Ligand bradykinin

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Basic Ligand Information

Molecular Structure
Picture of bradykinin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C50H73N15O11
bradykinin
QXZGBUJJYSLZLT-FDISYFBBSA-N
Synonyms:
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg, n-bradykinin, RPPGFSPFR

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (22 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
bradykinin + H2O = ?
show the reaction diagram
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bradykinin + H2O = ?
show the reaction diagram
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bradykinin + H2O = ?
show the reaction diagram
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bradykinin + H2O = ?
show the reaction diagram
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Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O = Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + arginine
show the reaction diagram
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bradykinin + H2O = ?
show the reaction diagram
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bradykinin + H2O = ?
show the reaction diagram
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bradykinin + H2O = ?
show the reaction diagram
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bradykinin + H2O = ?
show the reaction diagram
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bradykinin + H2O = fragments of bradykinin
show the reaction diagram
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bradykinin + H2O = ?
show the reaction diagram
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bradykinin + H2O = ?
show the reaction diagram
-
bradykinin + H2O = ?
show the reaction diagram
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bradykinin + H2O = ?
show the reaction diagram
-
bradykinin + H2O = ?
show the reaction diagram
-
bradykinin + H2O = ?
show the reaction diagram
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bradykinin + H2O = Arg-Pro-Pro-Gly-Phe-Ser-Pro + Phe-Arg
show the reaction diagram
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ATP + H2O + bradykinin/out = ADP + phosphate + bradykinin/in
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (18 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
kallidin + H2O = Leu + bradykinin
show the reaction diagram
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Met-Lys-bradykinin + H2O = Met + Lys + bradykinin
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-
-
high molecular weight kininogen profactor + H2O = activated kininogen + bradykinin
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high molecular weight kininogen + H2O = Met-Lys-bradykinin + Lys-bradykinin + bradykinin + ?
show the reaction diagram
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-
ATP + H2O + bradykinin/out = ADP + phosphate + bradykinin/in
show the reaction diagram
-
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Substrate in Enzyme-catalyzed Reactions (68 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
bradykinin + 2-oxoglutarate + O2 = 4-hydroxyproline containing bradykinin
show the reaction diagram
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bradykinin + H2O = ?
show the reaction diagram
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RPPGFSPFR + H2O = Arg + PPGF + SPFR
show the reaction diagram
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bradykinin + H2O = ?
show the reaction diagram
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Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O = Arg + Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
show the reaction diagram
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Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O = Arg-Pro-Pro + Gly-Phe-Ser-Pro-Phe-Arg
show the reaction diagram
-
bradykinin + H2O = ?
show the reaction diagram
-
bradykinin + H2O = ?
show the reaction diagram
-
bradykinin + H2O = Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + Arg
show the reaction diagram
-
bradykinin + H2O = ?
show the reaction diagram
-
bradykinin + H2O = ?
show the reaction diagram
-
bradykinin + H2O = fragments of bradykinin
show the reaction diagram
-
bradykinin + H2O = fragments of bradykinin
show the reaction diagram
-
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O = Arg-Pro-Pro-Gly-Phe-Ser-Pro + Phe-Arg
show the reaction diagram
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bradykinin + H2O = Arg-Pro-Pro-Gly-Phe + Ser-Pro-Phe-Arg
show the reaction diagram
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bradykinin + H2O = ?
show the reaction diagram
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bradykinin + H2O = ?
show the reaction diagram
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RPPGFSPFR + H2O = RPPG + FSPFR
show the reaction diagram
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bradykinin + H2O = ?
show the reaction diagram
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bradykinin + H2O = ?
show the reaction diagram
-
bradykinin + H2O = ?
show the reaction diagram
-
bradykinin + H2O = ?
show the reaction diagram
-
bradykinin + H2O = ?
show the reaction diagram
-
bradykinin + H2O = ?
show the reaction diagram
-
bradykinin + H2O = ?
show the reaction diagram
-
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O = Arg-Pro-Pro-Gly-Phe-Ser-Pro + Phe-Arg
show the reaction diagram
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bradykinin + H2O = 9-citrulline bradykinin + NH3
show the reaction diagram
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ATP + H2O + bradykinin/out = ADP + phosphate + bradykinin/in
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (33 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
kallidin + H2O = Leu + bradykinin
show the reaction diagram
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Met-Lys-bradykinin + H2O = Met + Lys + bradykinin
show the reaction diagram
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Met-Lys-bradykinin + H2O = Met + Lys + bradykinin
show the reaction diagram
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kallidin + H2O = Lys + bradykinin
show the reaction diagram
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high molecular weight kininogen + H2O = Met-Lys-bradykinin + Lys-bradykinin + bradykinin + ?
show the reaction diagram
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ATP + H2O + bradykinin/out = ADP + phosphate + bradykinin/in
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
endothelium-dependent vasodilator that stimulates the release of t-PA. Causes a dose-dependent increase in plasma t-PA antigen and activity concentrations in the infused arm of both pregnant and non-pregnant women. The increase in t-PA activity is greater in the nonpregnant women. Bradykinin increases the net release of t-PA antigen and activity in both pregnant women and non-pregnant women. Both net release of active t-PA and plasma t-PA/plasminogen activator inhibitor type 1 ratios are markedly reduced in pregnant women
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Inhibitor in Enzyme-catalyzed Reactions (21 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
prevents caspase-3 activation in neurons
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mixed competitive-noncompetitive
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negative modulator
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (51 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
121
-
-
33.8
-
-
11
-
pH 7.5, 37°C
2.5
-
37°C

KM Value (57 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
10
-
-
4.2
-
pH 7.3, 37°C
0.041
-
-
0.00104
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pH 7.5, 37°C
0.0000654
-
-
0.047
-
-

Ki Value (7 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0094
-
-
0.000001278
-
-
0.162
-
hydrolysis of Leu5-enkephalin
0.00536
-
inhibition of hydrolysis of 7-methoxycoumarin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl)
0.00811
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inhibition of hydrolysis of 7-methoxycoumarin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl)

IC50 Value (3 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.007
-
IC50: 0.007 mM, degradation by EC 3.4.24.15

References & Links

Links to other databases for bradykinin

ChEBI
PubChem
ChEBI
PubChem