, S.; De Keyser, N.; Saliez, A.; Maernoudt, A.S.; Sokal, E.M.; Stilmant, C.; Rider, M.H.; Buts, J.P.

Am. J. Physiol.

280

G229-G240

640899

12101241

TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor

2002

Marshall, A.J.; Krahn, A.K.; Ma, K.; Duronio, V.; Hou, S.

Mol. Cell. Biol.

22

5479-5491

640900

11781359

Reduced expression of the murine p85a subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

2002

Mauvais-Jarvis, F.; Ueki, K.; Fruman, D.A.; Hirshman, M.F.; Sakamoto, K.; Goodyear, L.J.; Iannacone, M.; Accili, D.; Cantley, L.C.; Kahn, C.R.

J. Clin. Invest.

109

141-149

640901

8558020

Requirement for phosphatidylinositol 3'-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor

1996

Minshall, C.; Arkins, S.; Freund, G.G.; Kelley, K.W.

J. Immunol.

156

939-947

640902

11054408

Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes

2001

Miyakawa, Y.; Rojnuckarin, P.; Habib, T.; Kaushansky, K.

J. Biol. Chem.

276

2494-2502

640903

9620264

Inositide signaling in Chlamydomonas: characterization of a phosphatidylinositol 3-kinase gene

1998

Molendijk, A.J.; Irvine, R.E.

Plant Mol. Biol.

37

53-66

640904

8662856

CpK is a novel class of Drosophila PtdIns 3-kinase containing a C2 domain

1996

Molz, L.; Chen, Y.W.; Hirano, M.; Williams, L.T.

J. Biol. Chem.

271

13892-13899

640905

9642681

Convergence and divergence of the signaling pathways for insulin and phosphoinositolglycans

1998

Muller, G.; Wied, S.; Piossek, C.; Bauer, A.; Bauer, J.; Frick, W.

Mol. Med.

4

299-323

640906

11246877

Insulin resistance with enhanced insulin signaling in high-salt diet-fed rats

2001

Ogihara, T.; Asano, T.; Ando, K.; Chiba, Y.; Sekine, N.; Sakoda, H.; Anai, M.; Onishi, Y.; Fujishiro, M.; Ono, H.; Shojima, N.; Inukai, K.; Fukushima, Y.; Kikuchi, M.; Fujita, T.

Diabetes

50

573-583

640907

8106399

Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase

1994

Okada, T.; Sakuma, L.; Fukui, Y.; Hazeki, O.; Ui, M.

J. Biol. Chem.

269

3563-3567

640908

8106400

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin

1994

Okada, T.; Kawano, Y.; Sakakibara, T.; Hazeki, O.; Ui, M.

J. Biol. Chem.

269

3568-3573

640909

9774384

Functional association of platelet endothelial cell adhesion molecule-1 and phosphoinositide 3-kinase in human neutrophils

1998

Pellegatta, F.; Chierchia, S.L.; Zocchi, M.R.

J. Biol. Chem.

273

27768-27771

640910

9655291

Increased levels of phosphatidylinositol 3-kinase activity in colorectal tumors

1998

Phillips, W.A.; St.Clair, F.; Munday, A.D.; Thomas, R.J.S.; Mitchell, C.A.

Cancer

83

41-47

640911

10744689

Phosphorylation of PDE3B by phosphatidylinositol 3-kinase associated with the insulin receptor

2000

Rondinone, C.M.; Carvalho, E.; Rahn, T.; Manganiello, V.C.; Degerman, E.; Smith, U.P.

J. Biol. Chem.

275

10093-10098

640913

7895667

Insulin and dexamethasone regulate insulin receptors, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in Fao hepatoma cells

1995

Saad, M.J.A.; Folli, F.; Kahn, C.R.

Endocrinology

136

1579-1588

640914

8613966

Effects of wortmannin analogs on bone in vitro and in vivo

1996

Sato, M.; Bryant, H.U.; Dodge, J.A.; Davis, H.; Matter, W.F.; Vlahos, C.J.

J. Pharmacol. Exp. Ther.

277

543-550

640916

7624799

Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

1995

Stoyanov, B.; Volinia, S.; Hanck, T.; Rubio, I.; Loubtchenkov, M.; Malek, D.; Stoyanova, S.; Vanhaesebroeck, B.; Dhand, R.; et al.

Science

269

690-693

640917

9162050

Purification and characterization of Gbg-responsive phosphoinositide 3-kinases from pig platelet cytosol

1997

Tang, X.; Downes, C.P.

J. Biol. Chem.

272

14193-14199

640918

-

Lysophosphatidic acid stimulates glucose transport in Xenopus oocytes via a phosphatidylinositol 3'-kinase with distinct properties

1996

Thomson, F.J.; Moyes, C.; Scott, P.H.; Plevin, R.; Gould, G.W.

Biochem. J.

316

161-166

640919

11473054

Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (z/l) activities

2001

Tremblay, F.; Lavigne, C.; Jacques, H.; Marette, A.

Diabetes

50

1901-1910

640920

9876321

Insulin signaling in heart involves insulin receptor substrates-1 and -2, activation of phosphatidylinositol 3-kinase and the JAK 2-growth related pathway

1998

Velloso, L.A.; Carvalho, C.R.O.; Rojas, F.A.; Folli, F.; Saad, M.J.A.

Cardiovasc. Res.

40

96-102

640921

8663140

Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain

1996

Virbasius, J.V.; Guilherme, A.; Czech, M.P.

J. Biol. Chem.

271

13304-13307

640922

7628435

A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system

1995

Volinia, S.; Dhand, R.; Vanhaesebroeck, B.; MacDougall, L.; Stein, R.; Zvelebil, M.J.; Domin, J.; Panaretou, C.; Waterfield, M.D.

EMBO J.

14

3339-3348

640923

9738010

Insulin stimulation of the fatty acid synthase promoter is mediated by the phosphatidylinositol 3-kinase pathway. Involvement of protein kinase B/Akt

1998

Wang, D.; Sul, H.S.

J. Biol. Chem.

273

25420-25426

640924

-

Actin filaments participate in the relocalization of phosphatidylinositol 3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes

1998

Wang, Q.; Bilan, P.J.; Tsakiridis, T.; Hinek, A.; Klip, A.

Biochem. J.

331

917-928

640925

8058065

The level of insulin receptor tyrosine kinase activity modulates the activities of phosphatidylinositol 3-kinase, microtubule-associated protein, and S6 kinases

1994

Wilden, P.A.; Kahn, C.R.

Mol. Endocrinol.

8

558-567

640926

-

Phosphatidylinositol 3-kinase acts at an intracellular membrane site to enhance GLUT4 exocytosis in 3T3-L1 cells

1996

Yang, J.; Clarke, J.F.; Ester, C.J.; Young, P.W.; Kasuga, M.; Holman, G.D.

Biochem. J.

313

125-131

640927

10048588

MAP kinases, phosphatidylinositol 3-kinase, and p70 S6 kinase mediate the mitogenic response of human endothelial cells to vascular endothelial growth factor

1999

Yu, Y.; Sato, J.D.

J. Cell. Physiol.

178

235-246

640928

11591769

IL-10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate-2 and phosphatidylinositol 3'-kinase

2001

Zhou, J.H.; Broussard, S.R.; Strle, K.; Freund, G.G.; Johnson, R.W.; Dantzer, R.; Kelley, K.W.

J. Immunol.

167

4436-4442

640929

8950603

Cytoplasmic and nuclear localization sites of phosphatidylinositol 3-kinase in human osteosarcoma sensitive and multidrug-resistant Saos-2 cells

1996

Zini, N.; Ognibene, A.; Bavelloni, A.; Santi, S.; Sabatelli, P.; Baldini, N.; Scotlandi, K.; Serra, M.; Maraldi, N.M.

Histochem. Cell Biol.

106

457-464

640931

9144573

Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K

1997

Brown, R.A.; Ho, L.K.; Weber-Hall, S.J.; Shipley, J.M.; Fry, M.J.

Biochem. Biophys. Res. Commun.

233

537-544

640932

8413204

Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity

1993

Cafferkey, R.; Young, P.R.; McLaughlin, M.M.; Bergsma, D.J.; Koltin, Y.; Sathe, G.M.; Faucette, L.; Eng, W.K.; Johnson, R.K.; Livi, G.P.

Mol. Cell. Biol.

13

6012-6023

640934

10870104

A phosphatidylinositol 3-kinase of Candida albicans: molecular cloning and characterization

2000

Eck, R.; Bruckmann, A.; Wetzker, R.; Kunkel, W.

Yeast

16

933-944

640935

8186460

TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast

1994

Helliwell, S.B.; Wagner, P.; Kunz, J.; Deuter-Reinhard, M.; Henriquez, R.; Hall, M.N.

Mol. Biol. Cell

5

105-118

640936

2247081

Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae

1990

Herman, P.K.; Emr, S.D.

Mol. Cell. Biol.

10

6742-6754

640940

7772832

Phosphatidylinositol-3 kinase in fission yeast: a possible role in stress responses

1995

Kimura, K.; Miyake, S.; Makuuchi, M.; Morita, R.; Usui, T.; Yoshida, M.; Horinouchi, S.; Fukui, Y.

Biosci. Biotechnol. Biochem.

59

678-682

640941

8139567

The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity

1994

Klippel, A.; Escobedo, J.A.; Hirano, M.; Williams, L.T.

Mol. Cell. Biol.

14

2675-2685

640942

8387896

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

1993

Kunz, J.; Henriquez, R.; Schneider, U.; Deuter-Reinhard, M.; Movva, N.R.; Hall, M.N.

Cell

73

585-596

640943

8978685

The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth

1996

Leevers, S.J.; Weinkove, D.; MacDougall, L.K.; Hafen, E.; Waterfield, M.D.

EMBO J.

15

6584-6594

640944

-

Molecular cloning and biochemical characterization of a Drosophila phosphatidylinositol-specific phosphoinositide 3-kinase

1997

Linassier, C.; MacDougall, L.K.; Domin, J.; Waterfield, M.D.

Biochem. J.

321

849-856

640945

8749393

A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction

1995

MacDougall, L.K.; Domin, J.; Waterfield, M.D.

Curr. Biol.

5

1404-1415

640946

8246975

A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins

1993

McWhirter, J.R.; Galasso, D.L.; Wang, J.Y.

Mol. Cell. Biol.

13

7587-7595

640947

9514948

Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain

1998

Misawa, H.; Ohtsubo, M.; Copeland, N.G.; Gilbert, D.J.; Jenkins, N.A.; Yoshimura, A.

Biochem. Biophys. Res. Commun.

244

531-539

640949

8700226

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

1996

Morris, J.Z.; Tissenbaum, H.A.; Ruvkun, G.

Nature

382

536-539

640950

9516481

A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration

1998

Ono, F.; Nakagawa, T.; Saito, S.; Owada, Y.; Sakagami, H.; Goto, K.; Suzuki, M.; Matsuno, S.; Kondo, H.

J. Biol. Chem.

273

7731-7736

640951

12139614

Cellular responses to environmental salinity in the halophilic black yeast Hortaea werneckii

2002

Petrovic, U.; Gunde-Cimerman, N.; Plemenitas, A.

Mol. Microbiol.

45

665-672

640952

9878262

cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12

1998

Rozycka, M.; Lu, Y.J.; Brown, R.A.; Lau, M.R.; Shipley, J.M.; Fry, M.J.

Genomics

54

569-574

640953

8385367

Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting

1993

Schu, P.V.; Takegawa, K.; Fry, M.J.; Stack, J.H.; Waterfield, M.D.; Emr, S.D.

Science

260

88-91

640954

9094719

The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101

1997

Stephens, L.R.; Eguinoa, A.; Erdjument-Bromage, H.; Lui, M.; Cooke, F.; Coadwell, J.; Smrcka, A.S.; Thelen, M.; Cadwallader, K.; Tempst, P.; Hawkins, P.T.

Cell

89

105-114

640955

9043658

Cloning and mutagenesis of the p110 alpha subunit of human phosphoinositide 3'-hydroxykinase

1997

Stirdivant, S.M.; Ahern, J.; Conroy, R.R.; Barnett, S.F.; Ledder, L.M.; Oliff, A.; Heimbrook, D.C.

Bioorg. Med. Chem.

5

65-74

640957

-

Schizosaccharomyces pombe Vps34p, a phosphatidylinositol-specific PI 3-kinase essential for normal cell growth and vacuole morphology

1995

Takegawa, K.; DeWald, D.B.; Emr, S.D.

J. Cell Sci.

108

3745-3756

640959

7713498

Molecular cloning, cDNA sequence, and chromosomal localization of the human phosphatidylinositol 3-kinase p110 alpha (PIK3CA) gene

1994

Volinia, S.; Hiles, I.; Ormondroyd, E.; Nizetic, D.; Antonacci, R.; Rocchi, M.; Waterfield, M.D.

Genomics

24

472-477

640960

11096119

The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine

2001

Weisman, R.; Choder, M.

J. Biol. Chem.

276

7027-7032

640961

7972072

AtVPS34, a phosphatidylinositol 3-kinase of Arabidopsis thaliana, is an essential protein with homology to a calcium-dependent lipid binding domain

1994

Welters, P.; Takegawa, K.; Emr, S.D.; Chrispeels, M.J.

Proc. Natl. Acad. Sci. USA

91

11398-11402

640963

7565716

A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development

1995

Zhou, K.; Takegawa, K.; Emr, S.D.; Firtel, R.A.

Mol. Cell. Biol.

15

5645-5656

641768

2851325

Purification and characterization of a phosphatidylinositol kinase from A431 cells

1988

Walker, D.H.; Dougherty, N.; Pike, L.J.

Biochemistry

27

6504-6511

641769

4284712

Biosynthesis of diphosphoinositide in brain

1965

Colodzin, M.; Kennedy, E.P.

J. Biol. Chem.

240

3771-3780

641770

4290722

The phosphatidylinositol kinase of rat brain

1966

Kai, M.; White, G.L.; Hawthorne, J.N.

Biochem. J.

101

328-337

641771

1323033

Phosphatidylinositol 4-kinase and phosphatidylinositol-4-phosphate 5-kinase from bovine brain membranes

1992

Moritz, A.; Westerman, J.; De Graan, P.N.E.; Wirtz, K.W.A.

Methods Enzymol.

209

202-211

641772

-

Phosphatidylinositol and phosphatidylinositolphosphate kinases in plant plasma membranes

1988

Sommarin, M.; Sandelius, A.S.

Biochim. Biophys. Acta

958

268-278

641773

12747

Phosphatidylinositol kinase and diphosphoinositide kinase of rat kidney cortex: properties and subcellular localization

1976

Cooper, P.H.; Hawthorne, J.N.

Biochem. J.

160

97-105

641774

3037244

Phosphatidylinositol kinases from rabbit reticulocytes

1987

Tuazon, P.T.; Traugh, J.A.

Methods Enzymol.

141

210-222

641775

1323031

Phosphatidylinositol 4-kinase from yeast

1992

Carman, G.M.; Belunis, C.J.; Nickels, J.T.

Methods Enzymol.

209

183-189

641776

3002795

Polyamines stimulate the phosphorylation of phosphatidylinositol in membranes from A431 cells

1986

Vogel, S.; Hoppe, J.

Eur. J. Biochem.

154

253-257

641777

2540742

Separation and identification of two phosphatidylinositol 4-kinase activities in bovine uterus

1989

Li, Y.S.; Porter, F.D.; Hoffman, R.M.; Deuel, T.F.

Biochem. Biophys. Res. Commun.

160

202-209

641778

-

Purification and characterization of human erythrocyte phosphatidylinositol 4-kinase. Phosphatidylinositol 4-kinase and phosphatidylinositol 3-monophosphate 4-kinase are distinct enzymes

1992

Graziani, A.; Ling, L.E.; Endemann, G.; Carpenter, C.L.; Cantley, L.C.

Biochem. J.

284

39-45

641779

2177464

Inhibition of phosphatidylinositol kinase by toyocamycin

1990

Nishioka, H.; Sawa, T.; Hamada, M.; Shimura, N.; Imoto, M.; Umezawa, K.

J. Antibiot.

43

1586-1589

641780

2829907

Properties of phosphatidylinositol kinase of human platelets

1987

Suga, K.; Kambayashi, J.; Tsujinaka, T.; Sakon, M.; Mori, T.

Biochem. Int.

15

769-777

641781

8380160

Purification and characterization of a phosphatidylinositol 4-kinase activator in carrot cells

1993

Yang, W.; Bukhardt, W.; Cavallius, J.; Merrick, W.C.; Boss, W.F.

J. Biol. Chem.

268

392-398

641782

2829981

Phosphatidylinositol kinase of bovine adrenal chromaffin granules: kinetic properties and inhibition by low concentrations of Ca2+

1988

Husebye, E.S.; Flatmark, T.

Biochim. Biophys. Acta

968

261-265

641783

6311802

Membrane-associated phosphatidylinositol kinase from Saccharomyces cerevisiae

1983

McKenzie, M.A.; Carman, G.M.

J. Bacteriol.

156

421-423

641784

1331109

Purification and characterization of a soluble phosphatidylinositol 4-kinase from the yeast Saccharomyces cerevisiae

1992

Flanagan, C.A.; Thorner, J.

J. Biol. Chem.

267

24117-24125

641785

1322897

Purification, characterization, and kinetic analysis of a 55-kDa form of phosphatidylinositol 4-kinase from Saccharomyces cerevisiae

1992

Nickels, J.T.; Buxeda, R.J.; Carman, G.M.

J. Biol. Chem.

267

16297-16304

641786

2827737

Bovine brain contains two types of phosphatidylinositol kinase

1987

Endemann, G.; Dunn, S.N.; Cantley, L.C.

Biochemistry

26

6845-6852

641787

2837470

Purification and characterization of a phosphatidylinositol 4-kinase from bovine uteri

1988

Porter, F.D.; Li, Y.S.; Deuel, T.F.

J. Biol. Chem.

263

8989-8995

641788

3014004

Identification and characterization of the phosphatidylinositol kinase in membranes of murine T lymphocytes

1986

O'Shea, J.J.; Harford, J.B.; Klausner, R.D.

J. Immunol.

137

971-976

641789

6296133

Identification of phosphatidylinositol kinase in rat liver lysosomal membranes

1983

Collins, C.A.; Wells, W.W.

J. Biol. Chem.

258

2130-2134

641790

2994750

Subcellular localization and enzymatic properties of rat liver phosphatidylinositol-4-phosphate kinase

1985

Lundberg, G.A.; Jergil, B.; Sundler, R.

Biochim. Biophys. Acta

846

379-387

641791

2830904

Purification and characterization of phosphatidylinositol kinase from porcine liver microsomes

1988

Hou, W.M.; Zhang, Z.L.; Tai, H.H.

Biochim. Biophys. Acta

959

67-75

641792

3036072

Purification of phosphatidylinositol kinase from bovine brain myelin

1987

Saltiel, A.R.; Fox, J.A.; Sherline, P.; Sahyoun, N.; Cuatrecasas, P.

Biochem. J.

241

759-763

641793

195630

Properties of human erythrocyte phosphatidylinositol kinase and inhibition by adenosine, ADP and related compounds

1977

Buckley, J.T.

Biochim. Biophys. Acta

498

1-9

641794

1657176

Purification and reconstitution of phosphatidylinositol 4-kinase from human erythrocytes

1991

Jenkins, G.H.; Subrahmanyam, G.; Anderson, R.A.

Biochim. Biophys. Acta

1080

11-18

641795

1649831

Phosphatidylinositol 4-kinase from Saccharomyces cerevisiae. Kinetic analysis using Triton X-100/phosphatidylinositol-mixed micelles

1991

Buxeda, R.J.; Nickels, J.T.; Belunis, C.J.; Carman, G.M.

J. Biol. Chem.

266

13859-13865

641796

1649187

Phosphatidylinositol 4-kinase is a component of glucose transporter (GLUT 4)-containing vesicles

1991

Del Vecchio, R.L.; Pilch, P.F.

J. Biol. Chem.

266

13278-13283

641797

1652438

Purification and characterization of phosphatidylinositol 4-kinase from human erythrocyte membranes

1991

Wetzker, R.; Klinger, R.; Hsuan, J.; Fry, M.J.; Kauffmann-Zeh, A.; Müller, E.; Frunder, H.; Waterfield, M.

Eur. J. Biochem.

200

179-185

641798

1655428

Purification and chemical modification of a phosphatidylinositol kinase from sheep brain

1991

Scholz, G.; Barritt, G.J.; Kwok, F.

Eur. J. Biochem.

201

249-255

641799

2549013

Legionella micdadei protein kinase catalyzes phosphorylation of tubulin and phosphatidylinositol

1989

Saha, A.K.; Dowling, J.N.; Mukhopadhyay, N.K.; Glew, R.H.

J. Bacteriol.

171

5103-5110

641800

2155029

Purification and kinetic properties of a membrane-bound phosphatidylinositol kinase of the bovine adrenal medulla

1990

Husebye, E.S.; Letcher, A.J.; Lander, D.J.; Flatmark, T.

Biochim. Biophys. Acta

1042

330-337

641801

2171662

Partial purification and characterization of phosphatidylinositol kinases from human platelets

1990

Kanoh, H.; Banno, Y.; Hirata, M.; Nozawa, Y.

Biochim. Biophys. Acta

1046

120-126

641802

2846568

Purification and characterization of membrane-bound phosphatidylinositol kinase from rat brain

1988

Yamakawa, A.; Takenawa, T.

J. Biol. Chem.

263

17555-17560

641803

2848810

Purification and characterization of phosphatidylinositol kinase from Saccharomyces cerevisiae

1988

Belunis, C.J.; Bae-Lee, M.; Kelley, M.J.; Carman, G.M.

J. Biol. Chem.

263

18897-18903

641804

-

Manganese-stimulated phosphatidylinositol 4-kinase from Dunaliella parva: purification and characterization

1994

Steinert, P.; Wissing, J.B.; Wagner, K.G.

Plant Sci.

101

105-114

641805

-

Characterization of a nuclear phosphatidylinositol 4-kinase in carrot suspension culture cells

1999

Okpodu, C.M.

Plant Physiol. Biochem.

37

473-480

641806

12749687

Mammalian phosphatidylinositol 4-kinases

2003

Heilmeyer, L.Jr.; Vereb, G.Jr.; Vereb, G.; Kakuk, A.; Szivak, I.

IUBMB Life

55

59-65

641807

9881689

Concanavalin A modulates tyrosine phosphorylation and activation of a type II phosphatidylinositol 4-kinase in rat splenic lymphocytes

1998

Fernandis, A.Z.; Subrahmanyam, G.

Mol. Immunol.

35

935-941

641808

11277933

Human phosphatidylinositol 4-kinase isoform PI4K92. Expression of the recombinant enzyme and determination of multiple phosphorylation sites

2001

Suer, S.; Sickmann, A.; Meyer, H.E.; Herberg, F.W.; Heilmeyer, L.M., Jr.

Eur. J. Biochem.

268

2099-2106

641809

12650639

Localization of a highly active pool of type II phosphatidylinositol 4-kinase in a p97/valosin-containing-protein-rich fraction of the endoplasmic reticulum

2003

Waugh, M.G.; Minogue, S.; Anderson, J.S.; Balinger, A.; Blumenkrantz, D.; Calnan, D.P.; Cramer, R.; Hsuan, J.J.

Biochem. J.

373

57-63

641810

10799551

Characterization of recombinant phosphatidylinositol 4-kinase beta reveals auto- and heterophosphorylation of the enzyme

2000

Zhao, X.H.; Bondeva, T.; Balla, T.

J. Biol. Chem.

275

14642-14648

641811

12228376

Purification and Characterization of a Soluble Phosphatidylinositol 4-Kinase from Carrot Suspension Culture Cells

1995

Okpodu, C.M.; Gross, W.; Burkhart, W.; Boss, W.F.

Plant Physiol.

107

491-500

641812

11526106

Interaction of neuronal calcium sensor-1 (NCS-1) with phosphatidylinositol 4-kinase b stimulates lipid kinase activity and affects membrane trafficking in COS-7 cells

2001

Zhao, X.; Varnai, P.; Tuymetova, G.; Balla, A.; Toth, Z.E.; Oker-Blom, C.; Roder, J.; Jeromin, A.; Balla, T.

J. Biol. Chem.

276

40183-40189

641813

12324459

Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP

2002

Wei, Y.J.; Sun, H.Q.; Yamamoto, M.; Wlodarski, P.; Kunii, K.; Martinez, M.; Barylko, B.; Albanesi, J.P.; Yin, H.L.

J. Biol. Chem.

277

46586-46593

641814

11923287

Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments

2002

Balla, A.; Tuymetova, G.; Barshishat, M.; Geiszt, M.; Balla, T.

J. Biol. Chem.

277

20041-20050

641815

10517842

Phosphatidylinositol 4-kinase associated with spinach plasma membranes. Isolation and characterization of two distinct forms

1999

Westergren, T.; Ekblad, L.; Jergil, B.; Sommarin, M.

Plant Physiol.

121

507-516

641816

12805633

Differential regulation of two Arabidopsis type III phosphatidylinositol 4-kinase isoforms. A regulatory role for the pleckstrin homology domain

2003

Stevenson-Paulik, J.; Love, J.; Boss, W.F.

Plant Physiol.

132

1053-1064

641817

12646710

Phosphatidylinositol 4-kinase type IIalpha is responsible for the phosphatidylinositol 4-kinase activity associated with synaptic vesicles

2003

Guo, J.; Wenk, M.R.; Pellegrini, L.; Onofri, F.; Benfenati, F.; De Camilli, P.

Proc. Natl. Acad. Sci. USA

100

3995-4000

641818

10930462

Distinct roles for the yeast phosphatidylinositol 4-kinases, Stt4p and Pik1p, in secretion, cell growth, and organelle membrane dynamics

2000

Audhya, A.; Foti, M.; Emr, S.D.

Mol. Biol. Cell

11

2673-2689

641819

7723587

Linkage of reduction in 1-phosphatidylinositol 4-kinase activity and inositol 1,4,5-trisphosphate concentration in human ovarian carcinoma cells treated with quercetin

1995

Prajda, N.; Singhal, R.L.; Yeh, Y.A.; Olah, E.; Look, K.Y.; Weber, G.

Life Sci.

56

1587-1593

641820

10549154

Purification and characterization of a type II phosphatidylinositol 4-kinase from rat spleen and comparison with a PtdIns 4-kinase from lymphocytes

1999

Verghese, M.; Fernandis, A.Z.; Subrahmanyam, G.

Indian J. Biochem. Biophys.

36

1-9

641821

12700357

Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells

2003

Olsen, H.L.; Hoy, M.; Zhang, W.; Bertorello, A.M.; Bokvist, K.; Capito, K.; Efanov, A.M.; Meister, B.; Thams, P.; Yang, S.N.; Rorsman, P.; Berggren, P.O.; Gromada, J.

Proc. Natl. Acad. Sci. USA

100

5187-5192

641844

9873063

Regulation of phosphatidylinositol 4-phosphate 5-kinase from Schizosaccharomyces pombe by casein kinase I

1999

Vancurova, I.; Choi, J.H.; Lin, H.; Kuret, J.; Vancura, A.

J. Biol. Chem.

274

1147-1155

643311

6288204

Biosynthesis of CDP-diacylglycerol in hog mesenteric lymph node lymphocytes

1982

Sribney, M.; Hegadorn, C.A.

J. Biochem.

60

668-674

643323

9407135

The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content

1997

Lykidis, A.; Jackson, P.; Rock, C.O.; Jackowski, S.

J. Biol. Chem.

272

33402-33409

644187

8349610

Activation of dynamin GTPase by acidic phospholipids and endogenous rat brain vesicles

1993

Tuma, P.L.; Stachniak, M.C.; Collins, C.A.

J. Biol. Chem.

268

17240-17246

644285

7074121

CMP-dependent incorporation of [14C]Glycerol 3-phosphate into phosphatidylglycerol and phosphatidylglycerol phosphate by rabbit lung microsomes

1982

Bleasdale, J.E.; Johnston, J.M.

Biochim. Biophys. Acta

710

377-390

645028

7673171

The beta-adrenergic receptor kinase (GRK2) is regulated by phospholipids

1995

Onorato, J.J.; Gillis, M.E.; Liu, Y.; Benovic, J.L.; Ruoho, A.E.

J. Biol. Chem.

270

21346-21353

645036

12788079

TNF-alpha and leptin activate the alpha-isoform of class II phosphoinositide 3-kinase

2003

Ktori, C.; Shepherd, P.R.; O'Rourke, L.

Biochem. Biophys. Res. Commun.

306

139-143

645293

4293959

The biosynthesis of phosphatidic acid and phosphatidylinositol in mammalian pancreas

1967

Prottey, C.; Hawthorne, J.N.

Biochem. J.

105

379-392

645294

4367970

On the solubility, stability and partial purification of CDPdiacyl-sn-glycerol: inositol transferase from rat brain

1974

Rao, R.H.; Strickland, K.P.

Biochim. Biophys. Acta

348

306-314

645295

907686

Synthesis of CDP-diglyceride from phosphatidylinositol and CMP

1977

Hokin-Neaverson, M.; Sadeghian, K.; Harris, D.W.; Merrin, J.S.

Biochem. Biophys. Res. Commun.

78

364-371

645296

18462

CDP-diglyceride:inositol transferase from rat liver. Purification and properties

1977

Takenawa, T.; Egawa, K.

J. Biol. Chem.

252

5419-5423

645297

-

Properties of cytidinediphosphodiacyl-sn-glycerol:myoinositol transferase of bovine mammary tissue

1977

Wootton, J.A.; Kinsella, J.E.

Int. J. Biochem.

8

449-456

645298

16660650

Phosphatidylinositol synthesis in castor bean endosperm

1978

Sexton, J.S.; Moore, T.S.

Plant Physiol.

62

978-980

645299

41587

Characterization of the forward and reverse reactions catalyzed by CDP-diacylglycerol:inositol transferase in rabbit lung tissue

1979

Bleasdale, J.E.; Wallis, P.; MacDonald, P.C.; Johnston, J.M.

Biochim. Biophys. Acta

575

135-147

645301

16662148

Solubilization of microsomal-associated phosphatidylinositol synthase from germinating soybeans

1982

Robinson, M.L.; Carman, G.M.

Plant Physiol.

69

146-149

645302

6300035

Phosphatidylinositol biosynthesis in Saccharomyces cerevisiae: purification and properties of microsome-associated phosphatidylinositol synthase

1983

Fischl, A.S.; Carman, G.M.

J. Bacteriol.

154

304-311

645303

6093865

Phosphatidylinositol synthase from canine pancreas: solubilization by n-octyl glucopyranoside and stabilization by manganese

1984

Parries, G.S.; Hokin-Neaverson, M.

Biochemistry

23

4785-4791

645304

2579070

Inhibition of phosphatidylinositol synthase and other membrane-associated enzymes by stereoisomers of hexachlorocyclohexane

1985

Parries, G.S.; Hokin-Neaverson, M.

J. Biol. Chem.

260

2687-2693

645305

3005284

Phosphatidylinositol synthase from Saccharomyces cerevisiae. Reconstitution, characterization, and regulation of activity

1986

Fischl, A.S.; Homann, M.J.; Poole, M.A.; Carman, G.M.

J. Biol. Chem.

261

3178-3183

645306

2840949

Presence of a Ca2+-sensitive CDPdiglyceride-inositol transferase in canine cardiac sarcoplasmic reticulum

1988

Kasinathan, C.; Kirchberger, M.A.

Biochemistry

27

2834-2839

645307

2539091

Characterization of a salt-extractable phosphatidylinositol synthase from rat pituitary-tumour membranes

1989

Cubitt, A.B.; Gershengorn, M.C.

Biochem. J.

257

639-644

645308

1323046

Phosphatidylinositol synthase from yeast

1992

Carman, G.M.; Fischl, A.S.

Methods Enzymol.

209

305-312

645309

1328172

Inhibition of CDP-DG: inositol transferase by inostamycin

1992

Imoto, M.; Taniguchi, Y.; Umezawa, K.

J. Biochem.

112

299-302

645310

8385029

Characterization of reactions catalysed by yeast phosphatidylinositol synthase

1993

Klezovitch, O.; Brandenburger, Y.; Geindre, M.; Deshusses, J.

FEBS Lett.

320

256-260

645311

-

Purification and characterization of phosphatidylinositol synthase from human placenta

1994

Antonsson, B.E.

Biochem. J.

297

517-522

645312

8008017

Characterization of phosphatidylinositol synthase and evidence of a polyphosphoinositide cycle in Plasmodium-infected erythrocytes

1994

Elabbadi, N.; Ancelin, M.L.; Vial, H.J.

Mol. Biochem. Parasitol.

63

179-192

645313

-

Identification of rat liver phosphatidylinositol synthase as a 21 kDa protein

1994

Monaco, M.E.; Feldman, M.; Kleinberg, D.L.

Biochem. J.

304

301-305

645314

7696330

Compared selectivities of the phosphatidylinositol-synthase from maize coleoptiles either in microsomal membranes or after solubilization

1995

Justin, A.M.; Hmyene, A.; Kader, J.C.; Mazliak, P.

Biochim. Biophys. Acta

1255

161-166

645315

8740418

Candida albicans phosphatidylinositol synthase has common features with both Saccharomyces cerevisiae and mammalian phosphatidylinositol synthases

1996

Antonsson, B.E.; Klig, L.S.

Yeast

12

449-456

645316

9370331

Phosphatidylinositol synthase from mammalian tissues

1997

Antonsson, B.

Biochim. Biophys. Acta

1348

179-186

645318

9370330

Phosphatidylinositol synthase from yeast

1997

Nikawa, J.; Yamashita, S.

Biochim. Biophys. Acta

1348

173-178

645319

11054108

Molecular cloning, functional complementation in Saccharomyces cerevisiae and enzymatic properties of phosphatidylinositol synthase from the protozoan parasite Toxoplasma gondii

2000

Seron, K.; Dzierszinski, F.; Tomavo, S.

Eur. J. Biochem.

267

6571-6579

645320

10809447

Cloning of Arabidopsis thaliana phosphatidylinositol synthase and functional expression in the yeast pis mutant

2000

Xue, H.W.; Hosaka, K.; Plesch, G.; Mueller-Roeber, B.

Plant Mol. Biol.

42

757-764

645321

11856479

Overexpression of phosphatidylinositol synthase enhances growth and G1 progression in NIH3T3 cells

2002

Deguchi, A.; Segawa, K.; Hosaka, K.; Weinstein, I.B.; Umezawa, K.

Jpn. J. Cancer Res.

93

157-166

645322

11985617

Phosphatidylinositol synthesis and exchange of the inositol head are catalysed by the single phosphatidylinositol synthase 1 from Arabidopsis

2002

Justin, A.M.; Kader, J.C.; Collin, S.

Eur. J. Biochem.

269

2347-2352

645323

12005437

Crystal structure of inositol 1-phosphate synthase from Mycobacterium tuberculosis, a key enzyme in phosphatidylinositol synthesis

2002

Norman, R.A.; McAlister, M.S.; Murray-Rust, J.; Movahedzadeh, F.; Stoker, N.G.; McDonald, N.Q.

Structure

10

393-402

645324

-

Membrane lipid biosynthesis in Chlamydomonas reinhardtii. Partial characterization of CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase

2003

Blouin, A.; Lavezzi, T.; Moore, T.S.

Plant Physiol. Biochem.

41

11-16

645325

14563413

Synthetic capacity of Arabidopsis phosphatidylinositol synthase 1 expressed in Escherichia coli

2003

Justin, A.M.; Kader, J.C.; Collin, S.

Biochim. Biophys. Acta

1634

52-60

645351

2999154

Purification and properties of UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase. Activation and inhibition of the enzyme

1985

Kaushal, G.P.; Elbein, A.D.

J. Biol. Chem.

260

16303-16309

645354

16665105

Properties of solubilized UDP-GlcNAc:dolichyl phosphate-GlcNAc-1-P-transferase from soybean cultured cells

1986

Kaushal, G.P.; Elbein, A.D.

Plant Physiol.

82

748-752

645807

8424947

Inhibition of tyrosylprotein sulfotransferase by sphingosine and its reversal by acidic phospholipids

1993

Kasinathan, C.; Sundaram, P.; Slomiany, B.L.; Slomiany, A.

Biochemistry

32

1194-1198

646357

9200713

Interaction of smooth muscle myosin phosphatase with phospholipids

1997

Ito, M.; Feng, J.; Tsujino, S.; Inagaki, N.; Inagaki, M.; Tanaka, J.; Ichikawa, K.; Hartshorne, D.J.; Nakano, T.

Biochemistry

36

7607-7614

646448

2555336

The discovery of a 3-phosphomonoesterase that hydrolyzes phosphatidylinositol 3-phosphate in NIH 3T3 cells

1989

Lips, D.L.; Majerus, P.W.

J. Biol. Chem.

264

19911-19915

646449

1655747

Isolation and characterization of two 3-phosphatases that hydrolyze both phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate

1991

Caldwell, K.K.; Lips, D.L.; Bansal, V.S.; Majerus, P.W.

J. Biol. Chem.

266

18378-18386

646450

11504939

Characterization of an adapter subunit to a phosphatidylinositol (3)P 3-phosphatase: Identification of a myotubularin-related protein lacking catalytic activity

2001

Nandurkar, H.H.; Caldwell, K.K.; Whisstock, J.C.; Layton, M.J.; Gaudet, E.A.; Norris, F.A.; Majerus, P.W.; Mitchell, C.A.

Proc. Natl. Acad. Sci. USA

98

9499-9504

646451

12646134

Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases

2003

Schaletzky, J.; Dove, S.K.; Short, B.; Lorenzo, O.; Clague, M.J.; Barr, F.A.

Curr. Biol.

13

504-509

646486

10937880

Glycosylphosphatidylinositol-specific phospholipase D of human serum--activity modulation by naturally occurring amphiphiles

2000

Rhode, H.; Schulze, M.; Cumme, G.A.; Gohlert, A.; Blume, E.; Bublitz, R.; Schilling, K.; Horn, A.

Biol. Chem.

381

471-485

646584

2917980

Purification and characterization of an alpha-1,2-mannosidase involved in processing asparagine-linked oligosaccharides

1989

Forsee, W.T.; Palmer, C.F.; Schutzbach, J.S.

J. Biol. Chem.

264

3869-3876

648418

10446155

Characterization of two recombinant Drosophila calpains. CALPA and a novel homolog, CALPB

1999

Jekely, G.; Friedrich, P.

J. Biol. Chem.

274

23893-23900

648769

7852313

Glycan requirements of glycosylphosphatidylinositol phospholipase C from Trypanosoma brucei. Glucosaminylinositol derivatives inhibit phosphatidylinositol phospholipase C

1995

Morris, J.C.; Ping-Sheng, L.; Shen, T.Y.; Mensa-Wilmot, K.

J. Biol. Chem.

270

2517-2524

648770

8349664

Partial purification and characterization of a (glycosyl) inositol phospholipid-specific phospholipase C from peanut

1993

Butikofer, P.; Brodbeck, U.

J. Biol. Chem.

268

17794-17802

648776

8663180

Phosphatidylinositol hydrolysis by Trypanosoma brucei glycosylphosphatidylinositol phospholipase C

1996

Buetikofer, P.; Boschung, M.; Brodbeck, U.; Menon, A.K.

J. Biol. Chem.

271

15533-15541

648778

9574933

The properties and function of the glycosylphosphatidylinositol-phospholipase C in Trypanosoma brucei

1998

Carrington, M.; Carnall, N.; Crow, M.S.; Gaud, A.; Redpath, M.B.; Wasunna, C.L.; Webb, H.

Mol. Biochem. Parasitol.

91

153-164

648781

10514079

Conditional expression of glycosylphosphatidylinositol phospholipase C in Trypanosoma brucei

1999

Ochatt, C.M.; Buetikofer, P.; Navarro, M.; Wirtz, E.; Boschung, M.; Armah, D.; Cross, G.A.

Mol. Biochem. Parasitol.

103

35-48

649330

11395409

Regulation of phosphoinositide-specific phospholipase C

2001

Rhee, S.G.

Annu. Rev. Biochem.

70

281-312

649641

12440695

Glycosylphosphatidylinositol-anchored proteins: structure, function, and cleavage by phosphatidylinositol-specific phospholipase C

2002

Sharom, F.J.; Lehto, M.T.

Biochem. Cell Biol.

80

535-549

649682

-

Neutral sphingomyelinase activity dependent on Mg2+ and anionic phospholipids in the intraerythrocytic malaria parasite Plasmodium falciparum

2000

Hanada, K.; Mitamura, T.; Fukasawa, M.; Magistrado, P.A.; Horii, T.; Nishijima, M.

Biochem. J.

346

671-677

649683

10749672

Purification and characterization of secretory phospholipase B, lysophospholipase and lysophospholipase/transacylase from a virulent strain of the pathogenic fungus Cryptococcus neoformans

2000

Chen, S.C.; Wright, L.C.; Golding, J.C.; Sorrell, T.C.

Biochem. J.

347

431-439

650064

11331007

Mechanism of phosphatidylinositol-specific phospholipase C: Origin of unusually high nonbridging thio effects

2001

Kravchuk, A.V.; Zhao, L.; Kubiak, R.J.; Bruzik, K.S.; Tsai, M.D.

Biochemistry

40

5433-5439

650093

11583175

A catalytic diad involved in substrate-assisted catalysis: NMR study of hydrogen bonding and dynamics at the active site of phosphatidylinositol-specific phospholipase C

2001

Ryan, M.; Liu, T.; Dahlquist, F.W.; Griffith, O.H.

Biochemistry

40

9743-9750

650204

12600209

Engineering a catalytic metal binding site into a calcium-independent phosphatidylinositol-specific phospholipase C leads to enhanced stereoselectivity

2003

Kravchuk, A.V.; Zhao, L.; Bruzik, K.S.; Tsai, M.D.

Biochemistry

42

2422-2430

650231

12899624

Investigating the interfacial binding of bacterial phosphatidylinositol-specific phospholipase C

2003

Wehbi, H.; Feng, J.; Kolbeck, J.; Ananthanarayanan, B.; Cho, W.; Roberts, M.F.

Biochemistry

42

9374-9382

650390

12832083

Water-miscible organic cosolvents enhance phosphatidylinositol-specific phospholipase C phosphotransferase as well as phosphodiesterase activity

2003

Wehbi, H.; Feng, J.; Roberts, M.F.

Biochim. Biophys. Acta

1613

15-27

650395

12573445

Partial purification and characterization of phosphatidic acid-specific phospholipase A1 in porcine platelet membranes

2003

Miyazawa, D.; Ikemoto, A.; Fujii, Y.; Okuyama, H.

Biochim. Biophys. Acta

1631

17-25

650573

12488013

Listeria monocytogenes phosphatidylinositol-specific phospholipase C: Activation and allostery

2002

Ryan, M.; Zaikova, T.O.; Keana, J.F.W.; Goldfine, H.; Griffith, O.H.

Biophys. Chem.

101-102

347-358

650586

12719256

Allosteric interactions within subsites of a monomeric enzyme: Kinetics of fluorogenic substrates of PI-specific phospholipase C

2003

Birrell, G.B.; Zaikova, T.O.; Rukavishnikov, A.V.; Keana, J.F.W.; Griffith, O.H.

Biophys. J.

84

3264-3275

650910

10660303

Phospholipase D regulation and localization is dependent upon a phosphatidylinositol 4,5-bisphosphate-specific PH domain

2000

Hodgkin, M.N.; Masson, M.R.; Powner, D.; Saqib, K.M.; Ponting, C.P.; Wakelam, M.J.O.

Curr. Biol.

10

43-46

651281

11297746

Diacylglycerol effects on phosphatidylinositol-specific phospholipase C activity and vesicle fusion

2001

Villar, A.V.; Goni, F.M.; Alonso, A.

FEBS Lett.

494

117-120

651282

11377433

N-terminal EF-hand-like domain is required for phosphoinositide-specific phospholipase C activity in Arabidopsis thaliana

2001

Otterhag, L.; Sommarin, M.; Pical, C.

FEBS Lett.

497

165-170

651881

9593664

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1998

Maehama, T.; Dixon, J.E.

J. Biol. Chem.

273

13375-13378

652082

10692446

A novel phosphatidylinositol-phospholipase C of Trypanosoma cruzi that is lipid modified and activated during trypomastigote to amastigote differentiation

2000

Furuya, T.; Kashuba, C.; Docampo, R.; Moreno, S.N.J.

J. Biol. Chem.

275

6428-6438

652257

11912206

Role of tryptophan residues in interfacial binding of phosphatidylinositol-specific phospholipase C

2002

Feng, J.; Wehbi, H.; Roberts, M.F.

J. Biol. Chem.

277

19867-19875

652411

12714598

Optimizing the interfacial binding and activity of a bacterial phosphatidylinositol-specific phospholipase C

2003

Feng, J.; Bradley, W.D.; Roberts, M.F.

J. Biol. Chem.

278

24651-24657

652552

15155721

The catalytic role of aspartate in a short strong hydrogen bond of the Asp274-His32 catalytic dyad in phosphatidylinositol-specific phospholipase C can be substituted by a chloride-ion

2004

Zhao, L.; Liao, H; Tsai, M.D.

J. Biol. Chem.

279

31995-32000

653195

12132576

Partial purification and properties of a phosphatidylinositol 4,5-bisphosphate hydrolyzing phospholipase C from the soluble fraction of soybean sprouts

2002

Park, S.K.; Lee, J.R.; Lee, S.S.; Son, H.J.; Yoo, J.Y.; Moon, J.C.; Kwon, H.Y.; Lim, C.O.; Bahk, J.D.; Cho, M.J.; Lee, S.Y.

Mol. Cells

13

377-384

653348

10786701

Aggregated beta amyloid peptide 1-40 decreases Ca2+- and cholinergic receptor-mediated phosphoinositide degradation by alteration of membrane and cytosolic phospholipase C in brain cortex

2000

Zambrzycka, A.; Strosznajder, R.P.; Strosznajder, J.B.

Neurochem. Res.

25

189-196

653351

10905637

Regulation of phospholipase C activity by calcium ions and guanine nucleotide in the normoxic cat carotid body

2000

Strosznajder, R.P.; Pokorski, M.

Neurochem. Res.

25

739-743

657208

11051765

Molecular and cell biology of acid beta-glucosidase and prosaposin

2001

Qi, X.; Grabowski, G.A.

Prog. Nucleic Acid Res. Mol. Biol.

66

203-239

657566

15031649

Partial purification and characterization of a mannosyltransferase involved in O-linked mannosylation of glycoproteins in Candida albicans

2004

Arroyo-Flores, B.L.; Calvo-Mendez, C.; Flores-Carreon, A.; Lopez-Romero, E.

Antonie van Leeuwenhoek

85

199-207

659183

12068013

Definition of the first mannosylation step in phosphatidylinositol: Mannoside Synthesis. PimA IS essential for growth of mycobacteria

2002

Kordulakova, J.; Gilleron, M.; Mikusova, K.; Puzo, G.; Brennan, P.J.; Gicquel, B.; Jackson, M.

J. Biol. Chem.

277

31335-31344

660431

15039073

Purification and characterization of two recombinant human glucuronyltransferases involved in the biosynthesis of HNK-1 carbohydrate in Escherichia coli

2004

Kakuda, S.; Oka, S.; Kawasaki, T.

Protein Expr. Purif.

35

111-119

660449

15939292

Expression and purification of a functionally active recombinant GDP-mannosyltransferase (PimA) from Mycobacterium tuberculosis H37Rv

2005

Gu, X.; Chen, M.; Wang, Q.; Zhang, M.; Wang, B.; Wang, H.

Protein Expr. Purif.

42

47-53

660790

12413484

Phosphatidylinositol 3,5-bisphosphate: metabolism and function

2002

Cooke, F.T.

Arch. Biochem. Biophys.

407

143-151

660945

11931646

Hepatocyte growth factor activates phosphoinositide 3-kinase C2beta in renal brush-border plasma membranes

2002

Crljen, V.; Volinia, S.; Banfic, H.

Biochem. J.

365

791-799

660950

12523934

Saccharomyces cerevisiae contains a type II phosphoinositide 4-kinase

2003

Shelton, S.N.; Barylko, B.; Binns, D.D.; Horazdovsky, B.F.; Albanesi, J.P.; Goodman, J.M.

Biochem. J.

371

533-540

661041

16102733

Resveratrol inhibits type II phosphatidylinositol 4-kinase: A key component in pathways of phosphoinositide turn over

2005

Srivastava, R.; Ratheesh, A.; Gude, R.K.; Rao, K.V.K.; Panda, D.; Subrahmanyam, G.

Biochem. Pharmacol.

70

1048-1055

661892

12672472

Class I phosphoinositide 3-kinases

2003

Anderson, K.E.; Jackson, S.P.

Int. J. Biochem. Cell Biol.

35

1028-1033

662328

15634669

Distinct Golgi populations of phosphatidylinositol 4-phosphate regulated by phosphatidylinositol 4-kinases

2005

Weixel, K.M.; Blumental-Perry, A.; Watkins, S.C.; Aridor, M.; Weisz, O.A.

J. Biol. Chem.

280

10501-10508

662444

15576365

Interaction of neuronal calcium sensor-1 and ADP-ribosylation factor 1 allows bidirectional control of phosphatidylinositol 4-kinase beta and trans-Golgi network-plasma membrane traffic

2005

Haynes, L.P.; Thomas, G.M.; Burgoyne, R.D.

J. Biol. Chem.

280

6047-6054

662479

16233541

Increased alcohol acetyltransferase activity by inositol limitation in Saccharomyces cerevisiae in sake mash

2003

Furukawa, K.; Yamada, T.; Mizoguchi, H.; Hara, S.

J. Biosci. Bioeng.

96

380-386

662676

15569259

Pathophysiological concentrations of amyloid beta proteins directly inhibit rat brain and recombinant human type II phosphatidylinositol 4-kinase activity

2004

Wu, B.; Kitagawa, K.; Zhang, N.Y.; Liu, B.; Inagaki, C.

J. Neurochem.

91

1164-1170

662814

15635101

A plasma membrane pool of phosphatidylinositol 4-phosphate is generated by phosphatidylinositol 4-kinase type-III alpha: studies with the PH domains of the oxysterol binding protein and FAPP1

2005

Balla, A.; Tuymetova, G.; Tsiomenko, A.; Varnai, P.; Balla, T.

Mol. Biol. Cell

16

1282-1295

662815

15944223

Phosphatidylinositol-4-kinase type II alpha is a component of adaptor protein-3-derived vesicles

2005

Salazar, G.; Craige, B.; Wainer, B.H.; Guo, J.; De Camilli, P.; Faundez, V.

Mol. Biol. Cell

16

3692-3704

662885

15950747

FcepsilonRI cross-linking activates a type II phosphatidylinositol 4-kinase in RBL 2H3 cells

2005

Naveen, B.; Shankar, B.S.; Subrahmanyam, G.

Mol. Immunol.

42

1541-1549

664423

15717127

Head group specificity of phospholipase D isoenzymes from poppy seedlings (Papaver somniferum L.)

2005

Oblozinsky, M.; Ulbrich-Hofmann, R.; Bezakova, L.

Biotechnol. Lett.

27

181-185

667524

16288600

A Toxoplasma gondii phosphoinositide phospholipase C (TgPI-PLC) with high affinity for phosphatidylinositol

2006

Fang, J.; Marchesini, N.; Moreno, S.N.

Biochem. J.

394

417-425

670066

-

Bacterial phosphatidylinositol-specific phospholipase C as membrane-attacking agents and tools for research on GPI-anchored proteins

2004

Ikezawa, H.

J. Toxicol. Toxin Rev.

23

479-508

671183

16857245

Activation of phosphoinositide 3-kinase C2 beta in the nuclear matrix during compensatory liver growth

2006

Sindic, A.; Crljen, V.; Matkovic, K.; Lukinovic-Skudar, V.; Visnjic, D.; Banfic, H.

Adv. Enzyme Regul.

46

280-287

672504

17494916

Role of PI3-kinase and PI4-kinase in actin polymerization during bovine sperm capacitation

2007

Etkovitz, N.; Rubinstein, S.; Daniel, L.; Breitbart, H.

Biol. Reprod.

77

263-273

672858

16777618

Are class II posphoinositide 3-kinases potential targets for anticancer therapies?

2006

Traer, C.J.; Foster, F.M.; Abraham, S.M.; Fry, M.J.

Bull. Cancer

93

E53-E58

672995

17555516

Type II phosphatidylinositol 4-kinases promote Listeria monocytogenes entry into target cells

2007

Pizarro-Cerda, J.; Payrastre, B.; Wang, Y.J.; Veiga, E.; Yin, H.L.; Cossart, P.

Cell. Microbiol.

9

2381-2390

673232

17131383

Nucleolar localization of phosphatidylinositol 4-kinase PI4K230 in various mammalian cells

2006

Kakuk, A.; Friedlaender, E.; Vereb, G.; Kasa, A.; Balla, A.; Balla, T.; Heilmeyer, L.M.; Gergely, P.; Vereb, G.

Cytometry A

69

1174-1183

673414

17483288

Phosphatidylinositol 4-kinase III-beta is required for golgi maintenance and cytokinesis in Trypanosoma brucei

2007

Rodgers, M.J.; Albanesi, J.P.; Phillips, M.A.

Eukaryot. Cell

6

1108-1118

674380

16584625

Sphingosine kinase: biochemical and cellular regulation and role in disease

2006

Taha, T.A.; Hannun, Y.A.; Obeid, L.M.

J. Biochem. Mol. Biol.

39

113-131

674704

17003043

Phosphatidylinositol 4-kinase IIIbeta regulates the transport of ceramide between the endoplasmic reticulum and Golgi

2006

Toth, B.; Balla, A.; Ma, H.; Knight, Z.A.; Shokat, K.M.; Balla, T.

J. Biol. Chem.

281

36369-36377

674715

16249177

Lipid and peptide control of phosphatidylinositol 4-kinase IIalpha activity on Golgi-endosomal rafts

2006

Waugh, M.G.; Minogue, S.; Chotai, D.; Berditchevski, F.; Hsuan, J.J.

J. Biol. Chem.

281

3757-3763

674801

17379598

Arabidopsis phosphatidylinositol phosphate kinase 1 binds F-actin and recruits phosphatidylinositol 4-kinase beta1 to the actin cytoskeleton

2007

Davis, A.J.; Im, Y.J.; Dubin, J.S.; Tomer, K.B.; Boss, W.F.

J. Biol. Chem.

282

14121-14131

674864

17720810

Structural Insights into activation of phosphatidylinositol 4-kinase (Pik1) by yeast frequenin (Frq1)

2007

Strahl, T.; Huttner, I.G.; Lusin, J.D.; Osawa, M.; King, D.; Thorner, J.; Ames, J.B.

J. Biol. Chem.

282

30949-30959

674878

17088255

Binding of elongation factor eEF1A2 to phosphatidylinositol 4-kinase beta stimulates lipid kinase activity and phosphatidylinositol 4-phosphate generation

2007

Jeganathan, S.; Lee, J.M.

J. Biol. Chem.

282

372-380

675009

16522686

Gene silencing reveals a specific function of hVps34 phosphatidylinositol 3-kinase in late versus early endosomes

2006

Johnson, E.E.; Overmeyer, J.H.; Gunning, W.T.; Maltese, W.A.

J. Cell Sci.

119

1219-1232

676001

16772528

Phosphatidylinositol 4-kinase type IIalpha is targeted specifically to cellugyrin-positive glucose transporter 4 vesicles

2006

Xu, Z.; Huang, G.; Kandror, K.V.

Mol. Endocrinol.

20

2890-2897

676541

16649109

The highly charged region of plant beta-type phosphatidylinositol 4-kinase is involved in membrane targeting and phospholipid binding

2006

Lou, Y.; Ma, H.; Lin, W.H.; Chu, Z.Q.; Mueller-Roeber, B.; Xu, Z.H.; Xue, H.W.

Plant Mol. Biol.

60

729-746

676635

17496105

Phosphatidylinositol 4-kinase activation is an early response to salicylic acid in Arabidopsis suspension cells

2007

Krinke, O.; Ruelland, E.; Valentova, O.; Vergnolle, C.; Renou, J.P.; Taconnat, L.; Flemr, M.; Burketova, L.; Zachowski, A.

Plant Physiol.

144

1347-1359

677233

16793271

Phosphatidylinositol 4-kinases: old enzymes with emerging functions

2006

Balla, A.; Balla, T.

Trends Cell Biol.

16

351-361

678376

16674912

Preferable stimulation of PON1 arylesterase activity by phosphatidylcholines with unsaturated acyl chains or oxidized acyl chains at sn-2 position

2006

Nguyen, S.D.; Sok, D.E.

Biochim. Biophys. Acta

1758

499-508

678790

16495653

Purification and characterization of phospholipase B from Candida utilis

2006

Fujino, S.; Akiyama, D.; Akaboshi, S.; Fujita, T.; Watanabe, Y.; Tamai, Y.

Biosci. Biotechnol. Biochem.

70

377-386

680601

8567632

Purification and characterization of diacylglycerol pyrophosphate phosphatase from Saccharomyces cerevisiae

1996

Wu, W.I.; Liu, Y.; Riedel, B.; Wissing, J.B.; Fischl, A.S.; Carman, G.M.

J. Biol. Chem.

271

1868-1876

680790

17510062

Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria

2007

Guerin, M.E.; Kordulakova, J.; Schaeffer, F.; Svetlikova, Z.; Buschiazzo, A.; Giganti, D.; Gicquel, B.; Mikusova, K.; Jackson, M.; Alzari, P.M.

J. Biol. Chem.

282

20705-20714

681627

16602701

Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment

2006

Elortza, F.; Mohammed, S.; Bunkenborg, J.; Foster, L.J.; Nuehse, T.S.; Brodbeck, U.; Peck, S.C.; Jensen, O.N.

J. Proteome Res.

5

935-943

685820

18522757

Unique motifs identify PIG-A proteins from glycosyltransferases of the GT4 family

2008

Oswal, N.; Sahni, N.S.; Bhattacharya, A.; Komath, S.S.; Muthuswami, R.

BMC Evol. Biol.

8

168

687738

18458076

Characterization of the yeast DGK1-encoded CTP-dependent diacylglycerol kinase

2008

Han, G.S.; OHara, L.; Siniossoglou, S.; Carman, G.M.

J. Biol. Chem.

283

20443-20453

690219

18484710

Structure-based design of an Organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity

2008

Xie, P.; Williams, D.S.; Atilla-Gokcumen, G.E.; Milk, L.; Xiao, M.; Smalley, K.S.; Herlyn, M.; Meggers, E.; Marmorstein, R.

ACS Chem. Biol.

3

305-316

690911

18922025

Identification and characterization of the nuclear isoform of Drosophila melanogaster CTP:phosphocholine cytidylyltransferase

2008

Tilley, D.M.; Evans, C.R.; Larson, T.M.; Edwards, K.A.; Friesen, J.A.

Biochemistry

47

11838-11846

691015

19281241

Listeria monocytogenes phosphatidylinositol-specific phospholipase C: Kinetic activation and homing in on different interfaces

2009

Chen, W.; Goldfine, H.; Ananthanarayanan, B.; Cho, W.; Roberts, M.

Biochemistry

48

3578-3592

692257

18563288

A thermostable dolichol phosphoryl mannose synthase responsible for glycoconjugate synthesis of the hyperthermophilic archaeon Pyrococcus horikoshii

2008

Urushibata, Y.; Ebisu, S.; Matsui, I.

Extremophiles

12

665-676

693238

18812320

Phosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis

2009

Carman, G.M.; Han, G.

J. Biol. Chem.

284

2593-2597

694255

17578896

Low-dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of epidermal growth factor receptor (ERBB1)-phosphatidyl inositol 3 kinase signaling

2007

Mitchell, C.; Kabolizadeh, P.; Ryan, J.; Roberts, J.D.; Yacoub, A.; Curiel, D.T.; Fisher, P.B.; Hagan, M.P.; Farrell, N.P.; Grant, S.; Dent, P.

Mol. Pharmacol.

72

704-714

694606

19251290

Substrate specificity in phospholipid transformations by plant phospholipase D isoenzymes

2009

Dippe, M.; Ulbrich-Hofmann, R.

Phytochemistry

70

361-365

702037

19168031

A lipid binding domain in sphingosine kinase 2

2009

Don, A.S.; Rosen, H.

Biochem. Biophys. Res. Commun.

380

87-92

703326

19421754

The Aspergillus nidulans pigP gene encodes a subunit of GPI-N-acetylglucosaminyltransferase which influences filamentation and protein secretion

2009

Pilsyk, S.; Paszewski, A.

Curr. Genet.

55

301-309

703374

19465602

Down syndrome critical region protein 5 regulates membrane localization of Wnt receptors, Dishevelled stability and convergent extension in vertebrate embryos

2009

Shao, M.; Liu, Z.Z.; Wang, C.D.; Li, H.Y.; Carron, C.; Zhang, H.W.; Shi, D.L.

Development

136

2121-2131

704533

19638342

New insights into the early steps of phosphatidylinositol mannoside biosynthesis in mycobacteria: PimB is an essential enzyme of Mycobacterium smegmatis

2009

Guerin, M.E.; Kaur, D.; Somashekar, B.S.; Gibbs, S.; Gest, P.; Chatterjee, D.; Brennan, P.J.; Jackson, M.

J. Biol. Chem.

284

25687-25696

706331

20007442

Phosphoenolpyruvate carboxylase from C4 leaves is selectively targeted for inhibition by anionic phospholipids

2010

Monreal, J.; McLoughlin, F.; Echevarría, C.; García-Mauriño, S.; Testerink, C.

Plant Physiol.

152

634-638

707504

19548649

Fluorescence correlation spectroscopy of phosphatidylinositol-specific phospholipase C monitors the interplay of substrate and activator lipid binding

2009

Pu, M.; Roberts, M.F.; Gershenson, A.

Biochemistry

48

6835-6845

707877

20015408

Evidence that phosphatidylinositol 3-kinase is involved in sperm-induced tyrosine kinase signaling in Xenopus egg fertilization

2009

Mammadova, G.; Iwasaki, T.; Tokmakov, A.A.; Fukami, Y.; Sato, K.I.

BMC Dev. Biol.

9

68

708110

19715685

Effect of synthetic and natural phospholipids on N-acylphosphatidylethanolamine-hydrolyzing phospholipase D activity

2009

Petersen, G.; Pedersen, A.H.; Pickering, D.S.; Begtrup, M.; Hansen, H.S.

Chem. Phys. Lipids

162

53-61

708146

18688045

Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning

2008

Ban, K.; Cooper, A.J.; Samuel, S.; Bhatti, A.; Patel, M.; Izumo, S.; Penninger, J.M.; Backx, P.H.; Oudit, G.Y.; Tsushima, R.G.

Circ. Res.

103

643-653

708336

18403485

Distinct modes of activation of phosphatidylinositol 3-kinase in response to cyclic adenosine 3',5'-monophosphate or insulin-like growth factor I play different roles in regulation of cyclin D1 and p27Kip1 in FRTL-5 cells

2008

Fukushima, T.; Nedachi, T.; Akizawa, H.; Akahori, M.; Hakuno, F.; Takahashi, S.

Endocrinology

149

3729-3742

708568

19273082

Phosphatidylinositol 3-kinase: a key regulator in adherens junction formation and function

2009

Rivard, N.

Front. Biosci.

14

510-522

708746

19401153

Activation of phosphatidylinositol 3-kinase is required for tumor necrosis factor-alpha-induced upregulation of matrix metalloproteinase-9: its direct inhibition by quercetin

2009

Hwang, M.K.; Song, N.R.; Kang, N.J.; Lee, K.W.; Lee, H.J.

Int. J. Biochem. Cell Biol.

41

1592-1600

708996

18801733

A Trypanosoma cruzi phosphatidylinositol 3-kinase (TcVps34) is involved in osmoregulation and receptor-mediated endocytosis

2008

Schoijet, A.C.; Miranda, K.; Girard-Dias, W.; de Souza, W.; Flawia, M.M.; Torres, H.N.; Docampo, R.; Alonso, G.D.

J. Biol. Chem.

283

31541-31550

709003

19224914

Knockdown of Ron kinase inhibits mutant phosphatidylinositol 3-kinase and reduces metastasis in human colon carcinoma

2009

Wang, J.; Rajput, A.; Kan, J.L.; Rose, R.; Liu, X.Q.; Kuropatwinski, K.; Hauser, J.; Beko, A.; Dominquez, I.; Sharratt, E.A.; Brattain, L.; Levea, C.; Sun, F.L.; Keane, D.M.; Gibson, N.W.; Brattain, M.G.

J. Biol. Chem.

284

10912-10922

709019

19369255

Modulation of Bacillus thuringiensis phosphatidylinositol-specific phospholipase C activity by mutations in the putative dimerization interface

2009

Shi, X.; Shao, C.; Zhang, X.; Zambonelli, C.; Redfield, A.G.; Head, J.F.; Seaton, B.A.; Roberts, M.F.

J. Biol. Chem.

284

15607-15618

709207

18288489

Additive effects of PI3-kinase and MAPK activities on NB4 cell granulocyte differentiation: potential role of phosphatidylinositol 3-kinase gamma

2008

Scholl, S.; Bondeva, T.; Liu, Y.; Clement, J.H.; Hoeffken, K.; Wetzker, R.

J. Cancer Res. Clin. Oncol.

134

861-872

716165

20668164

Intracellular phospholipase A1 and acyltransferase, which are involved in Caenorhabditis elegans stem cell divisions, determine the sn-1 fatty acyl chain of phosphatidylinositol

2010

Imae, R.; Inoue, T.; Kimura, M.; Kanamori, T.; Tomioka, N.H.; Kage-Nakadai, E.; Mitani, S.; Arai, H.

Mol. Biol. Cell

21

3114-3124

719899

20843801

Acceptor substrate discrimination in phosphatidyl-myo-inositol mannoside synthesis: structural and mutational analysis of mannosyltransferase Corynebacterium glutamicum PimB

2010

Batt, S.M.; Jabeen, T.; Mishra, A.K.; Veerapen, N.; Krumbach, K.; Eggeling, L.; Besra, G.S.; Fuetterer, K.

J. Biol. Chem.

285

37741-37752

721555

22885339

The role of phosphatidylinositol 4-kinases and phosphatidylinositol 4-phosphate during viral replication

2012

Delang, L.; Paeshuyse, J.; Neyts, J.

Biochem. Pharmacol.

84

1400-1408

721713

21601653

Genetic and functional studies of phosphatidyl-inositol 4-kinase type IIIalpha

2011

Szentpetery, Z.; Szakacs, G.; Bojjireddy, N.; Tai, A.W.; Balla, T.

Biochim. Biophys. Acta

1811

476-483

721967

22750097

Phosphatidylinositol 4-kinases, phosphatidylinositol 4-phosphate and cancer

2012

Waugh, M.G.

Cancer Lett.

325

125-131

722098

22791894

Type II phosphatidylinositol 4-kinase regulates trafficking of secretory granule proteins in Drosophila

2012

Burgess, J.; Del Bel, L.M.; Ma, C.I.; Barylko, B.; Polevoy, G.; Rollins, J.; Albanesi, J.P.; Kraemer, H.; Brill, J.A.

Development

139

3040-3050

722121

23146885

Phosphatidylinositol 4-kinase IIalpha function at endosomes is regulated by the ubiquitin ligase Itch

2012

Moessinger, J.; Wieffer, M.; Krause, E.; Freund, C.; Gerth, F.; Krauss, M.; Haucke, V.

EMBO Rep.

13

1087-1094

722857

20530568

The phosphatidylinositol 4-kinase PI4KIIIalpha is required for the recruitment of GBF1 to Golgi membranes

2010

Dumaresq-Doiron, K.; Savard, M.F.; Akam, S.; Costantino, S.; Lefrancois, S.

J. Cell Sci.

123

2273-2280

723072

21697487

Hepatitis C virus stimulates the phosphatidylinositol 4-kinase III alpha-dependent phosphatidylinositol 4-phosphate production that is essential for its replication

2011

Berger, K.L.; Kelly, S.M.; Jordan, T.X.; Tartell, M.A.; Randall, G.

J. Virol.

85

8870-8883

723136

20881054

Oxysterol binding protein-dependent activation of sphingomyelin synthesis in the Golgi apparatus requires phosphatidylinositol 4-kinase IIalpha

2010

Banerji, S.; Ngo, M.; Lane, C.F.; Robinson, C.A.; Minogue, S.; Ridgway, N.D.

Mol. Biol. Cell

21

4141-4150

723140

22298425

GPI-anchor synthesis is indispensable for the germline development of the nematode Caenorhabditis elegans

2012

Murata, D.; Nomura, K.H.; Dejima, K.; Mizuguchi, S.; Kawasaki, N.; Matsuishi-Nakajima, Y.; Ito, S.; Gengyo-Ando, K.; Kage-Nakadai, E.; Mitani, S.; Nomura, K.

Mol. Biol. Cell

23

982-995

723392

22318862

Arabidopsis type-III phosphatidylinositol 4-kinases beta1 and beta2 are upstream of the phospholipase C pathway triggered by cold exposure

2012

Delage, E.; Ruelland, E.; Guillas, I.; Zachowski, A.; Puyaubert, J.

Plant Cell Physiol.

53

565-576

723609

22412376

Metabolism of phosphatidylinositol 4-kinase IIIalpha-dependent PI4P is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity

2012

Bianco, A.; Reghellin, V.; Donnici, L.; Fenu, S.; Alvarez, R.; Baruffa, C.; Peri, F.; Pagani, M.; Abrignani, S.; Neddermann, P.; De Francesco, R.

PLoS Pathog.

8

e1002576

723790

22633842

Phosphatidylinositol 4-kinases: hostages harnessed to build panviral replication platforms

2012

Altan-Bonnet, N.; Balla, T.

Trends Biochem. Sci.

37

293-302

723791

21282087

Coordination of Golgi functions by phosphatidylinositol 4-kinases

2011

Graham, T.R.; Burd, C.G.

Trends Cell Biol.

21

113-121

727905

22057268

Identification of gene encoding Plasmodium knowlesi phosphatidylserine decarboxylase by genetic complementation in yeast and characterization of in vitro maturation of encoded enzyme

2012

Choi, J.Y.; Augagneur, Y.; Ben Mamoun, C.; Voelker, D.R.

J. Biol. Chem.

287

222-232

729401

23332071

Does changing the predicted dynamics of a phospholipase C alter activity and membrane binding?

2013

Cheng, J.; Karri, S.; Grauffel, C.; Wang, F.; Reuter, N.; Roberts, M.F.; Wintrode, P.L.; Gershenson, A.

Biophys. J.

104

185-195

729728

22673525

Regulation of lipid biosynthesis by phosphatidylinositol-specific phospholipase C through the transcriptional repression of upstream activating sequence inositol containing genes

2012

Rupwate, S.D.; Rupwate, P.S.; Rajasekharan, R.

FEBS Lett.

586

1555-1560

729893

23506313

Cation-pi interactions as lipid-specific anchors for phosphatidylinositol-specific phospholipase C

2013

Grauffel, C.; Yang, B.; He, T.; Roberts, M.F.; Gershenson, A.; Reuter, N.

J. Am. Chem. Soc.

135

5740-5750

730009

23457299

The Legionella pneumophila Dot/Icm-secreted effector PlcC/CegC1 together with PlcA and PlcB promotes virulence and belongs to a novel zinc metallophospholipase C family present in bacteria and fungi

2013

Aurass, P.; Schlegel, M.; Metwally, O.; Harding, C.R.; Schroeder, G.N.; Frankel, G.; Flieger, A.

J. Biol. Chem.

288

11080-11092

731293

22452743

Allosteric activation of the phosphoinositide phosphatase Sac1 by anionic phospholipids

2012

Zhong, S.; Hsu, F.; Stefan, C.J.; Wu, X.; Patel, A.; Cosgrove, M.S.; Mao, Y.

Biochemistry

51

3170-3177

735573

25792450

Roles of acyl-CoA:diacylglycerol acyltransferases 1 and 2 in triacylglycerol synthesis and secretion in primary hepatocytes

2015

Li, C.; Li, L.; Lian, J.; Watts, R.; Nelson, R.; Goodwin, B.; Lehner, R.

Arterioscler. Thromb. Vasc. Biol.

35

1080-1091

736462

24356967

First step of glycosylphosphatidylinositol (GPI) biosynthesis cross-talks with ergosterol biosynthesis and Ras signaling in Candida albicans

2014

Yadav, B.; Bhatnagar, S.; Ahmad, M.F.; Jain, P.; Pratyusha, V.A.; Kumar, P.; Komath, S.S.

J. Biol. Chem.

289

3365-3382

737350

26143926

The high-resolution crystal structure of phosphatidylinositol 4-kinase IIbeta and the crystal structure of phosphatidylinositol 4-kinase IIalpha containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design

2015

Klima, M.; Baumlova, A.; Chalupska, D.; Hrebabecky, H.; Dejmek, M.; Nencka, R.; Boura, E.

Acta Crystallogr. Sect. D

71

1555-1563

737701

25375833

Distinct properties of the two isoforms of CDP-diacylglycerol synthase

2014

DSouza, K.; Kim, Y.J.; Balla, T.; Epand, R.M.

Biochemistry

53

7358-7367

737789

23619705

Type II phosphatidylinositol 4-kinase beta is an integral signaling component of early T cell activation mechanisms

2013

Sinha, R.K.; Bojjireddy, N.; Kulkarni, D.; Ratheesh, A.; Chiplunkar, S.V.; Gude, R.; Subrahmanyam, G.

Biochimie

95

1560-1566

738109

25168678

The crystal structure of the phosphatidylinositol 4-kinase IIalpha

2014

Baumlova, A.; Chalupska, D.; Rozycki, B.; Jovic, M.; Wisniewski, E.; Klima, M.; Dubankova, A.; Kloer, D.P.; Nencka, R.; Balla, T.; Boura, E.

EMBO Rep.

15

1085-1092

738465

26825532

Distinct requirements for vacuolar protein sorting 34 downstream effector phosphatidylinositol 3-phosphate 5-kinase in podocytes versus proximal tubular cells

2016

Venkatareddy, M.; Verma, R.; Kalinowski, A.; Patel, S.R.; Shisheva, A.; Garg, P.

J. Am. Soc. Nephrol.

27

2702-2719

738845

26885694

Design and structural characterization of potent and selective inhibitors of phosphatidylinositol 4 kinase IIIbeta

2016

Rutaganira, F.U.; Fowler, M.L.; McPhail, J.A.; Gelman, M.A.; Nguyen, K.; Xiong, A.; Dornan, G.L.; Tavshanjian, B.; Glenn, J.S.; Shokat, K.M.; Burke, J.E.

J. Med. Chem.

59

1830-1839

738939

24920820

Mapping of functional domains of the lipid kinase phosphatidylinositol 4-kinase type III alpha involved in enzymatic activity and hepatitis C virus replication

2014

Harak, C.; Radujkovic, D.; Taveneau, C.; Reiss, S.; Klein, R.; Bressanelli, S.; Lohmann, V.

J. Virol.

88

9909-9926

739027

26493613

Phosphatidylinositol kinase activities in Trypanosoma cruzi epimastigotes

2015

Gimenez, A.M.; Gesumaria, M.C.; Schoijet, A.C.; Alonso, G.D.; Flawia, M.M.; Racagni, G.E.; Machado, E.E.

Mol. Biochem. Parasitol.

203

14-24

739030

23676666

The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIalpha

2013

Ryder, P.V.; Vistein, R.; Gokhale, A.; Seaman, M.N.; Puthenveedu, M.A.; Faundez, V.

Mol. Biol. Cell

24

2269-2284

739359

26739232

Phosphatidylinositol 3-kinase promotes activation and vacuolar acidification and delays methyl jasmonate-induced leaf senescence

2016

Liu, J.; Ji, Y.; Zhou, J.; Xing, D.

Plant Physiol.

170

1714-1731

749960

26825689

Biochemical characterization of the tomato phosphatidylinositol-specific phospholipase C (PI-PLC) family and its role in plant immunity

2016

Abd-El-Haliem, A.M.; Vossen, J.H.; van Zeijl, A.; Dezhsetan, S.; Testerink, C.; Seidl, M.F.; Beck, M.; Strutt, J.; Robatzek, S.; Joosten, M.H.A.J.

Biochim. Biophys. Acta

1861

1365-1378

750062

25863059

End-product diacylglycerol enhances the activity of PI-PLC through changes in membrane domain structure

2015

Ahyayauch, H.; Sot, J.; Collado, M.I.; Huarte, N.; Requejo-Isidro, J.; Alonso, A.; Goni, F.M.

Biophys. J.

108

1672-1682

750911

25517221

Quantifying transient interactions between Bacillus phosphatidylinositol-specific phospholipase-C and phosphatidylcholine-rich vesicles

2015

Yang, B.; Pu, M.; Khan, H.; Friedman, L.; Reuter, N.; Roberts, M.; Gershenson, A.

J. Am. Chem. Soc.

137

14-17

751022

18812320

Phosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis

2009

Carman, G.M.; Han, G.S.

J. Biol. Chem.

284

2593-2597

751269

28097830

Plant phosphatidylinositol-specific phospholipase C at the center of plant innate immunity

2017

Abd-El-Haliem, A.M.; Joosten, M.H.

J. Integr. Plant Biol.

59

164-179

751277

30530634

Fat-regulating phosphatidic acid phosphatase a review of its roles and regulation in lipid homeostasis

2019

Carman, G.M.; Han, G.S.

J. Lipid Res.

60

2-6

752502

10681333

Inhibition of inositol phosphorylceramide synthase by aureobasidin A in Candida and Aspergillus species

2000

Zhong, W.; Jeffries, M.W.; Georgopapadakou, N.H.

Antimicrob. Agents Chemother.

44

651-653

752503

19047657

Inhibition of inositol phosphorylceramide synthase by the cyclic peptide aureobasidin A

2009

Aeed, P.A.; Young, C.L.; Nagiec, M.M.; Elhammer, A.P.

Antimicrob. Agents Chemother.

53

496-504

752588

12941304

Complex sphingolipid synthesis in plants Characterization of inositolphosphorylceramide synthase activity in bean microsomes

2003

Bromley, P.; Li, Y.; Murphy, S.; Sumner, C.; Lynch, D.

Arch. Biochem. Biophys.

417

219-226

752745

15222759

Effect of membrane perturbants on the activity and phase distribution of inositol phosphorylceramide synthase; development of a novel assay

2004

Aeed, P.A.; Sperry, A.E.; Young, C.L.; Nagiec, M.M.; Elhammer, A.P.

Biochemistry

43

8483-8493

754049

9368028

Synthesis of mannose-(inositol-P)2-ceramide, the major sphingolipid in Saccharomyces cerevisiae, requires the IPT1 (YDR072c) gene

1997

Dickson, R.; Nagiec, E.; Wells, G.; Nagiec, M.; Lester, R.

J. Biol. Chem.

272

29620-29625

754674

10888667

Inositol phosphorylceramide synthase is located in the Golgi apparatus of Saccharomyces cerevisiae

2000

Levine, T.P.; Wiggins, C.A.; Munro, S.

Mol. Biol. Cell

11

2267-2281

754973

21267500

Exploring Leishmania major inositol phosphorylceramide synthase (LmjIPCS) insights into the ceramide binding domain

2011

Mina, J.G.; Mosely, J.A.; Ali, H.Z.; Denny, P.W.; Steel, P.G.

Org. Biomol. Chem.

9

1823-1830

758569

28605587

Allosteric Regulation of Phosphatidylinositol 4-Kinase III Beta by an Antipicornavirus Compound MDL-860

2017

Arita, M.; Dobrikov, G.; Puerstinger, G.; Galabov, A.S.

ACS Infect. Dis.

3

585-594

758572

32966036

Structural Basis for Inhibitor Potency and Selectivity of Plasmodium falciparum Phosphatidylinositol 4-kinase Inhibitors

2020

Fienberg, S.; Eyermann, C.J.; Arendse, L.; Basarab, G.S.; McPhail, J.; Burke, J.E.; Chibale, K.

ACS Infect. Dis.

6

3048-3063

758648

31250883

Identification of salicylic acid-independent responses in an Arabidopsis phosphatidylinositol 4-kinase beta double mutant

2020

Kalachova, T.; Janda, M.; Sasek, V.; Ortmannova, J.; Novakova, P.; Dobrev, I.P.; Kravets, V.; Guivarch, A.; Moura, D.; Burketova, L.; Valentova, O.; Ruelland, E.

Ann. Bot.

125

775-784

758711

29362862

The development of an in vitro Pig-a assay in L5178Y cells

2018

David, R.; Talbot, E.; Allen, B.; Wilson, A.; Arshad, U.; Doherty, A.

Arch. Toxicol.

92

1609-1623

758830

32543181

Heterologous expression, purification, and functional analysis of the Plasmodium falciparum phosphatidylinositol 4-kinase IIIbeta

2020

Sternberg, A.R.; Roepe, P.D.

Biochemistry

59

2494-2506

758912

27090557

Purine analogs as phosphatidylinositol 4-kinase IIIbeta inhibitors

2016

Sala, M.; Koegler, M.; Plackova, P.; Mejdrova, I.; Hrebabecky, H.; Prochazkova, E.; Strunin, D.; Lee, G.; Birkus, G.; Weber, J.; Mertlikova-Kaiserova, H.; Nencka, R.

Bioorg. Med. Chem. Lett.

26

2706-2712

759061

30095206

Crystal structure of PigA a prolyl thioester-oxidizing enzyme in prodigiosin biosynthesis

2019

Lee, C.C.; Ko, T.P.; Chen, C.T.; Chan, Y.T.; Lo, S.Y.; Chang, J.Y.; Chen, Y.W.; Chung, T.F.; Hsieh, H.J.; Hsiao, C.D.; Wang, A.H.

ChemBioChem

20

193-202

759276

28507556

Differential effects of phosphatidylinositol 4-kinase (PI4K) and 3-kinase (PI3K) Inhibitors on stomatal responses to environmental signals

2017

Takahashi, S.; Monda, K.; Higaki, T.; Hashimoto-Sugimoto, M.; Negi, J.; Hasezawa, S.; Iba, K.

Front. Plant Sci.

8

677

759289

32800918

The type II phosphoinositide 4-kinase FgLsb6 is important for the development and virulence of Fusarium graminearum

2020

Chen, L.; Zhang, L.; Mei, X.; Wang, C.; Guo, Z.; Li, L.; Li, B.; Liang, Y.; Zou, S.; Dong, H.

Fungal Genet. Biol.

144

103443

759489

29907567

Ras signaling activates glycosylphosphatidylinositol (GPI) anchor biosynthesis via the GPI-N-acetylglucosaminyltransferase (GPI-GnT) in Candida albicans

2018

Jain, P.; Sethi, S.C.; Pratyusha, V.A.; Garai, P.; Naqvi, N.; Singh, S.; Pawar, K.; Puri, N.; Komath, S.S.

J. Biol. Chem.

293

12222-12238

759586

32418222

Novel defect in phosphatidylinositol 4-kinase type 2-alpha (PI4K2A) at the membrane-enzyme interface is associated with metabolic cutis laxa

2020

Mohamed, M.; Gardeitchik, T.; Balasubramaniam, S.; Guerrero-Castillo, S.; Dalloyaux, D.; van Kraaij, S.; Venselaar, H.; Hoischen, A.; Urban, Z.; Brandt, U.; Al-Shawi, R.; Simons, J.P.; Frison, M.; Ngu, L.H.; Callewaert, B.; Spelbrink, H.; Kallemeijn, W.W.; Aerts, J.M.F.G.; Waugh, M.G.; Morava, E.; We, W.e.v.

J. Inherit. Metab. Dis.

43

1382-1391

759590

30626625

A large scale high-throughput screen identifies chemical inhibitors of phosphatidylinositol 4-kinase type II alpha

2019

Sengupta, N.; Jovic, M.; Barnaeva, E.; Kim, D.W.; Hu, X.; Southall, N.; Dejmek, M.; Mejdrova, I.; Nencka, R.; Baumlova, A.; Chalupska, D.; Boura, E.; Ferrer, M.; Marugan, J.; Balla, T.

J. Lipid Res.

60

683-693

759597

28004945

Rational design of novel highly potent and selective phosphatidylinositol 4-kinase IIIbeta (PI4KB) inhibitors as broad-spectrum antiviral agents and tools for chemical biology

2017

Mejdrova, I.; Chalupska, D.; Plackova, P.; Mueller, C.; Sala, M.; Klima, M.; Baumlova, A.; Hrebabecky, H.; Prochazkova, E.; Dejmek, M.; Strunin, D.; Weber, J.; Lee, G.; Matousova, M.; Mertlikova-Kaiserova, H.; Ziebuhr, J.; Birkus, G.; Boura, E.; Nencka, R.

J. Med. Chem.

60

100-118

759607

29889526

Identification, characterization, and optimization of 2,8-disubstituted-1,5-naphthyridines as novel Plasmodium falciparum phosphatidylinositol-4-kinase inhibitors with in vivo efficacy in a humanized mouse model of malaria

2018

Kandepedu, N.; Gonzalez Cabrera, D.; Eedubilli, S.; Taylor, D.; Brunschwig, C.; Gibhard, L.; Njoroge, M.; Lawrence, N.; Paquet, T.; Eyermann, C.J.; Spangenberg, T.; Basarab, G.S.; Street, L.J.; Chibale, K.

J. Med. Chem.

61

5692-5703

759678

28864297

Structural analysis of phosphatidylinositol 4-kinase IIIbeta (PI4KB) - 14-3-3 protein complex reveals internal flexibility and explains 14-3-3 mediated protection from degradation in vitro

2017

Chalupska, D.; Eisenreichova, A.; Rozycki, B.; Rezabkova, L.; Humpolickova, J.; Klima, M.; Boura, E.

J. Struct. Biol.

200

36-44

759752

27798239

Phosphatidylinositol 4-kinase IIbeta negatively regulates invadopodia formation and suppresses an invasive cellular phenotype

2016

Alli-Balogun, G.O.; Gewinner, C.A.; Jacobs, R.; Kriston-Vizi, J.; Waugh, M.G.; Minogue, S.

Mol. Biol. Cell

27

4033-4042

759796

31475785

Nicotiana benthamiana phosphatidylinositol 4-kinase type II regulates chilli leaf curl virus pathogenesis

2019

Mansi, H.; Kushwaha, N.K.; Singh, A.K.; Karim, M.J.; Chakraborty, S.

Mol. Plant Pathol.

20

1408-1424

760009

27529511

Arabidopsis type II phosphatidylinositol 4-kinase PI4Kgamma5 regulates auxin biosynthesis and leaf margin development through interacting with membrane-bound transcription factor ANAC078

2016

Tang, Y.; Zhao, C.Y.; Tan, S.T.; Xue, H.W.

PLoS Genet.

12

e1006252

760068

28289207

Conserved role for Gga proteins in phosphatidylinositol 4-kinase localization to the trans-Golgi network

2017

Daboussi, L.; Costaguta, G.; Ghukasyan, R.; Payne, G.S.

Proc. Natl. Acad. Sci. USA

114

3433-3438

760073

33109721

Phosphatidylinositol-4-kinase IIalpha licenses phagosomes for TLR4 signaling and MHC-II presentation in dendritic cells

2020

Lopez-Haber, C.; Levin-Konigsberg, R.; Zhu, Y.; Bi-Karchin, J.; Balla, T.; Grinstein, S.; Marks, M.S.; Mantegazza, A.R.

Proc. Natl. Acad. Sci. USA

117

28251-28262

760185

30679637

Phosphatidylinositol 4-kinase IIIbeta (PI4KB) forms highly flexible heterocomplexes that include ACBD3, 14-3-3, and Rab11 proteins

2019

Chalupska, D.; Rozycki, B.; Humpolickova, J.; Faltova, L.; Klima, M.; Boura, E.

Sci. Rep.

9

567

760521

27470591

The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34

2016

Backer, J.M.

Biochem. J.

473

2251-2271

760595

30221923

The spastic paraplegia-associated phospholipase DDHD1 is a primary brain phosphatidylinositol lipase

2018

Inloes, J.M.; Jing, H.; Cravatt, B.F.

Biochemistry

57

5759-5767

760661

27935849

The class III phosphatidylinositol 3-kinase Vps34 in Saccharomyces cerevisiae

2017

Reidick, C.; Boutouja, F.; Platta, H.W.

Biol. Chem.

398

677-685

761792

32546622

Risk1, a phosphatidylinositol 3-kinase effector, promotes Rickettsia typhi intracellular survival

2020

Voss, O.H.; Gillespie, J.J.; Lehman, S.S.; Rennoll, S.A.; Beier-Sexton, M.; Rahman, M.S.; Azad, A.F.

mBio

11

e00820-20

761826

32632809

Subcellular Localization of PI3P in Arabidopsis

2020

Lee, H.N.; Jung, H.; Chung, T.

Methods Mol. Biol.

2177

109-118

762179

26906642

A pivotal role of phosphatidylinositol 3-kinase in delaying of methyl jasmonate-induced leaf senescence

2016

Liu, J.; Zhou, J.; Xing, D.

Plant Signal. Behav.

11

e1147642