Ligand nebularine

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Basic Ligand Information

Molecular Structure
Picture of nebularine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H12N4O4
nebularine
MRWXACSTFXYYMV-FDDDBJFASA-N
Synonyms:
9-(beta-D-ribofuranosyl)purine, 9-beta-D-ribofuranosylpurine, 9-[beta-D-ribofuranosyl]-purine, 9-[beta-D-ribofuranosyl]purine, a purine nucleoside, N-D-ribosylpurine, N-ribosylpurine, purine D-ribonucleosides, purine nucleoside, purine ribonucleoside, purineriboside, purine riboside
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
purine ribonucleoside + phosphate = purine + alpha-D-ribose 1-phosphate
show the reaction diagram
-
N-ribosylpurine + H2O = purine + D-ribose
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + 9-[beta-D-ribofuranosyl]-purine = ADP + 9-[beta-D-ribofuranosyl]-purine 5'-phosphate
show the reaction diagram
-
4-nitrophenyl phosphate + 9-(beta-D-ribofuranosyl)purine = 4-nitrophenol + 9-(beta-D-ribofuranosyl)purine 5'-phosphate
show the reaction diagram
-
purine riboside + H2O = purine + D-ribose
show the reaction diagram
-
purine riboside + H2O = purine + D-ribose
show the reaction diagram
-
nebularine + homocysteine = ?
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
10 min perfusion of the pre-ischemic heart or incubation of cardiomyocytes with 0.2 mM purine riboside results in activation of AMPD
-

Inhibitor in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.1 mM, 10-90% inhibition
-
competitive inhibition of deamination of adenosine 3'-phenylphosphonate
-
prolonged exposure (60 min) to purine riboside results in AMPD inhibition
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i.e. nebularin
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3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (7 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.78
-
pH 5.8, 25C
0.78
-
-

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.49
-
-

References & Links

Links to other databases for nebularine

ChEBI
PubChem
ChEBI
PubChem