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Ligand a 3-oxo acid

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.8.3.5

succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA

695186, 672216, 690880, 694193, 737365

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Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Substrate (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.8.3.5

succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA

695186, 672216, 690880, 694193, 737365, 762068

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Enzyme Kinetic Parameters

References & Links

Literature References (7)

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Show Reference (7 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

672216

17718512

Identification of the cysteine residue exposed by the conformational change in pig heart succinyl-CoA:3-ketoacid coenzyme A transferase on binding coenzyme A

2007

Tammam, S.D.; Rochet, J.C.; Fraser, M.E.

Biochemistry

46

10852-10863

690880

17685555

Nitration of tryptophan 372 in succinyl-CoA:3-ketoacid CoA transferase during aging in rat heart mitochondria

2007

Rebrin, I.; Bregere, C.; Kamzalov, S.; Gallaher, T.K.; Sohal, R.S.

Biochemistry

46

10130-10144

694193

17706444

Identification and characterization of a temperature-sensitive R268H mutation in the human succinyl-CoA:3-ketoacid CoA transferase (SCOT) gene

2007

Fukao, T.; Kursula, P.; Owen, E.P.; Kondo, N.

Mol. Genet. Metab.

92

216-221

695186

18648183

Liver-specific silencing of the human gene encoding succinyl-CoA: 3-ketoacid CoA transferase

2008

Orii, K.E.; Fukao, T.; Song, X.Q.; Mitchell, G.A.; Kondo, N.

Tohoku J. Exp. Med.

215

227-236

737365

24100554

Structure of succinyl-CoA:3-ketoacid CoA transferase from Drosophila melanogaster

2013

Zhang, M.; Xu, H.Y.; Wang, Y.C.; Shi, Z.B.; Zhang, N.N.

Acta Crystallogr. Sect. F

69

1089-1093

762068

29434981

3-Oxoacid CoA transferase 1 as a therapeutic target gene for cisplatin-resistant ovarian cancer

2018

Yang, S.D.; Ahn, S.H.; Kim, J.I.

Oncol. Lett.

15

2611-2618

762068

29434981

3-Oxoacid CoA transferase 1 as a therapeutic target gene for cisplatin-resistant ovarian cancer

2018

Yang, S.D.; Ahn, S.H.; Kim, J.I.

Oncol. Lett.

15

2611-2618

762068

2 entries

Links to other databases for a 3-oxo acid

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Show Links (1 entry)