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1 mM, complete inhibition
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0.03 mM, complete inhibition of methyl viologen reduction
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0.1 mM, complete inhibition of methyl viologen reduction
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decrease of enzyme mRNA level together with heme oxygenase-1 and glutathione S-transferase Ya
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0.001 mM, 62% inhibition, 10 mM nitrilotriacetic acid does not protect
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during the metabolism of Cr VI, glutathione reductase activity is inhibited
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GRd activity is markedly inhibited during the reduction of Cr (VI)
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hexavalent chromium causes pronounced inhibition of TrxR, the inhibition of TrxR is not reversed by removal of residual Cr6+ or by NADPH. In cells treated with 0.025 or 0.050 mM Cr6+ for 90 min, TrxR activity is inhibited by 71 and 77%, respectively, while after 180 min of the same treatments, TrxR is inhibited by 97 and 85%, respectively
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58% inhibition at 10 mg/l
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as Na2CrO4, induces clonogenic lethality
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80.9% residual activity at 1 mM
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CrVI, a heavy metal endocrine-disrupting chemical industrially widely used, gestational exposure to CrVI increases germ cell/oocyte apoptosis and advance germ cell nest (GCN) breakdown. CrVI increases X-prolyl aminopeptidase (Xpnpep) 2 (a marker for premature ovarian failure in humans) during germ cell nest (GCN) breakdown, it decreases Xpnpep2 during postnatal follicle development, and increases colocalization of Xpnpep2 with collagens Col3 and Col4. Phenotype, overview
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Heavy metal-induced inhibition of Aspergillus niger nitrate reductase: applications for rapid contaminant detection in aqueous samples
2003
Aiken, A.M.; Peyton, B.M.; Apel, W.A.; Petersen, J.N.
Anal. Chim. Acta
480
131-142
Hydrogenases in sulfate-reducing bacteria function as chromate reductase
2003
Chardin, B.; Giudici-Orticoni, M.T.; De Luca, G.; Guigliarelli, B.; Bruschi, M.
Appl. Microbiol. Biotechnol.
63
315-321
Adenylyl cyclase activity and its modulation in the gills of Mytilus galloprovincialis exposed to Cr6+ and Cu2+
2006
Fabbri, E.; Capuzzo, A.
Aquat. Toxicol.
76
59-68
Ascorbic acid differentially modulates the induction of heme oxygenase-1, NAD(P)H:quinone oxidoreductase 1 and glutathione S-transferase Ya by As(3+), Cd(2+) and Cr(6+)
2007
Elbekai, R.H.; Duke, J.; El-Kadi, A.O.
Cancer Lett.
246
54-62
Cr(VI) inhibits DNA, RNA and protein syntheses in hepatocytes: involvement of glutathione reductase, reduced glutathione and DT-diaphorase
2008
Gunaratnam, M.; Grant, M.H.
Toxicol. In Vitro
22
879-886
The interaction of chromium (VI) with macrophages: depletion of glutathione and inhibition of glutathione reductase
2007
Lalaouni, A.; Henderson, C.; Kupper, C.; Grant, M.H.
Toxicology
236
76-81
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Enzymatic recovery of platinum (IV) from industrial wastewater using a biosulphidogenic hydrogenase
2008
Rashamuse, K.; Mutambanengwe, C.; Whiteley, C.
Afr. J. Biotechnol.
7
1087-1095
Bypass of hexavalent chromium-induced growth arrest by a protein tyrosine phosphatase inhibitor: enhanced survival and mutagenesis
2009
Bae, D.; Camilli, T.C.; Chun, G.; Lal, M.; Wright, K.; OBrien, T.J.; Patierno, S.R.; Ceryak, S.
Mutat. Res.
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The effects of hexavalent chromium on thioredoxin reductase and peroxiredoxins in human bronchial epithelial cells
2009
Myers, J.M.; Myers, C.R.
Free Radic. Biol. Med.
47
1477-1485
Heterologous expression and characterization of a novel chitinase (ChiEn1) from Coprinopsis cinerea and its synergism in the degradation of chitin
2017
Niu, X.; Zhou, J.S.; Wang, Y.X.; Liu, C.C.; Liu, Z.H.; Yuan, S.
J. Agric. Food Chem.
65
6943-6956
Purification and biochemical characterisation of acid phosphatase-I from seeds of Nelumbo nucifera
2016
Khan, S.; Khan, S.; Batool, S.; Ahmed, M.
Nat. Prod. Res.
30
570-573
Identifying a novel role for X-prolyl aminopeptidase (Xpnpep) 2 in CrVI-induced adverse effects on germ cell nest breakdown and follicle development in rats
2015
Banu, S.K.; Stanley, J.A.; Sivakumar, K.K.; Arosh, J.A.; Barhoumi, R.; Burghardt, R.C.
Biol. Reprod.
92
67
Inhibitory effect of metals on animal and plant glutathione transferases
2020
Dobritzsch, D.; Grancharov, K.; Hermsen, C.; Krauss, G.J.; Schaumloeffel, D.
J. Trace Elem. Med. Biol.
57
48-56
Novel biochemical properties and physiological role of the flavin mononucleotide oxidoreductase YhdA from Bacillus subtilis
2020
Valenzuela-Garcia, L.I.; Zapata, B.L.; Ramirez-Ramirez, N.; Huchin-Mian, J.P.; Robleto, E.A.; Ayala-Garcia, V.M.; Pedraza-Reyes, M.
Appl. Environ. Microbiol.
86
e1688-20
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