Ligand diosmetin

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Basic Ligand Information

Molecular Structure
Picture of diosmetin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C16H12O6
diosmetin
MBNGWHIJMBWFHU-UHFFFAOYSA-N
Synonyms:
5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
UDP-glucose + diosmetin = UDP + diosmetin 7-O-beta-D-glucoside
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
diosmin + H2O = diosmetin + rutinose
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibits by 83%
-
i.e. 3',5,7-trihydroxy-4'-methoxyflavone, more than 90% inhibition at 0.006 mM
-
competitive, 50% inhibition at 0.00013 mM
-
IC50: 0.0048 mM, PDB2; IC50: 0.0144 mM, PDB1
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IC50: 0.015 mM, PDB5
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IC50: 0.0202 mM, PDE4
-
a flavone, 0.888 mM, pH 6.0, room temperature, 19.2% maximum inhibition
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
1.6
-
pH 7.5, 30°C, with UDP-glucose, recombinant enzyme

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.04327
-
pH 7.5, 30°C, with UDP-glucose, recombinant enzyme

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0026
-
-
0.00012
-
pH 7.5, 25°C

IC50 Value (6 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0057
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C
0.0076
-
25°C, pH 7.4, cell lysate
0.015
-
IC50: 0.015 mM, PDB5
0.0202
-
IC50: 0.0202 mM, PDE4

References & Links

Links to other databases for diosmetin

ChEBI
PubChem
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PubChem